Why do antidepressants take so long to work?
HTML-код
- Опубликовано: 14 окт 2024
- Buy "Memorable Psychiatry," "Memorable Psychopharmacology," and "Memorable Neurology" on Amazon! memorablepsych....
For someone struggling with depression, being told that an antidepressant will take weeks or months to work can be frustrating. Yet this delay is also the key to these medications' ability to help. Find out why in this video.
Papers that inspired this talk:
Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. www.ncbi.nlm.n...
How do antidepressants work? New perspectives for refining future treatment approaches. www.ncbi.nlm.n...
All music and video are under the public domain with the following exceptions.
Creative Commons license:
Background Music: "Divider" by Chris Zabriskie
Clouds Timelapse by Vincent Wolf
Corporate Building and Clouds Time Lapse by Beachfront
Car Driving Through Tunnel Slow Motion by Simon Waldock
Medical Pills on White Surface by Videvo
Young Couple Sat in front of Detroit Cityscape by Videvo
Clock Face Timelapse by Videvo
Panning Around Woman Watching Waterfall by Videvo.net, Kiril Dobrev
LA Mountain Sunrise by mikesteinkamp
Lady Overlooking Ocean by Videvo
Rain on Window Rack Focus by AHFilms
Ice Cream Melting by mitchp
Starting Stopwatch by Videvo
Iraqi Militiaman at Sabaa Nissan water plant in Baghdad, Feb 2003 by Christiaan Briggs
Close Up of Watch Face by Videvo
Child Putting on Shoe by RGB Parade
Germs Animated Background by Beachfront
Scientist Using Microscope by Videvo
Digital Clock Chaotic Time Lapse by Beachfront
Speed Radar Timelapse by Beachfront
Timelapse Sunset By Jama Jamon by Videvo
Crowded Small Bookshop by Videvo
Red Ink in Water Slow Motion by PVP
Black Cloud by Eugedius
Drinking Beer on the Beach at Sunset by Videvo
Single use commercial license, purchased:
Patient At A Reception At The Woman Doctor by mr_NightMan
Taking Pills by Pressmaster
Man Talking With His Therapist At Therapy Session by kopitin
Infusion by tuomatu
Unclear copyright status, but believed to be in the public domain:
The Human Brain by Encyclopaedia Britannica Educational Corporation
Antidepressants changed my life. I inherited depression from my father’s side and I always lived with functional depression, and I thought that was normal. Until recently that I started taking medication for it, I feel my whole thought process changed, and I do think I have more clarity and can make better decisions and be in peace with my emotions
What med you’re taking please?
Very happy for you 😊😊😊😊
Which antidepressant did you take ?can you inform me please..
@@skrd851 venlafaxine, it has double effect as antidepressant and anti anxiety, cuz I also have anxiety disorder
Ur comments just gave me hope. Already trying to get a place
one of the worst illnesses to have, invisible and impacts everything
en.m.wikipedia.org/wiki/Depression
Ruins your life 100%
I’m on my 3rd day of antidepressants only side effects so far 😩
@@ashleykinney4961 and now?
Anxiety is also a bad illness to have too
Learning to process being happy takes time when you've spent a lifetime being unhappy.
This is a brilliant and accurate comment
expecially with dysthymia, i had dysthymia since i was 12 and i am 25 now, it ruined my whole young age... just now i am on zoloft and starting to see joy
@@edward5247 brother how much did you take it..... Do it change something in you
Although I’m only 15 it’s quite hard to process happiness, after you’ve spent almost all your conscious life with ADHD and depression thinking “Yeah this is what happiness feels like.” And really it’s extremely temporary and then after that maybe week of enjoyment (not happiness) you feel hollow and think there’s something wrong with you. You think is what I’m feeling normal? Why does everyone look so accomplished and prideful? You get sadder and sadder and realize that things that once brought you joy don’t do anything for you anymore yet you still want to do them. You realize this and wonder, is this depression? You start to doubt yourself and think “No, I’m probably just making it up for attention.” :(
Love this i thought i was the only one who thought that
actually. i felt a difference after the first night taking setraline 50mg. been 2 weeks now and the negative thoughts are gone. ive been suffering with depression and suicidal thoughts for the last 10+ years. i finally have a calm mind to live my life. please if anybody reads this, please never give up. get help and do whatever it takes to get better. it is possible. no matter how long you've been suffering, it can be helped. best of luck to all of you :)
I just got prescribed setraline for my anxiety the same amount as you. I'm a little nervous about it though. I'm not depressed just have debilitating anxiety lol
@@MrJangofett123456 i also have a little anxiety. the medicine is helping with it as well. hope for you the best with your anxiety :)
Thank-you for your message of hope 🙏.
I also got quick positive results with sertraline for debilitating anxiety, not on day 1 though for the first week it made me feel kind of agitated and a little more anxious, but after 8 or 9 days taking it the side effects stopped and my anxiety level suddenly dropped away to almost nothing, it's such an incredible relief to me I'd actually completely given up on ever feeling relaxed, happy or normal again, now life is good again! 😊
I knew I felt different minutes after taking ssri. I thought that was just the placebo effect - me just hopeful after taking it.
Thanks for this video
en.m.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor
well it is the placebo effect, ur not supposed to feel an ssri untill a few weeks but good news is your depression is also just the placebo effect, neither happyness nor suffering is real
@@yankeenobonagu6411 then why do we feel it not saying I dont agree
@@royaldaughterofgodholygrai1878 i dont know, but you are aware of your depression ur aware of your happyness, your awareness is neither affected by happyness or depression (or fear for that matter)
Placebo effect, NO antidepressants works in minutes 😏🤦♂️
Now this is something that gives me an explanation. This is what makes me understand. I've always wondered and I went to many explanations and I've never really gotten the explanation in the form that I wanted. Just really long words, but this video and the way you put it together with the images and music made me process it. Thank you, you're doing a really good job.
When he said “within years” I immediately thought of myself. It took me 2 and a half years to get better . I was on 250mg of Zoloft(highest dose) and Wellbutrin 150 mg . It took me very long to be happy with myself. I am never getting off this medication ever again!!!
Do you drink alcohol?
That's a ridiculously high dose of either let alone both at once. Good Lord....
You must have been going through literal hell to need that high of a dose from both. Glad you’re happier
It’s still working?
Theres no way you took 250mg of zoloft WITH another drug. 250mg of sertralin are already very dangerous for your body
I'm overjoyed to see that you're still making videos. I found your Psychopharmacology series to be concise and fascinating. The mnemonics that you included make the content impossible to forget. Your latest material has been thought provoking and most informative. Please keep it up.
I take an ssri. After a few weeks, it lessened the number of panic attacks I had, the severity of my OCD, and probably lessened the amount of crying. I remember when I would go cold turkey off of it, I would curl up in a ball and ball my eyes out. I'm still very depressed and mostly focus on the negative. But I hardly ever cry now and I'm emotionless to alot of stimuli, things that should effect me don't, or I think about them with a sense of futility. Except anger, that seems to have increased after being on it for a decade. So maybe it turns you into a psycho long term, lol.
Which ssri you are useing nd dose
@@ehsanahmed1554 Was venlafaxine initially, I think 150mg. Hospital bumped it to 500+mg one time but that had no effect. Switched to sertraline a few years ago, was on 200mg for a while, 150mg most of the time.
It’s called emotional blunting. It may sound like a negative effect, but in a way it helps to limit being constantly consumed consumed by a negative emotional state.
Please don’t quit anti-depressants cold turkey.
Most need a slow weaning.
Probably one of the best videos I've ever watched on yt.
SSRI'S SAVED MY LIFE!!
THEY RUINED MINE
@@Mike-rh9zs why so
@@ishowspeedaf9986 gave me ED. Look up PSSD. Only took two pills of Lexapro and then 9 cymbalta 2 months later
@@Mike-rh9zs PSSD is now officially recognised, so they'll hopefully only give antidepressants to people who really need them. I take antidepressants because I'd be dead without them. Have you thought about asking for a testosterone test? I get ED if I don't use Testogel.
@Mathieu FortGay this was 11 months ago everything has cleared still should take that?
Alienation is the feeling of being isolated or separated from something, often a group or society. It can also refer to the sense of being disconnected from one's own feelings, thoughts, or identity. Alienation can be caused by a variety of factors, including social isolation, discrimination, and the experience of living in a society that is different from one's own values and beliefs. In some cases, alienation can lead to feelings of loneliness, isolation, and resentment. However, it can also be a source of creativity and individuality, as individuals may seek to find their own voice and place in the world.
The most painful illness ever.
I have OCD + MDD
I knew i had OCD form age 7, I remember when i walked alone at school and extremely bad ideas and something talk in my mind without begin able to stop it.
You get the craziest thoughts inteusive
I feel your pain
The reason Anti Depressants take so long is because the entire effect that causes the anti depressing is based on the brain building a tolerance to the anti depressant (At least with SSRI's) this takes at least a month in most people. Usually the actual first effect of anti depressant SSRI (on the first day of taking them) is more depression, oddly.
They drug manufacturers of SSRIs dont truly understand how they work. They just have a vague idea. Which is insane when you really think about it.
You have a good point! But the theory on BDNF is very possible even tho I'm not sure it has to be achieved via anti-depressants. I really don't buy it on the chemical imbalance thing on the brain because chemical imbalance is not the cause but symptoms. The cytokine theory is very possible IMO because fish oil can improve depression symptoms but they inhibit cytokines and increase neurogenesis
I felt a huuuuuge benefit when I first started taking SSRI - after 1.5 days and lasted for about 4-5 months....then it all kind of tapered off. I’ve been on them for probably 9 years and couldn’t reallly tell you what benefit I get today. Miss that early feeling - serotonin was on overload for sure.
Try lexapro. It seems some peoples body builds a tolerance to Zoloft.
R Provost it can happen for any of them. Antidepressants are supposed to be that way anyway, making small changes so you can adapt your lifestyle and live a happier life.
hello, is it still working??
KO S I’m on Lexapro 10mg and Welbutrin 300mg. It is really a very subtle improvement - it’s less about making me feel “good” and more about keeping The extreme lows away. I wish wish wish the feeling would have stayed from the beginning but honestly I was taking Paxil and about 40mgs a day / it was probably overload which is why I was flooded with serotonin. Your body regulates over time no matter what...plus weight gain is likely. At the end of the day - we’re probably not supposed to feel “that good” ALL the time...it’s natural to have ups and downs....as frustrating as it is. Just gotta ride the wave. 🤷♂️
Bill Evans there are no highs without the lows.
I'm at week 4 of SSRI and still feeling anxious. I'm taking it for Generalized anxiety disorder and OCD.
Very interesting topic. The really tricky part is that my experience with bipolar shows that this is doubtful. The function in bipolar people can change within a day when given these medications but this is due to a secondary system, ( the bipolar switch) but not due to the underlying effects of the medication. The person can switch easily without it anyway, the medication still takes effect in a few months and it may also aggravate the bipolar mixed episodes. This is very important because having the medications work too quickly becomes a serious and dangerous side effect. This seems to disprove part of the theory but it is still notable that CBT is very good at treating normal depression.
My 2 cents of theory and explanation of this is that it is likely that psychology can cause an issue in the serotonin systems in the brain that is of a neurological nature. This would mean that the symptoms seen are indirectly rather than directly determined by the depressive nature of the person and thus treatable by medication and psychology simultaneously.
I thought about putting in a brief aside about how this discussion would not apply to bipolar depression, but in the interest in keeping the video short and sweet I left it out. What we know from decades of research is that bipolar depression is a completely different thing than unipolar depression, both biologically and psychologically. Medications that work for unipolar depression do not work (and may even be harmful) when used for bipolar depression, and vice versa. So I don't know if I would agree that the effect of antidepressants on bipolar disorder disproves this theory necessarily; it's probably more accurate to say that this discussion only applies to unipolar depression and that something else entirely is going on with bipolar depression.
I completely understand where you're coming from, I myself have bipolar disorder. According to Polar warrior, up to 30% of us are initially diagnosed with MDD (me for example) and start taking ADs. But they trigger manic episodes and worsen mixed states, and yet it is still so widely common to be misdiagnosed. I do feel that it completely sets our brains off track when there isn't much balance to begin with.
I tried SSRI and SNRI, serotonin based typical antidepressants, for about two years, switched to different drugs within these classes too. NDRI so far has been the most effective. Bupropion and Ritalin, treats my ADHD too
I don't feel depressed like before, but I still face extreme anxiety, dissociation (DPDR), generalized, and I experience trauma flash back sometimes
I'm not overly sad, nor do I really experience joy, maybe happiness just isn't for me. It's stable, so maybe it's better this way
NDRIs will reduce your ability to feel pleasure over time and will increase anxiety at least in my experience. SSRIS are better for long term stability AND happiness
@@lizardman1582Bupropion is what has worked for me for many years. My depression is thought to be cause by my ADHD, but I do not take stimulants. Several SSRIs have given me suicidal ideation. Those types of beliefs are why I suffered for so long trying SSRIs.
Very useful video. The goal should be to take only one ADS of the lowest mg. In life there are only 2 problems--mind and the body. To feel better reduce negative thoughts [overthinking]. Your breathing is closely related to the brain [mind] and gives good relief from stress-anxiety. To relax sit on a chair or lie down, neck straight, eyes closed and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for 5-10-15 minutes or more. Don’t fight your thoughts. With daily practice the mind will relax. No deep breathing needed. Do the practice without any expectations when taking a walk, before sleep, in school, at work, when reading, etc. Like me, make this a lifetime daily habit to have a better life. Reduce negative social media, take morning sunlight walks and avoid constipation as it affects the mind instantly. Best wishes--Counsellor.
Good video. Been on anti-depressants, on and off, since 1992. This is very well said.
Do you still depend on them?
@@dwikafebrianto3016it doesn’t cure. It rids off from symptoms
your videos are awesome, they deserve way more views. Accurate information, and interesting portrayal of information!
except when he said her face betrayed loneliness....that was a bit depressing
Thank you...for your pharm videos, the insights, mnemonics, and dissection of material. Very helpful.
Ive been on Pristiq for GAD (general anxiety disorder) for over 6 years now... it took me around 20 days to start feeling better! OH MY GOD.. was it life changing?!
I recommend the use of psychedelic mushroom it’s all natural and it’s the best to cure anxiety and depression , I can’t remember when last I felt depressed, I was depressed until I got my hands on psychedelic mushroom, I was in pain and confusion now I work effectively and efficiently without worry and fear of the unknown, I get mine from an online vendor that specializes in the growth and sales of psychedelic products
*Formulah11*
@Mauro Figueiredo I dont know if I'm addicted... but after my first year on it, my doctor took me off it, because i kept telling him i didnt want to be on it forever... 6 months after that I had a major anxiety attack, so i went back to it... and i dont pressure my current doctore to take me off of it... if it happens, ill stop taking it, but know i dont ask my doctor when im gonna stop taking or if i am going to... i really dont feel like I need it anymore to be honest with you, but I'm not gonna be the one trying to stop taking it... if it happens, it happens... if it doesnt, ill just take it... im over it to be honest (over feeling bad for being on it, is what i mean)
Good explanation of the mechanisms behind SSRIs, but while Im happy they work for some, I took two of them years ago for panic disorder/anxiery and they did nothing, where as taking Klonopin for a year stopped my panic attacks almost overnight and kept me panic free for years.
Isn't Klonopin a Benzo? Isn't it dangerous to use Benzo's for such a long period of time.
@@joerobley8469 It can be depending on the individual. I personally think they are over stigmatized because a small minority of users abuses them. I did just fine on .5mg a day, then tapered myself off when I felt I didnt need it anymore.
@@jer1776 Benzos absolutely ruined my early life, not because I abused them, but because medical professionals told me they were a wonder drug and kept me taking more and more in increased quantities as they soon lose their effect on the lower doses. I took them in total for nearly twenty years and getting off them finally was a nightmare and made me extremely ill. Now 40 odd years later, I have been taking Fluoxetine an SSRI, after anxiety and depression following a stroke, but the doctor also insisted I took a 'modern' benzo called Oxazepam. In fact that made me feel like hell again and it has taken me a year to escape from its clutches. I want to eliminate Fluoxetine next, but I think of the two types of drug it is by far the preferable one. I would not recommend my worst enemy to take any form of benzodiazepine.
Ofcourse a benzo will be more effective.
Glad to see another great post from you
When someone drinks alcohol for the first time, he initially turns away from it. After a while he gets used to it and starts to feel enjoyment. So what happens in antidepressants may be similar to that (an addiction mechanism).
That's why antidepressants are not meant to be a long term solution. Antidepressants are meant to stabilize / improve the mood of depressed people. It should always be combined with a therapy sessions with a psychologist in which they learn better ways to cope with their issues or to better understand what causes their depression and how to function in the world even though you feel depressed for long term effects. Some people here say they use them for years but that's not what those drugs are made for.
@@maximilianwieland9304
In psychiatry, yes, psychiatric medicines have been used for years, as long as the patient feels depressed when leaving the medicine. This logic in psychiatry is the same as that used in all mental illnesses or disordrlers. According to their claims that mental disorders are the result of a chemical imbalance in the brain, and medications correct this chemical imbalance. Personally, I am not convinced of this explanation, even many psychiatrists believe that these are just theories and speculations (the theory of chemical imbalance in neurotransmitters and the like), but they consider psychiatric drugs as the possible solution
and the available solution now between our hands. Certainly if the patient is able to solve his psychological problems by using Cognitive Behavior Therapy or any Talk therapy with a change in his circumstances of his life, then this is considered the correct and excellent way. But this way cannot always solve mental disorders, which makes the need for medications justified and reasonable. I personally refuse to resort to medicines except for necessity, because they have severe side effects on the patient and deplete the body over the years and their long-term effect may lead to early death or other health problems, this is not to mention the dullness that the medication causes, which makes the patient like a zombie lead an empty, tasteless life. But medication is sometimes very necessary to go through a psychological crisis for a temporary period and is also necessary sometimes for long use when there is no alternative. But my motto is: Do not use the medicine unless necessary..
@@maximilianwieland9304 true.i know 4 people where meds saved their life,one has shizofrenia and wanted to kill himself.his doughter caled the ambulance he was 3 weeks in hospitall.two years of recovery and he now has his own business.true story i know the man
@@seabird9983 The goal should be to take only one ADS of the lowest mg to prevent side effects and habit forming. Benzos need to be avoided. Heal yourself. .In life there are only 2 problems--mind and the body. To feel better reduce negative thoughts [overthinking]. Your breathing is closely related to the brain [mind] and gives good relief from stress-anxiety. To relax sit on a chair or lie down, neck straight, eyes closed and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for 5-10-15 minutes or more. Don’t fight your thoughts. With daily practice the mind will relax. No deep breathing needed. Do the practice without any expectations when taking a walk, before sleep, in school, at work, when reading, etc. Like me, make this a lifetime daily habit to have a better life. Reduce negative social media, take morning sunlight walks and avoid constipation as it affects the mind instantly. Best wishes--Counsellor.
@@seabird9983 Most of this comment seems like unsubstantiated biases with little data suggesting it’s best for patients
mdma works in an hour. not only that but 1 use can radically change your outlook long term. should be legal
But also it should be tightly controlled.
but at the next day you feel like trash
@@PADARM not if you take a smaller dose. If you keep dropping it throughout the night you'll deplete your serotonin and thats probably why you feel like shit the day after.
Mdma is not a solution, u cant stay on mdma long term or even short term its really gonna mess u up, ur teeth, ur look and so on.. drugs is not a choice even weed
@@brrprr938 mdma is good shit, dangerous shit but
It is not just negative biases that causes all kinds of depression. Genes is one big factor for many.
Those genes may be causing those negative biases,nature and nurture interact from conception.
I very much believe this, my father was a very critical, hard to please, always found fault in things and even though when young I was the total opposite now his age I very much have become him.
Currently on anti depressants, hoping for the best 😇
Yapi Cop, The goal should be to take only one ADS of the lowest mg to prevent side effects. . In life there are only 2 problems--mind and the body. To feel better reduce negative thoughts [overthinking]. Your breathing is closely related to the brain [mind] and gives good relief from stress-anxiety. To relax sit on a chair or lie down, neck straight, eyes closed and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for 5-10-15 minutes or more. Don’t fight your thoughts. With daily practice the mind will relax. No deep breathing needed. Do the practice without any expectations when taking a walk, before sleep, in school, at work, when reading, etc. Like me, make this a lifetime daily habit to have a better life. Reduce negative social media, take morning sunlight walks and avoid constipation as it affects the mind instantly. Best wishes--Counsellor.
My advice would be to take them for at least 6 months once you're on them
@@wowftw120 Be careful. 6 months of benzos will make you addicted. If taking ADS stick to the lowest mg which usually does not have any side effects. If you have stress-anxiety read the msg I sent you and do the practice regularly. Best wishes. Sr. Counsellor.
Zoloft was the most commonly prescribed antidepressant in the USA in 2018 with over 38 million prescriptions.
The reason: clogged liver a.k.a fatty liver.
That's why when first effects appear you start to gain weight exponentially (especially is you consume refine sugar in any form which is common in people with depression). Also when you change medication, the new one doesn't take long to take effect. It's the same with anti-psychotics.
Antidepressants do NOT HEAL, they suppress symptoms to make YOUR HEAL (brain rewire, CBT, DBT) easier. Accelerating the healing process is important to reduce prolonged side effects of medication like obesity and sexual dysfunction (especially in adults).
I have a huge positive affective bias. Like I surround myself and am drawn to happy, successful imagery but then get down because of the gap between those images no my current status. I will be happy when i have that lifestyle, that amount of money, that travel experience... so like I don't know how that fits ha
SSRI's over time will change brain chemistry in ways that's not fully understood. I think that's why it takes so long to work.
Good thing I gave em up after 9 Days.
@@ammarqz2080 I made a mistake taking them in the first place.
Peter Berisha I Gave them up after 2 days do you think it changed my brain chem
Logan Crump it shouldn’t during that short amount of time and it’s like keeping a shit inside you for two days and then getting rid of it. As for side effects? Nope, none!
@@PeterBerisha side effects are minimal...
I'm bipolar and 10 mg of Paxil lifts me out of depression after 2-3 hours. Every time.
Life is suffering and it makes you beautiful .
So if they increase serotonin right away, would you be better off taking them in the morning rather than at night?
so is PSSD real? Are my genitals numb forever from SSRI and SNRI medications? on a very very VERY short term basis.
are you still having problems?
@@KeithKillingly yes
@@Mike-rh9zs Are you older? Could just be age. If you're youngish it should've gone away
@@KeithKillingly happened at 26 now I'm 28
@@Mike-rh9zs How are you now? The goal should be to take only one ADS of the lowest mg to prevent side effects. . Avoid benzos. In life there are only 2 problems--mind and the body. To feel better reduce negative thoughts [overthinking]. Your breathing is closely related to the brain [mind] and gives good relief from stress-anxiety. To relax sit on a chair or lie down, neck straight, eyes closed and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for 5-10-15 minutes or more. Don’t fight your thoughts. With daily practice the mind will relax. No deep breathing needed. Do the practice without any expectations when taking a walk, before sleep, in school, at work, when reading, etc. Like me, make this a lifetime daily habit to have a better life. Reduce negative social media, take morning sunlight walks and avoid constipation as it affects the mind instantly. Best wishes--Counsellor.
Please make a video about what happens to the receptors when tapering from an antipsychotic and ssri. Hope you see my message. Thanks mate. Im trying to understand my medication better.
Kristian Muus .. your receptors will down regulate because of a synthetic chemical is replacing the natural chemical your brain produces!
Aaron Maloney any info on this? I felt a huuuuuge benefit when I first started taking SSRI - after 1.5 days for about 4-5 months....then it all kind of tapered off. I’ve been on them for probably 9 years and couldn’t reallly tell you what benefit I get today. Miss that early feeling - serotonin was on overload for sure.
@@KillBill2114 that's why so many people questions anti-depressants' efficacy. If one can improve their depression symptoms by taking supplements such as SAMe, IMO doctors should suggest them as well.
I have question. Do the benefits of SSRIs continue even after discontinuing the drug?
Why then do psychostimulants prescribed for ADHD improve mood more quickly than antidepressants? Is it because they increase the amount of neurotransmitters in greater quantities, yes, and antidepressants slightly increase the amount of neurotransmitters and a little bit every day after taking antidepressants and therefore the bad mood then goes away? Probably the difference in time is due to the intensity of the increase in neurotransmitters, that antidepressants a little at each dose increase, normalize and stabilize the number of neurotransmitters, the brain is rebuilt more smoothly, and psychostimulants such as Ritalin increase the number of neurotransmitters at one time more strongly? Is this why antidepressants do not have such a strong risk of addiction as psychostimulants?
I was always more attracted to people not smiling, people that looked angrier or apathetic... I wonder if that'll change after the ssri I just began.
Please keep up the great work! Very insightful! I have to listen to this on x1.25 maybe it's just me
Andrei Cotofan he does talk slow but it’s good b/c people with depression and anxiety can focus better to what he says :)
I don't know if it's the placebo effect or a sensitivity to these drugs, but I feel a difference, good or bad right away. My shrink thinks I'm just imagining it all, but he's a quack with blood on his hands, he's old senile and not up on new developments in psychiatry.
Tramadol is the fastest antidepressant. It take just 1 and a half hour to start lifting a depression unlike SSRI'S that take 4 to 6 weeks to work
Miguel Gutiérrez Tramadol?
Victor Oliveira
I don’t agree
I take 5 mg srris
And 50 mg 4 times a week tramadol
3 days kratom
No issue
Keep low dose
You don’t lose tramadol effects if you keep it at same dose
It really does
Yes exactly I 100% agree with you. Its difficult to get it without prescription and this drug works for depression
@@kunalsoni1315 not an Ssirs,,hard to get because they are addictive
Gonna complete my first week on SSRI. But I still have questions, are there certain foods we have to avoid or can we eat anything?
How do you feel after 17 days?
I’m on 11th day of SSRI.
@@kifayatullah6761 17 days? Wait 4 to 6 weeks on your medication then most likely you’ll see a difference and ALWAYS talk TO YOUR DOCTOR, not RUclips. Everyone mechanisms is different that is why these drugs works on everyone differently.
@@chgofirefighter okay thank you for your priceless suggestion.
You need to avoid grape fruit juice
Is it normal to have vomiting after starting antidepressants?
Well to be honest as a person suffering social anxiety and taking antidepressants, its actually good that they works this way. It takes its time gradually and therefor it’s not strong and there’s no addiction! . benzodiazepines however on the other hand, are like alcohol. They hit you right away and therefor too much can be addictive! Doctors should only prescribe them as an occasional last resort once taken once in a while!
If SSRIs are so effective in relearning negativity and promoting a more positive view of life, why then is withdrawal from these drugs so very difficult? You might conclude that the new positive attitude would remain even when the actual drug and the levels of seretonin available to the receptors are in decline. But so many people experience depression renewed with an even greater force than before and often abandon the withdrawal from the drug.
SSRI are shown to have very little effect in comparison to what they believed at the time you made this video. New reserch also show that ssri can have terrible redrawl symptoms, and that this symptoms earlier was mistaken as "that the mental disease was back, therefore back on the pill", when they actually are redrawl symptoms.
Just be careful with Serotonin if you have ASD1 because it can cause mania or insomnia ❤
The embarrassment of admitting to depression kept me miserable for most of my life, it was a senseless and avoidable waste of my life . With all of the evidence that antidepressants work there are still some who refer to them as “Happy pills “ and the like making people reluctant to use them
I was drawn to the guy against the railing he seem sad
Me to.
I was drawn to their groovy hats 😂
I was drawn to the guy in the brown hat because he’s the only one facing the other way
😮 wow ,this video summarized books about depression.thanks man 👨 on this video,i will help millions ♥️♥️♥️♥️♥️♥️
Any tips on what to do until it starts working? Feel like I want to do something but at the same time don't want to do anything
Newest research suggests serotonin is not the cause of depression. And the best medicine for depression is actually exercise. Antidepressants have more or less the same effect as placebo.
And why do psychostimulants like Ritalin always almost instantly improve mood, unlike antidepressants? Because they more intensely and strongly inhibit the reuptake of neurotransmitters, and antidepressants weakly, gradually and little by little like microdosing?
I looked at the bottles on the table.
If I were to guess, I would say it's because antidepressants lower dopamine levels which is really stupid and except for a few do nothing with glutamate or GABA. I'm pretty sure a truly great antidepressant will increase dopamine, serotonin, and GABA while reducing glutamate.
is there any like that?
@@d1ssolv3r I wish.
ADHD meds increase dopamine.. So does Wellbutrin
A very interesting and much wanted to know about video, BUT as is more and more the case now, is the NEED to have (not for older people) 'noise' in the background of a really annoying and distracting fast thump, thump, thump beat sound that just distracted me from being able to watch it all. Really cannot comprehend why this is done, especially for a topic here for people who are naturally depressed. I would expect such sufferers of depression would not like distracting loud or heart beat raising background sound when wanting to truly understand what this YT is informing us. I wonder how many old people, like me, wanted to watch all of this and gave up after a short while and missed some very useful information. Please note, for most of my life I was a teacher, lecturer and professional presenter, so I do know a fair amount about getting people's attention.
Playing a instrument is best natural way to beat depression & it even releases stress
en.m.wikipedia.org/wiki/Musical_instrument
Agreed that’s why I got my piano. I need headphones for it though
Kurt cobain says hello
It doesnt treat clinical depression it just gives you a buffer against stress if its something yoh enjoy doing.
I'm 52 and practice 3 to 4 hours a day. It relieves depression and stress while playing only. Depression immediately returns when you stop.
Sublingual B12 1,000 mcg daily cured my depression. Don’t take too much though and if you start to feel worse stop taking it and only resume as needed
Excellent video
can you front load antidepressants?
thank you for this video!
S Ketamine doesn’t work. I tried 5 treatments in a private clinic in Texas. Maybe R Ketamine would work, but it gives more psychedelic effects. So, let’s try it… S and R Ketamine work to give you an insight of your identity, but ayahuasca gives you a plain and clear answer.
You cannot say that based on your own experience ,thats not how science works.
The music makes it almost impossible for me to concentrate. Needed to mute and read the auto-generated captions zzz
Anti-depressants Like the one I'm taking right now prozac helps with my anxiety depression and OCD Without this medication I wouldn't function
how long until it started working?
Because maybe for one it's not a stimulant and it gradually releases overtime and it reconstructs the brain in a sense if you're seriously depressed and lack a bit of serotonin and not getting enough rest and kind of have a bad diet it may take a bit longer and your metabolism is a factor but idk that's just my thoughts and opinions 💭
man as i thought the meds helped me i was wrong been on seraquel and zoloft for about 6 or 7 years now my memory is horrible i wont sleep if i dont tk the pills idk what to do . im now tking 50 mg i want to go down and get off of this mess
I felt it straight away but it wore off quickly aswel, until the 3rd week when the dose was doubled
There's an initial numbing/ europhic feeling but typically only lasts a day or two, that's not how they make you feel day to day
've been taking citalopram (10mg) daily for three weeks and I had a huge increase in anxiety after three days. It was so bad I went to hospital. I live in a rural area and my neighbour kindly drove me to hospital at 4.00am on the day. I wanted an injection to calm me and/or advice on how to stop the tablets. They talked to me instead which calmed me down and I dediced to continue. Since then I've had periods of high anxiety for a few hours here and there, the last few days it has worsened again (so from about day 18 to 21), and I sometimes go for a walk as I can't sit still and have considered going to hospital again but haven't yet. My doctor has prescribed me valium and another anti-anxiety medication to get me through. I am so hoping this anxiety surge is temporary, from what I've read 'the anxiety stops after a few weeks' and 'it can take six weeks for my system to fully get used to it' - so all I have to do is wait. Can people reading this, who had anxiety early on when taking citalopram - which later went away - please comment on their experience, and also how long it does take to go. Many thanks.
I have exactly the same problem as you have.. im on day 6 and it gets worse everyday.
My advice is to keep a diary detailing the very hours when you get an anxiety spell and when you don’t. If you are going crazy with anxiety for a few hours they’ll be many hours each day when you’re not. If you read the diary back this will reassure you, which will mean when you next have a high anxiety spell you can remind yourself it’s only brief, it’ll pass, and that will make the episode more bearable.
Stop putting that fucking garbage in your body and look into Psilocybin microdosing. Stop letting corrupt and greedy people think for you, antidepressants are pure shit. Psilocybin microdosing doesn't give one a high nor does it make you trip, it might cause mild introspection, yawning and some happiness but that's it. I'll take Psilocybin (which has a far higher safety profile) ANYDAY, I'm diagnosed clinical depression and social anxiety disorder. Microdosing on top of daily exercise has been a literal life saver. Psilocybin fits into the 5ht Serotonin receptor like a key, it's NON toxic and doesn't cause horrible withdrawals or life threatening side effects like antidepressants do.
9@@jeffoliver7491
So it reduces empathy??? Changing how you perceive an image of someone is strange. Unless it is neutral
3:24 original video?
Why do we focus only on brain chemistry and not in the quality of life?
because you can’t fix your life if you can’t even get out of bed
Interesting video.
Seratline work for me but it took me through a shitty worse 8 weeks and also it makes my eyes roll back in a weird way
please tell me that, rispond is in the thumbnail
Well if benzodiazepine medications can take effect immediately within 15 to 30 minutes and Adderall can take within 15 to 30 minutes why can't antidepressants just take 15 to 30 minutes to make you feel undepressed should not take note 6 weeks or 8 weeks to take 30 minutes and you feel better but that's a dangerous thing to give to someone with bipolar
most likely because these pils are mean too increase your levels of serotonin and serotonin has NOPTHING to do with depression. You are feeling better because that was the extend of you depressive episode, not because the pil is working
Medicines efect when start?
Great hattttssss of sir this video real helpful
No one wants to live in a state of "depressive realism", nor does anyone want to live in a world where everyone sees the world through that lens.
Thank you for this video
Antidepressants take 6 to 8 weeks to do something. Good or bad. Nobody knows. Kratom takes 30 minutes and is completely natural and it takes all the depression and anxiety away. But the government and the medical community want to take away the best treatment because it hurts their wallet.
Kratom cannot be taken daily/long term, so it isn't really comparable to antidepressants. Which is not to say kratom hasn't helped me greatly.
I take kratom daily , antidepressants too many side effects literally no sleep constant nausea .
It gives euphoria but doesn't take all the anxiety and depression.
Until you develop tolerance and go through withdrawal hell that is
Oh no, a keaton junkie
Wow.
Took me 3 days to feel the effects, weird...
I guess that could be the medicine that is different and now that I see I do indeed think more negative way
Dogs cats and sunsets 🌅 help or sitting at the base of a tree listening to nature focus your ears and see what’s the furthest noise you can hear
But people have to go to work, they can't just spend all their time in such lovely places
When it says CBT is just as effective I don’t gain much hope for meds :/
How much time does it take antidepressants to work?
Bout 2 to 6 weeks after that were thinking of switching.
Until your brain is damaged enough by those drugs to not recognize the side effects anymore... and then you're addicted. Perfect scam and too evil to believe.
Inflicting brain damage should be the absolute last resort, not the first reflex.
Up to 8
Interesting video
Negative affective bias may possibly be a more real view, but it is 100% a less useful view. We don't have the cognitive ability to see reality anyway
It’s a myth depression do nothing but destroy you it’s nothing but a illness
Thing is that doesn’t mean good things are not happening. It’s called a bias for a reason
@@MsKen420 How are you now? . In life there are only 2 problems--mind and the body. To feel better reduce negative thoughts [overthinking]. Your breathing is closely related to the brain [mind] and gives good relief from stress-anxiety. To relax sit on a chair or lie down, neck straight, eyes closed and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for 5-10-15 minutes or more. Don’t fight your thoughts. With daily practice the mind will relax. No deep breathing needed. Do the practice without any expectations when taking a walk, before sleep, in school, at work, when reading, etc. Like me, make this a lifetime daily habit to have a better life. Reduce negative social media, take morning sunlight walks and avoid constipation as it affects the mind instantly. Best wishes--Counsellor.
Absolutely, being right doesnt mean its the most helpful
About time day made one to work straight away. In stead of people saving for 3 months mucking there life up. What Research has been getting done
Fantastic! Fabulous!
so I should keep taking em and eventually it will work
been taking them over a month now but i still feel like shit
Don't worry. I saw a girl saying her medication worked in 4 weeks or do. She literally spoke how the SSRI is helpful for her to feel peace and be calm. She does not feel anxious any more and can make logical decisions in anxious environment.
Almost a week on zoloft 50mg. I felt much more calm and relaxed
How are you feeling now? I just started Zoloft and I’m just worried about all the long term side effects
but normally patient starts meds slowly with least dosage than icreasing it each two weeks or month
Someone with depression or panick doesn't have that long
Yuh thank you for saying it
They could be prescribed short term sedatives in the mean time and psychotherapy.The patient needs also to learn to tolerate their distress and manage themselves.
On lexapro. Very good cideo
2:37 the papi on the rail cause 🤭
They made me feel suicidal instantly, does it mean you have to believe they will work ?