Dr. Campbell, shout out from Tampa, Florida, USA. I have watched every one of your COVID-19 updates. I was so happy to see this lecture, as I'm struggling with the topic currently. You are perhaps one of the more formidable enemies of disease and disability :)
I'm studying the gate theory now, and it's completely different from this .. we have 4 components of the gate 1) the C fiber -for pain- 2) A beta fiber -for touch- 3) both of them end on a projection neuron 4) which is new (AN inhibitory inter-neuron that inhibit the projection neuron) and it is influenced by both fibers .. and their explanation that C fibers inhibits the inhibitory inter-neuron so activates the projection neuron and send the pain impulse up.. so C fiber opens the gate, while A beta fiber does the opposite it stimulates the Inhibitory inter-neuron so inhibit the transmission in the projection neuron (Closes the gate)
Thank you for the Informative and concise explanation of the gate theory. Loved the analogy, I might have been the stress but I made my friend I laugh!
Thank you Dr. Cambell, great and simple explanation!!!! Would you mine to explain what happened in the body (nervous system) when wir apply acupuncture because of pain or tell where could I find this information? Thank you very much!!!
sweet video Dr. However there's one questionmark I can't straighten out. I've learned that pain and thermal information travels through the spinothalamic tract whereas other sensory information, such as mechanical stimuli travels through the dorsal tract. now, I don't see why the touching of our elbow would then compete with pain, considering that they're not using the same tract? unless the inhibtion is descending (PAG), enkephalin induced or something like that.
They are ascending through different tracts but they both go through the dorsal horn... EDIT: Why am I even writing this, you probably figured out straight afterwards anyway.
There are two pathways. Descending is via periacqueductal grey matter opioid receptors and the release of opioids like enkephalin, endorphin and dynorphin which damp down pain by activating the substantia gelatinosa (or rexed lamina II) in the spinal cord. The substantia gelatinosa then inhibits the pain pathway. The 'ascending' is usually what people mean when they say the gate control theory of pain, as Dr.Campbell made distinct early in the video. It involves mechanoceptor stimulation of A-beta nerve fibres by rubbing the area near the injury. This sends sensory signals to the spinal cord, synapsing with inhibitory interneurones which also activate the substantia gelatinosa and interfere with the signalling of pain. The mechanism is called synaptic inhibition. Hope this helps (and isn't too late!)
don't mention hypnosis or anything .... the inventors the theory were using hypnosis and discovered how to literally stop pain in tracks. cutting it short, are ya doc ?
Cant get over how well this man describes things.....wonderful simplicity
Thanks Stuart, glad the vids are useful for you.
love the fat people analogy lol
Did I say that? Opps.
Dr. John Campbell whole study group at uni for Veterbrate physiology were cracking up. we had you on our big screens.😂😂😂
Big screen - sounds a bit frightning.
hahahhahahhahahahhhh
What an analogy. Bravo, brilliant. helped me getting a better understanding. Thank you.
Dr., your explanation is so simple and precise !
Thank you for these videos- you're proving to be invaluable to my revision!
You are an exceptional teacher! Thank you very much!
Thanks Dr. Campbell,! Your videos really help me understand.
An excellent teacher, helping thousands to understand the complexities of anatomy and physiology. Thank you
Dr. Campbell, shout out from Tampa, Florida, USA. I have watched every one of your COVID-19 updates. I was so happy to see this lecture, as I'm struggling with the topic currently. You are perhaps one of the more formidable enemies of disease and disability :)
Very good explanation Dr. Campbell .. Thanks a lot for putting this up here !!
Really helpful video, analogy cracked me too :)
I'm studying the gate theory now, and it's completely different from this .. we have 4 components of the gate 1) the C fiber -for pain- 2) A beta fiber -for touch- 3) both of them end on a projection neuron 4) which is new (AN inhibitory inter-neuron that inhibit the projection neuron) and it is influenced by both fibers .. and their explanation that C fibers inhibits the inhibitory inter-neuron so activates the projection neuron and send the pain impulse up.. so C fiber opens the gate, while A beta fiber does the opposite it stimulates the Inhibitory inter-neuron so inhibit the transmission in the projection neuron (Closes the gate)
And It all happens in lamina I and II.
ur videos are awesome.... it really helps in clearing my doubts.... thanks a lot🙏
thank you so much for explaining it so beautifully, and briefly
Thank you for the Informative and concise explanation of the gate theory. Loved the analogy, I might have been the stress but I made my friend I laugh!
Thank you Dr. Cambell, great and simple explanation!!!!
Would you mine to explain what happened in the body (nervous system) when wir apply acupuncture because of pain or tell where could I find this information?
Thank you very much!!!
Very good information, explained in a simple way. Thank you Sir
Thanks for summarizing this theory!
This was amazing! Thank you!
Thanks! Helped me understand what I couldn't from my lecturer and textbook!
Thank you. This is really helpful.
you've made it very easy to understand thank you..
that was quick and efficient thank :)
Thank You so much! I understand it now!
I'm love with this man
Great! Thought i wouldn't understand a word but made perfect sense!
6 fat people disliked this video lol, love all your videos, helped me so much. Thank you!!!
Im not as lean as I would like to be myself.
ahhahahahaha
very helpful for my 3rd year of my degree exams. Thanks!
Superb video sir ♥️
Thanks for explaining!
This made it very easy to understand. Thanks!
this is great, i have a neuro exam in an hour
Thanks sir. that was very well explained :)
Best. Explanation. Ever.
HAHAHAHAH Spat my coffee all over the table at the fat people analogy xD BEST VID EVER
thanks, good explanation.
Very helpful sir 🤗🤗🤗🤗
@dr. john-isnt presynaptic inhibition of pain pathway by an inhibitory neuron another explaination in the gate theory?
Amol Tayade correct. he is possibly explaining to first year undergraduates.
Correction: Mind is not a physical entity but brain is.
True
I love you professor
some...BULK..haha thanks for the vid, very helpful :)
Thank You
How do you make everything so EASY to understand sir?
Dayıcım ağzına sağlık, yanaklardan öpüyorum 🙌❤
thanks for sharing...
Very good
So what are the main criticisms of the Gate control theory?
thanks 😍😍😍
omg thanks!!
very helpful thanks
so funny explanation nice job
*hypothetical* can a sensation of pain in my lower body say legs, be left behind by a more severe hand pain ?
Sushil Sharma technically yes.
Sir, is there any role of descending pain pathway in Gate control theory?
Yes, descending gate theory.
Gate control theory has been shown to be only partially correct.
I am a pain fellowship trained academic neurosurgeon...
Do tell us more, interesting.
You wrote ascending inhibition in the tag line above. Did you mean descending inhibition?
sweet video Dr.
However there's one questionmark I can't straighten out.
I've learned that pain and thermal information travels through the spinothalamic tract whereas other sensory information, such as mechanical stimuli travels through the dorsal tract.
now, I don't see why the touching of our elbow would then compete with pain, considering that they're not using the same tract?
unless the inhibtion is descending (PAG), enkephalin induced or something like that.
They are ascending through different tracts but they both go through the dorsal horn...
EDIT: Why am I even writing this, you probably figured out straight afterwards anyway.
My books describe the mechanism as a descending pathway????
There are two pathways.
Descending is via periacqueductal grey matter opioid receptors and the release of opioids like enkephalin, endorphin and dynorphin which damp down pain by activating the substantia gelatinosa (or rexed lamina II) in the spinal cord. The substantia gelatinosa then inhibits the pain pathway.
The 'ascending' is usually what people mean when they say the gate control theory of pain, as Dr.Campbell made distinct early in the video. It involves mechanoceptor stimulation of A-beta nerve fibres by rubbing the area near the injury. This sends sensory signals to the spinal cord, synapsing with inhibitory interneurones which also activate the substantia gelatinosa and interfere with the signalling of pain. The mechanism is called synaptic inhibition.
Hope this helps (and isn't too late!)
Not sure the ‘Fat People’ analogy was the best analogy or even appropriate. Other than that, very interesting.
SOP CLASS OF 2018
don't mention hypnosis or anything .... the inventors the theory were using hypnosis and discovered how to literally stop pain in tracks. cutting it short, are ya doc ?
@dr. john-isnt presynaptic inhibition of pain pathway by an inhibitory neuron another explaination in the gate theory?
Yes, I think this would be a mechanism of descending inhibition.