i spent hours trying to understand the difference between confounding and effect modifier . your video explained the difference very simply and clearrly Thank you so much. Keep up your good work!
Thank you so so much noor for this! Though I was a little confused till the very end but that Reye Syndrome example made everything clear! If you can add like 3-4 more examples they would really help. Best!
Such a great explanation. My particular case is funny because right now i'm doing a question from UWorld Qbank for Step 1 from Biostatistics and is exactly the same as your example. Thanks for the insights!
I'm a student and I'm not sure if I'm right, but in the last example, if age was a confounder, we would see the same effect, and the results wouldn't differ between children and adults. So it's not just if we didn't see association.
Can you tell me if this is right: Confounding: The relation you see is not real, there is something else that is the actual cause of relation. Effect Modification: The relation you see is real, but this relation will only be seen when a modifier is present/absent.
Loved it! Made more sense and last example of Reyes sx summarized it all. So to avoid confounding, do u use stratification? U hinted on it somehow. Thanks lots
Thank you Solomon! To avoid confounding from the start we match all variables (some of which are potential confounders) except the variable we are interested in. So we should match all smokers together and then start asking about alcohol use. Now if we didn’t match from the start but suspected there may be a confounder after we saw the results then stratification should eliminate the confounding effect. I hope this makes sense
Hello Noor. In the example of effect modification, there is no increased risk of DVT in patients treated with Estrogen who dont smoke but increased risk in those who smoke. This shows that estrogen dosent lead to DVT alone who dont smoke. Cant this be called as cofounding due to smoking?
Very clear and thanks. but I still have a quick question. could we say there is no association between determinants and outcomes regardless of confounders? (which is mentioned at 8:52 in this video.) I think the etiologic research is interested in finding the causal relationship between the determinant and outcomes. The researchers have to try to eliminate the effect that the confounders make in the occurrence relation but should we say the opinion above?
In 8:50, there’s a true association only in the presence of the effect modifier (age). There’s no true association in adults. Aspirin is the determinant, liver failure is the outcome and there’s no confounders
the part of the question that says "In non-smokers, no increased risk of DVT is evident with the use of drug RR:0.96" Implies that the drug doesnt actually have an effect. While in effect modification the primary variable [drug] has an effect and the effect modifier plays on the extent of the effect either by increasing it or decreasing it... do you get what I mean?
@@acingmedicine I did watch the entire video. I really love your other videos. I felt that this video was worded a little complicated. I watched it a couple of times and I understood it though. With peace and love 💞
I have an MPH degree but I haven't understood this so clearly until now. You're a good teacher! Thank you!
Thank you so much this comments means so much!!❤️
i spent hours trying to understand the difference between confounding and effect modifier
. your video explained the difference very simply and clearrly
Thank you so much. Keep up your good work!
It’s my pleasure!
Thank you so so much noor for this! Though I was a little confused till the very end but that Reye Syndrome example made everything clear! If you can add like 3-4 more examples they would really help. Best!
Such a great explanation. My particular case is funny because right now i'm doing a question from UWorld Qbank for Step 1 from Biostatistics and is exactly the same as your example. Thanks for the insights!
You’re welcome! My pleasure
Very much well explained. Truly grateful.
Glad you like it!
Thanks a lot for the explanation. I got the exact question (4:00) in Uworld and your explanation made so much more sense.
I’m so glad it helped!
The last example made so much sense! Thank you!!
You're welcome! I'm glad it helped :)
THIS IS REALLY GOOD. I can't believe I understand everything. THANK U
You’re welcome! Glad you liked it :)
Wonderful clear and concise, well done
Glad it was helpful!
I finally understand the concept. Thank you for simplifying!
I’m so glad Suneet!
elegant as usual, Very very good examples, Thank you
Thank you so much I’m glad you liked it!
Noor I'm so grateful to you, the Reye's syndrome example in the end really helped❤️
My pleasure!
Thanks a lot from the heart.. i got cleared of the concept now ..
You’re welcome Saima!
Beautiful explanation. Thank you!!!
Glad it was helpful!
Amazing explanation, really helped me out here!
Glad to hear that!
Very good explanation with precise images!
Thank you!
I'm a student and I'm not sure if I'm right, but in the last example, if age was a confounder, we would see the same effect, and the results wouldn't differ between children and adults. So it's not just if we didn't see association.
Such a great video, thank you so much!!!
You’re welcome! Glad to help :)
Its a good way to explain but it would be highly appreciated if u could come up with more examples
Thank you so much! Helping with grad school epi:)
I’m glad it’s helping :) ❤️❤️
lovely explanation!! thank you so much!
You’re welcome ! Glad it helped :)
Can you tell me if this is right:
Confounding: The relation you see is not real, there is something else that is the actual cause of relation.
Effect Modification: The relation you see is real, but this relation will only be seen when a modifier is present/absent.
Exactly!
Perfect that is so helpful
Glad it was helpful!
very helpful video thank you
You’re welcome!
great explanation🤩🤩🤩
Thank you!
Loved it! Made more sense and last example of Reyes sx summarized it all. So to avoid confounding, do u use stratification? U hinted on it somehow. Thanks lots
Thank you Solomon! To avoid confounding from the start we match all variables (some of which are potential confounders) except the variable we are interested in. So we should match all smokers together and then start asking about alcohol use. Now if we didn’t match from the start but suspected there may be a confounder after we saw the results then stratification should eliminate the confounding effect. I hope this makes sense
Love this video thanks so much!!
Glad you enjoyed it! anytime :)
Hello Noor. In the example of effect modification, there is no increased risk of DVT in patients treated with Estrogen who dont smoke but increased risk in those who smoke. This shows that estrogen dosent lead to DVT alone who dont smoke. Cant this be called as cofounding due to smoking?
well prepared thank you very much 👍🏻
I'm glad it helped Osman!
once again noor rocked and we shocked such an easy explanation ...keep it up...thank you for ur hard work ..jazakALLAH
Thank you so much! Glad it helped!
Thanks alot for the helpful explanation
Anytime!
Great Video
Thank you!!
Good topic👏
Thank you!
It was really thorough
Glad you liked it!
Very clear and thanks. but I still have a quick question. could we say there is no association between determinants and outcomes regardless of confounders? (which is mentioned at 8:52 in this video.) I think the etiologic research is interested in finding the causal relationship between the determinant and outcomes. The researchers have to try to eliminate the effect that the confounders make in the occurrence relation but should we say the opinion above?
maybe is at 8:50
In 8:50, there’s a true association only in the presence of the effect modifier (age). There’s no true association in adults. Aspirin is the determinant, liver failure is the outcome and there’s no confounders
How about intermediate factor (something that underly in causal pathway)? Do you have any explanation for this?
Te quiero mucho Noor 😁
You’re welcome anytime!
Very nice explanation.
P.S. Also loved the donkey sound in the background at 3:00.
😂😂 sorry was recording in the farm
Great thank u❤
You’re welcome!
Thank you for this ❤
You’re welcome!
WOW THANK YOU😍
You’re welcome!
thank you
you're welcome!
The second question got me so confused
the part of the question that says "In non-smokers, no increased risk of DVT is evident with the use of drug RR:0.96" Implies that the drug doesnt actually have an effect. While in effect modification the primary variable [drug] has an effect and the effect modifier plays on the extent of the effect either by increasing it or decreasing it... do you get what I mean?
I found this video difficult to understand. 😕☹️
I’m really sorry if it wasn’t up to expectations, did you watch till the end? If you have any questions DM me on instagram
@@acingmedicine I did watch the entire video. I really love your other videos. I felt that this video was worded a little complicated. I watched it a couple of times and I understood it though. With peace and love 💞
@@tejasviniv6902 I’m sorry again Tejasvini, thank you for rewatching. Will try to simplify my next videos more. All the best on your journey ❤️