Part 2: New Study Confirms that Cancer Cells Ferment Glutamine
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- Опубликовано: 6 фев 2025
- The publication of our recent paper, which showed that cancer cells ferment the amino acid glutamine, lead many of you to ask which dietary habits will lower glutamine levels in the body. However, while diet can greatly reduce blood glucose levels, there is no dietary practice that can meaningfully lower glutamine.
Additionally, glutamine is essential in several body processes, including the immune system. While intermittent glutamine inhibition via glutamine targeting drugs can be effective against cancer, it should be done carefully and under the supervision of a knowledgeable caregiver.
We are working to determine the proper dosing, timing, and scheduling of such diet-drug combined therapies.
Read the paper here: www.tandfonlin...
Link to previous video discussing glutamine fermentation: • New Study Confirms tha...
You can also follow Professor Seyfried's work on X: x.com/tnseyfried
Protect this man at all cost!
Why would he have to be protected? Who would be a threat to him? And why?
And all the teams working toward this protocol!
I don't know who would protect him because people in political power are also pawns and allies of the pharmaceutical medical complex that makes tremendous profits from existing cancer treatments.
So all of them would see this inexpensive and easy way to treat cancer as a big threat to their profits.
Who would protect him?
All of the people in political power are pawns and allies of the pharmaceutical medical complex that profits tremendously from current expensive cancer treatments.
This easy and simple way to treat cancer is a big threat to their profits.
@@dickschwanzstein1789 It's just a way to say that we love him so much... :D
This man should be recognized as a hero. I just wonder how long will it take for this protocol be the norm, or at least easily attainable for those in need that have found his work.
Keto is available to most who pursue it. Difficult part is inhibiting glutamine uptake at cellular level. Others experts are studying the clinical data for more easily available means to mess with glutamine metabolism.
Just a reminder: According to Dr. Seyfried, glutamine should only be blocked intermittently or in pulses because the body needs and makes glutamine for other bodily functions.
Look up Joe Tippens Protocol on using Fenbendazole for cancer.
Yes, the keto part is easy, it's the whole glutamine targeting aspect that I was referring to.
All our food contains Glutamine...
Fantastic Professor Seyfried. Thank you for let us know that for actual cancer patients the metabolic approach is just a hope than a real solution basically because it needs more research and more specialist involve. Have you thought that cancer could be an infection?
Hopefully these studies will be recognized globally.
If it can be shown they save lives, it will gain traction.
@@dickschwanzstein1789 Don’t hold your breath. This information has been around since 1929 and won a Nobel Prize in 1931.
@@dickschwanzstein1789 There are some very compelling metabolic human case studies. People with terminal stage 4 now at NED (no evidence of disease). But yes, larger human trials are needed.
For those who don't have a functional physiology background (biochemistry, endocrinology, neurology, genetic expression, …), the concept that diet (better term: nutrition), is not at the heart of your research is not obvious. Glad you spelled it out a bit as I am interested in what can I do to allow my body to function optimally esp when we're bombarded with carcinogens and toxins left and right in addition to stress triggers. Finding good information amidst all the noise is a challenge. I'll see if I can make sense of your paper ;-)
Extract from the paper, "It is important to mention, however, that dietary changes alone are unlikely to control tumor progression in most patients."
Retired oncology nurse with a PSA of 37 prior to ketogenic diet, lost 50 lbs in a year, 6’ tall was 268 lbs, down to 220 and still losing about 2 lbs a month. I was 185 lbs when graduating USN basic training in 1981.
Will re check my labs this spring.
Try Dr. Casey Peavler for additional glutamine strategies.
2 lbs a month???? what kind of diet is that diet coke?
@@bernardmauge8613 eggs, meat, fish poultry butter and cheese, limited vegetables green beans, cabbage, Brussels sprouts cauliflower and broccoli.
Less then 50 carbs a day,
5 carbs a day ideally.
This is the 2nd time in 3 years I have had these results, after the first year from 268 to 220 I added breads, rice,pasta and potato’s back into my diet and gained back all the weight 268lbs so I started keto diet again and after a year lost the weight currently back to 220 and completely convinced from my degree in Health sciences that corroborates my experience in health care and my own personal experience and that of family.
My Father died of bladder cancer at age 58, his brother and sister both died of cancer at the same age, my younger sister died of cancer last summer,
Diabetes also runs in my family, I am 1 of 4 children
@@bernardmauge8613 oops accidentally clicked reply.
So I am the only one of my siblings not diabetic, I was pre diabetic before starting keto diet and no longer am.
No alcohol, Flour, grains, corn, potatoes rice, Pasta, sugar or fruit. (Berries in small amounts are ok)
No foods with ingredients listed on packaging.
This has proven effective for me twice.
@@bernardmauge8613after a 50 lb loss it does slow down. Still heading the right direction
Glad to see you're looking into the mechanisms of how other repurposed drugs seem to have efficacy - fenbendazole and ivermectin.
He's the greatest. Anyone that gives a cancer patient a sugary treat should be charged with assault.
But, informed toward better understanding, so they can help join into the development and support for this work!?!
I wish I had known that over a decade ago when my mother died of brain cancer. She developed a wicked sweet tooth toward the end and was constantly sucking on hard candies. Now I realize that was the cancer crying out to be fed.
The first thing they offer you in a transfusion center is a coke!!
@@Jef-1-f It would be fine to have a treat, it's the overall pattern day in and day our that matters, and going through periods of suppressing glucose and glutamine.
I feel like I was assaulted for sure. And it wasn't the sugar, it was Big Cancer
Thanks so much To Thomas Seyfried for doing this research and getting the message out !
Low GKI is auto healing mode for the body. Mr Tomas Seyfried I love you my good sir you are a Gem.
As much as I admire his work, unfortunately I don't have the time to wait for Dr. Seyfried to work out the scheduling. At the moment all I can do is try to block as many of the cancer cells' pathways as I can and hope the conventional treatment picks up the slack.
You missed the point regarding scheduling. "It's got be adjusted for each person." "While intermittent glutamine inhibition via glutamine targeting drugs can be effective against cancer, it should be done carefully and under the supervision of a knowledgeable caregiver." You don't need to wait for years of fine tuning to be done.
@Noniksleft and how are you going to find a knowledgeable caregiver in this? I'm not. Certainly not in Medicaid.
@@MrKanti-yy5ux Some people just go it alone and get what info they can find online. There is dose and schedule info out there. Choose your own path and tell your doctors what you are doing. Be warned they will likely be very much against it so it would be a good idea to take some resources for them to look at.
Curcumin
Quercetin
EGCG
Artemisinin
Berberine
Silymarin
Sulforaphane -
Vitamin D -
Black seed oil
Black pepper
Rosemary - take 2 heaping teaspoons, emulsify them in mct oil, and consume with meal
Pomegranate seed oil -
Pomegranate extract/ellagic acid
Luteolin
Try taking vitamin D, a decent daily dose, like 10,000 iu or more.
He's so intelligent and sensible!
Why this is not taught to medical staff? My husband had AML. When dietitian came to advise on diet I asked about cutting sugar. She was surprised and said there is no need for it. Shocking!
Because medical associations and access to legitimacy is gate kept by people deeply embedded in the private for profit pharmaceutical industrial complex.
Naturopathic medical schools give a good introduction to this stuff... just gotta look outside the established, profit-driven model of western trained pharma docs 😉
@@magdalen5108 And, deeper than that as well, just the never-ending drive toward wealth accumulation of the 100 wealthiest families in the world. And, isn't that much like the uncontrolled-growth definition of cancer?
They are just pig pharm tools to keep people on meds
Not yet; times to change practices take still some time. The sharing of studies and those talks help shortening useless time wasting.
Very important and useful information... thank you! 😊
So impressive. I support you wholeheartedly.
We need more people like you....TY
This guy is just cool. The best for sure.
Thank you keep the info coming
I've been working on improving my GKI for almost a year. For the first 3 months I went vegan keto. Great improvement on my PSA count. I have metastatic prostate cancer. But couldn't keep from losing more weight. I got down to 134 pounds. Tried adding in more protein and my PSA went back up. Now I'm entirely focused on diet and consume about 1400 calories a day, 10 grams of carbs and 65 grams of protein. Exercise daily, and include red light sauna, cold plunges. I've tried HBOT and vitamin C IV's. Couldn't see measurable benefits from those but I blame my gki being too high.
At this point, my gki is under 2.0 part of the time and unless I fast I don't know how to get it lower. I pulse with DON when it's around 2.0. and take many supplements and other drugs like metformin and mebenzadole. If any has additional suggestions let me know or if you have questions I can help with, let me know as well.
God bless you and I hope you recover well and soon. Have you read Jane McClelland's book 'Starving Cancer'?
Where did you get DON from? It seems to me, that it is not easy to find a health care provider, who is willing to prescribe it.
You could add Chaga (mushroom) to your coffee or your tea, or make a tea from it, but it helps. And perhaps Increase your vitamin d levels to 15,000 IUs per day. You'll beat this, your mind is already seeing the days ahead where your health and vitality are fully restored and your only problem is old age. ❤
"I pulse with DON" is not something I expected to see. How did you get access to DON? I know there are some therapeutic doses reported in various studies, where the doses may or may not be optimal, probably many are unnecessarily high as Prof. Seyfried keeps saying that, but to me it seems that getting access to DON would be biggest obstacle in this approach to fight cancer.
@@neilnewinger3059 As far as I know, being willing to prescribe is not main issue, but it being only available/licenced "for research use only" or something like that. Unlike the standard chemo drugs that are commonly available for all oncologists.
Now combine with Ivermectin and fenbendazol
Great podcast,Thank You.
Great video but it cut off
Wow what a video!
Right or wrong, I do believe that blood glucose levels is most inmportant. This G/K index shifts focus from for in stone Metformin or other glucose and or glycolysis reducing medicine. On the other hand such a strategi focus will increase ketones. Will come with my own paper on this!
@@hobrosture3537 I agree intuitively I believe the glucose levels matter via diet! According to Hippocrates disease begins in the gut! And it seems science is getting on board with that assessment! Drugs don’t heal, they may assist, but it’s the body that heals!
Well spoken.
I would say best is just to over move/excercise, have some periods with food defficiency. Imagine to not eat 4hours, then go for a long run, and after that? Protein bar, shake, bread, fruit? NO just starve a few more hours.
yea thats how we used to live.
This is fascinating. As a healthy individual, should I be avoiding large amounts of glutamine, such as in regular consumption of bone broth for fear of feeding nascent cancers, or is this taking these conclusions too far?
No, do not avoid glutamine.
I would like to hear the Professor's view on pancreatic cancer cells utilisation of uridine, where it rips a ribose sugar for energy metabolism. Is this the only case of cancer cells repurposing more pathways for energy and how does it impact the press/pulse protocol?
Yes, uridine can replace glucose but, unlike glucose, there is not enough uridine in the microenvironment to sustain growth. It is a logistical issue.
I believe Dr. Seyfried understands there may be other pathways for cancer cell energy but these are not strong enough on their own to keep the cell alive for very long when both glucose and glutamine are withheld. That is the claim, I think. Not positive.
We just need a way to understand acetyl/methyl manipulation and we could do a lot to permanently halt cancer.
But where can I get? Fenbendazole and other repurpose parasite medicine.!💊 Thanks
amazon
@ send me a link 🔗 here mahalo
@@tourdelance3698 It's called Panacur C made by Merek
Isn't having low glutamine levels for a bit, better than having chemo and radio and all that toxic stuff?
I'd say so
What should I take, with metastatic prostate cancer? What anti-parasitic, if any? Thx.
The understanding of cancer cells using glutamine fermentation and metabolism has evolved over several decades:
1. Early 20th Century (1920s-1930s): Otto Warburg first identified the "Warburg effect," noting that cancer cells prefer glycolysis even in the presence of oxygen. While his work focused on glucose metabolism, it laid the foundation for exploring alternative energy sources like glutamine.
2. 1950s-1970s: Studies began identifying glutamine as a critical nutrient for rapidly proliferating cells, including cancer cells. Researchers noted that cancer cells consumed large amounts of glutamine, but the specific pathways were not well understood.
3. 1980s: The concept of glutaminolysis as a metabolic pathway in cancer was proposed. Scientists discovered that glutamine could feed into the TCA cycle and be used for biosynthetic purposes.
4. 1990s: Advances in molecular biology and biochemistry allowed more detailed studies on glutamine metabolism in cancer cells. The role of glutaminase and α-ketoglutarate production became clearer.
5. 2000s: With the advent of metabolomics and cancer genomics, researchers established the critical role of glutamine in supporting cancer cell proliferation, redox balance, and biosynthesis. The link between oncogenes (e.g., MYC) and glutamine addiction in cancer cells was also identified.
6. 2010s to Present: Further research has explored the therapeutic implications, leading to the development of drugs targeting glutaminase and other steps of glutamine metabolism. The role of glutamine in tumor microenvironments and its interaction with immune cells has also been a focus.
In summary, while the idea of glutamine's importance in cancer metabolism dates back to the mid-20th century, detailed knowledge of its role in fermentation-like processes and biosynthetic support has been developed over the past 40-50 years, with significant breakthroughs occurring in the last 20 years.
Excellent summary. Thank you.
What do you make of Dr. Seyfried's claim that his new paper is the first ever definitive demonstration that cancer cells ferment glutamine?
What is GKI
Interesting. So even prolonged fasting isn't enough to reduce glutamine sufficiently to starve the cancer?
The whole idea of "starving" cancer is flawed.
It is all about signalling, not energy substrate availability!
Animal-food-based substances like taurine or carnosine have been found to normalize cancer-cells!
@@btudrus What’s the best way to “signal” them out of existence?
It can be. For example, Fred Evrard did decrease his colon tumor size 50 % in just three weeks or 21 days of water fasting. He took scans before and after, the tumor was 10 cm wide at first and 5.5 cm after the fast. He got from Stage 3 colon cancer to no cancer in just 4 months. But unfortunately, after being cancer-free for some time, the cancer eventually returned with a vengeance and this time he didn't make it. :( So a glutamine-blocking drug would be a very welcome tool.
@@Kiihhu2 wow. I remember watching his account. I wonder if he tried fasting again the second time. That's scary. Sounds like we definitely need glutamine targeting drugs.
@ »What’s the best way to “signal” them out of existence?«
That's the wrong question.
The right question is: How to change the hormonal and/or the intracellular signalling so that a cancer-cells starts to behave like a normal cell...
Of course, this depends on the level of "aggresivity" of that cell. Sometimes lowering/normalizing insulin is just enough in a more benign / early stage tumor.
In a really aggresive tumor it is very hard...
Doc seyfried...are venom proteins identified in your research and have you used nicotine to taget these proteins?
I'm struggling to eat anything at the moment. Cancer is evil 😢 I'm losing weight because of this. Never know what to eat for the best, plus i don't like everything suggested.
Fermenting Glutamate (not Glutamine).
If your trying to lower glucose,and raise keytone,s how can what you eat not matter? And let's not forget something, treating cancer AFTER it's taken hold,is completely different than doing what can be done to prevent it.
Diet cannot influence glutamine availability to tumor cells. Glutamine targeting drugs are needed according to the information in our open access paper published in Nutrition & Metabolism entitled: Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. The glucose/ketone index (GKI) will let you know what you can or cannot eat to maintain nutritional ketosis. Each person is unique in what they can eat to maintain a low GKI.
Some cancers like prostrate and pancreas feed of fatty acids
Not according to our findings.
This sounds complicated? I’ve taken glutamine supplements in the past to combat ME/CFS! And by now having been diagnosed with breast cancer--I need to reduce glutamine and yet not?!
@@Essssss36999 the idea is to go off it for a brief time while glucose is also low. It's not a chronic thing.
I'm also suspicious of needing to supplement glutamine even for what you have. The body makes it so easily
not what he said. your body circulates an abundance of glutamine regardless of diet. he said that the glutaminolysis pathways need to be inhibited by targeted repurposed drugs on cycle and in absence of glucose..
@ I get the glucose needs to be reduced via keto diet or low glycemic or adapted to your situation (individualized) are you saying the glutaminolysis pathways need to be inhibited by the drugs in order to reduce glutamine?
@@Essssss36999 Hi. not "in order to reduce glutamine" but to stop the use of glutamine as an energy source inside the cell. glutaminolysis is a cellular metabolic mechanism that ferments glutamine to produce energy for the cancer cell (in absence of glucose). it happens inside the cancer cell. it uses glutamine as its fuel. the drugs mentioned are meant to inhibit this cycle, their effect is not to reduce glutamine inside or outside the cell. As far as i understand.
@@Essssss36999 What he's saying is get into a specific range of GKI so the cancer can't run on glucose. Then it begins to run on the secondary fuel of glutamine in a less agressive fashion. When it's "pressesd" down by this, then you come in with the glutamine drugs and "Pulse" them on and off (FenBen or DON are ones he mentioned being studied). The instructions on the box for FenBen (Panacur C by Merek) for example are to take it 3 days in a row. So for example 3 days on and 4 days off and repeat why keeping GKI index in control the whole time. Hence the "Press, Pulse" system. Not saying this works or not, just translating what he means so you understand it. The doctor does seem to believe this works and it makes sense to me
OMGoodness I just said this the other day. Parasitic drugs most likely work because the parasites seem similar to me as the 'cancer' cells. I think they act and grow quite similarly. Now this ketone and glucose index and ways to lower it and measure it is something you need to do which I didn't know.
Yes, well consider that cells that come to have their mitochondrial functionality reduced, become less able to supply the energy necessary, and finally the mitochondria have to give up, and switch into the much less efficient energy production necessary w/o adequate mitochondrial function. The cancer cells are likely just doing what is necessary for them to exist as basically 'bacteria' again. They then require much more (30 times) the glucose supply than normal cells do, in order to maintain their reduced energy state of metabolism. I think 'they don't WANT to have to do this switch, but we have had too much mitochondrial dysfunction pressure of our normal cells, that force the cancer cells to become 'cancer'. We must make our normal cells STAY normal, by doing what we can preventibly to reduce the need for this physiologic shift away from mitochondrial health that forces the cancer. The science emerging about how this actually happens is now being clarified, to inform better lifestyle changes! Support the whole scientific method, not just the parts of it that create products for corporations to sell! IMHO.
How do you calculate this GKI. Just glucose/ ketones?
ruclips.net/video/7_EKW5H1jsU/видео.htmlsi=bOJ32UKJDrLjBU0T
@@TalkingCancer-u4k thank you!
What about prevention
Make use of available cancer screening. Back off sugar and carbs, significantly. Avoid processed foods. Eat healthy, exercise, moderate sunshine. Reduce anxiety by means that work for you, meditation, mindfulness, prayer, philosophy, recreation, hobbies, good sleep hygiene. Stress and anxiety release cortisol in fight or flight response and cortisol raises blood glucose. Avoid environmental toxins. No tobacco, very little or no alcohol.
What can be more important than prevention?!? There is a LOT of information being discovered by working on this protocol that can be very important clarifying prevention, as well as for treatment. And, very important to learn more about our diet of 'junk' light indoors.IMHO
Are there any medical people in other countries using
this protocol? I've heard of Paleo Medicina. They use
a different protocol. Surely, some doctor in some other
country is following Dr. Seyfried's work and is using it.
All I know it's been used in Egypt, with consultation from Prof. Seyfried, and coupled to Egypt's current standard of care. Their standard of care doesn't seem to be as strict and written in stone as it is in many western countries, they seem to be more open-minded to new strategies, which is great.
What about keto adopted people? I am on keto for about 20 years. No matter what I eat I will never get my ketones higher than 0.9. My usual ketone level is 0.5. My glucose is usually is something about 3.9. But even if I will be eating nothing or just fat meat or fish or whatever with no single gram of carb, I will not get my ketones higher than 0.9.
What does your protein/fat intake look like? I find that if I go too much on protein, and it doesn't take a lot, my ketones drop significantly.
Your BG is so low I don't think you have anything to worry about. You are producing plenty of ketones. Your body is just using them for energy. I don't think the GKI is that useful a tool for you. You might be able to manipulate the ratio by eating a lot more fat, but what sense does it make to force feed yourself fat if you're already in a good place.
You might try to fast and add some exogenous ketons.
exercise and do fasting. resets everything !
@@mishaspektor coffee and especially beer, whiskey or glycerol will put them through the roof but use moderation you probably just need to kick start your metabolism. Exercise will also help.
What would you recommend if someone got cancer today other than aiming for below 2 GKI and avoid processed foods etc?
Live outside as much as you can IMHO. Light quality sets the timing for your biology to run as we are adapted over countless thousands of years to thrive in. Skip the sunglasses as soon as you can adapt to letting the light back into your eyes like everyone used to do. Allow skin to slowly tan without burning, it feeds your brain. Don't be afraid of getting cold sometimes, it renews mitochondria. Eat real FOOD and real LIGHT, not that stuff in hospitals, schools, grocery stores, and our homes.
lisanti told cancer grows fast using ketones in the reverse warburg effect; who's right?
Sounds like we need better (smarter) glutamine inhibitors?
It does. And they need to be easily available!
Vitamin D3.
the natural glutamine inhibitors can be selective to only cancer, in fact majority are.
@@eliasvonbernstorff6762 examples?
I wish I could get this questions answered…if one is taking L-Glutamine to help heal leaky gut, should one stop?
No, don't stop.
@@JuliePeterson-12345 I'd stop because l glutamine doesn't heal the gut, it's n acetyl glutamine that the gut uses and cells use the other type
Apparently it is all about timing of supply, but just in that tumor microenvironment.
Have you met endurance athlete with cancer? I mean not professional using steroid, and not someone runs once per week and showing it on social media.
What you (anyone) think of the carnivore diet? my dads just been diagnosed with possibly high grade gliom and i need to work out a diet plan for him to starve that sucker (the tumor). In the hospital they still give him jam and honey and cookies. Cold water exposure and breath work will also be done after surgery.
yes good idea
👍🏼
Many have tried the D orally but had no success.
Because it's snake-oil.
@ The professor has done much research on it. I think it’s always been given by iv which is the hard part for diy
Well, I believe that it is most important to understand that supplemental D3 is far inferior to getting it the way we were evolutionarily adapted to thrive doing, through natural daylight sourcing. D3 has 15 to 20 known active analogues and metabolites, many of which we do not get via the supplement version of sourcing. These appear necessary. If you live too far north or south of the equator for good seasonailty to keep the benefits up adequately, perhaps careful use of light from lamps might be beneficial, but not as complete and wholly beneficial as through careful daylight sourcing. Search quantum biology of light, for clarification.IMHO
@ That’s. not the D i’m talking about. It’s the other D that the professor talks about.
@@raykinney9907 Have you heard of VDR gene mutation
Many people found antiparasitic drugs help. Any connection with this?
3:55 i can hear it now
Yes, cancer cells & parasites are dependent on similar energy pathways.
Unfortunately, life is much more complex than this theory. Prostate cancer is an exception to that rule. Some other tumors may be also glucose-/glutamine independent. Prostate cancer mutates and its most aggressive forms called neuroendocrine cancer are glucose- and glutamine-dependent. That occurs late in the course of that chronic disease. The early stages of prostate cancer are phospholipid-dependent.
We have no evidence to support your statements.
@thomasseyfried7451 Of course, we do! There are results of both clinical trials and experimental research. Prostate Cancer is not a single entitled. This term covers a variety of cancers with very different metabolism and genetics. In early states prostate cancers do not absorb much glucose or glutamine. That is why the FGD- CT is useless in diagnostics. Those cells need phospholipids to grow. The neuroendocrine form, a very advanced cancer do use glucose and glutamine. But this is very late in the course of disease and only about 5% of all cases.
@thomasseyfried7451 Of course, we do. There is enough clinical and experimental studies. Cells are complex supramolecular hierarchical systems. Therefore, searching for the starting event initializing phenotype transformation does not make sense. All intracellular events occur at the quantum level. Cells are not containers with liquid reagents. Metabolic processes occur over there with high precision and are associated with shifts of electrons, protons, radicals, photons among macromolecules organized in a kind of vector microchips. If you consider mutations in DNA, you see quantum phenomena such as tunneling. If you consider a mitochondrial chain of cytochromes, you see quantum phenomena again. All macromolecules interact at the quantum level with a variety of energy fields. Those oscillations can be stabilized, for example, by ions of heavy metals. That changes function of enzymes or causes DNA mutations.
The outlined theory is not complete. At least prostate cancer is an exception from the glucose/glutamine rule. Prostate cancer cells are not glucose/glutamine dependent except of the very late stage of highly aggressive, castration resistant neuroendocrine form of prostate cancer. In the early stages they need phospholipids. That is why clinical studies indicate that prostate cancer patients should avoid milk, milk products and animal fat, (e.g., pork). Instead, they should have vegeterian diet with a lot of faser feeding gut bacterias that synthesize for us butyric acid.
@@przemkowaliszewski3290 Please send me any article showing prostate cancer cells growing in the absence of glucose and glutamine.
@@przemkowaliszewski3290 😂😂
so diet is irrelevant in regards to weakining cancer cells in relation to what he said? i mean disregarding that there are a bunch of foods that increase your general health and cancer risks
Please read our published papers for answers to your questions.
Its not really sustainable to keep a GKI at 2.0 or below. Not sure how practical this is for people.
What causes the fermentation of the glutamine?
Cancer cells ferment glutamine through a process called glutaminolysis, which supports their high energy and biosynthetic needs. Here’s how it works:
1. Glutamine Uptake: Cancer cells often upregulate glutamine transporters to absorb large amounts of glutamine from the environment.
2. Glutaminase Activity: Inside the cell, the enzyme glutaminase converts glutamine into glutamate by removing its amide group.
3. Glutamate Metabolism:
Glutamate can be further processed by glutamate dehydrogenase or transaminases to produce α-ketoglutarate (α-KG), a key intermediate in the tricarboxylic acid (TCA) cycle.
In cancer cells, α-KG supports the TCA cycle but may be redirected toward anabolic processes rather than energy production.
4. Warburg-Like Effect:
Instead of completing the full oxidative phosphorylation pathway, cancer cells often divert TCA cycle intermediates (including those derived from glutamine) to biosynthetic pathways, such as lipid, nucleotide, and protein synthesis, to support rapid proliferation.
This "fermentation-like" process avoids efficient ATP production in favor of creating building blocks for new cells.
5. Production of Lactate and Other Byproducts:
Even though glutamine isn't directly converted to lactate like glucose in glycolysis, its carbons are often shunted to pathways that feed into lactate production.
Glutamine also contributes to redox balance by producing NADPH through the malic enzyme pathway, which helps cancer cells resist oxidative stress.
In summary, cancer cells ferment glutamine by converting it into intermediates that fuel their anabolic growth, mimicking fermentation in prioritizing biosynthesis over complete energy production.
Weird question. The cancer cells use glutamine for energy. The cancer cells are defective cells that prefer simple, fast and inefficient mechanisms like fermentation. The cancer cells that manage to evade the immune system, request new blood vessels and quickly ferment glucose and glutamine and multiply are the cancer cells that are selected for and it just gets worse and worse. It is called fermentation because it happens without oxygen and produces a bunch of byproducts like lactic acid instead of end products like CO2 and water. If you exert yourself above what you can sustain you get lactic acid in your muscles as they anaerobically breaks down glucose. This is the way cancer cells behave all the time (warburg effect).
What causes fermentation of glutamine, is the cell or technically its mitochondria losing their ability to make energy using oxygen. When that ability is lost, the only option is to make energy _without_ ogygen, which is called fermentation. The cell adapts to its new situation, otherwise it would die, there's no life without energy. It's all about survival, the cell doesn't want to die.
@@Kiihhu2 Yes, thus the NEED to support the functions of 'normal' mitochondria, and the damaged-mitochondria will not necessitate the switch in desperation for these cells to survive W/O O2.
Make mitochondria great again!
C’mon Elon Musk! Wanna do something that will change the world? Fund this man in a big way - please!
I think he knows the scheduling and method. He's been looking at this exclusively for years and riling down. He mentioned DON but it's unavailable. Why not give the best estimate he has for now? Doesn't sound like it'll hurt anything.
there are natural alternatives to DON, look at dr casey peavler
The devil''s in the details. If these doctors have been doing their due diligence science, I would caution against rushing to different conclusions and premature actions W/O consulting them.
Why does he sound angry and impatient?
Because 1,700 Americans are dying each day from cancer!!
How can a diet based on toxic plants (see phytotoxins such as oxalates, lectins, phytates etc.) be good for cancer patients? It will only make the cancer more aggressive !!!
We can actually leverage some supplements do help our situation. Circumin, Quercitin, Berberine, EGCG etc.
I agree, don’t eat the plant but use them for their medicinal benefits.
@@btudrus have you not listened to Seyfried? The primary and kind of only thing that makes a significant enough difference is starving the cancer of glucose and glutamine. If you do that, as far as the cancer is concerned you could eat only oxalate and lectins and it would still weaken and die. If those things matter, they matter very little by comparison.
It's like worrying that if your wartime enemies wear bandaids they can't be killed with bombs.
There is a potential problem if you zero in too much on select biomechanisms. Outcome research is more valuable since in would necessarily include any countervailing biomechanisms.
Also, to reiterate Dr. Seyfried's metabolic model: the two primary fuel sources for cancer cells are blood glucose and glutamine. Simultaneously deprived of BOTH these fuels the cancer cells soon start to die. Lack of fuel will disable the cancer from acting 'aggressively' or in any other manner other than to die.
@ "The primary and kind of only thing that makes a significant enough difference is starving the cancer of glucose and glutamine"
That is completely wrong.
Trying to kill the cancer-cell is always the wrong solution (with the exception of a complete removal).
Trying to kill the tumor will make it more aggressive (simple evolutionary pressure effect).
The reason why ketogenic diets may help against cancer is not that it would "kill" the cancer. It is because it may help to normalize the cancer-cells (by normalizing it's mitochondrial function )...
I like Dr Seyfried and his work a lot and keto may be helpful but it is known that animal protein can also drive cancer so keto is best done plant based. Also even more important than the cancer cell is the immune/gut function as this is this system that eliminates naturally occuring cancer cells. Cancer is a symptom of a failed immune/gut so much attention needs to go to repairing the immune system and engaging it with the cancer for long term success.
You're wrong. You're entitled to an opinion, but it should be an informed one to avoid misinforming others.
@@wilcurran3377 I am neither wrong nor misinforming anyone. I base my understanding on over 10 years of cancer research and finding that provoking immune involvement was the only thing that fully reversed my wifes advanced stage 4 met breast cancer after trying nearly everything (conventional/alternative) under the sun. With nearly 100 years of focus primarily on killing cancer cells without great long term success you might reserve your criticism for a scientific/medical system that has and continues to fail us all.
@@officespaceredstapler2287 Keto is not better done plant based and animal protein does not "drive" cancer. Perhaps methods of its preparation do (although that's debatable), but meat itself absolutely, unequivocally does NOT. You might base your understanding on 10 years of cancer research, but consider your last comment.. that scientific/medical system that's failing you is full of so called "educated professionals" who have spent more than 10yrs researching cancer and are often grossly misinformed, so again your opinion is only as good as the information it's been formed on and your comments are unarguably misinformed. Look at the research of legitimate scientists who have been in the trenches and published countless peer reviewed papers on the subjects of metabolic science and human biology, Professors Bart Kay, or Ben Bikman for a start will adjust your perspective on the consumption of meat and plants.
@@officespaceredstapler2287 Keto is not better done plant based and animal protein does not "drive" cancer. Perhaps methods of its preparation do (although that's debatable), but meat itself absolutely, unequivocally does NOT. You might base your understanding on 10 years of cancer research, but consider your last comment.. that scientific/medical system that's failing you is full of so called "educated professionals" who have spent more than 10yrs researching cancer and are often grossly misinformed, so again your opinion is only as good as the information it's been formed on and your comments are unarguably misinformed. Look at the research of legitimate scientists who have been in the trenches and published countless peer reviewed papers on the subjects of metabolic science and human biology, Professors Bart Kay, or Ben Bikman for a start will adjust your perspective on the consumption of meat and plants.
@@officespaceredstapler2287 😂😂😂
Is it not already obvious we all need mass mass mass amounts of exercise ! We should have 4-6 small veg green fruit meals a day.. and forage and run and play alllll day long till it’s dark!!!!!!!
Had leomyosarcoma 13 yrs ago, uterine. Its back in my lungs, lympnodes and bones. So far 4 rounds of doxarubicin and using iver and fen 4 days iver 3 days fen 1st Petct at end of month. Fingers crossed.
Good luck to you. Berberine might be a good addition to that if you aren't taking it.
Let us know how it goes 🙏
Treatment has become an ass’embly line process .. and there in .. is the problem.
Individual targeted nutritional process = T I M E = lost of revenue ..
… one size fits all - is the standard - with slight variations