I have been following you since day one and have been amazed at the continuous improvement of your content and the width of information. Matt Kaeberlein is an outstanding scientist, whom I have been admiring for years. Congratulations for having him on and for the immensely informative discussion!👍
My anecdotal story: I'm a 60 year old male in Palm Springs, CA. I started taking NR(NAD precursor) about 6 months ago. I dropped from 240 pounds to 190 pounds and have kept the weight down, but bounce up and down with about an 5 pound variation. I believe the benefit of NR was to stimulate my exercise program which is basically 1 hr walk in the morning, 1 hr walk in the evening, plus intermittent gym based light weight lifting on machines. I have also tried variants of fasting, but have found that a 5 day water fast consuming only water and green tea works extremely well from a psychology point of view. Once I get past the first 24 hr fast, then the next 4 days are much easier because my appetite is suppressed. I'm taking NR during the fast. Also, started watching Dr. Stanfield about the same time I started the NR regimen(began with 300 mg per day, but now take 600 mg per day). The youtube support from Brad and others is invaluable. Thank you for helping everyone.
Not sure how green tea fits into all that fasting. EGCG has been shown to increase senescence. Not what something one should aim for if one is over 60 .
Fascinating interview. Well done! I'm impressed that you're chasing the 'truth' not following the herd or chasing the $$$. I'm a 53yr old active male taking NR and Hardys Daily Essentials Micronutrients. I'm NZ based so would be interested in your Rapamycin trial if you're doing it locally Brad.
Brad, thank you for a thorough and thoughtful interview. This helped shed some light on the state of the research today and what we might want to try now as opposed to wait for more data. Excellent!
Finally, a definitive interview about resveratrol. For me, its time to close the chapter on it. Also, there was always something wrong about Dr Sinclair's impish smile, like he knew something that we don't, so now, we know it too.
Wow, that was uttmost helpful. So glad to see real experts talking (nonjournalists) so that the general public gets a true image of what is really going on inbetween the shiny finy marketing predictions made by companies (and sadly also scientsits for getting publicity) Thank you Brad, your is one of the best and trustful channels here on youtube.
Such channels always got a lot of vested interest. People who share similar views are interviewed. A truly impartial channel must interview all contrasting views
Thank you very much for the time stamps Brad . So apart from D3 and a.one time use of rapamycin which worked for him, he does not take any other supplements ☺️
Thanks Dr Brad and Dr Matt. I also learn that we have to honestly find out what works and what doesn't, when it works and when it doesn't. Be happy to know when there's a good finding that disproves our beliefs. Our beliefs are not the reality. The map is not the territory. It's very important to do reality check consistently in any discipline, and advices.
I really appreciate your willingness to host knowledgeable people who provide their understanding of the literature even when it might contradict “ conventional dogma”. Thanks for the pursuit of truth and for the effort that you put into educating those like me who are fascinated and interested in this new field of science.
This was super interesting. The best was the last minute. I love it when a scientist gets excited about anecdotal evidence. Makes me want to try rapamycin.
57:04 "Nobody has shown yet that you can do partial reprogramming in an old mouse and actually restore youthful function...", except David Sinclair's lab did a year ago.....the study was titled "Reprogramming to recover youthful epigenetic information and restore vision" and it was published in Nature. The lead author was Yuancheng Lu. How could he have missed that? "...or increase lifespan" - In order to do this you would have to deliver the gene therapy to an old mouse's failing internal organs. The concept is pretty sound, however, the required biological engineering to accomplish it remains to be worked out. That is why Sinclair's lab started with the eye, because it is a complex organ that can be accessed without cutting open the animal. I have to wonder, for a guy whose next big study is the effect of intermittent fasting on canines, why he feels the need to throw so much shade at people's work.
Exactly my thoughts as well… He was throwing in a shade without saying David Sinclair’s name. I listen to this video to get more insight on the updated findings on rapamycin supplementation; to add with David Sinclair’s research findings.
Great interview… I’ve been taking 1g NMN per day for 6 months with 30g olive oil. No discernible difference in resting HR; HR variability; sleep quality; body weight or FTP (cycling)… Still taking it though because I’m a sucker for an expensive placaebo
See, this is great. We need more videos like this. I think that my presence is not appreciated on several RUclips channels because I question David Sinclair's veracity and contributions to the field of anti-ageing. I know he likes attention and publicity, and that he is making A LOT of money at something. (Lab experimentation doesn't pay that well.) I have read through hundreds of papers (I am a chemist, but involved in art restoration) and do not find evidence for the life extending protocols that Sinclair promotes.
After seeing Sinclair using a youth enhancing filter, I'm not such a huge fan either. Anyway, with your research what do you think is the best way forward regarding longevity?
@@Pluvo2for1 Right now I usually refer people to the work of Valter Longo. He's a solid and sincere researcher who doesn't make outrageous claims. Periodic fasts or employing fast mimicking (Prolon or water fasting) for 5 days about 3x a year looks promising. A plant-based Mediterranean-type diet comes out at the top for good health, limiting protein intake and employing moderate IF (12-14 hours daily) to reduce mTOR, moderate alcohol consumption (1-2 glasses of red wine,) and moderate daily exercise - these are your best bets right now and dovetails with rapamycin research which looks promising. Also, do not look to purchase rapamycin - this needs to be researched more. Taking rapamycin unregulated can be dangerous. Make sure you get enough vitamin D + K and try to de-stress. Dr. Brad is doing some good work here. I'm impressed (and that's saying a lot. I've never been impressed with David Sinclair.) Feel free to ask any questions, Pluvo2for1. 🌹
@@Pluvo2for1 Right now I usually refer people to the work of Valter Longo. He's a solid and sincere researcher who doesn't make outrageous claims. Periodic fasts or employing fast mimicking (Prolon or water fasting) for 5 days about 3x a year looks promising. A plant-based Mediterranean-type diet comes out at the top for good health, limiting protein intake and employing moderate IF (12-14 hours daily) to reduce mTOR, moderate alcohol consumption (1-2 glasses of red wine,) and moderate daily exercise - these are your best bets right now and dovetails with rapamycin research which looks promising. Also, do not look to purchase rapamycin - this needs to be researched more. Taking rapamycin unregulated can be dangerous. Make sure you get enough vitamin D + K and try to de-stress. Dr. Brad is doing some good work here. I'm impressed (and that's saying a lot. I've never been impressed with David Sinclair.) Feel free to ask any questions, Pluvo2for1. 🌹
I have an anecdotal feeling that my very low biological age is mainly due to High Intensity Resistance Training 3-4 times a week over 45 years. I think it ultimately protects the immune system, stimulates hypertrophy (age 70 at 70kg and bench 100kg) and improves lactic acid utilisation through the cori cycle...
Fascinating and exciting interview! I was very surprised to hear that some people don’t or might not respond well to caloric restriction based on their genetics. I haven’t found any discussions about this online yet…I thought caloric restriction was nearly universal for most/all organisms for either extending lifespan or improving health. Can you or anyone in the comments section here clarify?
This guy may not agree with David Sinclair in many ways. But being over 50 years old, he shares one uncommon trait with David Sinclair, which everyone can tell. This is the most telling message I get from the long video.
He didn't specifically address fasting as a way to block mTOR aside from just calorie restriction. Do we have any data showing that fasting blocks MTOR as well as rapamycin? I'm thinking that his once a week rapamycin dose could be mimicked by weekend fasting? Any thoughts?
Great interview with a top tier researcher. My only disappointment is that I haven't seen anyone ask Matt about his opinion on young blood research compared to all the things you discussed.
I had a similar experience with a rotator cuff tendinopathy. After 9 months of pain, two cortisone shots and a couple of months of physical therapy it was still inflamed and not healing. I'm a biologist, so I hit the books on tendinopathy. Then I took fisetin for 4 days to kill senescent inflammatory cells and followed up by stacking collegen peptides, AKG and vitamin C (to build new collagen) and curcumin (to repress residual inflammation). The tendinopathy disappeared in less than three weeks and in two weeks more I had my range of motion back.
@@PakistanIcecream000 It was an integrated systems level approach - fisetin to stop the collagen destructive senescent SASP and the collagen stack to help remodel the damage. If I had to guess, I'd say fisetin was the more important, but the rest were synergetic.
44:44 I (and my 88yo mother) improved memory from the global anti-inflammatory supplement, PEA ( Palmitoylethanolamide ), taking 400mg morning and night, and quality sleep, along with healthy KETO diet (it has been shown to reduce amyloid plaque). It took about 4 weeks to start getting results (faster with 2 hours of HBOT @ 1.3 ATA every few days for 2 weeks).
Thanks Brad, great interview! Really curious about the results of the mentioned dog paper, although I have a feeling it'll lean towards time restricted feeding being beneficial
Nice video. A small question: Does it make sense on restday afternoons when i take berberin, to reduce my leucin rich proteins, to not interfere with mtor reducing effect of berberin? Or wouldnt it really matter?
Thanks for the great video! It would also be interesting to learn what people can do now. Especially when you are 70 or 80 years old and don't have so much time to wait for well-founded study results and established therapies... of course every year that you gain can decide if you reach age escape velocity … The question for me is always: what is applicable without major risks and of course no "snakeoil"
Being too sceptical is as useless as not being sceptical at all. He spent most of the interview negating pretty much everything, and the little research information he did have, he decided to withhold anyway. Don't forget about the power of placebo Mr Kaeberlein.
18:01 1. feeling mentally sharp is very different from actually being mentally sharp. you feel sharp on lower carb, bc of increased stress hormone concentrations (impaired mental ability across the board compared to moderate to high carb) 2. feeling physically sharp is very different from actually being physically sharp (low carb decreases work capacity, relative perceived intensity for the same intensity increase on low carb, motor unit recruitment decrease on low/lower carb ,which in turn lowers the potency of any working set done in the gym for a given movement) ......
finally someone is doing a study on rapamycin, eh? it's about tiiiiiime. thank goodness. and thank you! Cuz no one else seems to care I guess? Peter Attia and others have been talkin about rapalogs for years now I think. And he and Matt have said - few side effects, safe, and very good early results. gotta keep this video on my to watch later list so I can find it again. (I did watch the whole thing but I don't wanna lose this.)
Another amazing and informative video. Dr. Brad, Is it benefecial to be on metformin and rapamycin silmultaenously? Is there a overlap in benefits since the both inbihit Mtor? Or would you suggest cycle them in instead?
Rapamycin half life depends on type. Sirolimus half life is longer, ~60 hrs. Also depends if we are referring to terminal half life (~80hrs) or elimination half life, as Sirolimus' curve is parabolic as it drops sharply, at least pertaining to blood concentration likely due to cell entry. Everolimus has a much shorter half life.
1:15:37 An interesting comparison would be Rapamycin verses Metforman vs. 1-3 days of fasting. It could be that fasting provides the most benefit with AMPK activation (and with no side affects).
Glycans are a really interesting measure of biological ageing. In addition, it would be interesting to cross check with methylation. I'm in the process of checking this out on myself. I'll report back when I get the results.
Great interview! Matt was talking about taking rapamycin once per week at a certain “medium” dose, what would that be? Also, is getting rapamycin through an overseas lab safe?
Great and “ontnuchterend” (putting un back on the ground) are these words from Dr. Kaeberlein. A confident speaker. I have spend 2 months taking in 500mg of Resveratrol, can’t say I became Superman. Because I also started watching my diet and sugarintake, I feel better. I also take NMN, 1 gram per day. I must say (anecdotal) that my endurance has improved by around 20% without doing any workouts. I know because I did weekly self assessments. I have been watching RUclipsrs citing clinical human trials with NMN that did show improvements. I am therefore puzzled by what Dr. Kauberlein says here.
There is several key points to this presentation however I will narrow it down to this question 2017 NIH paper, Towards natural mimetics of metformin and rapamycin. Does metformin, berberine still fall in the mtor agonist category?
This is not my first time that I write comments which are only thanks to Dr Brad for his efforts to help us understand science or questions relating to scientific publications, nothing else, to my surprise they all disappear completely. Weird. Anyway Thank You
Can you talk about the subject of hormone replacement and if its good or bad to do when get older and if the synthetic hormones are as good as the natural.hormones or if there are side effects and reasons why taking them comes with riscs of side effects?
NMN for some reason gives me a very pleasant feeling. And with a growing number of studies coming out showing benefit I’m not concerned about what these two think about it.
Great discussion. I'm thinking of adding Rapamycin to my regimen. I'm already taking Metformin. Can the two be taken together safely? I'm seeing conflicting information, some saying it is safe some saying it isn't. Is anyone here taking both? Thanks in advance.
NADA precursers: 1. Has anybody duplicated Sinclair increasing mice lifespan by 25%? 2. Has anybody done any tests--on skin, muscle tissue, bone tissue, blood cells--to see whether NR or NMN supplements are getting past the liver to these tissues. And, if not, what's the delay? 3. Seems to me if we indeed can show NAD decreases with aging(any actual proof?), that #2 above would be easy to do.
My. Wife’s perimenopause was reversed rapidly with 3mg of Rapamycin (Sirolimus) per 10 days. Also, her HHT (a bleeding disorder) was ameliorated about 80%. For your study, seeing if women’s perimenopause could be reversed would be a quick and clear clinical endpoint.
@@PakistanIcecream000 No, it wasn’t prescribed to her. I read that Rapamycin may help with her HHT blood disorder, and I was already taking it for longevity and had some I’d ordered from India. So she started.
It's always alerting when c. elegans is used as a model organism for aging research. C. elegans has a programmed aging mechanism because it is evoltionary beneficial for them (limited number of descendants, very limited amount of resources, so it is beneficial to die when maxiaml number of descendants is reached). So it is realtively easy to slow down nematode's aging: all you need is to break the aging program (e.g. mutations in daf-2 and age-1 genes increase their lifespan 10-fold). That's why I always sceptical about results on c. elegans
Does rapamycin restore mtor sensitivity similar to keto for insulin resistance ? We always assume more is better but i feel the right amount at the right time and sufficient sensitivity would be wiser? Insulin is great but clearly we overuse it. Perhaps same for mtor?
I have been following you since day one and have been amazed at the continuous improvement of your content and the width of information. Matt Kaeberlein is an outstanding scientist, whom I have been admiring for years. Congratulations for having him on and for the immensely informative discussion!👍
Thanks for your support
My anecdotal story: I'm a 60 year old male in Palm Springs, CA. I started taking NR(NAD precursor) about 6 months ago. I dropped from 240 pounds to 190 pounds and have kept the weight down, but bounce up and down with about an 5 pound variation. I believe the benefit of NR was to stimulate my exercise program which is basically 1 hr walk in the morning, 1 hr walk in the evening, plus intermittent gym based light weight lifting on machines. I have also tried variants of fasting, but have found that a 5 day water fast consuming only water and green tea works extremely well from a psychology point of view. Once I get past the first 24 hr fast, then the next 4 days are much easier because my appetite is suppressed. I'm taking NR during the fast. Also, started watching Dr. Stanfield about the same time I started the NR regimen(began with 300 mg per day, but now take 600 mg per day). The youtube support from Brad and others is invaluable. Thank you for helping everyone.
You’re a legend, great job
You are a rockstar William ! Great to read ur message ! On On !!
Not sure how green tea fits into all that fasting. EGCG has been shown to increase senescence. Not what something one should aim for if one is over 60 .
@@DrBradStanfield sir whats your take on green tea? Does that increases senasense or is it good for anti-ageing?
@@shambhaveemishra9842 The concept of a natural substance increase senescence is per si mind-blowing
A whole new field of research may come from this
Wow! A true Scientist that is unbiased! This is the best interviews ever by a scientist that gives facts instead of hype!
this has officially became my fav youtube channel, pure logic, str8 to the point, great job dude!!!!
Love how straightforward this guy is.
Fascinating interview. Well done! I'm impressed that you're chasing the 'truth' not following the herd or chasing the $$$.
I'm a 53yr old active male taking NR and Hardys Daily Essentials Micronutrients. I'm NZ based so would be interested in your Rapamycin trial if you're doing it locally Brad.
Do you also take Resveratrol? When your personal take on Resveratrol?
wow what a great interview. shows how far we are from significant results w all the hype behind expensive supplements
Brad, thank you for a thorough and thoughtful interview. This helped shed some light on the state of the research today and what we might want to try now as opposed to wait for more data. Excellent!
Great interview Brad!
Finally, a definitive interview about resveratrol. For me, its time to close the chapter on it. Also, there was always something wrong about Dr Sinclair's impish smile, like he knew something that we don't, so now, we know it too.
This was one of the most valuable videos I've ever seen.
Wow, that was uttmost helpful.
So glad to see real experts talking (nonjournalists) so that the general public gets a true image of what is really going on inbetween the shiny finy marketing predictions made by companies (and sadly also scientsits for getting publicity)
Thank you Brad, your is one of the best and trustful channels here on youtube.
Didn't Sinclair demonstrate epigenetic reprogramming in the mouse retina study
I've just discovered your channel and love it. I'm binge watching because your content is excellent.
Informative. One of the best and most down-to-earth conversations on this topic. Thank you.
Hello Dr Brad: Are you going to change your supplement stack?
Such channels always got a lot of vested interest. People who share similar views are interviewed. A truly impartial channel must interview all contrasting views
Thank you very much for the time stamps Brad . So apart from D3 and a.one time use of rapamycin which worked for him, he does not take any other supplements ☺️
I’ve been following Professor Matt Kaeberlein for a while.
Thanks Dr Brad and Dr Matt. I also learn that we have to honestly find out what works and what doesn't, when it works and when it doesn't.
Be happy to know when there's a good finding that disproves our beliefs.
Our beliefs are not the reality. The map is not the territory.
It's very important to do reality check consistently in any discipline, and advices.
Watched the full interview in full, was really informative. Please, keep it up, we really need an objective view on aging research as you provide!
Amazing interview Dr Brad!! Keep the good work in 2022. Congratulations and long live
When the dog data publishes it would be great if you could review it for us and share your opinion!
Definitely
I started losing muscle and lost 60% strength in the gym, was wondering why, then I read about resveratrol impacting exercise.
Great episode! Subheading could be”Tell me Dr Sinclair is a hypeman, without telling me he’s a hypeman.”
🤣
😬🙄
@@LeslieAlysonLawrence Sinclair talks and talks and is not giving any thing new i mean any good research for the last few years 😬
@@shambhaveemishra9842 true. At this point, it looks like he’s just a PR guy.
I warned of Sinclair over a decade ago! He was written off back then , but he appears to have a revival by new people interested in this field
awesome job with the timestamping Brad. Thanks!
I really appreciate your willingness to host knowledgeable people who provide their understanding of the literature even when it might contradict “ conventional dogma”. Thanks for the pursuit of truth and for the effort that you put into educating those like me who are fascinated and interested in this new field of science.
Whether you agree or disagree with him, this is one sharp dude.
This was super interesting. The best was the last minute. I love it when a scientist gets excited about anecdotal evidence. Makes me want to try rapamycin.
57:04 "Nobody has shown yet that you can do partial reprogramming in an old mouse and actually restore youthful function...", except David Sinclair's lab did a year ago.....the study was titled "Reprogramming to recover youthful epigenetic information and restore vision" and it was published in Nature. The lead author was Yuancheng Lu. How could he have missed that?
"...or increase lifespan" - In order to do this you would have to deliver the gene therapy to an old mouse's failing internal organs. The concept is pretty sound, however, the required biological engineering to accomplish it remains to be worked out. That is why Sinclair's lab started with the eye, because it is a complex organ that can be accessed without cutting open the animal. I have to wonder, for a guy whose next big study is the effect of intermittent fasting on canines, why he feels the need to throw so much shade at people's work.
Exactly my thoughts as well… He was throwing in a shade without saying David Sinclair’s name. I listen to this video to get more insight on the updated findings on rapamycin supplementation; to add with David Sinclair’s research findings.
@@msnewmind328 He said his name in the beginning.
@@danbuckles2745 thank you 😊
I agree
Puzzling why Sinclair’s studies can not be replicated!!!!!!!!
Great interview… I’ve been taking 1g NMN per day for 6 months with 30g olive oil. No discernible difference in resting HR; HR variability; sleep quality; body weight or FTP (cycling)… Still taking it though because I’m a sucker for an expensive placaebo
3 years of 1g of NMN for me. My memory is definitely better, that I know for sure.
For me Niacin Or Nicotinic acid works best for me with the palpitations I get and energy which boost NAD also
Wow wow wow!!!......... Thank you Dr. Brad for sharing this "bomb" with us, you deserve a huge applaud for that.
See, this is great. We need more videos like this.
I think that my presence is not appreciated on several RUclips channels because I question David Sinclair's veracity and contributions to the field of anti-ageing. I know he likes attention and publicity, and that he is making A LOT of money at something. (Lab experimentation doesn't pay that well.) I have read through hundreds of papers (I am a chemist, but involved in art restoration) and do not find evidence for the life extending protocols that Sinclair promotes.
After seeing Sinclair using a youth enhancing filter, I'm not such a huge fan either. Anyway, with your research what do you think is the best way forward regarding longevity?
@@Pluvo2for1 Right now I usually refer people to the work of Valter Longo. He's a solid and sincere researcher who doesn't make outrageous claims.
Periodic fasts or employing fast mimicking (Prolon or water fasting) for 5 days about 3x a year looks promising. A plant-based Mediterranean-type diet comes out at the top for good health, limiting protein intake and employing moderate IF (12-14 hours daily) to reduce mTOR, moderate alcohol consumption (1-2 glasses of red wine,) and moderate daily exercise - these are your best bets right now and dovetails with rapamycin research which looks promising.
Also, do not look to purchase rapamycin - this needs to be researched more. Taking rapamycin unregulated can be dangerous.
Make sure you get enough vitamin D + K
and try to de-stress.
Dr. Brad is doing some good work here. I'm impressed (and that's saying a lot. I've never been impressed with David Sinclair.)
Feel free to ask any questions, Pluvo2for1. 🌹
@@Pluvo2for1 Right now I usually refer people to the work of Valter Longo. He's a solid and sincere researcher who doesn't make outrageous claims.
Periodic fasts or employing fast mimicking (Prolon or water fasting) for 5 days about 3x a year looks promising. A plant-based Mediterranean-type diet comes out at the top for good health, limiting protein intake and employing moderate IF (12-14 hours daily) to reduce mTOR, moderate alcohol consumption (1-2 glasses of red wine,) and moderate daily exercise - these are your best bets right now and dovetails with rapamycin research which looks promising.
Also, do not look to purchase rapamycin - this needs to be researched more. Taking rapamycin unregulated can be dangerous.
Make sure you get enough vitamin D + K
and try to de-stress.
Dr. Brad is doing some good work here. I'm impressed (and that's saying a lot. I've never been impressed with David Sinclair.)
Feel free to ask any questions, Pluvo2for1. 🌹
@@rosevanderreijden Great advice. 👍🌟 We get to save some serious ＄＄ too.
@@rosevanderreijden so no NAD precursors for you?
Thanks Brad. Great interview, great guest and thank you for broadening the spectrum of the discussion.
I have an anecdotal feeling that my very low biological age is mainly due to High Intensity Resistance Training 3-4 times a week over 45 years. I think it ultimately protects the immune system, stimulates hypertrophy (age 70 at 70kg and bench 100kg) and improves lactic acid utilisation through the cori cycle...
Fascinating and exciting interview! I was very surprised to hear that some people don’t or might not respond well to caloric restriction based on their genetics. I haven’t found any discussions about this online yet…I thought caloric restriction was nearly universal for most/all organisms for either extending lifespan or improving health. Can you or anyone in the comments section here clarify?
I'm concerned about this as well. I was under the impression that that was universally beneficial
I love these conversations! Keep it up.
What an impressive presentation. Thank you Dr. Stanfield. 👍
I am crushed about the comments on Resveratrol and NAD. I need Rapamycin!!!!
Both NAD and resveratrol has a caffeine like effect on me. They're impact on me is exactly the same way.
What a fantastic guest and interview, thank you for sharing this.
Great interview, Brad!! Absolutely wonderful discussion. 💖
Love this podcast. Thanks
55:46 "Rapamycin is the most effective, non-genetic (other than Caloric Restriction) way to increase lifespan & healthspan in mice... by far."
And there is no place we can get it :(
@@TheSaassaf No place? Says who? At the VERY least, you can go to another country, like Mexico.
This guy may not agree with David Sinclair in many ways. But being over 50 years old, he shares one uncommon trait with David Sinclair, which everyone can tell. This is the most telling message I get from the long video.
what is the trait?
@@gamblinguru33 I think he's saying they both look very good for their age
He didn't specifically address fasting as a way to block mTOR aside from just calorie restriction. Do we have any data showing that fasting blocks MTOR as well as rapamycin? I'm thinking that his once a week rapamycin dose could be mimicked by weekend fasting? Any thoughts?
I had the same question
I am 50 and take 3mg Rapamycin (amongst other things, including NMN) on a Monday and lift weights (split routine) on Thursday, Friday, and Saturday.
Where do you buy Rapamicin?
Are u taking once a week Rapamycin or u r taking 3mg / day? Any noticeable change?
@@jaimemarun2841 this
@@shambhaveemishra9842 If you re-read my comment you will see I take 3mg on a Monday 🤓
@@HaMashiachSaves Where do you buy Rapamycin?
Resveratrol stopped my back pain a ton! I'm on it for the 3rd day and I have no pain. No pain killer ever did this!
Interesting data based perspectives. Very informative, clear and concise interview. Thanks for the presentation.
Great interview with a top tier researcher. My only disappointment is that I haven't seen anyone ask Matt about his opinion on young blood research compared to all the things you discussed.
Please tell us what the best dog feeding strategy is as soon as it's published!!!
I'd venture a guess it's once per day with slight caloric restriction.
Loved the oral improvement part. I got huge oral improvement from akg.
I'm looking forward to the findings of the paper on feeding frequency.
Great interview! Love it 🙌
I had a similar experience with a rotator cuff tendinopathy. After 9 months of pain, two cortisone shots and a couple of months of physical therapy it was still inflamed and not healing. I'm a biologist, so I hit the books on tendinopathy. Then I took fisetin for 4 days to kill senescent inflammatory cells and followed up by stacking collegen peptides, AKG and vitamin C (to build new collagen) and curcumin (to repress residual inflammation). The tendinopathy disappeared in less than three weeks and in two weeks more I had my range of motion back.
Out of the many ingredients and approaches you used, which one in your opinion did the trick?
@@PakistanIcecream000 It was an integrated systems level approach - fisetin to stop the collagen destructive senescent SASP and the collagen stack to help remodel the damage. If I had to guess, I'd say fisetin was the more important, but the rest were synergetic.
what was your daily dose of fisetin?
Thank you for the great interview and iniciative and relevant questions. It is so helpful.
44:44 I (and my 88yo mother) improved memory from the global anti-inflammatory supplement, PEA ( Palmitoylethanolamide ), taking 400mg morning and night, and quality sleep, along with healthy KETO diet (it has been shown to reduce amyloid plaque). It took about 4 weeks to start getting results (faster with 2 hours of HBOT @ 1.3 ATA every few days for 2 weeks).
Thanks Brad, great interview! Really curious about the results of the mentioned dog paper, although I have a feeling it'll lean towards time restricted feeding being beneficial
Nice video. A small question: Does it make sense on restday afternoons when i take berberin, to reduce my leucin rich proteins, to not interfere with mtor reducing effect of berberin? Or wouldnt it really matter?
Thanks for the great video! It would also be interesting to learn what people can do now. Especially when you are 70 or 80 years old and don't have so much time to wait for well-founded study results and established therapies... of course every year that you gain can decide if you reach age escape velocity … The question for me is always: what is applicable without major risks and of course no "snakeoil"
Thank u Dr. Brad a valuable interview. Where can you buy Rapamycin and the mg needed..?
Finally a refreshing view rather than the overly sold Sinclair narrative which I warned about over a decade ago
Being too sceptical is as useless as not being sceptical at all. He spent most of the interview negating pretty much everything, and the little research information he did have, he decided to withhold anyway. Don't forget about the power of placebo Mr Kaeberlein.
18:01
1. feeling mentally sharp is very different from actually being mentally sharp. you feel sharp on lower carb, bc of increased stress hormone concentrations (impaired mental ability across the board compared to moderate to high carb)
2. feeling physically sharp is very different from actually being physically sharp (low carb decreases work capacity, relative perceived intensity for the same intensity increase on low carb, motor unit recruitment decrease on low/lower carb ,which in turn lowers the potency of any working set done in the gym for a given movement)
......
Ok..so what is something this guy WOULD take to impact health and longevity...and I volunteer for the rapamycin trial.
finally someone is doing a study on rapamycin, eh? it's about tiiiiiime. thank goodness. and thank you! Cuz no one else seems to care I guess? Peter Attia and others have been talkin about rapalogs for years now I think. And he and Matt have said - few side effects, safe, and very good early results. gotta keep this video on my to watch later list so I can find it again. (I did watch the whole thing but I don't wanna lose this.)
Are you afraid of death?
Do you have any followup on the section around 40m about data on the optimal dog diet? Have the results been published yet?
Another amazing and informative video.
Dr. Brad,
Is it benefecial to be on metformin and rapamycin silmultaenously?
Is there a overlap in benefits since the both inbihit Mtor?
Or would you suggest cycle them in instead?
Rapamycin half life depends on type. Sirolimus half life is longer, ~60 hrs. Also depends if we are referring to terminal half life (~80hrs) or elimination half life, as Sirolimus' curve is parabolic as it drops sharply, at least pertaining to blood concentration likely due to cell entry. Everolimus has a much shorter half life.
Loving this content. X
One of your best ever videos Dr thank you
Fantastic content Doc ! Keep em coming ! Thank you !!
Great interview and great information! I would love to know the results of the dog feeding experiment when it comes out.
1:15:37 An interesting comparison would be Rapamycin verses Metforman vs. 1-3 days of fasting. It could be that fasting provides the most benefit with AMPK activation (and with no side affects).
I am 63, train like a bodybuilder, but have limitations due to shoulder "arthritis." Please sign me up for your Rapamycin trial!
Glycans are a really interesting measure of biological ageing. In addition, it would be interesting to cross check with methylation. I'm in the process of checking this out on myself. I'll report back when I get the results.
Very professional! Thank you!!!
this guy is so unbiased towards everything else that he is biased on rapamycine
Excellent! Thanks very much…
Cool guy who makes a lot of sense. Cheers Brad
Great interview! Matt was talking about taking rapamycin once per week at a certain “medium” dose, what would that be? Also, is getting rapamycin through an overseas lab safe?
3mg
Great interview! Thanks a lot!
Great diskussion!
Does nmn have to be kept cold or it breaks down and is no longer affective?
Great and “ontnuchterend” (putting un back on the ground) are these words from Dr. Kaeberlein. A confident speaker.
I have spend 2 months taking in 500mg of Resveratrol, can’t say I became Superman.
Because I also started watching my diet and sugarintake, I feel better.
I also take NMN, 1 gram per day. I must say (anecdotal) that my endurance has improved by around 20% without doing any workouts. I know because I did weekly self assessments.
I have been watching RUclipsrs citing clinical human trials with NMN that did show improvements.
I am therefore puzzled by what Dr. Kauberlein says here.
There is several key points to this presentation however I will narrow it down to this question 2017 NIH paper, Towards natural mimetics of metformin and rapamycin. Does metformin, berberine still fall in the mtor agonist category?
This is not my first time that I write comments which are only thanks to Dr Brad for his efforts to help us understand science or questions relating to scientific publications, nothing else, to my surprise they all disappear completely. Weird. Anyway Thank You
Can you talk about the subject of hormone replacement and if its good or bad to do when get older and if the synthetic hormones are as good as the natural.hormones or if there are side effects and reasons why taking them comes with riscs of side effects?
Low carbs or keto is the way to go for improving lifespan…. Well done MATT!!!!
NMN for some reason gives me a very pleasant feeling. And with a growing number of studies coming out showing benefit I’m not concerned about what these two think about it.
What about rapamycin side effects? I know the list is long and sounds scary, but how often do they occur especially worse ones?
Great discussion. I'm thinking of adding Rapamycin to my regimen. I'm already taking Metformin. Can the two be taken together safely? I'm seeing conflicting information, some saying it is safe some saying it isn't. Is anyone here taking both? Thanks in advance.
How do you get hold of these?
NADA precursers:
1. Has anybody duplicated Sinclair increasing mice lifespan by 25%?
2. Has anybody done any tests--on skin, muscle tissue, bone tissue, blood cells--to see whether NR or NMN supplements are getting past the liver to these tissues. And, if not, what's the delay?
3. Seems to me if we indeed can show NAD decreases with aging(any actual proof?), that #2 above would be easy to do.
Totally love the individuality point raised around fasting and diet. One size does not fit all.
DR Brad, Thank you for this interview. From this, do you still reccommend NAD precursor for the 50+ croud?
I personally still plan on using them
Great interview! Can having an undiagnosed autoimmune condition help getting a prescription for Rapamycin?
My. Wife’s perimenopause was reversed rapidly with 3mg of Rapamycin (Sirolimus) per 10 days. Also, her HHT (a bleeding disorder) was ameliorated about 80%. For your study, seeing if women’s perimenopause could be reversed would be a quick and clear clinical endpoint.
Was her rapamycin prescribed by her medical doctor or did she take it voluntary?
@@PakistanIcecream000 No, it wasn’t prescribed to her. I read that Rapamycin may help with her HHT blood disorder, and I was already taking it for longevity and had some I’d ordered from India. So she started.
It's always alerting when c. elegans is used as a model organism for aging research. C. elegans has a programmed aging mechanism because it is evoltionary beneficial for them (limited number of descendants, very limited amount of resources, so it is beneficial to die when maxiaml number of descendants is reached). So it is realtively easy to slow down nematode's aging: all you need is to break the aging program (e.g. mutations in daf-2 and age-1 genes increase their lifespan 10-fold). That's why I always sceptical about results on c. elegans
outstanding vid :)
Does rapamycin restore mtor sensitivity similar to keto for insulin resistance ? We always assume more is better but i feel the right amount at the right time and sufficient sensitivity would be wiser? Insulin is great but clearly we overuse it. Perhaps same for mtor?