Cyberpunk 2077 Melee only V vs Adam Smasher/Don't fear the reaper.

Highest difficulty.
Not my best run, but can reliably kill him in 1.5 - 3 minutes.
Level 60 characters with all skill maxed at 60 except net running (38).
No power up mods, I only used mods that alter V appearance/modifying the game graphic. The build can be recreated in vanilla assuming they don't change anything past 2.1+