What is Leptospirosis? How does it cause Organ Failure? & How to treat?
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- Опубликовано: 29 июл 2024
- This animation is about a Real Leptospirosis case I encountered during my training at Medical ICU. I talk about Microbiology, The initial symptoms, Complications & treatments for the disease. The causative bacteria are Leptospira, a zoonotic species that spread via the urine of infected rats, dogs & cattle. During the Immunological phase, the body produces antibodies against the pathogen. But these antibodies also attack the Liver, Kidneys & Other organs including blood vessels. The gold standard test is the Microscopic Agglutination test. The diagnosis is mainly clinical, & needs prompt treatment with Antibiotics (Cephalosporins, Penicillin). We arranged urgent Plasma exchange (plasmapheresis) for this patient as he developed severer pulmonary hemorrhages.
The Table of content.
00:00 Introduction
00:13 Microbiology (Leptospira)
01:03 Pathophysiology of Leptospirosis
01:32 Symptoms and Signs of Leptospirosis
02:03 Pulmonary Hemorrhage
02:22 Renal & Hepatic Failure
02:52 Investigations
03:22 Treatment of Leptospirosis
03:37 Plasma Exchange Therapy
Special Thanks: to Daci Sky for suggesting This Topic.
References:
1) Kumar and Clark's Clinical Medicine (10th Edition).
2) UpToDate page on Leptospirosis: www.uptodate.com/contents/lep...
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My brother is having Leptospirosis right now and he is hospitalised...Soo I searched about lepto from Google and found this...I had all the knowledge...Thank you very much❤️🙏
Did he live?
loving the story based format. it's helping a lot to sympathize with the subject. great job!
This is so informative in a nut shell
Thanks a lot, Joseph. Comments like yours encourage me to make more Interesting Medical cases.
thank you!
I love this story-driven format!
surprised and impressed with how much useful info is in this!
The way you expressed even I won't forget anything in rest of my life
That was so scary, happy that he survived.
Truly helpful! Thank you!
So glad!
Great video, very helpful👍Thank you🙏
WOW...I CAN ONLY SAY WOW! LIFESAVER!
I did not know about this..Thanks,as I always enjoy your programs.
Thank you Daci! I know that you are interested in Zoonotic diseases. I actually left a note in the description to thank you for the suggestion. Thank you, my friend.
thank you
This was really helpful and interesting 👏
Thank you!
U earned a new subscriber 👍 great work
amazing way of teaching ❤❤❤
Thank you!!
So thankful 🌹
You are so welcome!
I'm also here experiencing these type of case in sri lanka. Thank you very much for this valuable
Video
Why I didn't see this channel
Super explication Merci !
Thank u Thank u🙏
An amazing channel with great practical videos ✅
Thank you! Do you have any suggestions for me?
@@TinyMedicineI have one. Do uhhh Gerstmann-Straussler-(I don’t know how to spell dis part) syndrome
Love the videos as always, you really should be a lot bigger
You'll get there one day, I believe in you
Thank you so much for your kind words! & Thank you for believing in me! Let's get there together, my friend.
thank u
Lovely animation
Thank you mate!
Lost my friend last week 😥😥😥
In a top superspeciality hospital.
He owned small goat mutton shop..
Used to chop mutton.
so it's the body's heavy attack on bacteria with antibodies that causes organ damage not the bacteria?
Love from srilanka ❤
How long if human is left untreated?
From what I know abou leptospirosis, I feel it is clinically very similar to yellow fever. One physician (bacteria already had been discovered in his time, but no viruses) actually felt yellow fever _was_ leptospirosis, I think.
Yes. Yellow fever has similar symptoms. But it's a viral illness.
@@TinyMedicine Which makes it much more difficult to treat as of nowadays :/
Please , make a explanation animation video about Decompression sickness.
Thank you for the suggestion! Will definitely make that happen.
This nearly killed me so much so the doctors told me I couldn't make it.
thank you! could the englisch sweet fiber be related to Leptospirosis? or what could it be?
❤ from 🇱🇰
Sir my sister is suffering from this decease
What are the things that we should do right now
She is admitted in the hospital
Please reply Sir
INTERESTING!!! But how common is this infection getting this serious ?? 🙄🙄
About 10% according to CDC.
Happa?
*Microbiology* (Leptospira)
1) What is the most common pathogenic species that causes leptospirosis?
2) Morphological characteristics of Leptospira?
*Pathophysiology:*
3) How does the bacteria enter the human body?
4) How does Leptospira cause damage the the liver, kidney, and blood vessels
*Symptoms and Signs of Leptospirosis*
5) What are the signs & symptoms of leptospirosis
---------------------------------
Answers:
1) Leptospira interogans
2) Spiral shape, has hook ends
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3) Through abrasions in the skin
4) Immune response towards the bacteria - adaptive immune response => antibodies --- antibodies produced to eliminate the bacteria, can also cause damage to: liver, kidney, and blood vessels, including those in the lungs.
-----------------------
5) Signs & Symptoms:
3 Days After Exposure, Mild Leptospirosis
_1. Fever_
_2. Muscle Aches_
_3. _*_Conjunctival Suffusion_* - red patches in the eye; characteristic feature of leptospirosis
------
7th Day of Illness, Sever Leptospirosis
A. *Liver dysfunction or failure:*
_1. Yellowish Eyes (Jaundice:)_ Jaundice occurs when there is excess bilirubin in the blood. It is a sign of *liver* involvement in leptospirosis.
_2. Dark Urine (Coca-Cola-colored):_ Dark urine can also be a sign of *liver* involvement in leptospirosis.
Other Symptoms:
_3. Confusion_ - in severe cases, leptospirosis can lead to confusion or altered mental status.
_4. Rapid and Shallow Breathing_ - pulmonary involvement
serum creatinine
billirubin