Alzheimer's Disease: APP Processing & Amyloid Plaque Formation

In this video, we will cover the signaling events involved in the processing of Amyloid Precursor Protein, commonly called APP, that leads to the formation of Amyloid Plaque. To Learn More About Alzheimer's Disease Signaling Visit www.novusbio.c...
Learn more about beta Amyloid Antibody (MOAB-2):www.novusbio.c...

[@GazAllTheJuice]

absolute banger playing in the background

[@madsm8337]

the song from the background was such a bad idea

[@ahmadtaher8598]

So hard to pay attention to what he's saying with that song lol

[@Opiucus]

With all due respect i disagree, i liked the music very much and helped me concentrate

[@isaachester8475]

Important to note that APOE has different types, APOE e4 being the worst and most highly associated with Alzheimer’s disease. Meanwhile APOE e2 is considered to be beneficial in protecting against Alzheimer’s because it is much better at clearing out amyloid plaques.

[@johnmandrake8829]

The AICD fragment cleaved from the amyloidogenic pathway functions as a transcriptional factor for the expression of Ca2+ related genes and other genes resulting ultimately in neurodegeneration. Also the AICD in the non-amyloidogenic pathway is also simply degraded in some cases and does not act as a transcriptional regulator.

[@echelonrank3927]

im not a medical guy but something is unclear about an alzheimers brain using b-secretase instead of a-secretase. why is the wrong type of secretase there ?
does the Abeta40/42 itself cause the a-secterase to switch to the wrong type in a runaway chain reaction somewhat similar to mad cow disease BSE? or is b-secretase a completely different enzyme?
tell me, you sound like you might know.

[@user-qz1yg7tz4c]

Would you mind sharing some sources for this info, I am doing research for my master's. Thank you so much.

[@besarsinani318]

Helped so much with my ap bio research thx

[@micaelaroyocorrea6191]

This was so thorough, thank you so much!

[@taiyc1]

thank you!

[@jamshedfbc]

Nice illustration.

[@aria_5871]

question, does this mean that normally beta secretase is not involved at all? also, if so then how come it suddenly becomes involved in a disease brain?

[@libbycarney7946]

I am not positive, but in my research I figured out that there is genes for how APP is processed on the 21st chroosome- which may explain why AB is related to downs syndrome (21st chromosome deletion).

[@gibbyace5077]

I Wish i had a PhD in biology and or chemestry

[@kateforday1618]

Get one, silly

[@gibbyace5077]

@@kateforday1618 MY GOODNESS!
WHY DID I NOT THINK OF THAT?

[@kateforday1618]

@@Omar_Des lol why do I find it so funny when people comment on something 1 year+ later. I don’t even remember watching this video 😂 but yeah man why not get both PhD’s😂😂😂 *cries in struggling undergrad student*

[@pouryamomeni9938]

The background music is extremely annoying .it ruins everything

[@enesoguzbey1]

Türkçe çeviri lütfen

[@NabeelKhan-in7vd]

the music behind the video is ruining everything. please keep it plain
thankyou

[@timblackburn1593]

Ooops