Glycans - Carolyn Bertozzi (Berkeley)

www.ibiology.org/biochemistry...
A large part of an organism's complexity is not encoded by its genome but results from post-translational modification. Glycosylation, or the addition of sugar molecules to a protein is an example of such a modification. These sugars, or glycans, are often complex, branched molecules specific to particular cells. Cell surface glycans determine human blood types, allow viral infections and play a key role in tissue inflammation.

[@jeannelorraineamponin6822]

I just want to say that you're a great teacher! Passing on not only knowledge but also the passion!

[@dabigplaya2389]

Wish my university hired professors as passionate as you. :/

[@Stan_in_Shelton_WA]

NONYA BIZZ Passionate and she also speaks clearly!

[@user-tk5iq7ep6r]

you are a great teacher. I am so glad that you put your class online so that more people can appreciate your knowledge.

[@xuedoucet447]

It's powerful knowledge! Our company has products made of Glycans that were proven to be very very effective. Many many amzaing testimonies.

[@krupanidhi912]

Great explanation
Wonderful presentation
A few highlights
1. Compared excellently Genome, Proteome and Glycome
2. 5' and 3', N terminal and Carboxy terminal with Non-reducing and Reducing terminals of complex carbohydrates
3. Yet another imp is conserved region in glycans to bind to proteins across species as that of conserved domains in proteins and conserved seq of nucleotides in DNA
4. Blood groups are due to glucose derivatives from UDP. O group trigalactosamine, A group with tetra and B group again tetra with galactose.
5. Immune system recognises subtle difference within them
Great

[@aprilhicks3474]

Loved your introduction, had me totally engaged!

[@fardazidini7344]

Her explaination is amazing ,thank you so much

[@fernorsol]

Simply amazing!! I love watching these videos 😮😮

[@nabereon]

Such a brilliant teacher!

[@yourmajesty1361]

Very well explained!

[@user-tk5iq7ep6r]

thank you for your class

[@crush3095]

RIV-ET-TING

[@MegaMaede]

Wow!! this lecture is amazing!!

[@TheJoshtheboss]

She's amazing!

[@vivekdave6247]

Very nicely explained.. thank you

[@jenniferbosch1025]

Thank you!!!

[@xxxsmoke4lifexxx]

Great lecture, thanks a lot!

[@sagarrayamajhi]

very nice and informative talk

[@Lily-wp5do]

Awesome lecture

[@MJ-hj8wz]

great talk!

[@ajaykumar-iq5nf]

It is amazing lecture.

[@joelarnoldngassa8720]

Interesting video I just got interest in studying glycans

[@ashutoshmishra323]

excellent

[@Stan_in_Shelton_WA]

At 11:20 you discuss the bodies ability to assemble or manufacture the other 8 monosaccharides from Glucose. I hear the term gluconeogenesis in nutrition information pertaining to the bodies ability to make glucose from fats. This is why glucose is not on the list essential nutrients. Is this a misunderstanding on my part or is there conflict of beliefs in the academic community on this matter?

[@ZenTurtle786]

Been trying to figure this out myself and here I am.

[@patldennis]

Two different things.

[@oliverleslie7382]

@@patldennis Yep! GNG is a dire straights dynamic, starvation, it is not sustainable. A fat person will die still fat - if they don't eventually get dietary sugars. The liver can't provide enough sugars to make the fat we need as well sugar to do the many things we need, much less run a mile.

[@daveskinner5696]

Awesome

[@joelarnoldngassa8720]

I have a question what determines your blood type from birth is do we obtain it from our genome or what?

[@patldennis]

You can inherit A or B alleles or nothing (O) from either parent or any combination thereof.

[@joeschmo5699]

Rise of the Glycans.

[@nirmalyaghosh7187]

👍👍👍

[@annagracehilton1410]

I kinda have a celebrity crush on her NGL

[@srikanth7565]

watching this after she got noble price in 2022

[@MyWissam]

She’s an excellent lecturer. Too bad UC Berkeley lost her to Stanford...