8:18 Mirtazapine (Remeron) increases Serotonin about 30% - you could do as well with a brisk walk around the block. For reference, SSRIs increase Serotonin ~ 500% and MAOIs ~ 2000%. Fatal Serotonin Toxicity (if you must, Syndrome) takes place at about 15,000% Serotonin increase above baseline. Remeron is simply a strong antihistamine with some very weak effects at other receptors. Interestingly, it has been used as an ANTIDOTE to serotonin syndrome in the Netherlands.
The Mechanism of Action (MOA) is clever and the nomenclature arcane and highly esoteric. This is purposefully because it downplays the "Great Responsibility" Caveat by this presenter. I concur any time this Syndrome is observed the doctor has neglected such obvious result on a boosting sympatholitic psychotherapy. At any rate, these are state-employed pysch- opz....
Thank you for your lectures. My psychopharm lecturer speaks in a manner that none of us understand, presents approx 45-50 slides in an hour and plows through. He told us if we fail it's because we are idiots! Thank goodness you are there with your plain English lectures. Exam in 36 hours and counting!!
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my RUclips channel, so I get excited when I see other advocates. 💙❤
your psychopharm lectures are the best pharmacology lectures I've ever watched in my life - on the internet or real life - thank you so much , your data is concise, clear and very easy to remember
This video was great. It taught me more than just about the different kinds of drugs, it taught me how to actually remember things. Maybe this is why I failed school.
O M G Best psych pharm lecture and tips EVER!!!! From Squirt-traline to CeLEXUS needs a ECarG I will never mix my meds up again on a test!!!!! The mnemonics, from the drug names, to the neurotransmitter actions and all the SEs, they were ALL brilliant!!!!! From grateful nursing and med students everywhere, THANK YOU! Debbie Q Nur202 SUNY Orange Hudson Valley NY ❤️🇺🇸💙☺️
PS...the graphics are PERFECTION as well on all of your videos...so clean and simple that I know I will be able to close my eyes and visually see this presentation during an exam...especially the “periodic table”-like neurotransmitter symbols with + or - for their physiologic actions!!!!! Just wanted to mention that since I know a lot of the presenters here on RUclips like feedback, & we viewers know how hard you all work on designing the templates for your channel! Love the simple color schemes and the lovely main ‘orange’ theme drew me right in from the start as a SUNY Orange student lolol!
This was, for me, the best review of antidepressants. Appreciate the the inclusion of color-coded catecholamines w/(-) /(+) affected and the mnemonics. Thanks a💯
This is really good and concise, havent had any medical training, but this is very straight forward and serves good for an introduction, i think. Really good.
would you ever consider doing an add-on video for other antidepressants that don't fit into SSRI, SNRI, SARI, DNRI, TCA, or MAOi subclasses (e.g. an agent like vortioxetine/brintellix)?
Thank you for the content. I find it engaging, straight forward, and very useful. I have a few more months before I take boards and am so appreciative that you're here making these awesome videos! One criticism if I may, you talk really fast!!
this is an amazing video. your mnemonic works and your visual images are stimulating. I do use this technique to improve my recall but having something like this that is already done saves time. this is really helpful. thank you so much
jimbo calm down .... This is a great quick study for psych meds. About to take my psych exam for nursing - This keeps it simple and memorable. Jimbo i'm sure we would be more inclined to tell our pts to STAY AWAY from wine in general.
Thanks so much. I’ve never enjoyed studying and learning like I do with your vids and your book. 🤔 If this how I was fed info in elementary and high school, whew… I would have been 💭….
But mirtazapine isn't an SNRI, I felt like this was implied here. I'm forever on team mirtazapine though, it saved my life and makes going back to school possible! (But yeah, makes you pack on pounds and hold onto them)
subscribed!! love your lectures. Very creative and super informative. Keep up the good. You are great. I wish I can shrink you and carry you in my pocket
Hey there, thank you so much for your informative, clear and concise videos. I was wondering, if ADs are uppers and benzos are downers, how is it, from a molecular stand point, that it is a very common psychiatric combination? Aren't the ADs supposed to cancel the benzos effects, and vice versa?
No. You're taking too much of a reductionist view of two types of medications. Different antidepressants, depending upon their class and individual profiles, will yeild different effects. Benzos are an entirely different class of medications that work through a different mechanism of action.
At 17:50 - No. No. Any store-bought wine is fine - don't buy some fella's home-brewed beer or wine or aged cheeses and meats (jerky). That is all. With MAOIs most people will never have to change their diet because theres almost no TYRAMINE IN FOODS ANYMORE. Why? 1) Refrigeration of foods is much more consistent from manufacturer to retailer, and 2) Manufacturers now begin with starter cultures w/o decarboxylating enzymes, i.e., they remove a carboxyl group (-COOH), not to let people safely use MAOIs, but rather to keep the putrid stenches of cadaverine and putrescine from forming on their foods. Simple capitalism.
The wizardy of pharmaceuticals is useful in bromalogy ( science of food manufacturing)...I would not even consider these AntiDepressants let alone try dealing with Side Effects (SE) and potential Complications....lol
Pls is there anybody out there.. I think i might need help.. Have been taking serotonin reuptake inhibitors fluoxetine and amitriptyline.. For 4 year now.. Its has been working out fine in Cope with depression.. I stop taking amitriptyline abruptly still for 3 days while still on fluoxetine. Within 2days or so the medication stop working while i reintroduced amitriptyline back.. Dosages are flouxetine 20mg in morning.. amitriptyline 50mg + 20mg at night.. Pls help me cos am confused on whether am suffering. From withdrawal symdrome or serotonin symdrome.. Any suggestions pls
Again: No washout is needed to switch from an SSRI to a Tricyclic (TCA) Antidepressant. Why? The 2 TCAs that increase serotonin utilize the same mechanism of action. If you don't understand this, you aren't fit to be writing a book on pharmacology.
Best mnemonics ever!! I love coming back to this video and also your antipsychotics video
8:18 Mirtazapine (Remeron) increases Serotonin about 30% - you could do as well with a brisk walk around the block. For reference, SSRIs increase Serotonin ~ 500% and MAOIs ~ 2000%. Fatal Serotonin Toxicity (if you must, Syndrome) takes place at about 15,000% Serotonin increase above baseline.
Remeron is simply a strong antihistamine with some very weak effects at other receptors. Interestingly, it has been used as an ANTIDOTE to serotonin syndrome in the Netherlands.
The Mechanism of Action (MOA) is clever and the nomenclature arcane and highly esoteric. This is purposefully because it downplays the "Great Responsibility" Caveat by this presenter. I concur any time this Syndrome is observed the doctor has neglected such obvious result on a boosting sympatholitic psychotherapy. At any rate, these are state-employed pysch- opz....
Could I know where you found these percentages? I would really appreciate it!
Thank you for your lectures. My psychopharm lecturer speaks in a manner that none of us understand, presents approx 45-50 slides in an hour and plows through. He told us if we fail it's because we are idiots! Thank goodness you are there with your plain English lectures. Exam in 36 hours and counting!!
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my RUclips channel, so I get excited when I see other advocates. 💙❤
I don't even know how to express my gratitude for this series of videos 😭🙏🙏
your psychopharm lectures are the best pharmacology lectures I've ever watched in my life - on the internet or real life -
thank you so much , your data is concise, clear and very easy to remember
Agree- this is top notch teaching.
Ain't got nothing but love for you man, thanks a lot!
XD
i was so unmotivated to start studying pshych pharm for my USMLE but this is great!!!! thank you so much.
really really highlights how little primary care does before starting on antidepressants
This video was great. It taught me more than just about the different kinds of drugs, it taught me how to actually remember things. Maybe this is why I failed school.
I've searched high and low for a super helpful video and urs is by far the most helpful - thanks!
O
M
G
Best psych pharm lecture and tips EVER!!!! From Squirt-traline to CeLEXUS needs a ECarG I will never mix my meds up again on a test!!!!! The mnemonics, from the drug names, to the neurotransmitter actions and all the SEs, they were ALL brilliant!!!!!
From grateful nursing and med students everywhere, THANK YOU!
Debbie Q
Nur202
SUNY Orange
Hudson Valley NY
❤️🇺🇸💙☺️
PS...the graphics are PERFECTION as well on all of your videos...so clean and simple that I know I will be able to close my eyes and visually see this presentation during an exam...especially the “periodic table”-like neurotransmitter symbols with + or - for their physiologic actions!!!!!
Just wanted to mention that since I know a lot of the presenters here on RUclips like feedback, & we viewers know how hard you all work on designing the templates for your channel!
Love the simple color schemes and the lovely main ‘orange’ theme drew me right in from the start as a SUNY Orange student lolol!
I would listen to 0 + 1 pharm lecture.
This was, for me, the best review of antidepressants. Appreciate the the inclusion of color-coded catecholamines w/(-) /(+) affected and the mnemonics. Thanks a💯
Anyone else just learning this because it's fun?
Hell no!
Dude ur nerd as hell
Not really lol I have an exam tomorrow
No, I have an exam next week 😄
Me 😂
Right....
bro I love the tricks to memorize these meds, better than my nursing school lectures
Your lectures are phenomenal! Love all the mnemonics.
This is really good and concise, havent had any medical training, but this is very straight forward and serves good for an introduction, i think. Really good.
Good description of all antidepresants .good explanation most usefull .
Been practicing for awhile and I find your videos are awesome and a great review of what I learned in school! Great real world info
Best Psychopharmacology lecture ever! Thank you!
Antidepressants increase patient mortality by 33%!
dailynews.mcmaster.ca/article/antidepressants-associated-with-significantly-elevated-risk-of-death-researchers-find/
www.ncbi.nlm.nih.gov/pubmed/28903117
Are you mental?
YOU ARE THIS NURSING STUDENTS LIFESAVERRRR!!! thank you so much for this video!!
Thank you for making this available. Your lectures are really helpful and educative.
Can tryptomer. Be. Added. Wt ssri
would you ever consider doing an add-on video for other antidepressants that don't fit into SSRI, SNRI, SARI, DNRI, TCA, or MAOi subclasses (e.g. an agent like vortioxetine/brintellix)?
You are a life saver! I can't express how grateful I am.
Thank you for the content. I find it engaging, straight forward, and very useful. I have a few more months before I take boards and am so appreciative that you're here making these awesome videos! One criticism if I may, you talk really fast!!
Your lectures are marvelous. Thank you so much. I hope we see videos for other topics in medicine
Thanks for your comment! I am planning to release some new videos on general topics in psychiatry soon, so be on the lookout for those
Nice! How soon will you have the new videos out?
First one was just posted on Friday! ruclips.net/video/FHbRgjG9Ppc/видео.html
this is an amazing video. your mnemonic works and your visual images are stimulating. I do use this technique to improve my recall but having something like this that is already done saves time. this is really helpful. thank you so much
That this man was stimulated by your visual images
Great lecture! Your book is also awesome
Very helpful
This helped me to understand antidepressants and neurotransmitters
This is so helpful especially when you associate them with side effects, I personally always have trouble remembering ;~;. THANK YOU SO MUCHHHHHHH
U made it very easy to memorize pharmacology of psychiatry thanku so much for such helpful video☺
So incredibly helpful for memorization, thank you! Awesome video.
Your lectures are so interesting, Sir!
jimbo calm down ....
This is a great quick study for psych meds.
About to take my psych exam for nursing - This keeps it simple and memorable.
Jimbo i'm sure we would be more inclined to tell our pts to STAY AWAY from wine in general.
You did a fantastic job on this video
Glad I stumbled across this! So helpful! Thank You for doing these videos.
Thanks so much. I’ve never enjoyed studying and learning like I do with your vids and your book. 🤔 If this how I was fed info in elementary and high school, whew… I would have been 💭….
Prozac is the best man! I give it to all the addicts man also when patients complain of discontination ssri symptoms
Amazing . . . can you lecture at my school?
happy to see my city name in video (SOLAN, INDIA) in packing box of Amitriptyline..Great Videos.......very helpful
thanks a million. you are an awesome teacher
Hey!! These videos are amazing, do you think you may do the usage of other common drugs at some point? Caffeine, alcohol, MDMA, psychedelics etc?
They're already on this channel! Look for "recreational stimulants," "recreational depressants," and "cannabis and others."
@@MemorablePsych thanks will have a watch now :)
This is super helpful! Thank you for sharing!
you are amazing. thank you for making these
This is so amazing and helpful thank you !!
Is it possible to copy the captions? Perfect lecture.
All the right players in all the right places...love that song.
The book "30 Days to Reduce Depression" by Harper Daniels is recommended. Gives good daily mindfulness exercises. Worth a try.
Love these! Thank you so much!
Your lecture is marvelous. Thank you so much. 20/3/2019 😊
Nice, I see pharmacology is necessary now....
But mirtazapine isn't an SNRI, I felt like this was implied here. I'm forever on team mirtazapine though, it saved my life and makes going back to school possible! (But yeah, makes you pack on pounds and hold onto them)
Thank goodness for your channel
Super helpful, thank you!!
Great info and teaching
Thank you so much! These videos are amazing :)
Prozac have saved my life.
I’m currently studying for my mental health finals and this video really helped me to remember things! Thank you!
The best. Thank you 🙏
These lectures are amazing. Thanks!
You rock! Great mnemonics!
Super helpful. Thanks
Fantastic! Thank you so much!!!
Outstanding lecture!!! Thanks.
I like the butane analogy, it makes me think "I'll have to stop smoking after all the sex I'll be having on bupropion"
Bupropion makes you horny?
Very Helpful , Thank you SO MUCH
You went too far with that Hypertensive Crisis Memonic 😅 thank you for all this
That was so funny 😂 I thought the same
excellent - thank you so much!
Good presentation
Effexor is like tramadol ma guy. Decreased conc and less energy is wellbutrin more suited
Ty, but lecture notes are deleted from Dropbox. 😢
Thanks a lot! You make things very clear.
SSRI stands for selective serotonin reuptake inhibitor…. Idk what u said lol
Thanks!
subscribed!! love your lectures. Very creative and super informative. Keep up the good. You are great. I wish I can shrink you and carry you in my pocket
Sir melitracen tricyclic antidesprent it is secondary amine
Thanks so much 🙃
thank you so much
amazing thank you!
Tank you SOOO Mchhh
Mirtazapine is not a Nass?
What about the other effects of ssris ? Like weight gain or loss
ADH analog is safer for enuresis
Hey there, thank you so much for your informative, clear and concise videos. I was wondering, if ADs are uppers and benzos are downers, how is it, from a molecular stand point, that it is a very common psychiatric combination? Aren't the ADs supposed to cancel the benzos effects, and vice versa?
No. You're taking too much of a reductionist view of two types of medications. Different antidepressants, depending upon their class and individual profiles, will yeild different effects. Benzos are an entirely different class of medications that work through a different mechanism of action.
OMGGGG. YOUR VIDEOS ARE SO AMAZING!!!! thank you endlessly!
OMGGGGG your videos make things easy to remember but don't get the facts right. Yay!
Thank you !!!
so good, I thought he would say something about the rotten cheese....lol but he didn't
Would have preferred if 04:09 didn't show details.
Thank you for pointing this out! These details have now been blurred.
Old Umami: Macs
New Umami: Maxx
Yes
At 17:50 - No. No. Any store-bought wine is fine - don't buy some fella's home-brewed beer or wine or aged cheeses and meats (jerky). That is all. With MAOIs most people will never have to change their diet because theres almost no TYRAMINE IN FOODS ANYMORE. Why? 1) Refrigeration of foods is much more consistent from manufacturer to retailer, and 2) Manufacturers now begin with starter cultures w/o decarboxylating enzymes, i.e., they remove a carboxyl group (-COOH), not to let people safely use MAOIs, but rather to keep the putrid stenches of cadaverine and putrescine from forming on their foods. Simple capitalism.
The wizardy of pharmaceuticals is useful in bromalogy ( science of food manufacturing)...I would not even consider these AntiDepressants let alone try dealing with Side Effects (SE) and potential Complications....lol
citations?
Pls is there anybody out there.. I think i might need help.. Have been taking serotonin reuptake inhibitors fluoxetine and amitriptyline.. For 4 year now.. Its has been working out fine in Cope with depression.. I stop taking amitriptyline abruptly still for 3 days while still on fluoxetine. Within 2days or so the medication stop working while i reintroduced amitriptyline back.. Dosages are flouxetine 20mg in morning.. amitriptyline 50mg + 20mg at night.. Pls help me cos am confused on whether am suffering. From withdrawal symdrome or serotonin symdrome.. Any suggestions pls
It sounds like you are experiencing withdrawal from the amatriptalime. I know this was years ago. Hope you figured it out
perfect!!
My personal mnemonic for Selegeline is selective to B is that Selena Gomez chose Bieber (justine)
Im on Sertraline, get diarrhoea on it. No problems otherwise. TrazaBONE lol.
Great videos , im fascinated by the brain.
I fucking love this.
Thank you
Again: No washout is needed to switch from an SSRI to a Tricyclic (TCA) Antidepressant. Why? The 2 TCAs that increase serotonin utilize the same mechanism of action. If you don't understand this, you aren't fit to be writing a book on pharmacology.
interesting
thanks!!!
Paxil destroyed my life.
I’m so sorry to hear that 😔
Nice
❤