The Health Problems From High Homocysteine
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- Опубликовано: 6 июл 2023
- Are you trying to get more information on the health problems caused by high homocysteine?
My name is Dr. Terranella, and in this video we're going to look at those specific things. What health conditions are you more susceptible to when you have high homocysteine? And specifically if those are independent of B12, folate, or B6 deficiency.
Reference : www.ncbi.nlm.nih.gov/pmc/arti...
To understand the problems that come from elevated homocysteine levels, we first need to look at the research to understand the relationship of high homocysteine on human health.
What constitutes high homocysteine?
Different labs have different measurements or different parameters for what's considered high homocysteine. Some labs will designate anything over 10 micromoles per liter. Others will designate above 12 as high. In order to have hyperhomocysteinemia, the blood test needs to indicate a level over 15. So you can still have high levels, but in actual hyperhomocysteinemia, the level is going to be above 15. Optimal levels are usually going to be around seven to nine.
What does the research say about the impact of high homocysteine on human health?
Basically, hyperhomocysteinemia is a problem with too much homocysteine in the blood. This homocysteine is an amino acid that's floating around in the blood, and it's changed into different molecules as part of a cyclical pattern where one molecule turns into another and then turns into another and eventually turns back into homocystine. And these steps flow through enzymatic reactions, and those enzymes require certain B vitamins to do their job.
When the levels are high ongoing, it's thought that the homocysteine actually damages the blood vessels. And so high homocysteine levels have been associated with various health conditions. I'm going to tell you about all of them, and I'm going to highlight a few of them.
Health conditions associated with high homocysteine
Cardiovascular disease
Venous thrombosis
Mental health and cognitive impairment
Bone problems
Eye problems
Complications in pregnancy
Cancer
Cardiovascular disease and venous thrombosis
The link between cardiovascular disease and venous thrombosis is that the homocysteine is thought to damage the blood vessels in such a way that it creates more of a risk for clotting. And the exact mechanism behind this is not really clearly delineated. But there is this very common and clear association with hyperhomocysteinemia and DVTs and cardiovascular disease.
Mental health problems and cognitive impairment
We're going to go into more detail on this in another video, but basically it's probably linked to an increased risk of depression and anxiety. Due to the effects of, not the homocysteine itself, but the deficiency of the B vitamins causing homocysteine to be high.
Bone problems
So the bone problems I was not actually aware of prior to doing a little bit of research on this one, but high homocysteine levels are thought to weaken the bones and increase the risk for osteoporosis. There are several studies showing this, and I'll put a link to some of them in the description. One study found that women with higher homocysteine levels had lower bone mineral density and higher risk for fractures, and the authors suggested that the homocystine may be playing some of the role in collagen cross-linking and bone reabsorption. Other studies have suggested the same thing, but there may, may be simpler than that, that there's just an overall nutritional deficiency in these people. And people with high homocysteine are not only deficient in vitamins, but also calcium, vitamin D and other things. These studies weren't adjusted for in that way.
Eye problems
Eye problems in high homocysteine are associated, again with the damage of the homocysteine to the blood vessels. So this seems to be the reoccurring theme for hyperhomocysteinemia. The main impact that it seems to have independent of deficiency and B vitamins is damaging the blood vessels through some pro-inflammatory thing.
Pregnancy
Yeah, you're gonna have more complications like pre-eclampsia due to the high homocysteine's effect on the blood vessels. But of course, pregnancy is also requires a lot of genetics to, you know, make new DNA, making new cells, new tissues, nervous system tissues, etc. And if you have a high homocysteine, it suggests a B12 or folate deficiency, which is problematic for someone that is making a new baby inside of them. So it's important to test for people to check if they are getting pregnant or planning on it.
Conclusion
So, in conclusion, high homocysteine levels are associated with a number of health conditions, including cardiovascular disease, venous thrombosis, mental health problems and cognitive impairment, bone problems 
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Unfortunately we the patients have to do more research as standard GP was worthless at helping understand these non standard labs.
I have had to do numerous self research and private bloodwork to determine what is going on with me. I have high bp with no immediate cause.
@@georgeramsden3219 and they know that the average person won’t do this they’ll just lean on their general practitioner to guide them. So it’s kind of genius from a business standpoint but terrible from a humanity standpoint
@@Mindcoach1on1 I saw my GP last week, told him the extra tests I’ve been doing. Told him I had high homocysteine which I’ve read could be a cause, he shot me down and asked why I had been doing my own tests etc. could be really disheartening for people. I carry on though, feel more confident in myself.
It's time to get a new GP , they have a limited scope of knowledge, and the irony is that after becoming a doctor, they cease in many cases to continue to expand their knowledge. They become gatekeepers and gaslight the patient if you question your results . I wish you all the best
I felt like dying since 2 months, my homocysteine level is 15, and i have been in hospital 2 weeks, i begged them to consider my homocysteine because it happened in the past, but they didn’t care, at all! I came out of the hospital and went to my doctor that always cared for my homocysteine and he gave me Medyn Forte and vitamin D (as i have vitamin D deficiency) and i already feel better after two days
I have it at 24. What shall I do? My doc doesn’t care.
@@King311___ that’s horrible! Can you order only from Germany Medyn Forte? You need to take one pill a day for 30 days, check your homocysteine again, if it is still high, use one more month until it goes down. Once the homocysteine is down you can preventively take 10 times a month every month… it is b12, b6 and b9 this Medyn Forte. For me it helped the first time i did a treatment with it 8 years ago🙏🏻
i had my homocysteine over 100 for years and learned about it only recently.
Thank you- very helpful.
You're welcome!
I had to stop supplements for 3 months due to financial distress. I noticed my vision got suddenly worse. Just got my supplements back and hoping my vision comes back. 3 months time
Thank you. Gives me more to research.
Glad to help
My leg muscles get sore and potassium gets dangerously low.. b complex makes all this go away
This was EXCELLENT!❤
What test should we ask our dr.s for? Mthfr gene tesf? Any cardiology test, a bone density test? Not sure
My homocysteine is 15....
Thanks for your video 📹 👍🏾
Thank you, I have a homocysteine level of 15, but B12 and folate are good. Getting my methylated genes tested I’m falling down more rabbit holes, so confusing. Thank you for the information 🙏
Best of luck!
Yes! I personally find that the research you mentioned does correlate to this issue and it’s not just a vitamin deficiency. It’s all linked in with the genetic mutation of the conversion genes.
Yes but those genetic alterations require more vitamins to work properly.
What would cause high b12 without supplements or meat/dairy? Is there a risk
Lots of other videos on the channel on this topic, please check those out
I found out I had hyper homocysteinemia after my second miscarriage. I have been taking prenatal vitamins and super b complex ever since. Never had and children. After complications with hysterectomy dr sent me to a hematologist. 15 tubes of blood later, no one still can tell me if I need to continue with supplements or not. Only thing I was told was to stop daily baby aspirin. Anytime I tell a doctor or write on my paperwork that I have hyper homocystinemia, they look at me like I’m crazy or they have no idea what that means. 🙄🙄🙄
Yeah that is weird bc it seems pretty straightforward to me. Thanks for sharing
3:19 start
I tried to take methylated B vitamins but they caused a lot of irritability and anxiety. I tried to lower the dose and it was fine for a couple days but that feeling would always come back. What would cause that?
There is another form that won’t jack you up like that. Find a video by Dr. Peter Osborne on b vitamins or methylation. He named the form you might need to take.
I have heard some doctors talk about hydroxycobalamin have you researched that form ?
My doctor is testing me for multiple sclerosis. I still have MRI of brain and spine, but just got blood back and my homosystein is 31.9 & b12 is 161. I’m scared!!
Looks like b12 is low
@maloocope6846 Same with me. I've been seeing a neurologist for a couple of years now because of MS type symptoms. I am now on B12 shots weekly and my symptoms were better but now they are flaring again. My vit D was low too so I supplement that as well. I am negative for MS based on the MRIs but I still feel crappy. They ruled out anemia, Lyme, antibody issues and other stuff also. I haven't had Homocystine levels checked however. My Iron is actually high but not extreme, tested for Hemochromatosis which was negative as well. I think the high iron is somehow related but no one has figured it out and I'm frustrated.
B12 deficiency is often misdiagnosed as MS.
@hygqueensav check your ferritin and folate levels as well. They are both involved in b12 deficiency.
Can one do heavy workouts if have high homocysteine??
yeah that's not a problem
@@swintegrative thank you very much 🩶🩶
@@swintegrative and can i intake high protein?
I have high homocysteine. I had Mthfr test done. A1298c was detected. What supplements should I take?
I can’t give specifics like that but u can watch other videos one MTHR and homocysteine to get a feel for that. Or see a doctor that can help you.
He won’t but I’ll share personal experience - Biomatrix adrenal support / SAM-e it’s been life changing - if you also have high histamine levels probably not able to make the enzyme DAO in your gut to meet the needs of your diet and and might need H1/H2 . This is all OTC. But can be hard to find.
@@wininets thank you so very much. What’s H1/H2 ?
TMG - Trimethylglycine. Not too much or mood changes. Homocysteine should be 6 to 8.
@@chrismyers9951 my homocysteine level is 11.6 and heterozygous. I can’t find any ND to help me
Hi I was wondering if u have any videos on how to find a good doctor in my area to help me work towards hormone optimization and also what tests to ask a doctor for when trying to get a better picture of my hormone health. I live in southern Arizona about two hours out of Phoenix where ur practice is.
Maybe recommendations of good doctors too
There is a video on hormones to check. Look under the playlist hormones
*Promo SM* 🎊
The quality of audio recording is very bad. I know audio engineering. You need to buy a good quality microphone, and stop using noise-removing filters and noise cancellation.
Thanks for the feedback. I plan to make some adjustments.
It’s not bad. I heard you just fine
This was EXCELLENT!❤
What test should we ask our dr.s for? Mthfr gene tesf? Any cardiology test, a bone density test? Not sure
My homocysteine is 15....
Thanks for your video 📹 👍🏾
This was EXCELLENT!❤
What test should we ask our dr.s for? Mthfr gene tesf? Any cardiology test, a bone density test? Not sure
My homocysteine is 15....
Thanks for your video 📹 👍🏾
This was EXCELLENT!❤
What test should we ask our dr.s for? Mthfr gene tesf? Any cardiology test, a bone density test? Not sure
My homocysteine is 15....
Thanks for your video 📹 👍🏾
This was EXCELLENT!❤
What test should we ask our dr.s for? Mthfr gene tesf? Any cardiology test, a bone density test? Not sure
My homocysteine is 15....
Thanks for your video 📹 👍🏾
This was EXCELLENT!❤
What test should we ask our dr.s for? Mthfr gene tesf? Any cardiology test, a bone density test? Not sure
My homocysteine is 15....
Thanks for your video 📹 👍🏾
Thank you. See other videos on high homocysteine