Professor Patrick Chinnery - Mitigating mitochondrial mutational meltdown: can we save the species?

Mitochondria are sub-microscopic organelles present in every cell. They convert the breakdown products of food into a form of energy the cell needs to function and survive. An unfortunate by-product is the generation of toxic oxygen free radicals that can damage DNA within each mitochondrion. With a limited capacity for repair, these mutations are passed down the maternal line, where they predispose to disease, can shorten our lifespan, and are threatening our own survival. New biological insights have cast light on the mechanisms involved, but is Homo sapiens facing mutational meltdown?
Patrick Chinnery is Professor of Neurology at the University of Cambridge, head of the Department of Clinical Neurosciences and an Honorary Consultant Neurologist at Cambridge University Hospitals NHS Trust. He is a Wellcome Trust Principal Research Fellow with a lab based in the MRC Mitochondrial Biology Unit and jointly chairs the NIHR BioResource for Translational Research in Common and Rare Diseases. He was elected a Fellow of the Academy of Medical Sciences in 2009 and was appointed as MRC Clinical Director in 2019.

[@ArkadiProkopov]

This is a highly valuable presentation that elucidates the most important pathways of diseases and and origin of aging in general. Great job of a brilliant scientist!

[@AJKeefe]

This is very interesting. I think the loss of selective pressures on mitochondria themselves during our life can contribute to the problem. Meaning a decrease in mitochondrial turnover (e.g., less mitophagy due to less exercise and caloric over consumption) would allow deleterious mitochondria to persist and be passed on. Also, the role of muller's ratchet in Y chromosome degeneration (which does not undergo recombination) is another factor accelerating mutational meltdown.

[@gregsLyrics]

This is one of the most important vids I have ever watched. The science is amazing, the intellectual wisdom equally amazing. I believe Mito is responsible for our health - everything else is downstream. Thank you Dr. Chinnery for leading the way! Now I am going to watch the vid again and make notes and tell all my medical friends the importance of your work.

[@petercyr3508]

Your mitichondria are under attack from a constant overload of glucose; the glucose you consume. Sugars and starches. Your liver makes all the glucose you need. You literally do not need to eat any. Any you eat is extra and has to be burned or stored. Being in a constantly fed anabolic state is harmful to your mitochondria. Your mitochondria need you to allow them to get some fat and ketones besides all the glucose. You need to do some fasting and be in a catabolic state to allow autophagy.

[@davidford8539]

Can methylation repair these dna mutations ?

[@MarksThinkTank]

What an astonishing talk. Well done!

[@arnyarny77]

i saw the word mitochondria and the first thing that enters my mind is METHYLENE BLUE

[@PaulHigginbothamSr]

What I just listened to was that paternal mito added to mothers was weaker than only mother mito dna. But this study showes no such thing. So mother only is false and gives us hope that good mitochdrial function is more complex than we thought. 60% from the mother and 40% from the father is hopeful.

[@ResidualSelfImage]

Identifying how mitochondria genetics influence inherited defects and disease risks. big biological concept take away: mitochondria genetic code integrates and embeds itself into Cellular DNA and Cellular DNA impacts the creation of mitochondria genetic code creation in new cell creation. Mitochondria genome is different among different cell types and Mitochondria genome will vary inside one cell.

[@PaulHigginbothamSr]

I doubt seriously we could even make a mitochondria be more efficient than it now is. In fact a nano machine we build would be 100dreds of times less powerful than this wonder.

[@kyks6771]

🥖🍣

[@quantumcat7673]

I did not watch this piece for two reasons: ''can we save the species?''
You could have specify which species you're talking about but choose not to! Now it is unclear and misleading!
You are using some sort of sensationalist jargon to bait click people! Sorry dude but the more ''decontract'' you want to ''appear'' the less credibility you have for me! Start by being humble first and we'll see if you deserve any credit. You should recycle at Hollywood, the land of the fake and the deception!