Fasting and Ketosis to treat Dementia With Dr. Matthew Phillips
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- Опубликовано: 9 июн 2024
- Metabolic neurology is a growing field focusing on the connection between metabolic and neurologic health, and encompasses neurodegenerative diseases like Alzheimer's, Parkinson's, other types of dementia, and more. Dr. Matthew Phillips is leading the way as a clinician and researcher exploring the use of metabolic therapies, like intermittent fasting and nutritional ketosis to help treat and prevent neurocognitive diseases. Dr. Phillips shares with us what he has learned from his research studies, and what he feels are the top tips for neurologic and brain health. He also explores how metabolic therapies can, and should, usher in a new era of healthcare.
Expert featured in this video:
Dr. Matthew Phillips, clinical and research neurologist at Waikato Hospital in NZ
www.metabolicneurologist.com/
Twitter: @drmclphillips
Papers Referenced:
Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease
pubmed.ncbi.nlm.nih.gov/33622...
Metabolic Strategies in Healthcare: A New Era
pubmed.ncbi.nlm.nih.gov/35656...
Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial
movementdisorders.onlinelibra...
Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma Multiforme
clinicaltrials.gov/study/NCT0...
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at metabolicmind.org/
About us:
Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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#KetoForMentalHealth
#MetabolicPsychiatry
#Dementia
#AlzheimersDisease
#KetoForDementia
#MetabolicNeuroscience
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#NutritionalKetosis
#MentalIllnessTreatment
#mentalhealthismetabolichealth
#ParkinsonsDisease
First we stopped all added sugar. Then we stopped all processed food. We then increased our fats & started with short fasts. We adopted one meal a day over time, and now it is a lifestyle we can easily manage. Our extended families think we’re a bit mad, but your evidence encourages us to keep it up & know that we’ll experience the benefits long term. Thanks for your video: SO helpful!!
77 years old and find that keto serves me well, my lab tests are all in the normal range, and I am doing very well. I am increasing the MCT and coconut oil to add to my cognitive skills.
I could have easily listened to Dr Phillips for another hour or two.
Us too! We really enjoyed the discussion and hope to build upon it in the future
He's collaborating with another hospital on a glioblastoma trial/study right now. Can't wait to see how that goes.
Very interested in what an OMAD keto Mediterranean food plan looks like. Please. Thank you.
Until you first get somebody off of the standard American diet you’ll never be able to get them to do intermittent fasting because they are just too hungry between meals. The first thing you’ve got to do is get somebody on a low carb high fat diet; get them adjusted to it and then incorporate the fasting. There’s just no way you can do it with somebody eating high carbs, low fat or basically a very high carb diet.
We’ll said! I’ve been thinking this very thing lately.
This is a great interview! I have a brain disease. They can't figure out what it is. Progressive Supranuclear Palsy or Cortical Basil Degeneration
I immediately went keto and have not gotten as bad as they said I would. All the neurologists have done is prescribe drugs which I won't use. You have given me some hope!
Try eating carnivore diet. High saturated fats, zero sugar, zero carbs. The constant war on cholesterol, aided by statin meds, is destroying our mental health. The brain is 25% cholesterol.
Check out vitamins
Cut out wheat
Read your own blood tests, drs miss a lot of things near the end of scale
The brain loves ketones .They help it to function better . Like high octance fuel in a racecar engine .A ketogenic /Carnivore diet can also help metabolic health , which makes us better equipped to fight illnesses.
Could I suggest a couple more things you could add for possible benefit? Hyperbaric Oxygen therapy (HBOT) and red light therapy. Check out RUclips videos by Dr. Harch of Louisiana on HBOT (amazing actual videos of patients improving over time). You are already feeding your brain more effectively with ketones, and HBOT gets more oxygen to more neurons in the brain (you can use low-pressure chambers for as low as $100 per dive, if you live near a large city or even rent or buy a chamber). The red-near red light therapy stimulates mitochondrial activity and cell repair. I have an inexpensive $50 red light I use 3 or 4 times a week at home with other positive benefits … helps my Dad’s cognitive decline symptoms, too. These therapies are virtually no risk for potentially great benefit, and are pleasant and non-invasive. I pray you find a good solution for your disease … God bless you.
So glad you are doing better than they predicted! So cool that you got the idea to do keto rght away- Keep us updated - would
Love to learn more :)
It’s great you get such a wide view from different experts. I totally agree on the fasting. I am doing keto since may with intermittent fasting, all I can say is WOW WOW WOW to the difference to my life!! Happy, healthy, energised. Loving life, from Carb coma! I do 2mad mainly (I have done OMAD but I think 2MAD suits me as a woman and mother) I did 2 three day water fasts and one 10 day water fast. So amazing!!! 🎉❤
Thank you for sharing your experience!
My mother in law has been diagnosed with Vascular Dementia. Her husband, my father-in-law thinks we are liars when we suggested they try this with her. The consultant just thinks it’s stay at home and just get worse until you go into a nursing home. There is NO interest in seeking solutions!!even family members are angry at us for suggesting this and MCT Oil!! But we tried! (But now we are in the naughty corner!!) 🤯
Thank you for interviewing Dr. Phillips. This was a really fantastic conversation.
Understanding the Taoist principles on yin and Yang has been so vital to my recovery from bipolar in terms of rest, exercise and nutrition. Really enjoying this episode.
Also eating within a 6 -8 hr window with 2 good size meals
This channel gives me hope
Me too. I love that he quotes the old useless mantra eat less move more.
Eat breakfast, Healthy whole grains. Five portions of fruit and veg ( including pizza)
Eat vegetable oil not butter.
Fruit all year round.
Sugar free soda as part of your calories.
And also calories in calories out.
All nonsense.
He's a good man and a good example. Looks super healthy!
Dr Phillips is amazing. I live in Auckland and New Zealand is way behind on preventative metabolic health. Keep up the brilliant work
Sadly 2020 - 2022 was a missed opportunity in NZ for getting people interested in metabolic health as a means to improve outcomes during a pandemic.
We're lucky to have Dr Phillips, who goes way above and beyond. We're also lucky his place of work has allowed him to work this way in the public healthcare setting...in that respect we're ahead of the field. Now, if we could clone him and have one in every hospital.. haha.
I so agree with both of you. There was an article in the Taranaki Daily news (Stuff) a couple of weekends ago about Dr Phillips and two of his Glioblastoma patients.
I'd be a happy camper to be healed of chronic long-term severe depression. It's exhausting. Been Keto since 2016 and do intermittent fasting as well. No improvements. But I keep going and keep hoping.
What are you trying to heal? I have been Ketovore for 6 months to stop my 2 monthly seizures from a Brain Injury in 2004. I stopped all fruit & veg.
You probably have nutrition deficitis and gut issues. Try GAPS diet.
Only the carnivore diet helped me with my severe depression. It’s been a night and day difference.
Try carnivore and then also lion diet ...only ruminant meat for a time ...hope this helps❤
Stop watching television.
i’m on my walk, so do five sets of 10 squats and 10 lean forward push-ups as well as a 3 to 4 mile walk which contributes to my morning regimen. Morning shots of combine ginger, turmeric, ACV and orange juice are very helpful. I also do a vitamin B complex,
Potassium, and vitamin D three. I often do a 16 to 8 fasting with eggs and bacon one morning and course oats the other morning.
Lunch is often salmon or sardines with arugula. Evening meal is chicken or beef.
Pork is not good for brain.
Love Dr. Phillips work shared his talk on parkinson's with a friend. Metabolic neurology 😊
My late father was a neurologist. He never believed nutrition had anything to do with brain health. He would be amazed at the research now. One thing, he always knew this plaque theory as the cause of Alzheimers was bunk. He never wanted to prescribe the expensive, useless meds targeting the plaques but patients, desperate for anything, would demand it. If those patients only knew about fasting...
I am a 77-year-old male for the last four years has been often on a keto diet. I have lost 60 or 70 pounds, my one C is 5.4 and I find that reduced carbs and consumption of fat as well as an abundance of eggs is most beneficial to be functioning on a daily basis. I go for morning walks and do five sets of
There are so many people suffering these diseases, we hear about the celebrities. If these celebrities would embrace these treatments and get better, then the word would spread!! I think about Michael J Fox, a fellow Canadian - I wonder if he'd be up for this experience (or indeed has he tried it??)
Thanks so much for this fascinating interview.
I'm doing every other day, it is way easier than OMAD, because on the eating day you are so satisfied the next day is no problem. But, I eat a very healthy vegan diet and I do use a very good quality MCT pea/pumpkin protein as a creamer in mushroom coffee, every day, even on fasting day. But, it's less than 500 calories and it's for sure Ketogenic.
Thank you! Just a comment: it might be harder to fast when following a high carb processed food diet with insufficient nutrients, healthy fat and protein. In my experience, the LCHF whole food diet goes hand in hand with fasting. ❤
I agree. Although fasting can fit with any dietary pattern, clinical experience seems to indicate that low carb and/or high protein eating patterns are likely the easiest and most successful.
MIGHT be harder? LOL... Before keto, I spent about 20 years being fat and hungry all the time. After adjusting to keto for a few months, there would be days where I realized in the evening that I had forgotten to eat. It definitely makes the fasting part a breeze.
@@metabolicmind It would be noce to do a deep dive into how to do keto on alternate diets. I prefer vegetarian but cannot maintain ketosis if I am carbbing. Is it just that we must combine vegetarianism with fasting? The contradiction here may be the sugar addiction I struggle with when eating carbs, I have a more difficult time fasting. Hope that makes sense.
I think it depends on the person, perhaps? Fasting was easier than anything I'd done before (after the initial week or so of adjustment). Only later did I start restricting carbs: I'm not sure I could've done that first and been successful without the deep plunge of fasting.
I couldn’t fast even 16/8 leave alone 42 or 72 hours if I were not in ketosis.
Keto makes it easy to fast - you’re never hungry
Dr. Phillips is absolutely fantastic!
How the brain creates reality - how cool. I was just cogitating on the fact that I can look at my oversized tummy but it doesn't seem to translate into taking steps to reduce it. Funny how that works!
Thank you, Dr. Scher.
So helpful. Love this new focus.
Love love to learn from Dr. Mathew Phillips ❤
Excellent information. Great understanding of people’s mindset.😊
Really interesting and a game changer. I'm critical of you tube for the usual reasons, but as a venue for new approaches to disease, its the best.
You guys give me hope, thanks ❤
The comments on being 'stuck' in germ theory was a light bulb moment...great interview!!
Brilliant! Thank you!
Hope and a plan. Love that!
Good vid but, to the good Dr. Phillips - panache vs. panacea?
Hi Ben! Yep, my bad...my brain and mouth don't always connect properly. :) Very best, Matt.
I hear that nutritional ketosis can help that! ;-) Cheers Matt. @@drmclphillips
Very interesting!
I would love to know how much damage drugs that alter brain chemicals. I have been trying to get as many papers from Pub med and NHS and there are quite a few that are confirming that in a lot of cases where SSRI and anti-psychotic meds are used the longterm affects are quite severe.
So to use a diet or a way of eating that has been used for epilepsy and has shown great results seems a no brainer ( pun intended).
😂 Nice pun.
Love this channel ❤️
Thank you for the kind words!
The ones that will try this approach is perhaps those at the end of their rope. Thinking "it is Snake Oil but what the heck I'm desperate to get off this ledge" then they feel better, medical conditions reversed and get in here and shout to the world the wonders of this method.
So we keep shouting some day they will know
Carbs are not essential
Nutritional ketosis is good
Fasting is good
Meat doesn't cause cancer
I pray it happens soon
Thank you Brad I loved what you did at Dietdoctor and I love even more what you are doing here❤
I am religiously OMAD too!
Thank you!
I think I’ve got a crush on Dr Phillips. So pleased he and Dr Bret Scher have found each other. I listen to Dr Scher all the time. Have only found Dr Phillips today, random!!!!
As effective as this may be for intervention, i believe it really shines in prevention. I believe ketones are required from birth for brain health.
100%. We should experience a mild state of ketosis overnight at least.
0:00: 🧠 Dr. Bret Scher and Dr. Matthew Phillips discuss the intersection of metabolic health and neurologic health, particularly in relation to brain diseases.
4:11: 🧠 The speaker's interest in the brain originated from various sources and they started exploring it more after finishing their training in neurology.
8:41: 🧠 The video discusses the importance of metabolic and mitochondrial health for neuron function in disorders like Alzheimer's and Parkinson's.
12:41: 🕒 Resting properly with exercise is important for avoiding long-term damage to the body.
16:54: 🧠 A randomized trial showed significant improvement in activities of daily living and quality of life in Alzheimer's patients on a ketogenic diet compared to a low-fat diet.
21:08: 🧪 The results of the trial were encouraging, but there is room for improvement.
25:29: 🥦 The ketogenic diet is a method, not a specific diet, and can be adapted to different cuisines.
29:47: 🔑 Mitochondria play a crucial role in our cells and are affected by excess meals and glucose spikes, leading to lifestyle disorders.
33:57: 🔑 The speaker believes that having psychedelic therapy as an option in medical practice is necessary due to its effectiveness, broad range of benefits, and self-empowerment it provides.
Recap by Tammy AI
A farewell to glioblastoma would be great!
thank you for this... I 'naturally' fast for 16-17hrs per day. But I do have a cup or two of black half/caff in the morning. Does a small scoop of Collagen and a teaspoon of coconut oil BREAK my fast? I've heard both yes & no. Please help!
That's a good question about what does or does not break a fast. Part of that depends on what you're trying to do. If you are trying to reduce calories, then it likely isn't significant. If you are trying to keep insulin low, it is also likely not significant as there may be a very small insulin effect, but not likely meaningful. If you are trying to stimulate autophagy, that's a hard question that is difficult to measure.
I prefer two meals a day for my mother. Sometimes even 3 meals. I always give her something if she asks for food. But, very, very, low carb.
At 93, I've noticed favorable improvements.
Less aggressive, more interested in daily life. A1C lowered to a good number.
Why do you think spiking her insulin theee times a day instead of once is good for her?
Another excellent conversation, Dr. Scher. Thank you! At 35:42, Dr. Phillips describes how it's human nature to not even be able to see new concepts which are counter to those we already know. David Brooks describes this phenomenon in his book, "How to Know a Person". Here is the excerpt:
'…This is called “conceptual blindness” and explains why very smart people can sometimes do phenomenally stupid things. Think, for example, of those generals in World War I. They were educated as cadets in the age of the cavalry charges, and they built up models of war that were appropriate in the era of horses and rifles. But decades later, after they had become generals, they found themselves leading troops in the age of machine guns. Only they hadn’t updated their models. Year after year, they sent millions of men charging directly into machine gun nests, and to their deaths, because they couldn’t see that their models were obsolete. It was mass slaughter. Conceptual blindness can happen to anyone.'
I believe cultural change consultant, Dr. Gustavo Grodnitzky, Phd, coined the term...Thank you, Metabolic Mind, for all you're doing to help us overcome our blindness and to adopt changes that promise to reduce so much unnecessary suffering. 🙏
I have parkinsons and i will do anything to skow this disease. I have started a keto diet and fasting. When i tell people their reaction is is that healthy. When i tell them i am building up to a long fast to release to naturally release stem cells they look at me like i am mad. I eat meat, green veg, cheese, and healthy fats like olive oil, butter, and animal fats, no peas. I'm tryimg high dose vitamin b1 as well.
How are you doing now?
@@danellekelly1214 High dose vitamin B1 1000mg twice a day makes a difference. Still on keto with meat, veg and cheese same oils. Lost 28lbs in weight, waste dropped by 5 inches.
@@michaeloconnor9465 awesome! I hope you continue to do well :) Thank you for replying!
In my experience the older one is or more importantly how long one has been following SAMS, Sad American Medical System. The longer one has been damaging our bodies, the longer the water fast/no food fast must be taken to“reset” their bodies.
I walked away from the SAMS after losing my hubs to cancer. I'd learned all I needed to know about why the system doesn't create health.
As was said, the current therapies are not working for Dementia, why not try intermittent fasting/ketosis with a Doctor who understands it, and see what happens?
I have Epilepsy and starting dementia, been looking for that Dr too!!!
👍👍👍
Please do a video on narcolepsy and keto
This episode still isn't appearing in my podcast app, even though episodes before and since have appeared in it.
Are you talking about your audio podcast app? We are staggering our releases, so it comes out on video and then as an audio podcast a few weeks later. Sorry about the confusion!
@@metabolicmind Yes, my Google Podcasts app. I see now that subsequent episodes actually haven't yet appeared in the app.
Curious about the balance of maintaining muscle mass and just one meal a day. People are starting to suggest keeping three meals but eating them closer together I. A smaller window to get the protein needed for muscle mass and associated improvements in metabolism and health
Thats a great point. Protein is a crucial macronutrient for muscle growth. If someone is eating OMAD every day, it is still important to get adequate protein.
How about end of life care for Alzheimer's patients? Especially ones that are bed bound, cannot do anything themselves, and have no teeth to chew?
@metabolic mind How do we follow a Keto way of dieting but can gain weight instead of losing please ? Many thanks
Great question. For those who don't have weight to lose, ketogenic diets often don't result in further weight loss. But for those who experience unwanted weight loss, here's an educational guide that may help with more detailed information. www.dietdoctor.com/low-carb/gain-weight
I want to read a book that explains all the mechanisms of fasting including prolonged fasting. Does anyone know such a book? I watch so many videos but it’s hard to keep up with the science!!
Obesity Code, Dr. Fung, Chapter 20, and Ketogenic The Science of Carb Restriction from Nutrition Network, Chapter 10 Therapeutic Fasting 😊🌸
Here's an educational guide (not a book) with links to multiple studies. This may be a good place to start. www.dietdoctor.com/intermittent-fasting
@@metabolicmind Thanks so much! I appreciate all the ideas. I LOVE Dr. Fung and have read his books. I was looking for a very scientific explanation. I’ll check out the guide!
@@metabolicmind 37:57
Dr Mindy Pelz/Fast like a girl.
She has a channel in RUclips.
Is OMAD really easier on a high carb diet as a starter? Or even 8/16 on high carb? Won't people be hungry a few hours after their last high carb meal? I came to the conclusion that telling people "eat when hungry" on lchf is much easier.
In my case at least, the longer my fasting became.. and gradually over time, the easier it was for me to move away from highly processed foods and carbohydrates in general.
Dr. Phillips says at 10:27 "... one thing you could do to improve the health of the Western population, ... would be simply to implement a proper fasting protocol in people."
And I meant to emphasize that if OMAD is doable as a starter.. in that it doesn't create too much stress.. it's fine. But most people who are used to eating carbs cannot do this as a starter. Gradual.. begin where one is.. only 8 or 10 hours if that is all that one can do to begin the habit and get to a healthier 12 or 16.
In our experience, we agree that listening to satiety cues and following time restricted eating is much easier when eating low-carb or keto.
I always respect Dr. Scher what he has to say and his guests. Dr. Matthew Phillips has great research and explains his subject well. I believe he has the word PINACHE (swagger, flair, style) confused with PANACEA ( cure all, remedy ). He is way to smart to confuse these very distinct words.
I meant to ask him about that. Could it be a New Zealand thing? Any New Zealanders out there who can comment?
Thanks Diana! Maybe not so smart - not an NZ thing, I just mispronounced the word (I am prone to that on occasion). Best wishes, Matt.
My sister has lost 20 lbs quickly and has been diagnosed with AD. She is having trouble holding on to weight and strength. Would keto help or hurt. ??She can't afford to lose any weight.She is 5'3" 105 lbs.
Clinical experience suggests that those who don't have weight to lose will stabilize on a keto diet. But it could help to work with a dietician to make sure that is the case
Could a person achieve these same results eating complex carbs (such as beans and lentils) practicing intermittent fasting eating one meal a day?
That's a great question. And for some people, that may work. But not for everyone. There is a fair amount of individual variability, so that's where working with a professional and testing for your most important outcomes can be important. Thanks for the question!
Thank you for always responding@@metabolicmind
I try to fast every day but I can't eat a meal big enough to have just one meal a day. I can't get that much food into me in one sitting. I'm already close to being under weight.
Thanks for your comment. Luckily, fasting doesn't have to be one meal per day. Many people see improvements with an 18:6 or 16:8 fasting protocol. It's important to still get enough protein and nutrients when intermittent fasting, and for some, that can be difficult with only one meal.
The most hard hitting learning point being that Alzheimer’s is doubling every 20 years. So clearly the germ theory response is borderline crazy. Sure, medical treatment for Alzheimer’s etc might eventually come on stream and I hope so. But clearly the rapid growth in the incidence Alzheimer’s and of poor metabolic health generally is connected to something in our human environment. Dr. Philips infers that the reason is something to do with something in our food. Well it’s probably a bit more than an inference but it’s not yet proven beyond reasonable doubt. If I could place a bet on him being right I would place a large bet at very short odds and I would expect to win a lot of money. I think it’s only in the last year or so that I have learned that there might be a connection between the ridiculous dietary advice we have all been labouring under these last 40 years and rising dementia incidence. So infuriating. Anyway more power to dr. Phillips. Very important work.
"...something to do with something in our food." Yes, he implies this but also let's not forget his important message about Western humans eating all day and not having regular daily fasting periods to give our body rest and develop healthy mitochondria.
@@AzaleaBee yup I agree. Indeed he strongly believes that we require a longish fast each day. Against he’s probably correct. Personally I find a 14 hour fast to be tricky but based upon this video I’m just about to push that out to 16 hours. And he does seem to think that time restriction trumps what is actually eaten. All this really needs to be parsed out with more study. It’s all incredibly interesting.
@@MrBlaxjax All I know is that daily IF (at least 14 hours) and one weekly 36 hour is good for me now, for weight management, food control, and some pain management.
When I was obese.. longer and more frequent extended fasts were needed to help me escape it. After an injury the same (to get me off and keep me off prescription pain meds).. well not really "the same". I fasted long, hard, and frequently.
The only things humans should be eating is proteins and fats, thats it. If you start from there you see where the problems arise.
@@MrBlaxjaxskip breakfast and dont eat till the afternoon then theres you 16 + hrs easily achieved.
Is weight loss to reach a healthy fat mass the reason this works? That is what improves diabetes and BP and insulin resistance.
The effect is likely multifactorial, with improved metabolic health being part of it. But providing a different fuel source for the brain, namely ketones, also likely plays a direct role as studies have shown these cells have impaired ability to use glucose.
Sabbath, a day of rest.
No money to be made from fasting.
Yep, it's an issue. But it also means fasting is much less prone to marketing-induced corruption, so I kind of like that aspect. Kind regards, Matt.
2:28 Good luck finding a doctor who will support your low-carb WOE.
Here are some great resources to start with to find someone
www.diagnosisdiet.com/directory
www.dietdoctor.com/low-carb/doctors
@@metabolicmind Thank you! I just learned of one within 30 minutes of me. That's a blessing. So far, I haven't been able to get my calls returned, so maybe I'll just show up so it will be impossible to ignore me. 😆
@@Squee_Dowwondering if you have tried and been successful by showing up ? I am in another state
of Aus and am also desperate for help .
Most diet
claim to lose weight etc whereas I need to gain weight, I am 67 trim and reasonably fit with a recent Pet scan showing level 3 amyloid plague ie they are everywhere in my brain… There is a trial I can join to remove the plague but this process could cause brain bleed … I also have heard (from another youtube clip) about the potential corruption in the approval & funding for “Amyloid Plague is the cause and hence curing Alzheimer’s by removing it” ( this is in the US, some of the formally submitted photos were photoshopped),
I feel lonely in trying to find out the real cause and how to help myself not entering the dark cloud of Alzheimer’s looming right in front of me.
Thinking of travelling to Mel to find Dr Phillips myself.
If by any miracles Dr. Phillips read this and could help I would be over the moon.