hsCRP: What's Optimal, Which Factors May Reduce It?

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  • Опубликовано: 27 авг 2024

Комментарии • 99

  • @petersharpe007
    @petersharpe007 Год назад +11

    The active anti-inflammatory molecule in Turmeric is Curcumin. This is not readily absorbed unless accompanied by black pepper (peperine) or fat.
    I noticed that black pepper was also listed. This suggests it is the Curcumin/peperine molecule that is active in reducing HsCRP.

  • @beardays4038
    @beardays4038 Год назад +8

    How much exercise is too much is always a question I'm pondering. It feels like there may be a lower ceiling to benefits for cardio than there is for strength. Looking forward to a future video on this subject! 🙏

  • @viracocha2021
    @viracocha2021 Год назад +3

    I love this new format of showing all the correlations! I was definetly eating much more brocoli than you so I may play with the amount to see if I too have a correlation there.

  • @abdelilahbenahmed4350
    @abdelilahbenahmed4350 Год назад +5

    Thx Prof.LUSTGARTEN for this another featured presentation.
    Intresting , and also intriguing to see that a certain volume of physical activity could be inflammatory.
    As for me , during the last Ramadan (dry fasting) I stopped any physical exercise with a minimal activity, eating (1 or 2 meals a day) a tasty cuisine rich in fish,fruits,vegetables, good fats and also as always in turmeric ( in addition to numerous other herbs and spices , sometimes maybe as potent as turmeric) , switched from drinking coffee to green tea. At the end of Ramadan my hsCRP dropped from 3 to O.01 mg/dl and my Apo B was 66.
    So, I am excited to see that you are going to address a hot topic rarely raised elsewhere : "Is the amount of physical activity that optimize fitness different from the amount that optimize longevity". My Heart rate is already in the range 55-57 bpm.

    • @monnoo8221
      @monnoo8221 Год назад +1

      while it is true that exercise can trigger a short-term inflammatory response, it definitely should NOT influence the hsCRP. hsCRP reflect overall inflammatory conditions, and that means that most likely either there is some hidden chronical separated infection, or the liver is involved. any exercise lower than athlete level is ANTI-inflammatory in the long run.

    • @anjumsafdar2960
      @anjumsafdar2960 Год назад +2

      Please share the herbs or supplements which you use...and spices if any

    • @abdelilahbenahmed4350
      @abdelilahbenahmed4350 Год назад +1

      @@anjumsafdar2960 a long list including oregano, rosemary, ginger , galangal, cinnamon, caper,flaxseed,dill seeds....but everyone is different and, for therapeutic purposes, we shouldn't take spices or herbs without the consent of a Medical Doctor, especially if pregnant....

    • @davidgifford8112
      @davidgifford8112 Год назад +3

      What labs can measure hsCRP down to 0.01 mg/ml?

    • @abdelilahbenahmed4350
      @abdelilahbenahmed4350 Год назад

      @@davidgifford8112 I personally had an hsCRP of 0.01 mg/ml measured here in Morocco and it not an error. High technology equipments are nowadays available everywhere.

  • @ok373737
    @ok373737 Год назад +4

    Same for me: a CRP of 0.4 with a moderate & vigorous exercise combo in 3 consecutive tests. Down to 0.3 when I had a knee injury which forced me to do only moderate exercise.

  • @soez_strg6166
    @soez_strg6166 Год назад +5

    Hey Michael, a small critique here: but the video seems to be very low volume, had to turn my speakers up all the way to be able to hear you.
    But other than that, love your content, keep it coming, brother!

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +2

      Hi Soez_strg, and thanks! That’s strange about the volume, as I use an external microphone. I just checked the video’s sound on my end, and it’s ok…

  • @user-wm7qc5jk3v
    @user-wm7qc5jk3v Год назад +1

    your videos are incredibly well made, excellent work

  • @thomastoadally
    @thomastoadally Год назад +1

    Excellent video as always, you have the key. Keep up your insight that makes more sense than many others. Thank you again!

  • @user-fo1jn8rv5d
    @user-fo1jn8rv5d 9 месяцев назад +1

    Great explanation with help of Statistics. I understand very well as i am from Statistics background. Great work keep it up.

  • @osamaabdelfattah5469
    @osamaabdelfattah5469 Год назад +2

    Very informative. Thanks for your efforts

  • @Ivana.0405
    @Ivana.0405 Год назад +3

    It is interesting that broccoli correlates with CRP. It is such a healthy vegetable. In any case, for me, CRP significantly declined when I significantly increased the intake of vegetables and spices. I need to double-click on which vegetables and spices may be causing the decline. Also, improved body composition may have had an impact on the CRP decline.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад

      Hi David, I was eating as much as 1000g/day, so it could be a matter of scale. With a current average of 50g/d, CRP is < 0.3 mg/L for 10 tests in a row. Yep, it could be lots of factors, even body composition...

    • @Ivana.0405
      @Ivana.0405 Год назад +1

      @@conqueragingordietrying1797 1000g! That is a lot of broccoli for sure, I hope they give you vegetable volume discounts at the grocery store :)

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +3

      @@Ivana.0405 ha, I wish! Having my own farm someday is on the to-do list, which would save on cost!

    • @thomasmuller1850
      @thomasmuller1850 Год назад +1

      What spices do you use?

    • @Ivana.0405
      @Ivana.0405 Год назад +4

      @@thomasmuller1850 Mainly turmeric, ginger, oregano, cumin and black cumin, coriander seeds (in tea), cinnamon, organic/unsweetened cacao powder. My subjective feeling is that tea with Coriander seeds - with garlic and lemon - helps a lot as it has a very profound calming effect in me. I have several cups per week. From time to time: Thyme, rosemary, cayenne pepper.

  • @terryjackson9395
    @terryjackson9395 Год назад +2

    Nice video. The black pepper may correlate simply because it increases absorption of the tumeric as a CYP3A4 inhibitor.
    Also, I wonder if the broccoli and spinach you had been eating that raised CRP were raw, steamed or cooked? As cooking or steaming makes those particular foods 'healthier' in some ways.
    Lastly as far as longevity, we've all seen the studies that moderate exercise, is better than zero exercise, which is better than too much exercise such as marathon trainers. Also huge bodybuilders don't live long at all, so it seems one must decide whether they want to eat a lot of protein and get jacked, or be a long-lived dweeb at the beach.

  • @beatusaestate1778
    @beatusaestate1778 Год назад +1

    Thank you for all the time you spend on the health topic. A problem with assuming broccoli to be a cause for higher hsCRP is the fact that Bryan Johnson(Blueprint) is eating 16.5 lb of broccoli each month and his hsCRP value is 0.20. My general feeling about food and supplements is that is is a personal complex optimization problem.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      Note that these are correlations, I can't claim causation. I love broccoli, but my biomarker data is worse with too much broccoli (1000g/d).

    • @beatusaestate1778
      @beatusaestate1778 Год назад

      @@conqueragingordietrying1797 One kg of broccoli per day is very much for most people. Do you want to speculate over which molecule or group of molecules in broccoli that might be correlated with an increase in hsCRP?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад

      @@beatusaestate1778 tbh, I have no idea, but I'm following the correlation (i.e. eating less broccoli).

  • @monnoo8221
    @monnoo8221 Год назад

    your work is incredible useful. it motivated me to check for some key parameters (currently i cannot afford extensive testing as you do), and track food as well. Especially helpful are your depictions of the age related changes of the targeted parameters. Thank you so much!
    (I have sth more to say but YT removes it because it is too long :( )

  • @caroldemas8019
    @caroldemas8019 Год назад +2

    Interesting to see the difference between broccoli and collards. They are just different cultivars of the same species. I wonder if there were differences in how they were prepared and if that in part might have accounted for the different R values.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      Both are cooked, so it’s not likely that, but it could be scale-at most I eat 330 of collards/d, but was eating as much as 1000g of broccoli/day.

  • @wann9333
    @wann9333 Год назад

    Hi doc, you are phenomenal. I really appreciate your work and effort. Thank you so much.

  • @mikesymth7243
    @mikesymth7243 Год назад +1

    Many thanks for another great video. Didn't know that turmeric had such a negative correlation with hCRP. Also didn't know venalla bean had a positive correlation. I'm going to stop using vanella flavored protein powder and see if my hCRP decreases. It used to be 0.5 before I started with the Vanilla protein powder and now it's 1.0

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +3

      Hey Mike, note that what may be true for me may not be for others, but I’d encourage self-testing to find out!

    • @DavidRodriguez-er4rq
      @DavidRodriguez-er4rq Год назад

      Also your protein might have additives, artificial ingredients, and sucralose which is gentoxic.

  • @nootri
    @nootri Год назад +1

    Depending on what stayed on your plate and what not, the tininess of the amounts involved, I see accurate measuring of black pepper most challenging. I would have expected for this to go in the other direction too.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      My food scale measures as little as 100 mg, so 1g shouldn’t be an issue for its measurement.

    • @nootri
      @nootri Год назад +1

      @@conqueragingordietrying1797 I'm not doubting the scale, but how much goes lost. If 30gs a month is what you use up though, I'd measure out 90gs and only care about it being gone in those 90 days.

    • @nootri
      @nootri Год назад +1

      @@conqueragingordietrying1797 I'm saying parts might be lost and scales measure accurately only starting after the first few digits. If your scale only does decigrams, trying to weigh anything

  • @greensmoothieparty
    @greensmoothieparty Год назад

    My mom is 84.5 years old and she had a hsCRP test a couple of weeks ago and it was 0.4mg/L. I plugged this into the Levine Biological Age Calculator along with her other bloodwork test results and it shows that she has now aged minus 18 years during the last 4 years. She had been a type 2 diabetic for 12 years prior to that and she had been aging prematurely, but thankfully that trend has been reversed. Her physician said that she was very impressed with the 0.4 number for her hsCRP.

    • @anjumsafdar2960
      @anjumsafdar2960 Год назад

      Please share your moms diet plan.....is she taking any supplements or herbs

    • @greensmoothieparty
      @greensmoothieparty Год назад +1

      @@anjumsafdar2960 Here is my mother's menu for a typical day:
      Breakfast: Organic steel cut oats with some buckwheat and wild blueberries, raspberries, 1/2 banana, tablespoon of ground flax and ground chia seeds, tablespoon of hemp seeds, organic soy milk, Ceylon cinnamon.
      Lunch: Green smoothie heavy on the low-oxalate greens (frozen kale or collard greens, frozen pineapple, banana, orange, lemon wedge with rind, organic soy milk, avocado sliver, amla powder, dulse flakes, apple cider vinegar, blackstrap molasses, nutritional yeast, small scoop of hemp protein powder, fresh ginger, medjool date, fresh kale) with a small handful of almonds and walnuts - or - some soup and salad.
      Before dinner snack: one apple.
      Dinner: Variety of simple meals including spaghetti, chili, vegetable soup with beans, lintel miso soup with organic tofu cubes/onions/mushrooms/kale, split pea soup with onions/mushrooms/carrots/celery/potato, roasted vegetables (squash/carrots/potatoes), rice and beans bowl with onions/mushrooms/kale/peppers/salsa, organic tofu scramble with onions/mushrooms/peppers/kale/turmeric/nutritional yeast, broccoli, asparagus, green beans, etc.
      Dessert: frozen banana whip with papaya or strawberries topped some days with a couple of macadamia nuts or a Brazil nut - or - some red grapes.
      Make sure to include G-Bombs every day for optimal immune system (i.e. - greens, beans, onions, mushrooms, berries, seeds).
      Avoid most processed foods. Include tofu perhaps twice a week but not more. Stop eating after an early dinner except for a few pistachios before bedtime.
      Supplements: Alive Women's 50+ multivitamin (daily), Vitamin D 1000 iu (daily), Algae based EPA/DHA (daily), B12 sublingual (twice a week)
      Good luck and good health to you and your family!

  • @victora9544
    @victora9544 Месяц назад +1

    Hi there. I'm a huge fan of your channel. I learn so much from your videos every day.
    What do you think about Oxalates regarding your longevity journey? Tumeric for instance. Thanks
    Regarding training for longevity rather than fitness, Doctor Kiltz, who advocates minimising sporting activities and sleeping more during the day, might be on to something.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Hi @victora9544, and thanks. There's a lot of talk about oxalate these days-below is the most recent video on the channel, but you read my mind, I'm working on another...
      ruclips.net/video/zqnNvA-DNfg/видео.html
      In short, many variables impact oxalate absorption, including a low calcium diet. If one is unsure about how much calcium is too much, measuring kidney function is also good.

  • @framexdd
    @framexdd Год назад +2

    Damn new video and it's wednesday, what a treat lol

  • @usernwn7qe
    @usernwn7qe Год назад +3

    Just a word of caution, i´ve had infections with a very low CRP

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      What was your CRP in those situations?

    • @usernwn7qe
      @usernwn7qe Год назад +1

      @@conqueragingordietrying1797 So over the past 7 years never over 0.8 mg/L, typically ~0.5 -ish. No matter what i had (abscessed tooth, flu, cold etc. ). The older bloodwork (before hsCRP) came back ALWAYS < 3.0. The only time i recall having it elevated was when i used to smoke in my teens, (usually around 10-12 mg/L) that got me thinking it might be triggered mostly by LPS since tobacco contains quite a lot.

  • @justsaying7065
    @justsaying7065 Год назад +2

    Thanks for the video. Can you do this type of video for all biomarkers?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +3

      Thanks Just Saying, Ttat’s the goal!Eventually, in a book, too.
      The channel is a side project (for now), but with more time I can make all those videos sooner, rather than later…

  • @mariocovino8250
    @mariocovino8250 Год назад +1

    Please confirm...as its contrary to all nutritional advice...
    That broccoli & bananas & cheese & Spinach increases inflamation and intake should be avoided/minimised.
    (As shown by your diagram at 5-minute mark.)

    • @mariocovino8250
      @mariocovino8250 Год назад +1

      But a great video, i always enjoy your content.
      Tumeric will permanently be part of my diet going forward.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад

      At no pint have I claimed causation-these are correlations. That said, if some of the correlations are positive, including broccoli, note that my data may not translate to others-the key is measuring your own hsCRP,, tracking diet, and seeing what correlates.
      Also note that I was eating 1000g of broccoli/day, and my current broccoli intake is 50g/d, with 11 consecutive tests for hsCRP < 0.3 mg/L. So it could be a matter of scale, too.

  • @InquilineKea
    @InquilineKea Год назад +1

    My CRP is always ultra-low but I'm always concerned about my glycation levels...

  • @sabincioflec8413
    @sabincioflec8413 Год назад +2

    Can you make sense of the foods that are supposed to be healthy but clearly show a higher hsCRP? like spinach i guess has a ton of oxalates, but so do almonds and turmeric. Broccoli has sulforaphane so maybe the hormetic stress is too much and just a smaller dose needed if one at all?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +2

      Spinach’s oxalate content is above and beyond all other foods. For example, for the 2g of turmeric that I eat every day, it has 47 mg, whereas the same amount of calories from spinach has 7x that amount.
      Lots of stuff, as you mentioned, could impact the why, so I’m not sure.

  • @newdata
    @newdata Год назад +1

    wonder if vanilla bean can be generalised to all beans

  • @debstayblessed9549
    @debstayblessed9549 Год назад +1

    Thanks for the video. Very informative. Since hsCrp is only one biomarker for inflammation which do you give more weight to? Thanks.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +2

      Thanks @debstayblessed9549 I weigh them all equally, especially within groups to assess organ/systemic function.

  • @vedransimic86
    @vedransimic86 9 месяцев назад +1

    In an other video I heared you mention fat intake inversely being correlated with hs-CRP. Does that correlation no longer apply and are just foods in this video correlated with hs-CRP?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  9 месяцев назад +1

      Hi Vedran, total fat isn't significantly correlated with hsCRP (0.13, p=0.48, 31 tests). Yep, just foods for that video, so much to include!

    • @vedransimic86
      @vedransimic86 9 месяцев назад

      Allright, thanks for the update, Michael! I am going to recommend those to some patients of mine with periodontitis from now on!

  • @Vested_Investor
    @Vested_Investor Год назад +2

    If there are about 9.54 grams of turmeric powder in a tablespoon, then are you consuming about a teaspoon of turmeric a day?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      1/2 a teaspoon, ~2g/day. Diet composition including that data is in this video (turmeric is #35): ruclips.net/video/ZvmJFh4XgVY/видео.html

  • @victoratanasov9680
    @victoratanasov9680 Год назад +1

    Isn't hsCRP correlated with CVD? If so, it's a good idea to lower it. How does it correlate with NAD+ level?

  • @ricke6854
    @ricke6854 Год назад +1

    So eat strawberries with your banana, and mushrooms with your broccoli, and you're all good...

  • @Brainy-tn8wb
    @Brainy-tn8wb Год назад +1

    I dont like the conclusions from food correlations. If low mortality is correlated with low hsCRP and low hsCRP is correlated with certain foods, then the link between that food and mortality is very, very weak, not to mention causality. Brokkoli for example i usually considered healthy because of other ingredients.

  • @karlint39
    @karlint39 Год назад +1

    Is hsCRP fundamentally different from plain old CRP? Is it measuring something different? My blood tests usually have 2 digits -- like 1.7 or 3.9 or something like that. The blood test result print outs just say CRP. At one hospital, it specifically says hsCRP and has more digits of significance, like 1.732 (maybe only 1.73). But since the number bounces around so much, I don't see the point of having the extra digits. So what's the point of hsCRP vs regular old CRP?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      It's the same test, but hsCRP is able to detect closer to 0, whereas standard CRp isn't that sensitive. The units are important-is it mg/L or mg/dL?

    • @karlint39
      @karlint39 Год назад +2

      @@conqueragingordietrying1797 Where I am, it's reported in mg/dL, but I think in the US mg/L is a more common way of reporting CRP. For a point of reference, I might previously get a CRP of 0.04 mg/dL (so like 0.4 mg/L) but due to various issues, my numbers are higher these days. For example 0.82 mg/dL, the equivalent of 8.2 mg/L. Very very rarely there will be one less digit of significance, like 0.4 mg/dL. But its so rare that when I see that I think "what the heck kind of test are these guys doing???" But thanks, I get it that hsCRP can detect, even if the number is very low -- so perhaps 0.01 mg/dL (0.1 mg/L) But if someone has that little inflamation, they must be ecstatic. As a point of reference the Jupiter trial (2008) to investigate the impact of Rosuvastatin on patients with LDL 2 mg/L, that number is way over the lower range of CRP that my "ordinary" CRP blood tests report.

  • @tedschwartz2142
    @tedschwartz2142 Год назад +1

    THERE IS NO CLINICAL EVIDENDE THAT TURMERIC HAS AHTIAGING BENEFITS ..

    • @shiftgood
      @shiftgood Год назад +4

      All caps is the universal sign of the true intellectual.

  • @tommyortiz6623
    @tommyortiz6623 Год назад +1

    How many reps/sets do you do when you do resistance training?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      For a few examples,
      Pullups-21
      Overhead Press, 70lbs:12, 90lbs: 4-5
      Pushups: 4 sets, 65 total reps (targets per set: 21-16-15-13)
      Rows: 2 body weight sets, 16 reps each
      Deadlifts: Depends on how my lower back is feeling (I have a chronically herniated disk)
      Lunges: BW: 20 total reps; Holding 30 lbs, another 20
      These are the targets for every workout, and the goal is to never do less, especially over time. So far, so good.

    • @tommyortiz6623
      @tommyortiz6623 Год назад +1

      @@conqueragingordietrying1797 yeah feel you on deadlifts they tend to cause more problems just like back squats do to lower back. This workout is pretty solid!

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      @@tommyortiz6623 Those are the basics, there's a bunch of other stuff aimed at mobility, balance, flexibility, calisthenics, too.

  • @Rick_Sanchez_Jr.
    @Rick_Sanchez_Jr. 8 месяцев назад

    High dose astaxanthin will lower hsCRP significantly

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  8 месяцев назад

      Got some papers showing that data, or even better, your own data, for a CRP reduction with astaxanthin?
      The big question is, can it (or any agent) reduce CRP to < 0.3 mg/l, which is associated with lowest all-cause mortality risk? if the reduction is from 1 to 0.9 mg/L, that's not as impressive.

  • @gustavojavierperal7420
    @gustavojavierperal7420 Год назад

    are you telling me that broccoli and spinach are pro inflamatori foods,....... are pro hsCRP ???

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад

      I'm not saying that at all. These are correlations, who knows about causation. But, it does show that when my broccoli intake was at its highest (1000g/d), so was hsCRP. Broccoli is still a regular part of my approach, but in much smaller amounts (50g/d average).

  • @johntaylor7952
    @johntaylor7952 Год назад

    Hi Michael, is this the reason you switched from Spinach to Collards? Tx, jt

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад +1

      Hi John, in part-full analysis is in this video:
      ruclips.net/video/ujpBbAWQ0fg/видео.html

    • @johntaylor7952
      @johntaylor7952 Год назад +1

      @@conqueragingordietrying1797 Thanks so much Michael!

  • @floydald
    @floydald Год назад

    I don’t see meats ?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад

      For animal products, I mostly eat fish and sardines (and some cheese), and neither was significantly correlated with CRP in my data.

  • @retire14pattaya9
    @retire14pattaya9 3 месяца назад

    Mine is 0.2 at 70+

  • @aclearlight
    @aclearlight Год назад +1

    Great work and some very interesting surprises! I was shocked to see broccoli raising CRP. This would seem to collide rather soundly with copious recent data suggesting a multitude of anti-inflammatory/brain-protective/anticancer properties for the sulforaphane/myrosinase combo (esp from broccoli sprouts) as well as epidemiologic data indicating health benefits from broccoli in general. Do you have any thoughts on this?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Год назад

      Ah, these are correlations-causation can't be inferred. That said, if there is some amount of causation, I'm hypothyroid, and broccoli has goitrogens, which could make my thyroid function worse in high amounts (I was eating up to 1000g of broccoli/d).