DNA Translation Made Easy
HTML-код
- Опубликовано: 20 сен 2024
- Download Marrow Free : marrow.roundsap...
Cells need translation to stay alive, and understanding how it works (so we can shut it down with antibiotics) can save us from bacterial infections. Let's take a closer look at how translation happens, from the first step to the final product.
The genetic code
In an mRNA, the instructions for building a polypeptide come in groups of three nucleotides called codons. Here are some key features of codons to keep in mind as we move forward:
There are 616161 different codons for amino acids
Three “stop” codons mark the polypeptide as finished
One codon, AUG, is a “start” signal to kick off translation (it also specifies the amino acid methionine)
These relationships between mRNA codons and amino acids are known as the genetic code (which you can explore further in the genetic code article).
In translation, the codons of an mRNA are read in order (from the 5' end to the 3' end) by molecules called transfer RNAs, or tRNAs.
Each tRNA has an anticodon, a set of three nucleotides that binds to a matching mRNA codon through base pairing. The other end of the tRNA carries the amino acid that's specified by the codon.
Translation: Beginning, middle, and end
A book or movie has three basic parts: a beginning, middle, and end. Translation has pretty much the same three parts, but they have fancier names: initiation, elongation, and termination.
Initiation ("beginning"): in this stage, the ribosome gets together with the mRNA and the first tRNA so translation can begin.
Elongation ("middle"): in this stage, amino acids are brought to the ribosome by tRNAs and linked together to form a chain.
Termination ("end"): in the last stage, the finished polypeptide is released to go and do its job in the cell.
Our polypeptide now has all its amino acids-does that mean it's ready to to its job in the cell?
Not necessarily. Polypeptides often need some "edits." During and after translation, amino acids may be chemically altered or removed. The new polypeptide will also fold into a distinct 3D structure, and may join with other polypeptides to make a multi-part protein.
Many proteins are good at folding on their own, but some need helpers ("chaperones") to keep them from sticking together incorrectly during the complex process of folding.
Some proteins also contain special amino acid sequences that direct them to certain parts of the cell. These sequences, often found close to the N- or C-terminus, can be thought of as the protein’s “train ticket” to its final destination. For more about how this works, see the article on protein targeting.
Though it is 5 years back vedio bt still ur explaination as fresh as now in 2024..Thnks fr this...😊
I’m
We are here
I Would love to hear your views on this!
MEDSimplified very useful
Very very very Useful
Very helpful
👌👌👌👌
Very helpful
The pronunciations are entirely clear ,and speed of explanation is well appreciable
Thanks a lot for the appreciation
@@MEDSimplified I LOVE YOUR VIDEOS MAN
@@MEDSimplified u forgot link in description 😑
I am in grade 12 preparing for neet, teachers also struggle a lot explaining this topic, so it was hard for me to understand, the visual representation, clear pronunciation everything made it so much simpler, thank u so much, this video was really the best!!!!! ❤
I am so glad you found this helpful
@@MEDSimplified 😊
how did your neet go?
This is BY FAR the best video over translation I have ever seen! My teacher is horrendous so I go to YT for help. I cannot thank you enough for this video existing. It helped me tremendously!
5:08 Adenine and guanine are purines(double ring structures) and thymine and cytosine are pyrimidines(single ring structures)
Please correct that. The video was awesome!
yup....he switched the adenine and thymine
Bruhh nice observation. I missed. But I think he do not wanted to explain those rings to us but he just wanted to write the names of it
I was about to comment, then I saw your comment, so I stopped and instead commented on your comment
Making my semester easier. Thank you for such short, illustrative, and easy to understand videos making life easier. You are a gem!
Bs karaha hai tu
Hain shoaibi?
Thank you man, This is literally the most simple video I've ever seen and its so understandable
Damn, brother you really delivered the topics in the most simplified way possible. Your channel will grow in no time. Be continue with your awesome simplified content.
As you know "SIMPLICITY IS THE KEY"
Thank you.
Thankkk you so so much Rahul. 😉Your appreciation and suggestions means a lot brother
I had never seen a person teaching so amazingly wonderful. God bless you. I was always confused with genetics, no matter how many times I study it. But today I have seen the video and my each and every single doubt got clear. Thank you so much
By far the best biology concepts explaining channel on RUclips.
Never seen such simple way if understanding, I wish my school and college teacher were like you. God bless
You are helping me learn translation and trancription at 10.30 at night with my exam exactly 12 hours from now
Being a student of biology
I must say u hv great talent of explaining.👌🏻
Thank u so much.
All my doubts are crystal clear ❤
Thanks for fantastic explanation 💙
Nice
One of the best video on translation, I have ever seen....
Thank you so much ! I read 3 different books and still couldn't get the idea so as to what translation is but your video cleared out everything ! God bless you ! Keep up the amazing work .
Thank you so so much 😆😭my teacher failed to explain this topic i couldn't understand even little bit and teacher gave us difficult notes 😭i have exam today and at last minute i thought to read it. I was originally planning to leave this topic but now i totally understand it😆i can write this thank you so so much medsimplified team . you guys are doing so great 😆🥳
Love the explanation. I tried watching many videos on yt to clear this topic but i was not able to understand.After watching your video and reading ncert the whole topic is cleared.❤
At 5:07 the structures are wrongly depicted
Adenine and guanine should be double ringed structutes
Cytosine and thymine should be single ringed structures
Exactly 👍
Yes
yes, that's exactly what I was going to comment. I hope that the other informations are all correct.
I saw that too
Great video though! 👍🏽👍🏽👍🏽
This was so well explained. From the animation thing to the diagrams and colour codes and live voice memo with short written points....great job... thanks
You are doing a great job.. Many people like me are getting benefitted by your awesome job.. Hope you will continue to produce more amazing conceptual videos like this..
And a request please make videos on anatomy of human body.. Your efforts will be appreciated.. Thanks
Thankk u so much man. I am glad you found the content helpful. Sure i will try to make more videos. U appreciation means a lot
Your videos are amazing. You summed up this topic in the best way possible. Please continue making these helpful videos. Thank you so much for your help!
omg this is SO good. watched a lot of videos from various sites and could not understand, so this really
came as a surprise.
Man, you made my day. Very clear and concise explanation. Well done!
Thanks a lot for clearing the concept. And covering all the basic things most of the videos on RUclips don't provide knowledge so deeply as you did 👍
Ahh your videos and the concepts explained in an understandable manner is just WOW ❤️ THANK YOU FOR EXISTING
Besides the silly mistakes. This explanation is simple yet complex and understandable. 🙏🏻
Thankyou this really helped me complete the 12th class chapter
You've explained this difficult topic in very easier way in just 10 min. You're amazing 🤩
OMG this is the simplest explanation I have heard pouring concepts
cant believe its 5 yrs ago and such a brilliant explanation thank you so much
I think there are many biology teacher for tution but they can't make understand us.....but you are so unique.....your teaching techniques are excellent.....kash sab biology tution teacher aise samjhate ham logo ko to students ko padhai me maan vi lagega aur exam me vi top karega.....and their future will be bright.....⚡⚡⚡⚡⚡⚡⚡⚡
This has to be the most difficult damn topic in the book but your video helped. Cheers mate.
Sir, pls make vedio on revising full syllabus before few days of final exam. Pls like to support
Am studying for neet pg yet its so much of confusing topic
But you made it clear like a real master sir
Hands off
5:03 Wrong placement - A and G are the bigger ones , while T and C are the small ones.
Yess
Yeah as they are purine they are bigger in size
Yeah
Yes this made me douth a little bit!!
This channel is soo underrated man
thankyou so much... i was struggling a lot to understand this topic ...and you saved me...keep going your journey...all the best...
Juz a tip of iceberg .... Much more interesting to know more about ... And they are connected in this covid pandemic , vaccine development ....
Great work . It's so clear to understand. Thank you so much ❤️
Thank you . Best explanation ever with main events point within short period ❤
B.E.S.T of translation, literally the BESTT
I'm preparing for mcat and this is truly helpful, thanks a lot, jazakAllah
Bro me too..
Really a nice explanation, if someone wants to understand these type of concepts in less time, this is the place for you.... thank you so much sir. Which software do you use for animation dear sir
I use sparkol videoscribe for these animations. Glad u liked the video
@@MEDSimplified its amazing thank you for responding sir
5:05 You show adenine as having a single ring (being a pyrimidine) when it actually has two rings (is a purine), and you have thymine and uracil having two rings (being purines) when they actually have a single ring (are pyrimidines).
So eloquently explained! watch this in 0.75x speed.
Thankkk u😊😊
1 min silent prayer for those who disliked this video😠😤 .....i literally gained the top score and passed bcz of #MEDsimplified🙏😍
Yes no doubt 😇
Its 2024 and i am watching this!! Thank u so much sir for the explanation.... really this is very much helpfull .
I can't leave without liking this video.......Its very helpful and wonderful👍👍👍
thank you for saving me from slipping to depression
human body has trillions of cells, and this complex process is happening trillions of places and constantly throughout our lifetime? it is hard to even comprehend.
Sir you explain this process is in very simple format.
Thank you so much sir.
Best ever explanation I got on RUclips.
Thanks a lot
The same video, I did watch before ug exams, and watching again just before pg exams 🫣
You makes the biochemistry more easy to learn men . Tell me one , are you a doctor or teacher?
Let me know
Sir plz upload a video of MITOSIS and MEIOSIS
6:43 You have the mRNA orientation backwards: from left to right, it should run 5'->3'
sir you will always get students blessing and love for such awesome video thank you
7:48 is UAU, Tyrosine.
UAA is stop codon
ur animations are excellent,,more than the lecture I watched ur animations bro
Love your videos mate...but there's a small correction at 6:49, AUG was depicted in the wrong direction.
It saved my life ❤
Just a big thanks 🙏
It's really very simplified explanation.
Thank u buddy
Sprr bro, u made it easy I just found your vedio late but I understood all the points very happy
Really thank you for such good explanation it helped a lot
the ring structures of the nucleotides are interchanged. Purine (A, C) have 2 rings and T,G,U have a single ring
Purine is A and G which is double ringed and pyrimidine in case of RNA is C and U which is single ringed structure.
@@sirirangdale yeah my bad! A, G are double ringed
Outstanding lectures...thnku medsimiplified
sir aap...Activation of Amino acid btana bhul...gaye
Amazing lec my concepts are cleared 😍😍😍
I haven’t watched the video yet I hope it’s as good as the comments say...cause the comments feel like a paid ad.
This concept wont be problematic anymore❤
I understood everything from this 10 min video compared to the 1 hr lecture my teacher gave.
I loved ur concept
Such a helpful video, everything is clear so well
This video is a masterpiece .
thank you for making this subject easier
Awesome video plz make a video on operon system
Sure i will try!
Plz make a video on gene expression in prokaryotes.... translation video giving me a more knowledge...plz sir explain gene expression
AUG on the mRNA should be written GUA. The right direction is 5'AUG3'
Loved the explanation, thankyou so much!
Superb you are after watching your videos i am in love wd biology 😇
No one explained like u....thanks a lot
A is formed by two rings where T is formed by one ring But u showed opposite here
The same I noticed
Crystal clear explanation.......
I am from Bangladesh...The video is so much helpful for me💟Thank u 🥰
You got one new subscriber!
Thanks a lot for the vids. Really helpful. :D
You are most welcome
Same here!!
Oh I was hoping for a brief explanation of wobble when it comes to the stop codons.
great video. i clearly understand this topic now.
There is a mistake in 5:16 minute on the video. You switch between the thymine and adenine in terms of the number of rings.
Thankyou. It really helped.
I think Adenine and Guanosine are Purines (dicyclic) while the remaining two i.e. Cytosine and thymine (or uracil in case of RNA) are puridines(monocyclic).
Here you showed Adenine as monocyclic amd thymine as dicyclic.
Please answer me if i am wrong ASAP.. So that i can correct myself..
In btw.. Nice explanation.. Thanks 🙏
Edited: in the video At 5:09...
At 5.04 THERE IS A MISTAKE: adenine was shown as single ring structure and thymine is shown as double ring structure.
U did it very simple and easy to understand sir
Thank you
I hve wasted . My time in Watching five videos for this
But at last it made me clear
Thanks
Nice video presentation!!!..
plz make vedio on ovulation. it is tough part of biology. plz make it simple to understand for us...☺
In South Africa we say, "Danko" which means thank you. 🔥😊
Sir,u r awesome... your videos are so easy to understand.. please make more videos and keep it up👍👍
Thank you so much Abhishek 😁😁
outstanding video. no more words for such best video.
I salute to your efforts
Salute to you sir. A great work by you. I really appreciate your efforts.
Thank you for ur kind words 😍