That was an amazing yet very simple explanation! This is a concept that, despite very simple, can get very confusing at times, and that was the single better explanation for it I've seen so far. Thank you so much for you contribution! :)
Teachers often tend to use simple words invariably without knowing that these simple words could be confusing to students…I am a medical graduate yet the concept of tubular secretion wasn’t clear untill today…you explained it so beautifully, thanks a lot❤!!!
The clearance of a substance that is freely filtered but not reabsorbed or secreted is the GFR, but the clearance of a substance that is totally removed, whether by secretion or filtration is the RPF, right? Inulin is not completely removed. Great video.
I have a question, why we need secretion? I mean why the substance that got secreted didn’t get filter in the first place? Is it because of the size and charge of that substance?
Since its made from muscles., isn't the plasmaconcentration of Creatinin constantly changing depending on your activity ?In the equation we have a constant P. How will this work ? And how do we measure V in the equation ? doesnt it depend on many factors like if the patient drank a lot of water before so his V becomes higher ?
To the Creatinin - basicly yeah, it's also proportional to your muscle amount and even goes up with decreased GFR. The V is basicly your pee volume. F.e 4l/24 hours. While it does go up with drinking water, the concentration of the substance you're measuring goes down proportionaly.
I'm interested in how you chose the name "macrophage" of all the medical terms available. We've got Osmosis, StompOnStep1, First Aid.... Were you just like macrophages are cool, let's roll with it?
That is correct. When we say "totally secreted", we don't mean that none of it is filtered. We mean that all the PAH that enters the efferent arterioles (whatever wasn't filtered) gets secreted.
Thanks! Better than Wikipedia, which says: "Inulin is uniquely treated by nephrons in that it is completely filtered at the glomerulus", which is not true as not all inulin is filtered.
That was an amazing yet very simple explanation! This is a concept that, despite very simple, can get very confusing at times, and that was the single better explanation for it I've seen so far. Thank you so much for you contribution! :)
Teachers often tend to use simple words invariably without knowing that these simple words could be confusing to students…I am a medical graduate yet the concept of tubular secretion wasn’t clear untill today…you explained it so beautifully, thanks a lot❤!!!
It was very helpful .. thank you for saving my life 🙏🙏
Allen Dank an Dr. Jerome, dass er mich von meiner polyzystischen Nierenerkrankung geheilt hat, Sir. Ich werde für immer dankbar sein, Sir.
Done watching. Thank you for your clear explanation which is extremely helpful for revision.
most useful explanation of the topic
i owe my life to u. thank u!
You made it look so easy ;)
The clearance of a substance that is freely filtered but not reabsorbed or secreted is the GFR, but the clearance of a substance that is totally removed, whether by secretion or filtration is the RPF, right?
Inulin is not completely removed.
Great video.
I think inuline is completely removed
I have a question, why we need secretion? I mean why the substance that got secreted didn’t get filter in the first place? Is it because of the size and charge of that substance?
a % of PAH is bound to plasma proteins which due to size are not filtered.
thank you so much sir , its a really helpful video
king Leon Hi
hey you
king Leon how are you ?
i'm fine , how are you man ?
I am fine , thank you. I want to know you ? ❤️❤️
Thanks for saving my life!
Thank you so much for this
So it's mean that clearence of inulin is also equal to renal plasma flow because all the inulin excreted freely?
Clearance of inulin is equal to the GFR
Great vid!
Thankyou
Excellent. Thanks a lot
Awesome teacher ..
Excellent
thank u very much , now i can talk that i understand ❤❤
Since its made from muscles., isn't the plasmaconcentration of Creatinin constantly changing depending on your activity ?In the equation we have a constant P. How will this work ?
And how do we measure V in the equation ? doesnt it depend on many factors like if the patient drank a lot of water before so his V becomes higher ?
To the Creatinin - basicly yeah, it's also proportional to your muscle amount and even goes up with decreased GFR.
The V is basicly your pee volume. F.e 4l/24 hours. While it does go up with drinking water, the concentration of the substance you're measuring goes down proportionaly.
Thank ypu
Can you please tell me what percentage of PAH is bound to plasma proteins and what percentage is freely filtered?
Thanks a lot :)
Thankyou you r amazinggggg
so precise and accurate!!
I'm interested in how you chose the name "macrophage" of all the medical terms available. We've got Osmosis, StompOnStep1, First Aid.... Were you just like macrophages are cool, let's roll with it?
Yes we think macrophages are cool, but also a macrophage represents gobbling up knowledge!
At 1:15 you accidentally called it insulin.
I dont get it. For inulin, the flow rate should also be renal plasma flow rate, why is it different?
Thank u soo much.. I really understood the concept.
isn't PAH partially secreted and partially filtered?
That is correct. When we say "totally secreted", we don't mean that none of it is filtered. We mean that all the PAH that enters the efferent arterioles (whatever wasn't filtered) gets secreted.
thank you ^-^
I love you
Thanks! Better than Wikipedia, which says: "Inulin is uniquely treated by nephrons in that it is completely filtered at the glomerulus", which is not true as not all inulin is filtered.