Asymmetry of Cell Membrane

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[@DinaAwd]

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[@shealasuarez8797]

so what came first...the membrane or the asymmetry? ;) thank you! you cleared up my grad school lecture in 20 minutes...

[@theamazingguy150]

I think asymmetry is caused when vesicles containing that consist of a lipid bilayer are transported from Golgi apparatus to the membrane.
The vesicle itself contains asymetric distribution of phospholipids and when the vesicle fuses with the membrane the asymmetry is also imprinted on to the membrane. In addition membrane proteins like flippase and floppase (Yes that is their actual name) will move phospholipids against their concentration gradient to maintain asymetry (I imagine they use ATP).
So I think asymetry came first and is maintained by membrane protein.
What is also interesting to note is that red blood cells will eventually lose asymetry overtime. Some lipids in the membrane with a net negative charge can end up in the outerleaflet, this signals macrophages to target the aged blood cell.

[@nikolavideomaker]

@@theamazingguy150 Interesting theory. Though, Scramblase has an even better name than flippase or floppase.

[@Cristianomessi70]

From where is this lecture was being given❤

[@paolalavinlps]

The sodium potassium pump doesn't work with ATP, it is a secondary form of active transport

[@AKLECTURES]

Oh yes it does. You just said it yourself.. Active transport = ATP

[@vushu619]

+AK LECTURES (Andrey K) I think she meant directly working with ATP. But great video, very clear! :)

[@unicornpower6952]

I don't understand, you said proteins can't flip flop but they can rotate from one leaflet to the other. what is the difference? the picture you drew shows a flip flop, is this not misleading if they can't do this?

[@zahrashiraz5262]

He also said they can not rotate

[@justinwong8676]

I love you

[@112287hihello]

can you help me, I couldn't understand what are the two mechanisms for generating the asymmetry in the lipid bilayer?

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