Simvastatin for Multiple Sclerosis [Neurologist Explains}

Believe it not, the old cholesterol medication simvastatin (zocor) actually reduced brain atrophy and disability in people with secondary progressive multiple sclerosis in a randomized controlled trial published in 2014 (the MS STAT study). This video explains why simvastatin might be beneficial and the results of several clinical trials. At the end, I give my personal opinion.
Sources:
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial: www.thelancet....
Information on simvastatin from MS UK:www.mssociety.....
Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis: www.pnas.org/d...
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation: pubmed.ncbi.nl...
Oral simvastatin treatment in relapsing-remitting multiple sclerosis: pubmed.ncbi.nl...
Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial: pubmed.ncbi.nl...
Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial: pubmed.ncbi.nl...
Multiple Sclerosis-Simvastatin Trial 2 (MS-STAT2): clinicaltrials...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.