Global Sequence Alignment & Needleman-Wunsch || Algorithm and Example

Global Sequence Alignment & Needleman-Wunsch || Algorithm and Example
In this video, we have discussed the types of common sequence alignment techniques used in Bioinformatics i.e Local alignment and Global alignment. We have also discussed the working of the Needleman-Wunsch algorithm and discussed how to do global sequence alignment with examples.
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[@nepzel42069]

You saved my semester.

[@randomvideos2293]

I was going to write the same thing

[@HelloPetsVlogs]

me too
@@randomvideos2293

[@shusrutorishik8159]

This is the simplest and clearest explanation of Needleman-Wunsch I have seen! Thank you!

[@codghosts3676]

you saved me, my professor kept stuttering for an hour and couldnt say any useful shit at the end in his hour long online lecture

[@nmz344]

This is amazing explanation, just saved me and my classmates from a major headache. Thank you!

[@borngreat2624]

You have done what my lecturer could not do. Thank you so much for this simplified and easy video. Looking forward for more wonderful videos like this brother

[@combatnikisi617]

😂😂😂 I agree

[@user_27357]

What a great video! you made this super easy to understand (you just saved my bioinformatics midterm grade). THANK YOU

[@user-kq9ld1hj4e]

simplest and clearest explanation of Needleman-Wunsch I have seen! Thank you!

[@amysacademy]

Sir literally I was trying to understand this for a whole week but not a single video on the internet explain this clearly and easily as you...

[@annmatt5837]

The video explains everything in a concise manner. It was very helpful to understand the concept clearly. Thank you Sir!

[@cankale8002]

this was the best video that i could found about this topic. Thank you so much

[@rowanterry1822]

Amazing, and even better explained than my lecturer👌🏾👌🏾👌🏾👌🏾🔥🔥🔥🔥🔥

[@khushichitania6009]

I was trying to understand it from the past few hours from ample of videos but this was the best one that explained the method very clearly and in an easy manner. Thanks a lot.

[@sumaib1]

you taught better than my teacher. helped in solving my assignment. thanks.

[@abhimannthakran5516]

Most appropriate video conceptually as well as in terms of explanation .Thank you so much sir!

[@News_In_Snap]

this is the single best explanation i found here, great job sir

[@tholkappianramasamy6111]

content and the quality and clarity in explaining the video is too good, Thank You.

[@jacquelinemattos]

Great explanation. Thank you very much!

[@kyungcheolkoh4517]

good explanation with great visual aids! keep posting bioinformatics videos!

[@Lynsha44]

Thank you for this !
Sequence 1 : CCGTCG
Sequence 2 : CCGCG
Aligned Sequence :
CCGTCG
CCG-CG

[@jingliu2524]

Nice video, explained everything clearly in a simple way!

[@karmanpreetkaur9156]

BEAUTIFULLY EXPLAINED

[@danieljanostoth8068]

Very very clear, big thumb up you all! Thank you

[@lililia1304]

thank you so much , finaaly i understand it

[@amarkar11]

Best video on. Global sequence alignment 👌👌👌

[@aliawedixvi]

THANK YOU, you are the best!

[@gamingwithnoobs8448]

The best lecture I have watched on global alignment !

[@smritiprajapati3068]

Thank you so much for making this video... I really needed to understand this concept. it was really nice learning this way.

[@aarondesalvio]

Thank you for the fantastic explanation!

[@milicaplavsic39]

Thank you! This explantion helped so much!

[@hMF580]

I have learnt it from the first time, thank you

[@skyescrawford9774]

Thank you, you saved me. They gave me 2 hours video and I got nothing. What a beautiful 11 minutes video here

[@justsoil15]

Thank for your example. It's very interesting.

[@pallabihojai8076]

Thank u so much .... Finnally I understood

[@neverever7821]

THANK YOU SO MUCH!!! YOU'VE SAVED ME!!!

[@ihorrible]

best explanation ever !!!!

[@bongmou2845]

Clearly explained , looking forward to more videos .Great job .

[@BioinformaticaYT]

We are glad that you liked our video 😊

[@bushraborsha6435]

Thank you sir,your teaching is so clear and good.

[@MBCGayathriM]

Very easy to understand, Thank you Sir

[@tanvirasraf7772]

Guys like you are changing the world.

[@HectorUch123]

Great video! Thank you.

[@umm2825]

I actually didn't get anything regarding bioinformatics, bein in 2nd semester, and having a little bit idea of this, i will try my best to understand this. Tysm sir. ◉‿◉

[@jyothishshailan6885]

Excellent explanation ❤️

[@mehmetalitoy3929]

This is a great explanation, thank you so much sir.

[@Sadi-dear]

Effective way of teaching 👍

[@ranaabcdabcd2084]

Best video i have ever watched❤thank you

[@tlili3990]

very informative, helped a lot, thank you!

[@JayantMaini]

Very well explained.....Thank you..!!!

[@Psyblader501]

Great video!

[@sandaruwaninayanthara4274]

Thank you best ever explanation so far 🥳🥳

[@sharonraj5964]

So so helpful, thank you so much

[@kahkeshantarannum5058]

Very helpful...
Thankuu so much

[@nabanitadash9581]

Nicely explained.

[@evadibisceglie1096]

thank you !!! very good

[@varsharamesh636]

Thank u soo much for this👍👍

[@angalenar8018]

Superb explanation Vineeth ...God bless you 🙏

[@lingha2]

wonderfully explained

[@psta2]

Thank you so so much 👍🏼👍🏼👍🏼

[@akmalazar2741]

First of all thank u very much. Very clear explanation!

[@BioinformaticaYT]

We are glad that you liked our video 😊

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you're better than my teacher, greetings from canada

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Thankuu soo muchhh finally i understand it thanks alott

[@aisyareza]

THANK YOU SO MUCHHHHHHH

[@himanskss3749]

Very good explanation sir.

[@s.campusano]

You are amazing! Thank you a lot!

[@BioinformaticaYT]

Happy to help 😊 😊

[@user-ru7be3jg3t]

This is gold

[@ibnaysaif2959]

Thank you.breif that easily

[@smritisrivastava3495]

Thank you so much..

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Thank you so much it is very helpful
😁😁

[@sakshamshrestha6081]

thank you!

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Tq .i got good understanding

[@04ananthrajj45]

Thank you 💥💥💥

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thanks a lot!

[@francescamazza7303]

great explanation, thanks a lot!

[@BioinformaticaYT]

Happy to help 😊

[@momitaboro2018]

Thnks for explanation

[@vaishnaviramani8875]

Thanks for helping 😌🥰

[@shreyashachoudhary480]

Superb!

[@todorbalabanov2620]

Really clear explained. Can you tell me the answers of Seq 1 CCGTCG and seq 2 CCGCG and again for se1 1 CGCTCGCT and seq 2 CACTCGT in regards to compare my answers. Thanks in advance.

[@ibtihegesouda2407]

thank you very much, it's soo clear

[@BioinformaticaYT]

We are happy to help 😊

[@gotaya855]

thank you so much for posting such interesting and well explained videos

[@BioinformaticaYT]

We are glad that you liked it 😊

[@yijingwang7308]

thank you for your video. But I have a question: can I traceback according to the largest value, so it would be 2, 1, 0, 0, 1, 0 instead of 2, 1, 0, -1, 1, 0?

[@saurishsengupta844]

Same question

[@arpitabadatia7308]

But according to this method you cannot go to 0 after 2,1,0 as it's a match (G and G) so you have to go diagonally, which is 2,1,0,-1. Note: here you can't go according to the highest value if the nucleotide sequence matches. If it doesn't match then you can go for the highest value.

[@neelambibi7426]

Thanks

[@aquarius_gaurav]

There can be multiple optimal answers as well.

[@gorimasahu8621]

Very verryyy very helpful vdio it is 🥰🥰🥰🥰

[@abhiraj2734]

Well Explained. Thank You !

[@BioinformaticaYT]

We are glad that you liked our video, Mr Abhi.
Please let us know if you are not able to understand any topic related to bioinformatics we would try to make video on that particular topic, Thank you 😊

[@abhiraj2734]

@@BioinformaticaYT Nussinov Algorithm, Zuker Algorithm, Protein Folding Algorithm, Hidden Markov Model, Viterbi Algorithm, = These are some from my syllabus.

[@jyotirmoygupta8809]

what are you studying brother ?

[@abhiraj2734]

@@jyotirmoygupta8809 BTech in CS. Have an optional subject- Bio Informatics

[@numankhan4319]

Sir...very zabrdast...exclnt...
Love from pakistan...

[@BioinformaticaYT]

Thank you so much numan, it means alot to us 😊😊

[@Kalinikathai]

Nice video. Bro. Well explained. Keep it up.

[@BioinformaticaYT]

Thank you

[@masoomahussain3898]

Very well explained..!
But I wanna ask some question.
Why do you add these digits - 2 , - 4 , - 6, - 8, - 10 & -2 , - 4, - 6 ,- 8 in
First row and column respectively why do we need to add this zero
These points are bit confusing please reply me..

[@arpitabadatia7308]

Because this is the 1st rule. Before filling up a matrix you have to fill the first row and column by adding the given score of a gap penalty (which is -2 here) with 0. And the first one will always have to be 0.

[@winstonliu4189]

I love u man.

[@km2052]

thx

[@hemastandard7649]

great video man

[@BioinformaticaYT]

Appreciate it

[@aryanitishpatel9971]

now my confusion is cleared

[@mohddilshad8166]

Great

[@rajagopal.g3533]

How you have aligned second sequence like A-GCT only .

[@Thriver21]

tq

[@Czarlsen]

based on what we adding -2, -4, -6? to row and columns

[@srgk26]

Thank you soo much for this! This explained what 1 hour of my lecture didn't lol

[@henny9862]

👍👍👍👍

[@evgenia._.b]

I want to ask, the right corner in global alignment has always the HIGHEST value? is it possible for an another cell to have higher value? Thanks.

[@nareshapat]

👍

[@santupaul5360]

👌🏻👌🏻👌🏻

[@ricodsanchez6792]

Hi there, where is the link using python with scoring matrices.
Thanks