Intuitive thinking about regulation of the TCA (citric acid cycle/Krebs) & adjacent rxns (e.g. PDH)

Front of mind when logic-ing your way through is to consider what the presence of each regulator implies. Then how that applies!
Compare and contrast what’s regulated by what in what way to determine how metabolic pathways are made to sway.
blog: bit.ly/metabolicpathwayregula...
PDF of expanded TCA chart: bit.ly/expandedTCA
Feel free to use, but please cite the bumbling biochemist if you do. Thank you and happy learning!
more Blog: bit.ly/metabolismglycolysis RUclips: • Regulation and use of ...
more on the context & chemical logic of the TCA: • TCA cycle (citric acid...
More on α-ketoacid dehydrogenase complexes here: bit.ly/isoleucinemsud  
 
more on glycolysis, gluconeogenesis, & metabolic logic: bit.ly/metabolismglycolysis ; parts 1-2: • Logic of metabolic "pa...   
 
more on the electron transport chain & oxidative phosphorylation: RUclips: • Electron Transport Cha...    
 
more on the malate-aspartate shuttle: blog form: bit.ly/aspartateshuttle ; RUclips: • Malate-aspartate shutt...  
more on all sorts of metabolic stuff: bit.ly/bbmetabolism
Great free review on the TCA and its regulation in mammals. (Found it after I heard a great talk by Dr Finley!) Arnold, P. K. and Finley, L. W. (2023). Regulation and function of the mammalian tricarboxylic acid cycle. Journal of Biological Chemistry, 299(2), 102838. doi.org/10.1016/j.jbc.2022.10...   
  
more about all sorts of things: #365DaysOfScience All (with topics listed) 👉 bit.ly/2OllAB0 or search blog: thebumblingbiochemist.com