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Looking at TOP Foldit coronavirus solutions (Plus: lab testing)

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  • Опубликовано: 11 мар 2020
  • In this special update we take a look at some of the best-scoring antiviral proteins designed so far by Foldit players. We then step into the laboratory to see what testing these molecules is actually going to look like.
    Foldit is FREE and not-for-profit: fold.it/
    Follow the latest #coronavirus puzzles: fold.it/portal...
    This video features Lexi Walls, Ph.D., who recently published important research on SARS-CoV-2 (the virus that causes COVID-19). Read Dr. Walls’ new open access paper here: www.cell.com/c...
    This video features Foldit scientist Brian Koepnick, PhD. It was produced by Ian Haydon.
    Note: Foldit is an interactive computer game and not a distributed computing project. If you would like to donate spare CPU cycles to science, please check out the Rosetta@Home project on BOINC at boinc.bakerlab...
    #COVID19 #COVID-19 #SARSCoV2 #CitizenScience

Комментарии • 54

  • @laadee3669
    @laadee3669 4 года назад +120

    guys, you definitely need to add some kind of "green cloud" or something that highlights the target binding part of the COVID protein, otherwise you'll accumulate many "off-topic" solutions and unfortunately loose time

  • @Littlesilvercrow
    @Littlesilvercrow 4 года назад +74

    throw this into steam. lots more eyes will see this, therefore lots more bugs youll gotta fix and a faster way to get things done.

    • @litvenplayosu
      @litvenplayosu 4 года назад +6

      Throw it in to 4chan and spike a he will not divide us flag in it. They'll be on it in hours.

    • @Th-Rbt
      @Th-Rbt 2 года назад +1

      Cannot be done, Rosetta restricts from being able to expand, once they Rosetta improves they will be working on things like that

  • @laadee3669
    @laadee3669 4 года назад +28

    also some other observation: many people (including me) complete tutorials and find the corona for Begginers not understandable as this goal/aim was not explicit in the tutorials. at least one video describing the goal and some basic means for this task would help for sure, it is understandable that you lack time, but some small investment into the tutorial might get important rewards; keep it up!

  • @donaldpackard3191
    @donaldpackard3191 4 года назад +15

    Awesome video, hope Lexi can be a repeat guest, with all the misinformation out there from social media loud mouths, it’s so comforting to hear someone with an actual related PhD. who’s willing to bring her knowledge to any questions. Really impressive guest with a great demeanor in sharing info in a way that’s clear to all

  • @speedcatification
    @speedcatification 4 года назад +31

    Guys! What no one is saying is that Lexi's hair looks like the molecule of the coronavirus. And that's not a diss. Lexi's hair is AWESOME. (fire emojis)

    • @RandomNullpointer
      @RandomNullpointer 4 года назад +4

      She's been working in the field long enough to get assimilated XD

  • @gonaye1
    @gonaye1 4 года назад +20

    Thank you for posting this! You guys are heroes! Can you also upload this video directly to Facebook? I’d love to share it there in as highly absorbable a fashion as possible

  • @aokaze-minotaur
    @aokaze-minotaur 4 года назад +32

    Wait... does this mean we'll have gamers winning Nobel Prizes now?

    • @rossboylan3162
      @rossboylan3162 4 года назад +4

      I'm sure there's Nobel Prize winners that play videogames!

    • @1987andragon
      @1987andragon 4 года назад

      duh ! i am on it already

  • @rupertjumpedfirst3964
    @rupertjumpedfirst3964 4 года назад +3

    That was really useful information! Please spread this video to more people, so they understand what computing programs like floding@home are doing and how it is put into practice. I‘m sure that once people understand the process they will contribute much more.

  • @lynmin7833
    @lynmin7833 4 года назад +5

    Very, very thank you, guys! really I have no other words to say how grateful I am to you guy

  • @tofolcano9639
    @tofolcano9639 4 года назад +3

    I'd say the tutorial is lacking a bit more puzzles because after finishing it I found many more tools in the real puzzle that I didn't know how to use.
    I also wish there was a way to build the protein from the connections up, like first add the bonds you need and then build the protein afterwards. That's just me I think I'd have an easier time that way.

  • @jonesbbq307
    @jonesbbq307 4 года назад +2

    Can someone explain to me why we need to design these proteins? Isn't it already on the virus?

  • @michelespagnoli2462
    @michelespagnoli2462 4 года назад +1

    Hello people! Have you already studied how it works the ACE receptor? Changing the spike structure would mean changing RNA virus, that could be dangerous, if any mutation occur.

  • @benthecaptain7419
    @benthecaptain7419 4 года назад +2

    Do you guys use Folding@home data?

  • @amirsafari7140
    @amirsafari7140 4 года назад +1

    This is so exciting,i wish more people involved in this game

  • @paulschmitt9790
    @paulschmitt9790 4 года назад +2

    I am wondering how you test the binding of your synthesized protein to your target protein? Thermofluor experiments or ITC or another technique?

    • @Maniclout
      @Maniclout 4 года назад

      Same, I really want to see them do tests.

  • @flatbetpoker2272
    @flatbetpoker2272 4 года назад +1

    Hello! I don't understand how fold it plays. But now, what do you think of "capsaicin"?

  • @shadowolf3998
    @shadowolf3998 4 года назад +4

    also give some reward to the players who really helped you find the cure because this thing is kinda demolishing economies world-wide at the moment.

    • @SimnVersloot
      @SimnVersloot 4 года назад

      Yeah, who would be content with the title of hero during pandemic? /s

  • @montgomerybojangles8644
    @montgomerybojangles8644 4 года назад +1

    What's the difference between the project you guys are running and the current SARS CoV2 F@H project?

    • @mike74h
      @mike74h 4 года назад

      Foldit is using players' human intuition whereas the Folding@Home and Rosetta clients are strictly computational. See also Wikipedia: en.m.wikipedia.org/wiki/Rosetta@home#Foldit

  • @xvandrex
    @xvandrex 4 года назад +3

    3:22 that protein looks a lot like the one i made. I only putted 4 helix connected by loops. But i dunno if that is mine

  • @JoeKickass324
    @JoeKickass324 4 года назад +1

    Is this on the steam store? It should be free trial for entire quaratine

  • @nspc69
    @nspc69 4 года назад +5

    Lexie hair look like a protein :D

  • @phenomenalphysics3548
    @phenomenalphysics3548 3 года назад

    How will binding the protein help in stopping of the virus?

  • @donna.p
    @donna.p 4 года назад +1

    Do you need a gaming computer to play this?

  • @phenomenalphysics3548
    @phenomenalphysics3548 3 года назад

    Did Anika use this to find the protein against covid 19

  • @AlRaymand
    @AlRaymand 4 года назад +3

    ___MAKE IT IN VR___ some brains work different and ill geuss we need more ideas.

    • @AlRaymand
      @AlRaymand 4 года назад

      also i like the idea of steam

  • @mihaleben6051
    @mihaleben6051 5 месяцев назад

    Btw i beat that level by changing some side chains.

  • @flinkidu6031
    @flinkidu6031 4 года назад +1

    If foldit for android available? and How to install?

    • @flinkidu6031
      @flinkidu6031 4 года назад

      *is

    • @sych9561
      @sych9561 4 года назад

      @@flinkidu6031 As far as I know it is unfortunately not. But you could check on theirs web site.

    • @flinkidu6031
      @flinkidu6031 4 года назад

      Thanks

  • @enriquerecabal8395
    @enriquerecabal8395 3 года назад

    y en español ????????

  • @snyld
    @snyld 4 года назад +1

    Why is Brain that so hot?

  • @Supremax67
    @Supremax67 4 года назад +1

    You guys should raise funds for the winning protein. Always keep in mind, some people do it for the challenge, others because it is a world pandemic, but you'll always have a minority that will do it for the payout. Not only will it be great publicity to advertise the prize for the winner, but you'll end up with way more contributors.

  • @Theorium
    @Theorium 4 года назад +1

    damn

  • @1987andragon
    @1987andragon 4 года назад +1

    tell to the video gamers (ME) Euros 10 million reward for a solution and you ll see.... how WE gonna figure it out in no time :P

    • @Maniclout
      @Maniclout 4 года назад

      I think a couple thousand should be more than enough lol

  • @g_g_luka
    @g_g_luka 4 года назад +1

    1

  • @jalesdoidaoo
    @jalesdoidaoo 4 года назад +1

    Download slow Zzzzzz.....

  • @g_g_luka
    @g_g_luka 4 года назад +2

    First