TWiV 1139: Long COVID with Dr. Judith Bruchfeld
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- Опубликовано: 10 сен 2024
- Vincent travels to the Karolinska Institute in Stockholm on to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.
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excellent talk, thank you both!
*Summary*
This podcast episode features Dr. Judith Bruchfeld, an infectious disease specialist at the Karolinska Institute in Sweden, discussing Long COVID with host Vincent Racaniello.
*What is Long COVID?*
* *[**00:04:41**]* Long COVID is a syndrome with over 200 described symptoms that persist or develop after an acute COVID-19 infection.
* *[**00:05:04**]* Symptoms typically last more than three months and can be constant or recurring.
* *[**00:04:44**]* There is no definitive diagnostic test for Long COVID.
*Common Symptoms:*
* *[**00:06:13**]* Fatigue
* *[**00:06:17**]* Palpitations
* *[**00:06:17**]* Pain
* *[**00:06:17**]* Brain Fog
* *[**00:06:17**]* Dyspnea
*Who Gets Long COVID?*
* *[**00:21:07**]* Studies suggest 10% of people who have had COVID-19 may develop Long COVID.
* *[**00:17:17**]* Demographics differ depending on initial infection severity:
* *[**00:17:24**]* Hospitalized Patients: Mostly male (75%), median age of 57, often with pre-existing risk factors.
* *[**00:17:47**]* Non-Hospitalized Patients: Mostly female (81%), median age of 45, generally previously healthy.
*Possible Explanations for Long COVID:*
* *[**00:08:47**]* *Viral Persistence:* The hypothesis is that the virus might not be fully cleared from the body, particularly in female patients.
* *[**00:13:40**]* *Immune System Dysfunction:* Inflammation may play a role in Long COVID.
* *[**00:16:09**]* Patients show signs of microvascular dysfunction in the heart.
* *[**00:13:54**]* High and persistent anti-spike antibodies.
* *[**00:15:59**]* Dysfunctional endothelial cells in blood vessels.
* *[**00:27:00**]* Altered levels of CD8 T cells.
* *[**00:18:16**]* *Hormonal Changes:* Hormonal shifts might contribute, especially in females experiencing menstruation cycle aberrations or early menopause.
* *[**00:36:18**]* *Genetic Predisposition:* Genome-wide Association studies are ongoing to investigate potential genetic risk factors.
*Treatment and Management:*
* *[**00:10:04**]* Paxlovid, an antiviral, is being tested in a randomized trial to address viral persistence. Results are pending.
* *[**00:21:50**]* Therapies are focused on symptom relief:
* *[**00:21:55**]* Medications to slow heart rate and improve energy levels.
* *[**00:22:08**]* Pulmonary and cardiac therapies.
* *[**00:22:11**]* Physiotherapy for breathing problems and postural issues.
* *[**00:39:44**]* Occupational therapy to support daily activities.
* *[**00:40:28**]* Psychological support.
*Key Takeaways:*
* *[**00:37:40**]* The impact of Long COVID is significant and ongoing, affecting millions worldwide.
* *[**00:23:58**]* Vaccination reduces the risk of developing Long COVID.
* *[**00:38:27**]* Patients experiencing lingering symptoms should consult their doctor and seek appropriate support.
* *[**00:41:35**]* Research is rapidly expanding to better understand the mechanisms of Long COVID and to identify effective therapies.
*This is an evolving field, and further research is necessary to fully understand and treat Long COVID.*
I used Google Gemini 1.5 Pro to summarize the transcript.
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Thanks for going to this effort.
I also thank you for this breakdown.
It breaks my heart every time I see a Dianna Cowern (Physics Girl) post. Scientists have to find the cause and a cure.
💙
Me too...Ive followed her content for so many years before COVID/ME/CFS ruined her life
I remain a subscriber in hopes that someday, hopefully soon, real help will arrive. We must support the many research efforts to figure this out and finally arrive at effective treatments and therapies.
Thanks Dr. Judith Bruchfeld
Great conversation. A treatment for long covid could not come soon enough for me. Was happy to hear Vincent bring up ME/CFS, as well as long term SARS1 outcomes.
Thank you both. I will be sharing this with family and friends!
What a a great discussion. Thanks to both of you.
The podcast should be recorded outdoors, especially in summer, glorious summer!
thanks, very realistic perspective and interesting discussion
4y 4m for a family member. Because they were infected at the height of the epidemic but not hospitalized they were not tested, and many studies require positive diagnosis, meaning a test in the respiratory phase. No energy, housebound, gets headaches from displays (phone, computer, etc). They have to careful "count their spoons" (see Spoon Theory). They live in Kansas, among the worst places to live in the horrible US "healthcare" system. SSDI denied, too. We help, and it helps some. The _only_ thing that measurably helped was cutting out high-histamine foods...their favorite foods as a vegetarian. How long will we play this game that effectively consigns these people to death. It's called economic eugenics.
I saw her at distance at Karolinska the other day, such a blessing ending up at that place after 2,5 years of struggle. Talked to Dr there, and finaly at least felt heard, so nice.
Long COVID always sounds a bit like autoimmune to me - persisting symptoms caused by multi-organ infection, women being affected more, etc.
I wonder if there are some ways to look into that more specifically
I had a 15 day course of antivirals and nothing changed. I have very high inflammation numbers, for me, I think some type of medication to bring down the inflammation might help some. I was diagnosed with chronic lyme, reactivated Epstein Barr, ME/ CFS and lastly long covid. Everyone is different so I'm glad antivirals have worked for some.
There is no such diagnosis as "chronic lyme".
Are you trolling for attention?
@@Gina-dn6xm The diagnosis of chronic lyme does not exist. It's not about belief. It's about a fake diagnoses by "lyme literate" quacks who are scammers and frauds.
@jaykanta4326 Why don't you present your research for your Opinion.
Why don't you mind your own business.
@@Gina-dn6xm pruebe con una dieta antiinflamatoria...sin harinas refinadas...azúcares refinados...
@@oscargranda5385 Thank you for your kind words. I will try your suggestions for inflammation. I learned some Spanish!
gracias!
Thanks! That was super informative.
That was really interesting,thank you.
During that physical stress on persistant infected patient S ( S1, S2 total Slevel present at detectable Levels? Maybe other viral proteíns both estructural or no?
35:48 I think the connection with lung damage and some long covid may be hypoxia: this would lead to a consistent erythropoietin response by the body to get more oxygen, along with shutting down hepcidin production in the liver to keep absorbing iron. This would explain the early menopause and blood vessels like a 90 yo. Women react more efficiently to hypoxia than men, so that may explain the difference. And of course, GI damage with B12 malabsorption from covid would directly lead to anemia and hypoxia, with the same responses as above
Toss in the fact it targets agiotensin converting enzyme which affects tone of our arteries and im not surprised overweight, cardiovascular challenged individuals die at higher rates.
How does Racaniello know so little about long Covid? Dr. Zyad Al-Aly did a presentation on it in the U.S. Senate Health Committee.
why do you think you know how much or how little he knows?
Giving ritonovir to the "placebo" group may skew results, as there are many strange associations between Sars 2 and HIV...
Her 18 year old EKMO patient story she treated is heartbreaking, according to RFK Jr. It doesnt happen. Maybe she is a pharmaceutical plant doctor. Im placing odds she is a pharmacy plant at .00001% chance she is. Im placing the odds RFK is FOS at 99.99999%
the probability that you’re correct is about 98.9%
My doctor has given up on me. I dont know what to do. I am a young man, I cannot live like this, with no way out and nothing I can do for myself
Follow Dr. Zyad Al-Aly. Racaniello doesn’t really care. He was pushing for kids to go back to class while sick.
Did cold agglutinine occur after SARS COV2 infection like after Mycoplasma pneumoiae infection ?
23:59 her body language says it all
Good chat with a commited doc from a society and government that embraces science. Thx for posting..
says what?
👍
Nice talk. Random thought. Lets say around 100,000 years ago. It seems like people wouldn’t have gotten much from small olds. Too low a population density. If a tribe got a cold, wouldn’t it be a very long time until their next exposure to another group?
Would the virus mutate even within a small tribe?
Did IgM antibody persist in long Covid ?
Long Covid being compared to the common cold? Get real. It’s SARS, not a cold.
Did N acetylcisteine decrease blood viscousity ?(induced by high IgM level)
Isnt that to increase/make nitric oxide more stable.
She say cure is not available: maybe connecting with REACT 19 group actually make process but vilified by Vincent and Paul offit but have been treating many long coviders and post vaccine injured. Please start communicating with them to help people.
"React19 is a patient-driven non-profit charity dedicated to providing support for individuals dealing with COVID-19 vaccine injury."
Anti-vaxxer.
The doctors from REACT 19 are ahead of of these guys treating long coviders. Anyone having these issues please contact them, as the main stream offers no hope at the moment. These seems to beg difference if you get long covid if you were vaccinated or not and they offer additional advice.
FO anti-vaxxer.
Thank you for attempting to get viewers of this podcast to embrace the scientific process by encouraging them to be more open to listening to doctors that have a different perspective. Many unfortunately are like @jaykanta4326.
@@riok6234 why don’t those “doctor” (not scientists) publish any research backing up their opinion?
MedicalDoctors tend to be horrible researchers especially the anecdotal loving ones@jaykanta4326
Wouldn’t that be wonderful if instead of attacking each other we could communicate and share ideas for those who are suffering?
Long covid can best be treated with Boosters.
Nope, that's a hypothesis and is being studied, but the null hypothesis says that NO, it doesn't.
@jaykanta4326 there are some studies already out that antivirals help and boosted people are better off than non. But your right the "null hypothesis " for these studies is they don't work. More problems for the anti vaxxers coming soon I bet!
Do you have any studies showing that?
@@catlyn777 No, its a JOKE
skämmas