W. salam sir1) sulphone group at 1st position and sulphonamide at 7th position. 2)EWE is nesscary for diuretic activity. 3)when the chlorothiazide react with formaldehyde.the hydrochlorothiazide is formed.by the reduction of 3&4 position of double bond.
W. Slam sir Ans:1 The position of suphone group in chlorothiazide is in 1st position and sulphonamide group is in 7th position. Ans:2 Effect of EWG has high diuretic effect such as chloro or trifluromethyl. Trifluromethyl-substituted diuretic are more lipid soluble & have longer duration of action than their chloro-substituted. Ans:3 Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide to give a 3,4 dihydro derivative produces diuretic that is 10 fold more active than unsaturated
Ghazala Parveen 18 1) The position of sulfonamide group in chlorothiazide is 7th while sulfonyl group is present in 1st position. 2) EWG ( halogen or CF3) at position 6 will increase activity .when electron releasing group ( methyl or methoxyl) are placed at position 6 activity is markedly reduced . 3) Saturation of double bond at position 3 and 4 chlorothiazide give hydrochlorothiazide which is 10 fold more active than the unsaturated derivative.
W\salam sir Ans1... Sulphone group 1st poistion while sulphonamide at 7th poistion... Ans2... EWG is nesesssary to be positioned at C6 for diuretic activity... Ans3...By saturation of double bond b/w 3 and 4 poistion of chlorothiazide given hydrochorothiazide....
1) In Chlorothiazide the sulfone group is present at 1st position and sulphonamide is present at 7th position. 2) EWG such as halogen or CF3at 6th position increases the diuretic activity while e releasing group such as methyl or methoxy group marketedly reduces the activity. 3) Saturation of double bondin position 3&4 give hydrochlorthiazide which is 10 fold more active than unsaturated derivative.
Aneeta Lohana 04 1. Sulphone on num. one position and sulphonamide on position 7 2. With electron withdrawing effect diuretic activity increases and lippphilicity increases 3. By saturation of double bond in chlorthiazide
1 Position-1 sulphonyl group & position-7 salfonamide group . 2 Both electron withdrawing & electron donating group at position-6 essential for diuretic activity. 3 Hydrochlorothiazide is synthesised by reduction of double bond at 3rd & 4th position in chlorothiazide by formaldehyde
W/Salam Sir Naila Ali Ans:1 Sulphone group at 1st position Sulphonamide at 7th position. Ans:2 EWE is necessary for diuretic activity. Ans:3 By saturation of double bond between 3 and 5 position Chlorothiazide gives Hydrochlorothiazide.
1) sulphone group at 1st position while sulphonamide at 7th position. 2) EWG is necessary to be positioned at c6 for diuretic activity. 3) By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
1....position of sulphone is 1st.. And sulphonamide is 7th.. 2..EWG is necessary for diuretic activity( cl).. Little activity is seen when hydrogen is present. 3..
Salfone group at 1st position while sulphonamide at 7th position. 2 ) EWG is necessary to be positioned at c6 for diuretic activity. 3)by saturation of of double bond between 3 & 4 of chlorothaizide gives hydrochlorothaizide.
1- Sulphone group at 1st position while sulphonamide at 7th position. 2- EWG is necessary to be positioned at c6 for diuretic activity. 3- By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
1. The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position. 2. The effect of EWF has high diuretic effect like chloro or triflouromethyl.Triflouromethyl substituted diuretic are more lipid soluble and longer duration of action than chlorosubstituted. 3. Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide that gives 3,4 dihydro derivative that produce diuretic that is 10 fold more active than unsaturated.
1. In chlorothiazide the sulphone group is present at 1 position & sulphoneamide group is present at 7 position 2. Ewe is important for diuretic activity 3. Hydrochlorthiazide is synthesised by reduction of double bond at 3rd & 4th is chlorthiazed by formaldehyde
Nimra khalid Ans 1 The position of sulfonamide group in chlorothiazide is 7th while sulfonyl group is present in 1st position Ans 2 EWG (halogen or CF3) at the postion 6 will increase the activity. When electron-releasing group (methyl or methoxyl) are placed at position 6, activity is markedly reduced. Ans 3 Saturation of double bond in position 3 and 4 of chlorothiazide give Hydrochlorothiazide which is 10-fold more active than the unsaturated derivative.
ANS (1): sulphone= C1position, sulphonamide= C7 position ANS (2): Electron withdrawing group at C 6 position is important for diuretic activity , in case of hydrogen atom at C 6 position there will be little activity. When electron donating group such as methyl group is present at C6 position then diuretic activity will be reduced ANS (3): Hydrochlorothiazide is formed by reduction of double bond of 4 6sulfonamido 3 chloroaniline at C3 4 position
Anum Zardari (06).. #1. Sulphone group is present at 1st position while sulphonamide group is present at 7th position. #2. Electron withdrawing & electron donating group at C6 are essential for diuretic activity. #3. By saturation of double bond b/w C3 & C4 position of chlorothiazide gives Hydrochlorothiazide.
Q-1 Position-1 sulphonyl group & position-7 salfonamide group . Q-2 Both electron withdrawing & electron donating group at position-6 essential for diuretic activity. Q-3 Hydrochlorothiazide is synthesised by reduction of double bond at 3rd & 4th position in chlorothiazide by formaldehyde.
Q1: Sulphone group present at C#01 and Sulphonamide gp present at C#07 in thiazide diuretics. Q2: EWG at position # 06 is necessary for enhancement of diuretic activity & Electron donating gp like methoxyl at position # 06 markedly reduced diuretic activity. Q3: Hydrochlorothiazide is synthesized by cyclization of 4,6-sulphonamido-3-chloroaniline by using paraformaldehyde simultaneously reduction of double bond occurs at position C3-C4.
Q no # 1 In choro thiazide the Sulphone group at the 1st position and sulphonamide is present at 7th position. Q no # 2 Electron with drawing group at 6th position increase the diaurtics activity, lipophilicity, and duration of action. Q no # 3 Saturation of double bond at position 3rd and 4th of the chalorthiazide give hydrochalorthiazide which is 10 fold more than the unsaturated derivatives.
Ans 1: In chlorothiazide the sulpone group is present at 1st position and sulphonamide is present at 7th position. Ans 2: EWG such as halogen or CF3 at 6 position increases the diuretic activity while electron releasing group such as methyl or methoxy group markedly reduce the activity. Ans 3: Saturation of double bond in position 3&4 of chlorothiazide give hydrochlorothiazide which is 10 fold more active than unsaturated derivative.
Q#1: In chlorothiazide the sulpone group is present at 1st position and sulphonamide is present at 7th position. Q#2: EWG such as halogen or CF3 at 6 position increases the diuretic activity while electron releasing group such as methyl or methoxy group markedly reduce the activity. Q#3: Saturation of double bond in position 3&4 of chlorothiazide give hydrochlorothiazide which is 10 fold more active than unsaturated derivative.
Ans1: In chlorothiazide the sulphone group is present at 1st position & sulphonamide is present at 7th position. Ans2: EWG such as halogen or CF3 at 6 position increases the diuretic activity while electron releasing group such as methyl or methoxy group markedly reduce the activity. Ans3: Saturation of double bond in position 3&4 of chlorothiazide give hydrochlorothiazide which is 10 fold more active than unsaturated derivative.
walikum Assalam sir ans 1. The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position. ans 2. The effect of EWF has high diuretic effect like chloro or triflouromethyl.Triflouromethyl substituted diuretic are more lipid soluble and longer duration of action than chlorosubstituted. ans 3. Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide that gives 3,4 dihydro derivative that produce diuretic that is 10 fold more active than unsaturated.
*Duaa Zehra _11* *Quiz Answers* *A1:* *Sulfonyl group* is present at the *Position 1* of the Compound. Whereas *Sulfonamide group* is present at the *Position 7.* *A2:* *Electron-withdrawing group* is necessary at *Position 6* for the *diuretic activity.* Those compounds having *Electron-withdrawing Groups* have higher activity. Whereas the compounds having *Electron-releasing Groups* have reduced activity. *A3: Synthesis of Hydrochlorthiazide:* Hydrochlorthiazide is synthesized either by *cyclization* of 4,6-sulfonamido-3-chloroaniline using *paraformaldehyde* or by *reduction* of double bond at *C3 and C4* in *Chlorthiazide* by formaldehyde.
Ans.1 In chlorothiazide sulphone group is present at position 1 ...and sulphonamide group is present at position 7 Ans.2 Substitution of electron withdrawing group like trifluromethyl and chloro causes increase in diuretic activity And substitution of electron releasing group like methyl / methoxyl causes decrease in diuretic activity. Ans.3 Hydrochlorothiazide is formed by saturation of double bond b/w 3 and 4 carbon gives 3,4 dihydro derivative (hydrochlorothiazide ) having 10 times more activity than unsaturated one .
Ans 1 Sulfone at 1 position Sulphonamide at 7 position Ans 2 EWG at 6 position increases the diuretic activity,lipophilicity and duration af action. Ans 3 The reduction of 4,6 disulfonamide 3 chloro aniline in the presence of formaldehyde forms hydrochlorthiazide.
Ans:1 The position of suphone group in chlorothiazide is in 1st position and sulphonamide group is in 7th position. Ans:2 Effect of EWG has high diuretic effect such as chloro or trifluromethyl. Trifluromethyl-substituted diuretic are more lipid soluble & have longer duration of action than their chloro-substituted. Ans:3 Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide to give a 3,4 dihydro derivative produces diuretic that is 10 fold more active than unsaturated.
Ans-1 The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position Ans-2 The effect of electron withdrawing has high diuretic effect like chloro- or triflouromethyl trifluromethyl substitute diuretic are more lipid soluble and longer duration of action than chlorosubstituted Ans -3 hydrochloro thiazide is formed by saturation of double bond in chlorothiazide in position 3,4dihydo derivative that produces diuretic that is 10 fold more active than unsaturated
1) In Chlorothiazide the sulfone group is present at 1st position and sulphonamide is present at 7th position. 2) EWG such as halogen or CF3at 6th position increases the diuretic activity while e releasing group such as methyl or methoxy group marketedly reduces the activity. 3) Saturation of double bondin position 3&4 give hydrochlorthiazide which is 10 fold more active than unsaturated derivative.
1)sulphone group at 1st position while sulphonamide at 7th position. 2) EWG is necessary to be positioned at c6 for diuretic activity. 3) By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
1- Sulphone group at 1st position while sulphonamide at 7th position. 2- EWG is necessary to be positioned at c6 for diuretic activity. 3- By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
Salfone group at 1st position while sulphonamide at 7th position. 2 ) EWG is necessary to be positioned at c6 for diuretic activity. 3)by saturation of of double bond between 3 & 4 of chlorothiazide gives hydrochlorothiazide.
1. The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position. 2. The effect of EWF has high diuretic effect like chloro or triflouromethyl.Triflouromethyl substituted diuretic are more lipid soluble and longer duration of action than chlorosubstituted. 3. Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide that gives 3,4 dihydro derivative that produce diuretic that is 10 fold more active than unsaturated.
Ans:1 suphone group in chlorothiazide present at 1st position and sulphonamide group is in 7th position. Ans:2 Effect of EWG has high diuretic effect such as chloro or trifluromethyl. Trifluromethyl-substituted diuretic are more lipid soluble & have longer duration of action than their chloro-substituted. Ans:3 Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide to give a 3,4 dihydro derivative produces diuretic that is 10 fold more active than unsaturated
Ans-1 The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position Ans-2 The effect of electron withdrawing has high diuretic effect like chloro- or triflouromethyl trifluromethyl substitute diuretic are more lipid soluble and longer duration of action than chlorosubstituted Ans -3 hydrochloro thiazide is formed by saturation of double bond in chlorothiazide in position 3,4dihydo derivative that produces diuretic that is 10 fold more active than unsaturated
Ans.1 In chlorothiazide sulphone group is present at position 1 ...and sulphonamide group is present at position 7 Ans.2 Substitution of electron withdrawing group like trifluromethyl and chloro causes increase in diuretic activity And substitution of electron releasing group like methyl / methoxyl causes decrease in diuretic activity. Ans.3 Hydrochlorothiazide is formed by saturation of double bond b/w 3 and 4 carbon gives 3,4 dihydro derivative (hydrochlorothiazide ) having 10 times more activity than unsaturated one .
1) sulphone group at 1st position while sulphonamide at 7th position. 2) EWG is necessary to be positioned at c6 for diuretic activity. 3) By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
![KSI - Thick Of It (feat. Trippie Redd) [Official Music Video]](http://i.ytimg.com/vi/At8v_Yc044Y/mqdefault.jpg)
W. salam sir1)
sulphone group at 1st position and sulphonamide at 7th position.
2)EWE is nesscary for diuretic activity.
3)when the chlorothiazide react with formaldehyde.the hydrochlorothiazide is formed.by the reduction of 3&4 position of double bond.
W. Slam sir
Ans:1
The position of suphone group in chlorothiazide is in 1st position and sulphonamide group is in 7th position.
Ans:2
Effect of EWG has high diuretic effect such as chloro or trifluromethyl. Trifluromethyl-substituted diuretic are more lipid soluble & have longer duration of action than their chloro-substituted.
Ans:3
Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide to give a 3,4 dihydro derivative produces diuretic that is 10 fold more active than unsaturated
Ghazala Parveen 18
1) The position of sulfonamide group in chlorothiazide is 7th while sulfonyl group is present in 1st position.
2) EWG ( halogen or CF3) at position 6 will increase activity .when electron releasing group ( methyl or methoxyl) are placed at position 6 activity is markedly reduced .
3) Saturation of double bond at position 3 and 4 chlorothiazide give hydrochlorothiazide which is 10 fold more active than the unsaturated derivative.
W\salam sir
Ans1... Sulphone group 1st poistion while sulphonamide at 7th poistion...
Ans2... EWG is nesesssary to be positioned at C6 for diuretic activity...
Ans3...By saturation of double bond b/w 3 and 4 poistion of chlorothiazide given hydrochorothiazide....
1) In Chlorothiazide the sulfone group is present at 1st position and sulphonamide is present at 7th position.
2) EWG such as halogen or CF3at 6th position increases the diuretic activity while e releasing group such as methyl or methoxy group marketedly reduces the activity.
3) Saturation of double bondin position 3&4 give hydrochlorthiazide which is 10 fold more active than unsaturated derivative.
Aneeta Lohana 04
1. Sulphone on num. one position and sulphonamide on position 7
2. With electron withdrawing effect diuretic activity increases and lippphilicity increases
3. By saturation of double bond in chlorthiazide
1
Position-1 sulphonyl group & position-7 salfonamide group .
2
Both electron withdrawing & electron donating group at position-6 essential for diuretic activity.
3
Hydrochlorothiazide is synthesised by reduction of double bond at 3rd & 4th position in chlorothiazide by formaldehyde
W/Salam Sir
Naila Ali
Ans:1
Sulphone group at 1st position
Sulphonamide at 7th position.
Ans:2 EWE is necessary for diuretic activity.
Ans:3 By saturation of double bond between 3 and 5 position Chlorothiazide gives Hydrochlorothiazide.
1) sulphone group at 1st position while sulphonamide at 7th
position.
2) EWG is necessary to be positioned at c6 for diuretic
activity.
3) By saturation of double bond between 3 and 4 position of
chlorothiazide gives hydroclorothiazide.
1....position of sulphone is 1st.. And sulphonamide is 7th..
2..EWG is necessary for diuretic activity( cl).. Little activity is seen when hydrogen is present.
3..
Salfone group at 1st position while sulphonamide at 7th position.
2 ) EWG is necessary to be positioned at c6 for diuretic activity.
3)by saturation of of double bond between 3 & 4 of chlorothaizide gives hydrochlorothaizide.
1- Sulphone group at 1st position while sulphonamide at 7th position.
2- EWG is necessary to be positioned at c6 for diuretic activity.
3- By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
1. The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position.
2. The effect of EWF has high diuretic effect like chloro or triflouromethyl.Triflouromethyl substituted diuretic are more lipid soluble and longer duration of action than chlorosubstituted.
3. Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide that gives 3,4 dihydro derivative that produce diuretic that is 10 fold more active than unsaturated.
1. In chlorothiazide the sulphone group is present at 1 position & sulphoneamide group is present at 7 position
2. Ewe is important for diuretic activity
3. Hydrochlorthiazide is synthesised by reduction of double bond at 3rd & 4th is chlorthiazed by formaldehyde
Nimra khalid
Ans 1
The position of sulfonamide group in chlorothiazide is 7th while sulfonyl group is present in 1st position
Ans 2
EWG (halogen or CF3) at the postion 6 will increase the activity.
When electron-releasing group (methyl or methoxyl) are placed at position 6, activity is markedly reduced.
Ans 3
Saturation of double bond in position 3 and 4 of chlorothiazide give Hydrochlorothiazide which is 10-fold more active than the unsaturated derivative.
ANS (1): sulphone= C1position, sulphonamide= C7 position
ANS (2): Electron withdrawing group at C 6 position is important for diuretic activity , in case of hydrogen atom at C 6 position there will be little activity. When electron donating group such as methyl group is present at C6 position then diuretic activity will be reduced
ANS (3): Hydrochlorothiazide is formed by reduction of double bond of 4 6sulfonamido 3 chloroaniline at C3 4 position
Anum Zardari (06)..
#1. Sulphone group is present at 1st position while sulphonamide group is present at 7th position.
#2. Electron withdrawing & electron donating group at C6 are essential for diuretic activity.
#3. By saturation of double bond b/w C3 & C4 position of chlorothiazide gives Hydrochlorothiazide.
Q-1
Position-1 sulphonyl group & position-7 salfonamide group .
Q-2
Both electron withdrawing & electron donating group at position-6 essential for diuretic activity.
Q-3
Hydrochlorothiazide is synthesised by reduction of double bond at 3rd & 4th position in chlorothiazide by formaldehyde.
Faiza roll no 13
Ans1 (a) sulphone C1
(B) sulphonamide C7.
Ans 2 in this halogen is at 6 position increase diuretic activity.
Q1: Sulphone group present at C#01 and Sulphonamide gp present at C#07 in thiazide diuretics.
Q2: EWG at position # 06 is necessary for enhancement of diuretic activity & Electron donating gp like methoxyl at position # 06 markedly reduced diuretic activity.
Q3: Hydrochlorothiazide is synthesized by cyclization of 4,6-sulphonamido-3-chloroaniline by using paraformaldehyde simultaneously reduction of double bond occurs at position C3-C4.
Q no # 1
In choro thiazide the Sulphone group at the 1st position and sulphonamide is present at 7th position.
Q no # 2
Electron with drawing group at 6th position increase the diaurtics activity, lipophilicity, and duration of action.
Q no # 3
Saturation of double bond at position 3rd and 4th of the chalorthiazide give hydrochalorthiazide which is 10 fold more than the unsaturated derivatives.
Ans 1: In chlorothiazide the sulpone group is present at 1st position and sulphonamide is present at 7th position.
Ans 2: EWG such as halogen or CF3 at 6 position increases the diuretic activity while electron releasing group such as methyl or methoxy group markedly reduce the activity.
Ans 3: Saturation of double bond in position 3&4 of chlorothiazide give hydrochlorothiazide which is 10 fold more active than unsaturated derivative.
Q#1: In chlorothiazide the sulpone group is present at 1st position and sulphonamide is present at 7th position.
Q#2: EWG such as halogen or CF3 at 6 position increases the diuretic activity while electron releasing group such as methyl or methoxy group markedly reduce the activity.
Q#3: Saturation of double bond in position 3&4 of chlorothiazide give hydrochlorothiazide which is 10 fold more active than unsaturated derivative.
Ans1: In chlorothiazide the sulphone group is present at 1st position & sulphonamide is present at 7th position.
Ans2: EWG such as halogen or CF3 at 6 position increases the diuretic activity while electron releasing group such as methyl or methoxy group markedly reduce the activity.
Ans3: Saturation of double bond in position 3&4 of chlorothiazide give hydrochlorothiazide which is 10 fold more active than unsaturated derivative.
walikum Assalam sir
ans 1. The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position.
ans 2. The effect of EWF has high diuretic effect like chloro or triflouromethyl.Triflouromethyl substituted diuretic are more lipid soluble and longer duration of action than chlorosubstituted.
ans 3. Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide that gives 3,4 dihydro derivative that produce diuretic that is 10 fold more active than unsaturated.
Very clear explanation. Thank you.
Thank you dear
*Duaa Zehra _11*
*Quiz Answers*
*A1:* *Sulfonyl group* is present at the *Position 1* of the Compound. Whereas *Sulfonamide group* is present at the *Position 7.*
*A2:* *Electron-withdrawing group* is necessary at *Position 6* for the *diuretic activity.* Those compounds having *Electron-withdrawing Groups* have higher activity. Whereas the compounds having *Electron-releasing Groups* have reduced activity.
*A3: Synthesis of Hydrochlorthiazide:*
Hydrochlorthiazide is synthesized either by *cyclization* of 4,6-sulfonamido-3-chloroaniline using *paraformaldehyde* or by *reduction* of double bond at *C3 and C4* in *Chlorthiazide* by formaldehyde.
Ans.1
In chlorothiazide sulphone group is present at position 1 ...and sulphonamide group is present at position 7
Ans.2
Substitution of electron withdrawing group like trifluromethyl and chloro causes increase in diuretic activity
And substitution of electron releasing group like methyl / methoxyl causes decrease in diuretic activity.
Ans.3
Hydrochlorothiazide is formed by saturation of double bond b/w 3 and 4 carbon gives 3,4 dihydro derivative (hydrochlorothiazide ) having 10 times more activity than unsaturated one .
Ans 1
Sulfone at 1 position
Sulphonamide at 7 position
Ans 2
EWG at 6 position increases the diuretic activity,lipophilicity and duration af action.
Ans 3
The reduction of 4,6 disulfonamide 3 chloro aniline in the presence of formaldehyde forms hydrochlorthiazide.
Ans:1
The position of suphone group in chlorothiazide is in 1st position and sulphonamide group is in 7th position.
Ans:2
Effect of EWG has high diuretic effect such as chloro or trifluromethyl. Trifluromethyl-substituted diuretic are more lipid soluble & have longer duration of action than their chloro-substituted.
Ans:3
Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide to give a 3,4 dihydro derivative produces diuretic that is 10 fold more active than unsaturated.
Ans-1
The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position
Ans-2
The effect of electron withdrawing has high diuretic effect like chloro- or triflouromethyl trifluromethyl substitute diuretic are more lipid soluble and longer duration of action than chlorosubstituted
Ans -3 hydrochloro thiazide is formed by saturation of double bond in chlorothiazide in position 3,4dihydo derivative that produces diuretic that is 10 fold more active than unsaturated
1) In Chlorothiazide the sulfone group is present at 1st position and sulphonamide is present at 7th position.
2) EWG such as halogen or CF3at 6th position increases the diuretic activity while e releasing group such as methyl or methoxy group marketedly reduces the activity.
3) Saturation of double bondin position 3&4 give hydrochlorthiazide which is 10 fold more active than unsaturated derivative.
1)sulphone group at 1st position while sulphonamide at 7th position.
2) EWG is necessary to be positioned at c6 for diuretic activity.
3) By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
1- Sulphone group at 1st position while sulphonamide at 7th position.
2- EWG is necessary to be positioned at c6 for diuretic activity.
3- By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.
Salfone group at 1st position while sulphonamide at 7th position.
2 ) EWG is necessary to be positioned at c6 for diuretic activity.
3)by saturation of of double bond between 3 & 4 of chlorothiazide gives hydrochlorothiazide.
1. The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position.
2. The effect of EWF has high diuretic effect like chloro or triflouromethyl.Triflouromethyl substituted diuretic are more lipid soluble and longer duration of action than chlorosubstituted.
3. Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide that gives 3,4 dihydro derivative that produce diuretic that is 10 fold more active than unsaturated.
Ans:1
suphone group in chlorothiazide present at 1st position and sulphonamide group is in 7th position.
Ans:2
Effect of EWG has high diuretic effect such as chloro or trifluromethyl. Trifluromethyl-substituted diuretic are more lipid soluble & have longer duration of action than their chloro-substituted.
Ans:3
Hydrochlorothiazide is formed by saturation of double bond in chlorothiazide to give a 3,4 dihydro derivative produces diuretic that is 10 fold more active than unsaturated
Ans-1
The sulphone group in chlorothiazide is present at 1st position and sulphonamide group is present at 7th position
Ans-2
The effect of electron withdrawing has high diuretic effect like chloro- or triflouromethyl trifluromethyl substitute diuretic are more lipid soluble and longer duration of action than chlorosubstituted
Ans -3 hydrochloro thiazide is formed by saturation of double bond in chlorothiazide in position 3,4dihydo derivative that produces diuretic that is 10 fold more active than unsaturated
Ans.1
In chlorothiazide sulphone group is present at position 1 ...and sulphonamide group is present at position 7
Ans.2
Substitution of electron withdrawing group like trifluromethyl and chloro causes increase in diuretic activity
And substitution of electron releasing group like methyl / methoxyl causes decrease in diuretic activity.
Ans.3
Hydrochlorothiazide is formed by saturation of double bond b/w 3 and 4 carbon gives 3,4 dihydro derivative (hydrochlorothiazide ) having 10 times more activity than unsaturated one .
1) sulphone group at 1st position while sulphonamide at 7th position.
2) EWG is necessary to be positioned at c6 for diuretic activity.
3) By saturation of double bond between 3 and 4 position of chlorothiazide gives hydroclorothiazide.