Myasthenia gravis - causes, symptoms, treatment, pathology
HTML-код
- Опубликовано: 28 авг 2024
- What is myasthenia gravis? Myasthenia gravis is an autoimmune disease that's categorized as a type II hypersensitivity that involves autoantibodies binding acetylcholine receptors on skeletal muscle cells. Find our full video library only on Osmosis: osms.it/more.
Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at osms.it/more. If you're interested in exploring an institutional partnership, visit osmosis.org/educators to request a personalized demo.
Follow us on social:
Facebook: osms.it/facebook
Twitter: osms.it/twitter
Instagram for med: osms.it/instagram
Instagram for nursing: osms.it/ignursing
TikTok: osms.it/tiktok
Linkedin: osms.it/linkedin
Our Vision: Everyone who cares for someone will learn by Osmosis.
Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: osms.it/mission
Medical disclaimer: Osmosis from Elsevier does not provide medical advice. Osmosis from Elsevier and the content available on the Osmosis from Elsevier properties (Osmosis.org, RUclips, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed healthcare provider. Always seek the advice of a physician or other qualified healthcare professional with any questions you have regarding a medical condition.
© 2024 Elsevier. All rights reserved.
I got it when I was 13. I’m 25 now. I take prednisone, pyridostigmine and I’ve had the thymus gland removal. For me my symptoms has become less and less frequent but it’s not completely gone
Which level have u been diagnosed at? (I...IV)
Did it decrease since?
wat was ur first symptm???wat ix u did to confirm it?
Did removing the thymus do you any good?
I am very happy for you and I think I must ask my doctor if it will be possible for my daughter to remove her thymus maybe it will help
How long after the surgery did it become less and less frequent ?
I am 63 years old and I have been suffering from the weakness periodically from the age of about 16. Every Time I went to a doctor all they wanted to test me for was MS. I was finally diagnosed 6 years ago. When I walked into the Neurologists office my first words to her were, "You are not testing me for MS I do not have MS I have been tested for it for the past 40 years and I don't have it" she told me " No you don't have MS but I do think I know what you do have." She did a neurological evaluation and then did some blood work and told me to come back in a 2 weeks. I was pretty sick at the time, but agreed. I went back and I was actually grey at the time. I was so weak I could barely walk even with the aid of my walker. She told me what I had was Myasthenia Gravis. She explained it to me in language I could understand, and told me I needed to be admitted right away. Well this was 2 days before Christmas and I had 35 people coming for Christmas dinner. I asked if it could wait till after the first of the year. She took one look at me and said you will not be alive at the first of the year, if you don't get treatment. I told her the situation I was in and we agreed I would go in right after Christmas. I was with my daughter in law and we had to stop and get a last minute gift for my grandson, I stayed at the front of the store because I felt so horrible. And to make it even worse people kept stopping and asking if I was okay and did I need an ambulance. Anyway she got the gift and I felt so bad I almost told her to take me back to the doctor so I could go to the hospital. By the time I got home all I could do was fall into a chair. I was beat, and in walks a friend ( one of my daughter in law's uncle's, who just happens to be a chief.) Any way he told me that was now his kitchen and if I wanted anything I was to tell one of my grandchildren and he would get it. Anyway Christmas went off great and I went into the hospital a couple of days later. Then came my first experience with plasmapheresis. I want to tell you, doctors need to know there is more out there then MS. I was beginning to think I was crazy, I even asked my primary care doctor to send me to a psychiatrist, because I had become convinced of it. After a couple of sessions, he revealed that I was not crazy and they symptoms were not in my head.
may god bless u with good health 😊
Christina Henry how are you now?
Hello, I hope you're doing good
Thank you for sharing
Hope you are doing ok.
This was 6 years ago
I hope you're still alive and in better health
Symptoms started at age 15 and I’m 19 now it’s been challenging but I still hope for the best.
Do you find it hard to hold things? Like phone or write with a pen for too long? I literally have all of the symptoms
@@whateverbabe yes and when I don’t have my medication I can’t do anything. Not to even talk. What medication do you take?
i got diagnosed by this. i have thymoma (not yet removed till now) , you guys probably won't believe me , but i actually a personal trainer . i've been on physical activities / organisation since age 16 . i got diagnosed at age 24 . i am a guy, not even young woman / old men yet.
my body fat around 11-13 % ( 72 kg, 172 cm, the body fat depend on what i do [cut/bulk] ) . my bench press around 135 kg , i can do front and backflip , i can do tornado kick both front and back foot.
don't give up people, even i diagnosed with this muscle grave sickness, i still can be superior on this physical activities. don't let this sickness take over your life.
oh yeah if you guys asking about the attack . i only got the attack when i'm really sick [i would say it's more like sleep paralysis but you didn't actually sleep + your breath is quite hard like you're doing sprint ] . maybe because i live healthy (i'm not smoking / drinking / rarely drink coffee [i drink this if i had deadline work] )
Thank you endlessly for such an inspiration!
Love the mentality! How are you doing now?
So did you get the thymoma removed by now?
Also do you take any prescriptions?
So inspiring, thank you!
I'll be having my thymectomy this Friday. I was diagnosed last January when I was in crisis state and being in the ICU for 2.5 weeks. After reading these comments, I'm happy to see I'm not alone.
Hope everything is okay now, I pray for your good health and happiness. All the love. xx
I'm also think about it before I thought I'm the only one who suffered mg . It's really annoying.
@@samdanegolam423 me too have IT for some years .WE Not alone
@@katharinavanderwinkel4574 what is the cure for it i have double vision the docs arent able to understand why. I checked with eye specialist and he said my eyes r fine
i'm in ICU currently for this as well
I am so impressed by the quality of this short video review on a topic that can be challenging to learners. Kudos to you! I am studying for my Pulmonary boards, and this was a neat review of basic science concepts. For other learners out there, don't forget that Myasthenia gravis crises should be treated aggressively with plasmapheresis or IVIG or high dose steroids. Make sure to monitor their respiratory status closely, and consider elective intubation if vital capacity (VC)
Yes
Yes
@@sallylockhart5383 jb 5y.😂❤
i think this condition is caused by leaking gut syndrome,this is easily healed with slippery elm bark powder,it takes about 14 days to heal the holes in the gut,that should be the end of m gus
Osmosis you deserve all the money I give to my university! Thank you again!
Happy to help! 😊
I really love your videos! You make it easier to grasp the whole concept of whatever topic you discuss in a few minutes!
I first got diagnosed with this when I was 28 years old. It was the hardest thing in my life. Nobody knew what it was OK going to different specialist. I am 41 years old now take your meds three times a day and you’ll be fine. Sorry for the people they got diagnosed with thisis very hard but this is the way that we are now
I have congenital myasthenia which is kind of like this but I was born with it. From some research I’ve found that it’s very similar to this so this really helped me understand what I have just a bit more thanks :)
Excellent video! I'll remember this for my neuropath exam:D
Great video on the topic although I think it may have been important to note that when treating myasthenia gravis it is important to watch for symptoms of cholinergic poisoning as this can be fatal. When testing for myasthenia gravis one must always carry it out in facilities capable of having respiratory support since one of the symptoms of cholinergic poisoning is paralysis (can impact the lungs and cause resp. paralysis)
My father has myasthenia gravis. He is 78. His condition has gotten progressively worse over a span of 12 years. I want to help my father get better but l don’t know how. I flew in my parents for Christmas from Florida to my home in Utah thinking we would have a beautiful holiday and it turned out that the cold weather greatly affected him. My father got weaker than usual and l was devastated.
Just found out my mom has it she’s 82
How is your father doing
@@user-rt7vo5fr8e Thank you for asking. His condition is worse. This is a neurological condition that progresses rapidly, faster than Parkinson. He goes to physical therapy twice a week.
Thank you! i have recently been diagnosed with MG, this video was helpful to share with family and friends
hi, how are you feeling now? Have you been able to get cured? there's a doctor who can help you dr isibor on youtube!!!
Great video! There is also Seronegative MG (can be confirmed via SFEMG, Tensilon test) and 3 other antibodies that have been recently discovered- these include LRP-4, Agrin, and Cortactin.
good to know! thanks
Thank you so much? Which lab is doing that tests? Some of lab people have no idea about it.
@@veravero5715 I posted that 4 years ago. At that time, there were various sites around the world, mainly universities, running the tests. Now, I’m not sure.
@@j.l.c.1398 k you so much for the reply.
I love your videos! I am an Optometry student and these videos have been so helpful to me! Thank You So Much!
I got myasthenia when I was 7 yrs old, and I have had my thymus removed at age 8 or 9 and don't take prednisone anymore, but I still take pyridostigmine. I am better, but it's not gone yet and I have had around 3-5 myasthenic crisis, (which were very severe).
hi, how are you feeling now? Have you been able to get cured?
Hello! How are you now
I went to a new job today. Everyone else there was fine, before lunch I became so weak and painful that vomited from the pain. Ive never experienced anything like this. I recently went through 6 full weeks of Shingles and am getting a little concerned (okay alot concerned). I have other auto-immune disease as well, i.e. crohns, hashimotos to name a few.
Pharmacy student here: your videos help tremendously and follow our pathophys notes almost exactly
That's great! Where do you attend pharmacy school? We often offer school-based discounts.
Osmosis I go to university of Kentucky COP
Awesome! Please email us at support@osmosis.org if you'd like to arrange access to more of our resources, including our pharmacology video series: www.osmosis.org/playlist/pharmacology
Thanks! This is the easiest way to understand the disease.
Best explanation of myasthenia gravis so far
Thank you so much, Harlidamu1! Did you know that if you like & review us on Facebook then you’ll get access to our videos hours or even days before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
Hello I love your videos, you make learning fun but can I suggest a correction? Myasthenia is a Greek word not Latin from Greek "μυς" meaning muscle and "ασθένεια" meaning weakness. Thanks
Ur voice is music to my ears ! :D Thanks for all the amazing videos
Tks for this video l has received one case of myastenia crise today...
I ABSOLUTELY thought that drawing of the junctional folds in the synaptic cleft were microvilli/cilia and spent about an extra 40mins trying to figure that out, but otherwise great resource! Thank you for creating it!
I am also suffering since 2009.
That’s a perfect video , I am preparing for NCLEX and that’s help me a lot 🔥
Glad that we're able to help and best of luck, Ali! 🥰❤️🙏🏼
you made pathology fun
thanks
Can u tell how is it now is it gone? bcoz i have it and i have double vision its been 3 to 4 months.
The thing I love most about Osmosis is the Arabic translation❤️❤️❤️🇩🇿
I am a 13 year old boy. I was born with Myasthenia Gravis. I've always been bullied for my eyes being "crossed". I get double vision all the time and sometimes I black out. I can say, it sucks. My eyes never look quite right. We've tried surgery after surgery and nothing works. Always wondered what they'd look like if my right eye wasn't droopy. That's okay though.
We hope that you're doing better and advanced happy birthday! 🥰❤️🙏🏼
I’m glad you’re here 💗
I used to have crossed eyes because of Myasthenia too, it stopped when I started taking my meds more times a day. Hope you're doing good bud.
Hi! Have you thought about mesenchymal stem cell therapy for this? In Mexico we work with MSCs and there are clinical trails that improve the symptoms of MG and stimulate complement regulator DAF/CD55 with MSCs therapy.
Amazing !! this video helped me a lot with my neurology exam!! love you guys ♡♡
Glad it helped, Christine! ❤️
Thank you for all the videos you have posted! Its been a huge help! :)
This topic was covered in class last tuesday but i fall asleep in class
Now i know ,,tq tq soo much
Glad we could help, Sonam! If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ
Thank you very much.
One question though, how does the patient wake up every morning feeling fine and worsen as the day goes by if there is an injury in the receptors...
Does the cell remake the receptors at night? And if so why do they not get destroyed??
Rest is the key factor. Rest during the day will help the patient.
From an ex-mentor teacher presently working in cancer education, I am appreciative of this excellent presentation. So well done, the visual along with the spoken is effective. Thanks.
More treatment options: intravenous immunglobulin (fast effect start), cortisole, some other immunesuppresants.
Azathioprine (: 1-3mg/kg
ive had diplopia and muscle weakness since 6 years old. last year i began having problems with swallowing and breathing, i experience weakness and dizziness often. my neurologist suspected MG already when i was a child, but it was never confirmed. im going to get an EMG this week and ask to be tested for MG again, 12 years later. im glad im not alone.
Such a great concise informative video. Thank you very much osmosis!
Thats just amazing how concise your videos are ! please make a video on all pathways of complement system !
Glad you liked it! 🥰
Excellent video i remember this for my neuro exam you make it easier!!Thank you
Watch the lecture of Dr uut
The video was very useful for exam. Thank you.
perfect! It helps me with my pharmacology exam
Glad it helped, Marina! ❤️
Thank you so much Osmosis😍😍😍
Great video, all really useful for my exam revision (Y)
Glad it helped, Elle! 😊
My favorite channel ever❤️❤️
Thanks! 😊
Where would i be without my efficient Osmosis❤
mbchb 5 exam preps 👏thanks
Happy to help and best of luck! 🥰
Was Dx with this disorder just over 2 years ago although by history have had it just over 25 years. I am male, 69 yrs of age and when I first started having "problems" in the military I was told that I was not conditioning properly. I worked hard to stay in the military until I was able to retire but continued to have episodes of sudden weakness and double vision. Recently I was admitted to hospital because I kept falling, could not get up. I was found to have URI, UTI with aggression of Myasthenia Gravis. Again, more PT, OT and god knows how many new medications. I also have COPD and asthma. Looking to try to get into an assisted living facility.
I'm so sorry to hear about that, sir. I pray for your good health, happiness and a life without difficulties. All the love. x
Your videos helped me a lot
Our pleasure to help, Snabil! 🥰
Hi I really love your videos. It is very informative and easy to understand.
You made study fun and easy ...thank you so much for your awesome video's...
Thank you for the information! Very well presented.
I got diagnosed four year's ago they said l was born with mysthenia gravis but didn't get diagnosed until four years ago.
I'm 68 years old and had double vision for 3 years now okay.
Trouble swallowing getting better.
Leg pain getting better.
Prednisolone tabs and calchi chew tab and b 12 tab I'm ok just now.
Your and Dr uut lectures videos are osm
Just curious that will the removal of thymus cause in any problem in normal immune system of person ?
Great video!! very helpful and fun graphics !! good review at the end
Does beta blocker causing myasthenia gravis symptom from blocking the muscle receptors?
thanks for swift explanation
Always welcome! 💕
Great video. Relation to Graves' disease please
We will eventually! You can vote for upcoming videos by becoming an Osmosis Prime subscriber. You can sign up for a free trial here: bit.ly/2ut5ZEJ
These videos are amazing! Keep up the good work!
Thanks, Mahdi! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
very good video , thank you
Not a single word about the Tensilon test (Edrophonium test) ??
Not done nowadays bc of arrhythmias risk
@@farhatmushtaq4176 yeah but examiners keep asking the same tensilon shit :(
may ALLAH give my lofe to u so that u can help hummanity more
Excellent video
Lol, this was on my final this morning. Barely missed it!
This is my life.. Get ur shit together! :p
I was diagnosed with Myasthenia Gravis (MG) disease in November of 2012. I was told I had a year to live, no more than two at best. I believed the doctors for only a short time, then decided that dying of MG was not acceptable. My husband, Williams and I, embarked on a journey to heal. We were introduced to an African herbal medicine doctor whose herbs caused a turn around in my life. I've been on these African herbal drugs and i'm doing greatly. no more and now i can use my arms and feet. all thanks to dr Isibor the great African Herbal dr Isibor If he can do mine, he can help you!!!!!
Kinda strange, that autoimmune disorders is responsible for nearly all diseases... even cardio-vascular is said to be caused by the inflammation/repair.
Of the four ways mentioned that can get myasthenia gravis neuromuscular disease
(
1. b-cell antibodies to nictonic acetycholine receptors ,
2. inflammation due to a bacterial infection on the surface of the muscle cell that leads to destruction of the muscle cell
3. muscle specific receptor tyrosine kinase that attacks proteins under the muscle cell surface
4. paraneoplastic syndrome due to cancer (thymic neoplasm)
)
would #4 be relatively fast spreading (weeks?).. while in the others the disease progresses much more slowly (months, years, decades?) Or do they all progress at about the same rate thru the classifications (I, II, IIa, IIb, III, IIIa, IIIb, IV, IVa, IVb, V)? Are there blood markers that give specific classification, or is it all based on patient symptoms?
And in addition to the treatments mentioned,
(
acetylcholinesterase inhibitors
thymectomy to prevent T-Cells->B-Cells
)
Kinda strange that MG happens as you get older, when the Thymus starts to degrade.. but perhaps it's not so much the immune system is weaker, but rather it malfunctions.
I've heard that ice acts as an acetylcholinesterase inhibitors.. if so, is it possible that ice-baths and hyper-thermia (sauna) may help re-regulate the type-2-hypersensitive immune system?
Or any thoughts to increasing the signal by taking acetyl/choline supplements?
you rock!!! please keep the videos comming
It was really helpful.. Thank you
I hate this thing so much I sleep all day because I just can’t get up and I need to sleep sleep sleep sleep and more sleep it just makes it worse I have congenital myasthenia but they are very similar life is so hard and I try my best to power throw it but every day gets harder for me.
Very helpful videos for students like me
Glad to hear that! 🥰
Recently I have been suffering form myasthenia gravis. It's been 4months now.. I am 27 year old. On Google it shows rare cases but seeing in the comments box, seems there alot. at my state hospital, there is no neurological doctor. I have been referred.. And It's very difficult and irritating having such symptoms.. Can't eat or chew properly, cannot concentrate on studies either. Drooping eyelid feel for heavy like something has been tied up on eyelid.. While sleeping sudden choke and can't fully breathe. Fatigue all day like a 6or7 year old kid inside me not Muscular strongness within body.. Cannot talk either.. Stuttered every time... I am dying.. This symptoms getting into my nerve... And making me mentally weaker.. Cannot socialize.. Feels unwanted.
Thank you!
Really helpful! Thank you for the animation.
Thank you so much ❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
my brother have MG pray for him he is in the hospital in a bad condition and inmy country we dont have good medical care so pray for him please
Hope He geting better .god Bless u and Ur family
Dear God, please heal this person's brother. Please God, answer their prayers.
In Jesus' name, I pray.
Amen.
God, please heal this person's brother. Please God, answer their prayers. I ask in Jesus' name. Amen.
hi, how are you feeling now? Have you been able to get cured?
Shit my dad lives in usa hospitals there piece shit nobody want to take his insurance from state. State gives u insurance is garbage
Great job! Thank you!!!!
Our pleasure! 🥰
Great Job!! thanks
Thank you too! 🙏🏼
Thanks 👏💜
Estos videos me sirven tanto *w * muchas gracias!
Most welcome, Camila! 🙏🏼
I am just a little bit confused. In one of the Ted Talk questions it asked which age group and sex does the disease target. The correct answer was women over the age of 40. But as your video showed, it affects young women in their 20s-30s or older men in their 60s-70s. The answer doesn't seem to match up with what you have in your little presentation.
Best videos...!!! Very helpful
is there a certain anti-body test that can identify if you have this disorder? some of the symptoms mimic many other A/i diseases, or other diseases in general. thank you
nice presentation
thank you so much sir.. You are saving lives.
My mother recently got diagnosed with this disease.
I've watched a couple of videos of people making good recoveries and having their normal lives back again.
But how long does it typically take for someone to make a near-full recovery?
My mother is also suffering from myasthenia gravis. Can it be cured? Is there any remedy? reply please!!🙏
Is it possible this is what I could be dealing with? I woke up randomly two weeks ago unable to swallow anything thicker than soup basically. I wake up sometimes totally fine but my throat closes and gets tighter throughout the day. Hospitalized twice with no answers as to what it could be. No obvious scaring of the throat, esophagus from X-rays looked fine. I just want to eat again. It sucks
Thanks to you we are greatful
Our pleasure to help! 😊
thank you!
thankyou for this short video
Our pleasure! 😊
is this related to parkinsons dse and stroke?
Thank you
Hi.. Im a little bit confused now.. Is it muscuranic or nicotinic receptor?
thanks
Nice one
I have his disease and I am having surgery on February 10th 2016 and I'm only 10
Take it easy young warrior.
Good Man it's not my fault I was born with it
Nicolette Bessent I know
I hope the surgery went well Nicolette.
I was diagnosed with it when I was about 10 as well. Had surgery too. That was about seven or eight years ago.
Great explanation! :)
Well done thank u very much🌹
plz make vedio about GBS
Great Video thanks...
plz do thymomas......
thanks osmosis...
Thanks a lot sir 🤗