Robust Mouse Rejuvenation - Aubrey de Grey at Longevity Summit Dublin 2023
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- Опубликовано: 2 окт 2024
- Clear evidence for the rejuvenation of specific biological functions is now available in model organisms for a growing range of treatments. Achieving full medical control of aging, however, will certainly require the use of not just one, but an arsenal of longevity therapies. Aubrey de Grey explained how the Robust Mouse Rejuvenation program under way at LEV Foundation has been designed to identify synergies - and conflicts - between existing interventions with a credible path to clinical translation, thus laying the groundwork for future multifactorial therapy in humans.
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#RejuvenationResearch #AubreydeGrey #MouseStudies #LongevityTherapies #LifespanStudies #HealthspanGoals #ModelOrganisms #LEVFoundation #BiologicalRejuvenation #CombinationTherapies #MultifactorialTreatment #RobustMouseRejuvenation #AgingControl #ClinicalTranslation #LongevityScience #SynergisticInterventions #FutureTherapies
Need to get rich so I can donate LEV some money
Me too.
Gotta say, if I was Musk or Bezos I'd be funding and overseeing these trials myself.
Bezos seems to avoid non-profits unfortunately, but at least he's put resources into startups like Altos Labs and Unity Biotechnology. Musk is surprisingly close-minded and has publicly stated people shouldn't live longer.
100% people like bezos, the Google guys, and thiel are looking into it, BUT do you really think they're gonna make the research/results open to public? No way
@@niket527 Have you not followed the news around those companies? Unity has run several clinical trials; unfortunately only one hasn't failed so far, but a high failure rate is expected in biotech. Calico has begun a Phase 1 clinical trial with Abbvie. Altos Labs was just founded last year, but the former CEO of GlaxoSmithKline is the CEO, and GSK has extensive experience getting treatments to patients. These companies intend to go through clinical trials, regulatory approval, and broad commercialization like any other medical therapies.
@SirTenenbaum I knew Musk said he didn't want to live to 100 but he has no place saying anyone else shouldn't keep living. I think what he said shows he.has a mental illness. Looking at what he said publicly, I wonder if there are some other, more extreme signs of mental problems
Surprisingly Musk is against this field of research. I hope he will change his tune once he starts feeling the effects of old age.
If I were a multimillionaire I would spend most of my money on this.
Do you spend a good portion now?
Become one. It is not hard. Check out acquiring businesses
@@snorttroll4379 You first.
working on it. doing due diligence on a deal or three now. @@squamish4244
Or imagine being a billionaire!?!?you wouldnt have to give a crap where you put some millions..
Brb let me get rich so I can give you all my money
I sent him $5 bucks a few years back. It won't do anything for the cause but it will allow him to buy a beer and enjoy it before he dies of old age
Put that on auto donation each month and get a few friends to do the same
So send donations to LEVF?
yes. check out levf and their mouse experiments. promising stuff. @@verythrowaway8514
Enough of playing with mice Aubrey! Learn from Musk, stop repeating the same things for 20 years; get some balls and find a viable way for humans now!
First Mice then us!!!!
The error he mentions at 3:00 or so could be the 100 coming before the 80 ;)
Aubrey de Grey is 60 and looks it. I don't buy his "my biological age is a decade younger" crap. Not from a guy who drinks like he does. So if he wants LEV to happen in time for him, he had better hope there are major breakthroughs in literally a decade or two at the most.
And I'm coming up behind him, soon enough.
if someone had said back in the year 2000 when aubrey started giving his speeches that he would still be experimenting on mice in the year 2023 then i think most would have agreed that the longevity industry had failed. 20 years on and its a shame we still havent moved onto humans and larger mammals in that time. lets just hope the next 20 years proves to be significantly more fruitful than the last 20. we are all running out of time
Do the research. Buy some pigs or monkeys and get going
I would feel the same way too, except that the only reason we are still stuck on f*cking mice (and I am SO sick of hearing about mouse trials too) is because the $$$ just wasn't there until about five years ago and Aubrey was always clear that until the $$$ was there, nothing was going to happen. Also, AI is a big part of all of this and the big breakthroughs in AI only started 10 years ago. Now the money is in place and the tech is in place.
I don't get the insistence on still using mice though. I know a few companies have moved onto dog trials, including the one where they're using harvested piglet plasma on beagles. If *those* trials pan out, suddenly the prospects for humans look a lot better. Dogs are so much closer to us.
It's even stranger when I consider that loads of 80-year-olds would volunteer today for basically any trial just to stay out of a wheelchair. What's the worst that could happen - they could...die?
I agree 100% of course, big things have to happen in the next 20 years or most of us risk running out of time. I would also argue big things _have_ to happen, period, or we'll have a civilization consisting of nursing homes and dementia patients by 2050. The projections are stunning, and there is no other practical solution than some major success in aging research.
@@squamish4244 yes i agree that funding has increased and i believe AI will play a huge part in longevity science,, and i have always backed aubreys ideas, i do however believe that he has been overly too optimistic (and perhaps cynical) in his timeframe predictions wit the aim of attracting future investment . he is a very convincing public speaker and advocate, but i am not in agreement with his current estimates of when this technology will be here. if he is telling investors (especially VCs) that we have a 50/50 chance of 15 years then that is just enticing enough of them to consider investing, however if he says we have virtually no chance in 50 years then the money dries up, and who is going to invest in something that wont be realised in their lifetimes? its an ingenious tactic on his part, but overly underwhelming for the rest of us. i dont believe de grey to be nefarious in his intentions. if he is hoodwinking investors then he is going entirely the wrong way about it, but i do believe he is somewhat overstating the facts in order to maintain his position in the industry. only time will tell and i certainly hope he proves me completely wrong but i have my doubts sadly.
REAL geniuses would experiment on themselves. Not on innocent mice.
You need people who will take MATHEMATICS VERY SERIOUSLY, especially my field: differential algebra.
Would rapamycin be safe for solid tumor cancer patients as far as it slowing down mtor1 and cell growth? Any smart ppl here know?
Unsure, but you should look into metformin, berberine, dihydroartemesinin, and niclosamide for your intended purpose
Maybe the german guy should help with doing the adaptive trial
if anyone cures ageing itself you know it will be a German or Japanese man
SJWs will never be able to cancel aubrey de grey
Antiwhite ideologue's insistence on discriminating against white men to such a point where they're subjected to insane hyper-scrutiny for any any and all potential stepping out of line has no doubt already hindered massive amounts of progress. I have no doubt that without it, and without the legal discrimination, we would already be 15 years ahead of schedule in all sorts of things.
They tried to accuse him of sexual assault.
Why are you bringing your right-wing bullshit into this? How is politics relevant here?
@@keithhunt5328 He admitted to the accusations. It just never went to trial. The real reason he was fired from SENS was his failure to treat his alcoholism.
Link to statements?
REAL geniuses would experiment on themselves. Not on innocent mice.
If you are not vegetarian you have no right to say stuff like this
Mice are the reason for so many medical advances. It sucks that we have to subject them to a lot of crap to do this, but what's the alternative? We can't test a lot of stuff on humans right off the bat, we just can't. If humans die during trials due to dangerous drugs, that ends the trial. And as far as we can tell, mice are significantly less self-aware than us, so they suffer less. We can't prove this, of course, but it's our best guess based on current science.
@@squamish4244 there is a movement to get approval for people above certain ages to volunteer for human trials for longevity "the right to try" or something. I'm all up for it, specially when I get to 75 or so.
@@joemagicdeveloper Really? Very interesting. And good. I hope it is approved. We have literally nothing to lose.
I know A LOT of people who would be up for that. Including my early 70s parents. They are in good health but not looking forward to possible senility and decrepitude.
The effort that went into providing for my grandmother in very old age was huge, but manageable. In the nursing home 12 years ago I saw the warning signs, of just how much effort it takes to look after dementia and Alzheimer's patients.
The man who lived in the room next to my grandmother was 15 years younger and still mentally sharp, but had spasticity that forced him to be in be in a home surrounded by people he couldn't talk to. He was so lonely. He could not get adequate care, his daughter was a selfish bitch who lived halfway across the world and wouldn't move him to where she lived, and a year after my grandmother died he went to Switzerland on a 'vacation' - and never came back. Assisted suicide, age 75.
So many Boomers are in their 70s now, and there are so many more of them than any generation before to reach this age. If we want to keep them out of nursing homes in another decade or two we may have to resort to this "right to try".
The economic costs of nursing homes and private care are projected to TRIPLE by 2050, which is just staggering. We have max. 25 years to solve this problem.
think ive damaged my lungs permanently thru trying to seal windows to block out harmful pollutants, my varicose veins in a certain place hurt & my teeth hurt. think sunak's against me ... ?
Well of course. Lol. But please donate your inheritance to this. Then you might buy time to fix the other problems
You probably have OCD, look in to mindfulness. It's one of the major ways out of it.
@@snorttroll4379 You really are a troll.
You will need my differential algebra first, to solve this