Hmm based on a cursory understanding of the machanism, If i restore dormant/miniaturized hair via PP405 , will it make sense to discontinue the use of PP405 and maintain my gains with FIN/DUT?
Well that's just a theory. If it is that potent then perhaps it would be all you need as it can override whatever damaging effects DHT has on the hair follicle
@@Kyle_BuThis is the most interesting part, I also hope first of all that it is effective and secondly that it is so powerful that you do not need 5ari or anti-androgens. Kyle, I congratulate you so much for the videos, your work is impeccable.👏🏻
Sources: Emma Andrus, Associate Editor. (2024, August 19). Q&A: Pelage’s novel PP405 advances to Phase 2A for androgenetic alopecia. Dermatology Times. www.dermatologytimes.com/view/q-a-pelage-s-novel-pp405-advances-to-phase-2a-for-androgenetic-alopecia noeyys. (2024, December 29). PP405 Drug in Action: Picture From Official Company Website. www.reddit.com/r/tressless. Retrieved January 1, 2025, from www.reddit.com/r/tressless/comments/1hpcc92/pp405_drug_in_action_picture_from_official/ Pelage. (2024, February 23). Pelage Home 2 - Pelage. pelagepharma.com/pelage-home-2/ Pelage Pharmaceuticals, Inc. (2024, June 5). Safety, Pharmacokinetics and Efficacy of PP405 in Adults With AGA. clinicaltrials.gov. Retrieved January 1, 2025, from clinicaltrials.gov/study/NCT06393452 time4design, info@time4design.com. (2024, December 23). Dermatology Summit 2025 - Advancing Innovation in Dermatology. Advancing Innovation in Dermatology. advancing-derm.org/platform/conferences/dermatology-summit-2025/ Weng, C., MD, FAAD (Director). (2024, January 11). Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo. AAD Meeting Web App. Retrieved January 1, 2025, from am2024.aad.org/sessions/16895
Ok I've been on Fin 1mg and topical minoxidil 5% for 6 months. I love the change. However, I can tell that some part of my scalp will never "gain" back the lost hair, although the hair is tiny and fragile, I need somwthing to "wake" the hair up...
great find! would you say this recent news about leaks and this Q&A make you even more hype for PP405 than before? A lot of this is sounding great to me but we'll have to see lol also wonder what the CEO is gonna say at the summit 👀
Errrr it’s just a blued out image of the follicle. that doesn’t really tell us much about hair growth. Why would they put this out? It’s such an upstream effect it’s irrelevant to what both patients and their investors want to see. Does this stuff regrow hair ?
It is mechanistic. By the way, they didn't put this out. This was on their secondary version of their home page which is not easily accessible. Personally, I do think it is important to share that at the very least, at the moment in their research, the activation of these hair follicle stem cells is similar to what they have noticed in their pre-clinical animal studies. In those studies, the hair did grow back. Similarly this is reflected in ex-vivo human scalp hair. It is encouraging that the pattern is reflected in actual live human subjects, especially shortly after application.
@@Kyle_BuI agree but it’s been nearly 6 months since the trial began. If the results were encouraging we would be see something more substantive. We’ve been here before with amp303, scube etc. Just Lab hype. Also hair growth on grafts and animal studies are really not predictive anymore. So many drugs demonstrate this then fail
@homopolemicus3449 that's not how clinical trials work. They've only recently finished phase 2a as well with a primary completion this February 2025. This trial is also quadruple blinded...so why would they post results if Pelage isn't even recording the data directly? That's irresponsible.
@@homopolemicus3449 That's now how trials work at all, - someone who works in clinical research. You do not get data before the trial ends. Research sites execute the trial, the sponsor (pharma company) receives the data and compiles it based on the protocol parameters. They must follow strict guidelines as prescribed by the FDA and comply with the IRB regulations to ensure compliance.
I'm most interested in the percentage change of vellus to terminal hair conversion (ratio). If (vellus) scalp hairs are no longer cycling, does the mechanism hold true? Knowing the MOA is great but it could limit the effectiveness. If it kick starts the (dormant) follicles then I'll be super excited to add this into my stack!
Thanks for the great video. So in theory - a direct lactate injection could/should also help to activate hair follicle stem cells? How about some sort of a topical lactate solution? Ammonium lactate creams are easily available for example. Or does this only work when the backup kicks in? Super interesting... Maybe this is what we all hoped for...
I thought something like this as well, but, I don't think its enough for just injecting lactate. It could be confluence of things. Perhaps you need a certain cellular environment and the activation of various genes, some of which being downstream of ATF4. Some of those genes could also have special signaling properties to specific growth factors that can determine how hair follicles respond.
@@Kyle_BuYes, that's what I guess as well. I just googled a bit and interestingly there are some shampoos and lotions with lactate acid and they are rather new (a few years max) and some people claim their scalp health improved a lot. Will give it a try, but I guess when you have a specific med which is designed to penetrate the skin and does its magic there it has to be more efficient. Also, I could imagine that this backup mechanic needs to be triggered, so the "alternative fuel" is really used. As long as the primary mechanic is working, it probably is not as useful. It's the same with sports - as long as you have enough carbs, the body is not forced to burn fat. Only after a while of running the body is forced to use a different energy source.
Please don't make jokes like this dude. These people are doing us great work and it doesn't make sense to even make a meme like that. They aren't the issue and much of Pharma and BioTech isn't. These companies would love if we could use their medications and the most cutting edge technologies. But health insurance companies prevent this (in the United States). Health insurance companies would prefer us using older drugs that sometimes that aren't as efficacious as newer ones and typically have more side effects. So they are more likely to deny the coverage for newer medication and treatments. Nevertheless dude, I get you're telling a joke but considering the environment we're in, and even the suggesting that BioTech or Pharma is the issue, is risky, false, and dangerous.
Hmm based on a cursory understanding of the machanism, If i restore dormant/miniaturized hair via PP405 , will it make sense to discontinue the use of PP405 and maintain my gains with FIN/DUT?
Well that's just a theory. If it is that potent then perhaps it would be all you need as it can override whatever damaging effects DHT has on the hair follicle
@@Kyle_BuThis is the most interesting part, I also hope first of all that it is effective and secondly that it is so powerful that you do not need 5ari or anti-androgens. Kyle, I congratulate you so much for the videos, your work is impeccable.👏🏻
Sources:
Emma Andrus, Associate Editor. (2024, August 19). Q&A: Pelage’s novel PP405 advances to Phase 2A for androgenetic alopecia. Dermatology Times. www.dermatologytimes.com/view/q-a-pelage-s-novel-pp405-advances-to-phase-2a-for-androgenetic-alopecia
noeyys. (2024, December 29). PP405 Drug in Action: Picture From Official Company Website. www.reddit.com/r/tressless. Retrieved January 1, 2025, from www.reddit.com/r/tressless/comments/1hpcc92/pp405_drug_in_action_picture_from_official/
Pelage. (2024, February 23). Pelage Home 2 - Pelage. pelagepharma.com/pelage-home-2/
Pelage Pharmaceuticals, Inc. (2024, June 5). Safety, Pharmacokinetics and Efficacy of PP405 in Adults With AGA. clinicaltrials.gov. Retrieved January 1, 2025, from clinicaltrials.gov/study/NCT06393452
time4design, info@time4design.com. (2024, December 23). Dermatology Summit 2025 - Advancing Innovation in Dermatology. Advancing Innovation in Dermatology. advancing-derm.org/platform/conferences/dermatology-summit-2025/
Weng, C., MD, FAAD (Director). (2024, January 11). Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo. AAD Meeting Web App. Retrieved January 1, 2025, from am2024.aad.org/sessions/16895
Looks promising, best if it doesnt pull a pyrilutamide phase 3 on us
I need this on my head right now! I don't care if it kills me!
Ok I've been on Fin 1mg and topical minoxidil 5% for 6 months. I love the change. However, I can tell that some part of my scalp will never "gain" back the lost hair, although the hair is tiny and fragile, I need somwthing to "wake" the hair up...
In a few years we will have immortal mice with a thick head of hair.
@@DassPhotoElectronics yep and I'll still be an aging balding weirdo.
@@DassPhotoElectronics Mice will inherit the earth, or immortal super mice with awesome hair will
Was anything of substance said from the Pelage Pharmaceuticals staff?
if this truly works on most people. these people will become trillionaires and should be handed a noble prize
I agree. They deserve all the money.
Hopefully they IPO 🤣
yeah i will be buying some of their stock if they go ipo and get filthy rich while having tons of hair
I was waiting for this all week. Amazing. Wishing 2025 will the your best year yet. You are great. Love your channel. X
Thank you! You too!
great find! would you say this recent news about leaks and this Q&A make you even more hype for PP405 than before? A lot of this is sounding great to me but we'll have to see lol
also wonder what the CEO is gonna say at the summit 👀
Hey bro! I would say yeah. I'm very excited to see the news on phase 2a. I'm hoping this drug works out for everyone!
Please do video about Brezulla
When news comes out sure
If the test is successful, when will we be able to get the medicine?
Did you watch the video? No one knows
Errrr it’s just a blued out image of the follicle. that doesn’t really tell us much about hair growth. Why would they put this out? It’s such an upstream effect it’s irrelevant to what both patients and their investors want to see. Does this stuff regrow hair ?
It is mechanistic. By the way, they didn't put this out. This was on their secondary version of their home page which is not easily accessible.
Personally, I do think it is important to share that at the very least, at the moment in their research, the activation of these hair follicle stem cells is similar to what they have noticed in their pre-clinical animal studies. In those studies, the hair did grow back.
Similarly this is reflected in ex-vivo human scalp hair.
It is encouraging that the pattern is reflected in actual live human subjects, especially shortly after application.
@@Kyle_BuI agree but it’s been nearly 6 months since the trial began. If the results were encouraging we would be see something more substantive. We’ve been here before with amp303, scube etc. Just Lab hype. Also hair growth on grafts and animal studies are really not predictive anymore. So many drugs demonstrate this then fail
@homopolemicus3449 that's not how clinical trials work. They've only recently finished phase 2a as well with a primary completion this February 2025.
This trial is also quadruple blinded...so why would they post results if Pelage isn't even recording the data directly? That's irresponsible.
@@homopolemicus3449 That's now how trials work at all, - someone who works in clinical research. You do not get data before the trial ends. Research sites execute the trial, the sponsor (pharma company) receives the data and compiles it based on the protocol parameters. They must follow strict guidelines as prescribed by the FDA and comply with the IRB regulations to ensure compliance.
I'm most interested in the percentage change of vellus to terminal hair conversion (ratio). If (vellus) scalp hairs are no longer cycling, does the mechanism hold true? Knowing the MOA is great but it could limit the effectiveness. If it kick starts the (dormant) follicles then I'll be super excited to add this into my stack!
I'm wondering if there is a dose dependent response! :D
@@Kyle_Bu I could imagine this stacking nicely with GT20029 if the follicles were in fact reactivated from a dormant state. : )
What is the expected result from this do you think? Can we expect atleast 10-20% regrowth? Would that be too much to ask for?
I'm not sure. I'd hope it's efficacious
Hey bro do you think this can also work on retrograde alopecia or dupa?
Yes
does PP405 have to be used forever like minoxidil?
Most likely
Thanks for the great video.
So in theory - a direct lactate injection could/should also help to activate hair follicle stem cells? How about some sort of a topical lactate solution? Ammonium lactate creams are easily available for example.
Or does this only work when the backup kicks in?
Super interesting... Maybe this is what we all hoped for...
I dont think it is better than finasteride or min..this will also get invisible in some time
I thought something like this as well, but, I don't think its enough for just injecting lactate. It could be confluence of things. Perhaps you need a certain cellular environment and the activation of various genes, some of which being downstream of ATF4.
Some of those genes could also have special signaling properties to specific growth factors that can determine how hair follicles respond.
@@Kyle_BuYes, that's what I guess as well. I just googled a bit and interestingly there are some shampoos and lotions with lactate acid and they are rather new (a few years max) and some people claim their scalp health improved a lot.
Will give it a try, but I guess when you have a specific med which is designed to penetrate the skin and does its magic there it has to be more efficient.
Also, I could imagine that this backup mechanic needs to be triggered, so the "alternative fuel" is really used.
As long as the primary mechanic is working, it probably is not as useful.
It's the same with sports - as long as you have enough carbs, the body is not forced to burn fat. Only after a while of running the body is forced to use a different energy source.
will this turn minox vellus into terminal?
It could
Im unable to join the discord. Says the link is expired
Add me @ yummyvhs
@@Kyle_Bu added. My username is huhdog
No EOY Personal update?
I'll try to get that soon considering how I might be having to take legal action against those idiot hairdao people. But the videos are set up.
Opinion on topical lactate?
Can't be used on its own to grow hair
If all goes well and it is the miracle drug we all want and it releases 2027 ish. Will it available worldwide?
Unfortunately it looks like only the United States of America and maybe Europe Union markets at the moment.
@ Thank God, i live in the EU.
Hope they got FDA approved.
Me too!
Could someone as bald as vin diesel regrow hair with this ?
With family, anything is possible
Lifefuel
This sounds like the real deal
I need that PP
The next Brotzu lotion
lol
If it comes out and it's like $50k per vial imma pull a Luigi Mangione 😭😭😭
You can even blame it on muh neurosteroids :P
Please don't make jokes like this dude. These people are doing us great work and it doesn't make sense to even make a meme like that. They aren't the issue and much of Pharma and BioTech isn't.
These companies would love if we could use their medications and the most cutting edge technologies. But health insurance companies prevent this (in the United States). Health insurance companies would prefer us using older drugs that sometimes that aren't as efficacious as newer ones and typically have more side effects. So they are more likely to deny the coverage for newer medication and treatments.
Nevertheless dude, I get you're telling a joke but considering the environment we're in, and even the suggesting that BioTech or Pharma is the issue, is risky, false, and dangerous.
@@TyroneLangam lol