MOA Of Erythromycin, Azithromycin, Clarithromycin, Chloramphenicol & Clindamycin🩺

[@DoctorNajeeb]

To watch the complete video which includes following points:
1. Chloramphenicol; Adverse effects.
2. Why clindamycin and macrolide (Erythromycin) don’t produce gray baby syndrome?
3. Clinical co-relation; Competitive Inhibition;
4. Why clindamycin and erythromycin are not used together for the treatment of any infection?
5. Summary of the role of clindamycin in TSS.
6. Clinical co-relation; Cross-resistance.
7. Mechanism of resistance involving the changes at the binding site, 23s rRNA.
8. Mechanism#1; Mutant ribosomal protein.
9. Mechanism#2; Mutation of adenine group at target site, 23s rRNA.
10. Mechanism#3; Methylation of adenine group at target site, 23s rRNA.
11. Clinical co-relation; Cross resistance because of erm genes.
12. Clinical co-relation; post-antibiotic effect in relation to clindamycin, erythromycin
13. Secondary effect#1; Reduced quantity of proteins
14. Secondary effect#2; Distorted proteins.
15. Bacteriostatic action/ Bactericidal action
16. Surface bacterial proteins altered; Decreased adherence of bacteria.
17. Excellent choice for abscesses produced by the susceptible bacteria.
18. Penetration of drug; Bones.
19. Penetration of drug; Can’t cross BBB.
20. Summary of all effects produced by clindamycin.
21. Black box warning for Clindamycin.
22. Pathogenesis of Pseudomembranous colitis.
23. Risk factors for Pseudomembranous colitis.
24. Directions to be given to the patient while prescribing clindamycin.
25. Treatment for C. diff colitis.
26. Summary of Black box warning for Clindamycin.
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Best lectures on Mocrobiology

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Thank you for watching

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Excellent video very informative Thanxx

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Good lecture

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walaikum assalam