What “cognate” means in biochemistry, especially in the context of translation and cognate tRNAs

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  • Опубликовано: 19 окт 2024

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  • @박지원-t1q2s
    @박지원-t1q2s 2 месяца назад

    OMG. You're my heroine. You're genius. You saved my day. Keep doing this. You're one of a kind.

  • @thebumblingbiochemist
    @thebumblingbiochemist  Год назад +2

    further reading:
    Blanchet, S., Cornu, D., Hatin, I., Grosjean, H., Bertin, P., & Namy, O. (2018). Deciphering the reading of the genetic code by near-cognate tRNA. Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3018-3023. doi.org/10.1073/pnas.1715578115
    Joshi, K., Cao, L., & Farabaugh, P. J. (2019). The problem of genetic code misreading during protein synthesis. Yeast (Chichester, England), 36(1), 35-42. doi.org/10.1002/yea.3374
    Marcus Fislage and others, Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A, Nucleic Acids Research, Volume 46, Issue 11, 20 June 2018, Pages 5861-5874, doi.org/10.1093/nar/gky346
    Ogle, J. D., Murphy, F. V., Tarry, M., Ramakrishnan, V. (2002). Selection Of Trna By the Ribosome Requires A Transition From An Open To A Closed Form. Cell, 5(111), 721-732. doi.org/10.1016/s0092-8674(02)01086-3
    Rudorf S, Lipowsky R (2015) Protein Synthesis in E. coli: Dependence of Codon-Specific Elongation on tRNA Concentration and Codon Usage. PLOS ONE 10(8): e0134994. doi.org/10.1371/journal.pone.0134994
    more about all sorts of things: #365DaysOfScience All (with topics listed) 👉 bit.ly/2OllAB0 or search blog: thebumblingbiochemist.com

  • @petdoctor3
    @petdoctor3 Год назад

    I earned my BS in biochemistry in 1984, DVM in 1989. Now retired from veterinary medicine, I'm studying biochemistry as a hobby. Love your videos. I wish the www was available when I was in college.