KDEL & KKXX Sequence|ER RESIDENT PROTEIN|Protein Transport|COP I and COP II vesicle|Cell Biology|
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- Опубликовано: 13 сен 2024
- KDEL AND KKXX SEQUENCE
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Just Mind-blowing ..... First time see your video mam .... thanks 🙂❤️
I just love the way you explain ❤
You made this easy to understand
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Very helpful videos 🙏
Thank you mam for such a lucid explanation🙏
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Your video makes my preparation very smooth and easy.
Lots of love from Naveen ❤
Wonderful explanation ma'am
Ma'am plz clear one thing- ER transmembrane protein- KKXX sequence and ER luminal protein- KDEL sequence?
Yes
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Mam you are great❤❤❤❤
Means kdel receptors er ki memb or golgi ki memb dono pr present hota h????
2:41 cargo receptor protein
Please give lecture on clathrin coated vesicle
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U r awesome mam
I am not able to understand you are saying to receptor as membrane protein. Is receptor a membrane protein. Please clear the doubt.
Yes, you can call a receptor a membrane protein
Thank You So Much
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Thank u mam
Membrane receptor, protein ko deliver karke apni place me wapas kaise ata hain mam? For ex. ER ka receptor golgi me deliver karke ER me return kaise hota hain?
mam will golgi receptor remains attached to ER after release of KDEL PROTEIN???
KKXX sequence is present on receptor or cargo protein or membrane protein
KKXX is present on the ER resident transmembrane protein.
So once the Cop I vesicle fuses with the ER membrane to release the resident protein, what happens to KDEL receptor. Anyhow it does not belong there, so can we expect the formation of Cop II vesicle to deliver it back to golgi. ???
Same my question plz reply
Notes bhi send Kiya kijiye
Source is Bruce albert Or Cooper?
How will receptor of membrane protein will go back from ER when you are saying receptor of membrane protein are present only on Golgi complex ?
The receptor is present for soluble ER resident protein. The soluble ER resident protein which stay in the lumen of endoplasmic reticulum have KDEL sequence on the C terminal. This KDEL sequence is recognized by KDEL receptors which are transmembrane proteins. They are present in both Golgi and ER membrane. But they have high affinity for KDEL Seq protein in the golgi (due to low pH) and can bind to the KDEL protein. In the ER also the receptors are present, but here it has low affinity for the kdel protein (neutral pH). so it does not bind to it. Hope it is clear now!!!
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