Endocrinology | Pancreas: Glucagon Function
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- Опубликовано: 31 июл 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join us for this two part lecture series where Professor Zach Murphy will be teaching you about the pancreas. During this lecture we discuss the hormone glucagon and its function to act upon the liver to stimulate glycogenolysis and increase blood glucose levels. We hope you enjoy this lecture and be sure to support us below!
Correction @ 7:16 I referred to CCK and secretin as Glucagon stimulators, but they are actually glucagon INHIBITORS due to being released during the fed state. CCK and secretin are insulin stimulators, as their action is to lower blood glucose levels. Thanks!
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#ninjanerd #Glucagon #Pancreas
Regarding the relationship between low blood glucose and glucagon release... it looks confusing. But I guess the explanation by Ninja Nerd is the best at present moment. The link between low concentrations of glucose and depolarization of the cell membrane is still under debate. According to one of the hypotheses, they think ATP-dependent K+ channels (KATP) plays important roles as in beta cells but the downstream link seems to be not clear yet. At moderate inhibition of KATP (low glucose concentration), membrane is moderately depolarized to open Na+ channels, resulting in the opening of voltage-dependent calcium channels. At high glucose concentration, KATP is strongly inhibited and the membrane potential is strong enough to inactivate Na+ channels, and calcium channels cannot be activated. This is just one of the current hypothesis, and it is not still clear why this does not apply in the regulation of insulin secretion in beta cells.
this part was bugging in whole video... thanks you so much
@@vidhivora3578 even I came to comment section just to clear that part
@@saurabhranakoti7621 can u plz explain m not able to understand
@@vidhivora3578 can u explain
@@Easypeasy007 there's video on insulin just before watch that first and then this ..you will know why I got confused and the above explaination ..then I guess you might get answer to your doubt ..if not then I'll explain you ..
For anyone perplexed about the Ca Channels, I think the answer is : Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA).
Oh now it makes sense! Alpha cells, ones secrete glucagon has LVA Ca channels and beta cells has HVA Ca channels.
Exectly
Thank you! I was so confused in the beginning
Now I got it right. For Alpha cell the membrane is embedded by LVA calcium channel and for Beta cell it's HVA calcium channel. It's just a matter of cell type.
You all people....Thank you so much for being involved and to initiate this kind of discussion on calcium channel...❤ Its really really very helpful...
He is a gifted teacher!
i had my endocrine exam today and it went absoleutuly great, actually i aced it, thank u sooo much for all of these videos. this whole endocrine palylist was soo detailed yet so easy to understand.
You are a god's gift to medical students. Thank you so much for sharing your knowledge with us. Really very grateful!
You get all the concepts together and make them understandable in a very easy manner. Great work and thank u so much for all these videos
I love how you added glucagons effect on the myocardium... useful in beta blocker and CCB overdose. Great review!
Comprehensive information provided here.
You make life really easy in just 25 minutes. And after this, reading through text book becomes a breeze.
Keep up the work and would love to see more topics covered.
I appreciate the way you're enthusiastic about the things you explain - it makes the difference!! :D
This helped me so much in connecting the important key points and describing an overall picture of the process. So helpful .🙏🏻
Hey ! I am studying Biotechnology and have some exams in a few weeks. I just wanted to tell you that your videos are incredibly well explained. I could just watch them for fun. Congratulations for all the work and effort and thank you very much :)
I hope you reach 10 million subscribers
Very well explained, You are amazing teacher !
Lucky to have you Ninja nerd ❤️
yes !! i did enjoy the video !! and thank you for keeping these for free us students to learn and always come back to!! Much appreciation from a fellow med student.
hello Dr. WE need more videos of yours. start a new series of videos on any system. please keep em coming. we really love and appreciate your work.
I am now a fan. You are becoming my favorite RUclips channel. I am so glad you exist as a person and you do what you do. Keep making these videos and I'll keep watching them. Look for a patreon donation coming your way.
My favorite teaching on this subject. I am definitely subscribing. I am a visual learner. Thank you so much.
Pancreas-
Hetrocrine
Accini
Islets of langerhans.
Alpha cells glucagon hypoglycemia
Beta cells insulin hyperglycemia.
In alpha cells GLUT1.less ATP.
Less membrane depolarization.
Ca++ chhanel.
NE
CCK
SECRETIN.
GLUCAGON. IN blood.
Liver fasting state-
Glyogenolysis.
Glucogenesis.
Adipocytes-
Hormone sensitive lipase.
LIPOLYSIS.
Heart-
Ca++ uptake.
Thank you sir
AMAZING EXPLANATION! Wow, CLEAR explanation to the details! I'm a visual learner so your video really provides a complete picture for my understanding. Thank you very much! SUBSCRIBED!
One thing for you is, you are my Super hero for biology,
You gave me inspiration, and yeah man I am getting addicted to it.
Thanks a lot for these lectures, and I gonna meet you one day Mr biologist
thank you for sticking through the whole process of making this video
Thanks a lot for your great way of teaching.. I never thought I'd understand Biochemistry the way I start to understand it now..
You're an angel. I'll marathon your videos as prep for my licensure exam!!
My exams are all oral and your videos are precious for explaining and connecting dotes
surprisingly during my bodybuilding prep, your content has massively helped keep me productive & focused. I've learnt so much information from your videos which will significantly help me deliver a better service to my clients as a online nutritionist coach. Thank you
Thank you! This summer I aim to review all my physiology following your videos!! Thank you!!
Thank you man . Amazing as usual . Keep going my friend .
the best teacher... i wish i could pay my med school tuition to this king
I'm so addicted to all your vidss/ Love t them, start making shorts they actually help me even more
this is awesome... its helped me to more understand about glucagon.. thank you
Saved me. Amazing work. Love Ninja Science nerd.
You are one of the best teacher in the world 👍
This man👨💼 is so firm, confident and understandable in the era where people opt for confusion related data. 🙌
Just so in love❤ with you, your teaching skills and your management skills 🙌✌🌟
Kindly keep doing what you do 😍💕🌠
the best teacher on youtube.THank you for the effort
Awesome thank you very much. You're the gift to community and our blessing.
Dude best class on glucagon on have seen so far.
Fantastic.... man I am running out of words to comment.
Still feel like having notes or prints!
Zachcellent!
Beautifully explained. Awesome teacher
incredible lecture. Well done!!!
Every single time I feel like I had an epiphany watching your videos :D
Absolutely amazing thank you so much professor i have never understood more, such an amazing explanation really simple and clear bravo ✅❤️
Excellent talk!
at the end can you leave a picture of the board so it can be printed off?
Yes please, that would be very helpful. Thank you ninja nerd science.
Pleaseee
Omg yesssss
@@frayedendsofsanity1733 I go over the video, bit at a time, draw the diagrams and make notes of the explanations. I use coloured, erasable pens and this allows me to correct mistakes. Doing this means that I am re-listening to the lecture plus writing it down and then reviewing it whenever I want. This means a lot of revision of the topic: re-listening, note-taking, drawing, re-reading. I think this might help to truly learn rather than looking at a print-out?? I don't know; we all learn differently.
Pieguts123 same here ; )
Professor Zach! You are awesome! Thank you so much!!!
Who are the 20 people that didn’t like this video? Good job! Loved the refresher!
Thank you for making learning so enjoyable 💓💓💓
Love you sir,,sault to your effort,,you make very easy every topic for us,,a bundle of thanks sir...keep it up,,I am only depending on your sweet lecture...
I love your videos , you have a teaching gift .
Packed with information and the drawings really help for someone like me that is a visual learner. Im actually a IT guy thus well done cruizin through the medical sections
U are a Hero without a cape! Greets from Germany.
According to Costanzo CCK is a factor that stimulates glucagon secretion, so you were originally correct.
Thank you so so much for this gold as always
Ur videos are really helpful...uh did a great job...thanx for making these very informative videos 🌺✨
You are a heaven sent... Thank you soo much!!!!!! now I am feeling kinda Nerdy :D Great videos! very clear ! love it all, I don't even notice the time whenever I binge watch your videos..... Hope for some printed materials to guide medical students like me as well, practice quizzes and what not :)
Great job, thank you!
Sir, you are great teacher,
I am your big fan from India ❤️
THANK YOU FOR THIS VIDEOS YOUR AMAZING FOR DOING THIS
you make biochemistry so simple to understand
Good doctor ever
Amazing work 👍👍. Thankyou so much🤗♥️♥️
well defined and great lecture
Just amazing, good job man!
Laymen here. Interesting and mind challenging. Thank you
amazing explanation
brilliant explanation
In a short time presenting a lot of things ! If the time of lectures in this video would be one hour it would be so good to present all the information more simply & easily what you wanted to present that goes to be more understandable ! Lastly thanks a lot to present all these mechanisms deeply !!
Thank you 😊
god give u health and wealth professor ur incredible from algeria
Thank you my brother for the great info.😁🙏🏾🌈
Awesome explaination 👍
Excellent!
Lovel 💕💕💕💕 your lessons you are great explaining.
what an amazing explain
Thank you so much, this is awesome! You're absolutely mind blowing in your teaching skills.
+Elizabeth Charles wow thank You so much for your kind comment!! I am so glad we were able to help!
Secretin inhibits Glucagon secretion , while CCK stimulates it. So you were partly correct originally. Love your work, Zach just can’t thank you enough for your amazing videos ❤️
thank you so much
Great concepts bro😘😘stay blessed
Thank you so much for your great videos...love them💕
Can you please make a video on oversecretion and undersecretion of adrenal hormones......pathologies.
Eyvallah Ninja kardeş! 🙏🏽❤️
Zachcellent!
Thank you 🙏 ☺️ 😊
Thanks!
thank you
Can you do a video on fasting, glucagon and lipolysis? Key to fat loss?
thank you sooooo much
Good explanation amazing sir
U r genious brdr...
thank you sir
I am not a bio student but I can understand, thanks for ur video
Amazing!
Thank You
Thank you! :)
Cool presentation
Thank you so much ☺️👏🏻👏🏻👏🏻
Great sir . Thank Uh 💙💙
Thanks
thanks
Thnkk uu sir uu teach really really well
You. Are. Great.
Very interesting .
Good job