Vitamin D and Calcium Absorption - Biochemistry Lesson
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- Опубликовано: 12 фев 2017
- Lesson on the role and importance of Vitamin D (calcitriol) in calcium absorption and why we actually need vitamin D for proper absorption and utilization of calcium.
Hey everybody! Here is a lesson on the metabolism of vitamin D, the role of vitamin D calcitriol in calcium absorption and why we actually need vitamin D to absorb calcium in our diet!
Topics discussed in this video:
How is calcium absorbed in the body?
What is Vitamin D Calcitriol?
What is the role of Vitamin D Calcitriol in calcium absorption?
Why do we need to eat Vitamin D?
I hope you find this lesson helpful! If you do, please consider liking, subscribing and clicking the notification bell to help support the channel.
JJ
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JJ
Super helpful, exactly the level of detail I needed. Thanks!
A video that clears up my confusion after learning biochemistry. Furthermore, would you please offer reference papers or textbooks on how calcitriol promotes calcium absorption? Thanks❤️~
Wicked tutorial mate, cheers!
perfect and simple explanation. thanks a lot
That was great! I'm so excitedly nerdy right now
Thank you for your lesson.
I JUST LOVE IT!! but I would lve it more with the regulation of VIT D and how the PTH and P04 work with vit D
You probably dont care but if you're bored like me during the covid times you can watch all the new movies on instaflixxer. I've been binge watching with my girlfriend for the last few days =)
@Torin Karter Yup, I have been watching on InstaFlixxer for months myself :)
Excellent explanation
Thank you so much!
thanks for helping me do my project
I have a question : patient with Chronic Renal Failure.. what kind of Vitamin should be given...?
Great job!
Thank u ❤️
Thank you
I love your videos; will you ever get a chance to make a Vitamin A/Retinoids video?
Thanks for this very basic tutorial - Ca transport across the intestine is slightly more complex and it involves trans- and paracellular routes of absorption, which are both Vitamin D responsive.
yea and? so you know an extra google information "slightly more complex"
@@iphoneiphone4700 what? That’s just a good to know tidbit. Why did you sound so salty? Did he sound condescending to you or sth?
Very good!
Thanks Mario :)
Thanks u helped me pass 8 th class
Well this gonna be helpful for my graduation research
this is the kind of "how" video that i need
thank you for sharing your gifts, subbed
love this
What happens to the vit. d product after nuclear transcription. Does it get broke down. How is it regenerated or is it removed? This would be important in determining. If a person needed to continuously consume?
Please answer this question I toooo want😀😀😀😀😀
calcitriol vitamin 1,25OH2d3, the active hormone, is immediately degraded by enzymes. Keep in mind that this video is only about the endocrine (systemic release of calcitriol from the kidney, which is in very minute amounts on an as need basis regulated by the level of calcium, which regulates the level of PTH which is what then acts on the molecule (vitamin d binding protein + 25OH) to be converted to calcitriol. It is in very small amounts. As always every cell in the body uses calcitriol, but the majority of the cells in the body do not function using the "endocrine", but rather the autocrine/paracrine, and in that matter, the preferrable metabolite is not calcitriol, nor is it bound calcidiol (25OHd), but rather cholecalciferol the sun made/or supplement, that is then made inside cells to the active calcitriol to enable the cells to access to its own DNA instructions, or cytosol, of proper function of translation, transcription and gene expression. In this presentation, understandably focusing on only vitamin d and calcium,. but really the major job of vitamin d is immune modulation, gene translation, transcription and expression. see this article for a good summary of metabolites. The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes www.ncbi.nlm.nih.gov/pmc/articles/PMC3849670/
If some one has calcium deficiency,, need to take calcium and vitamin d tablets ??
Or only calcium tablet enough ?
Wow thank you though I didn’t quite understand
thanks man
Thank you, I actually thought vit D acts in the lumen, great to remember that lipid soluble vitamins act inside the cell.
Why would my stomach not be absorbing vitamin D, been taking it over the counter for years, eat healthy, get sun light, eat healthy, excercise, now on prescription for Vitamin D..prayers for everyone💛
Is it d3 you're taking?
Hello. Do you have any thoughts on if washing skin after sun exposure can reduce absorption? 🙂
I have heard this too... both yes and no... uggghhh
What can you take in vitamins if you have breast cancer osteoporosis and blury eyesite
I wonder if researchers actually see exactly what each nutrient, vitamin,(?) are doing (going through paths the diagram show) -- I mean how does one know all this?
thanks :)
If it helpps absorbbhow then or wt what point does itcause hypercalceamia. Pp
So if you have calcium deficiency and vit d deficiency. The best is to begin vit d supplements ?
Yes taking 4000iu a day is recommended for the average person over 11 in the winter.
Don't forget Vitamin D only brings calcium to the blood and doesn't help it get placed to the bones. K2 and Manganese both do this and should be taken with high doses of Vitamin D.
Amazing video, I am a pharmacy student and I was having a hard time visualizing this process thank you for the help.
Is 2000IU of vitamin D3 is too much for a day? Or it’s ok? I’m currently taking vitamin D3 from Kirkland and thinking to take Calcium 1000mg after watching this video. Thank you~
You can take as much as 10,000-40,000 iu of vitamin D3!
I would not take so much calcium, especially the Kirkland one . Green leafy vegetables have a lot of calcium!
Don't forget Vitamin D only brings calcium to the blood and doesn't help it get placed to the bones. K2 and Manganese both do this and should be taken with high doses of Vitamin D.
Sensible D supplementation, ~4,000 iu per day and up, will make you far LESS dependent on calcium supplements. If anything, slugging lots of extra Ca may produce a mild excess of the stuff.
i have been lifting weights for a year now, I'm 14, my joints started popping and cracking doing normal movements everyday, mostly in my wrists, shoulders and ankles. This started about 5 months ago. I have no pain when they crack, no visible swelling. I'm not sure why this is happening, I think it is because I am vitamin d and calcium deficient. Please help
Can be air in your body too
Take fish oil
Take 4000iu of Vitamin D, 100iu of K2 and 5mg of Manganese daily to help your body absorb calcium and place it in your bones as well as boosting your immunity. Cheers ✌
Go to a doctor, sounds serious than getting help from comments that can't observe your symptoms directly
@@daisiesandpandas1218 doctor said it's normal for any athletes to experience this, just happens from regular use of the joints, air moving around inside them
I have low Vitamin D with normal Calcium levels. How is it possible?
But the question is should I take Vitamin D or D3 better?
Great tutorial, however it should be known 600 IU a day will not provide adequate blood levels of vitamin D. It's more to the tune of 10,000 IU/day, which is what I've taken for 3 years now. My blood tests come out in the mid 50s ng/ml, which is ideal. The only way to know is to get tested.
Don't forget Vitamin D only brings calcium to the blood and doesn't help it get placed to the bones. K2 and Manganese both do this and should be taken with high doses of Vitamin D.
@@LlibertarianGalt agree
@@LlibertarianGalt hi, if one takes 4000IU of D3 every day then what should be the right intake quantity of calcium, K2 and Manganese?
@@cosmiccoder7225 i wouldnt supplement calcium but I take 200mcg of K2 and 15mg of manganese, cheers
Yup. The AMA, etc. acknowledge that most of the population is D deficient, but still recommend this absurdly small dose. Grrrr!
FWIW, I've been on 8K IU D3 per day for 2.5 years and this has done wonders for assorted inflamed joints. D is not 'supposed' to help with osteoarthritis, but my hip begs to differ. D was life-altering for me.
Vitamin K2, not K1, is needed to send the Ca into the bones and not into the soft tissue.
warning about Natto! I started eating Natto for the K2mk7 and my testosterone level dropped. Not a big deal, but muscles shrank and man boobs appeared
What about vit K2?
Excess calcium causes cell death no?
Adam Blaknovski absolutely
Who else is here from spooktober!
JJ u sexy bird, making me pass my biochemistry in med school
What happens if there is no calcium in the small intestine for Vitamin D to absorb?
In March 2020 I began taling large doses of D3 and I cut out calcium - now, 2 years later, I stated calcium again - after I did (last week) pain my left arm started and yesterday pain in my entire left leg started and is still there. I think it is growing pains, where bones are gowing back and yanking on muscles that grew smaller over the years as my body got its calcium from the bones, but I'm no doctor so I turn to RUclips - too bad calclium videos seem to contradict each other now and then
What brand is best. Many products are made of olive oil.
all Fat Vitamins (A, D, E & K) need a fat sources to be absorbed better. that is why u will notice in some supplements, they included either MCT or Olive Oil as their fat sources. of course u can choose without it but u need to has any fat sources in ur meals to consume all Fat Vitamins
How vitamin d enters enterocytes?
In 3:12 what does he say? Intersite?
My knees are paining me so much it's now 1 and half years . They told me it's vitamin D. ( checked my vitamin D was 18 ) the told me to drink milk eggs and fish and medicine but no change. Today someone told me to use calcitron hope it will help me..
You have to shock your system back to normal. I took 50,000 units D one pill a week for 6 weeks. But must be done under drs supervision.
@@srfh2 thankx so much
@@barbrabaliwo3021 Stop taking dairy products or vitamin d and calcium tablets it is one if the worst mixtures, especially for black women you need to research herbs and fruits and Veg their is more calcium in Kale than milk trust me i went through it, vitamin pills are highly acidic and toxic it will eventually cause more damage than good.
@@MrCameron86 thankx so much
Go low carb for a month (no sugar or starch) and watch the joint pain disappear 🤗✌️
The Calcium requirements are high due to the Diary Industry influence to have people consume more dairy products.
lol
Tell that to women in menopaus loosing bone density due to lack of estrogen, ending up with osteoporosis
@@marieelisa1 tbf, exercise, and to a lesser extent vitamin D, also has a big impact on the development of osteoporosis.
Calcium requirements are higher when natural nutrition is destroyed by pasteurization and dairy products are fortified with nutrients.
@@marieelisa1 “losing”. The letters inside words are there or not there for a reason. Stop being lazy.
Who ever make the Engineering of Human Body + animals +
And make all this bunch of little smart life inside our body, that works for us without even thinking... its probably have to be call GOD
True. That's a nice and easy answer, if you don't want to spend time learning the science behind evolution. I just don't understand why it's so confusing that we're a product of coincidences on an almost unimaginable timescale. No need to invoke an imaginary friend.
@@jnv1971 yes, this makes sense - because in all areas of observable life, things tend to get more neater and more perfect if left alone, right? Naturally, things become ordered all on their own. Like bedrooms if you leave them alone. They just get neater and put into place over time. It just takes a *lot* of time, see
@@jnv1971
Indeed, I would agree that humans are lazy and stupid -- to the point where they develop theories to shirk the duty of answering to their Creator when the evidence speaks so clearly in its favor.
Breaking down your claims, you maintain that thermal energy is the impetus for order. Again, can you please point to an observable example of this in nature, in which complete void and disarray lends itself to order simply based on its energy potential?
You see, giving something a name doesn't make it any more plausible.
Thanks for the reply in advance, brother. I'm enjoying our discourse despite the sparring :-)
@@jnv1971 The inception of the sun and the process of photosynthesis are not observable. Their effects, yes, are observable -- but their origin of being cannot be observed. It was given to us this way by nature. Let us take God completely out of the picture for a moment.
We are plopped here into existence by whatever process. Now we live in an environment that is ordered. We observe that water falls naturally to the earth and helps things grow, including a host of delicacies to feed from, many of which having natural packaging to protect it from the environment (peel and shells). We see a delicate chain of balance in organisms. We see all living beings naturally reproducing, even having sexual desire to encourage it. We observe the human body and its 11 systems working closely together to maintain homeostasis, having tissues perfectly suited to lining, absorbing, and protecting. The disgestive system alone is enough to inspire a human inventor. Nay, inventors all across time have looked at things in nature to inspire them, the airplane having been born out of the ingenuity of a bird's wings.
My question, then, is, the inception of this order. Every piece of sophisticated machinery that we see today, such as the iPhone, the computer, rockets, even the lowly toaster -- they were all constructed with intentional design for an intentional purpose - exactly like we see in nature around us.
In fact, structure and function are so closely linked in nature that we cannot discuss one without discussing the other. This was a prerequisite piece of knowledge for the study of anatomy.
No one would look at the computer and say that it didn't have an intelligent designer behind it, even if you were to leave the parts laying around for billions of years (leavinf aside the fact that the parts themselves are still designed for the function). It's nonsensical to say that things with intentional design in their functions have no intelligent mind behind them.
@@jnv1971 thanks for your insightful reply that answered my questions
❤❤❤❤❤
🙏🙏🙏🙏🙏🙏
No mention of Vitamin K2?
i thought D9K is expressed in enterocytes and D28K is expressed in the kidneys...
supeb
No you need more vit d3 than 800iu it's more like in the 4000iu even as high as 10000iu a day. If you live in sun deprived areas. You also need magnesium and vit k to stimulate the absorption of vit d3. Especially now people take more vit d3 than what the health professionals recommend there very guid line driven its frustrating man.
K2 not K they're different vitamins, despite sharing similar names! Cheers
This is why you need Magnesium Glycinate and Liposomal Vitamin C to make sure that D3 works and the liver and kidneys work
I don't understand how calcium gets into the bones after being in the blood
But I take calcium supplement that has 500mg ca & 200 IU vit D3. Is it ok? I'm 28 years old now
If you do not get much sun, take 4000 IU D3.
You need 500mg Magnesium, 1000mg calcium and 4700mg potassium everyday.
It is best to get it in the food you eat. Supplement with 200 mcg K2 if you do not get it in your food.
The K2 gets the calcium into the bones etc.
Stop taking your calcium supplement. You Don't need it, it will only do you harm.
Don't forget Vitamin D only brings calcium to the blood and doesn't help it get placed to the bones. K2 and Manganese both do this and should be taken with high doses of Vitamin D.
don't take calcium supplements
I wanna get taller
cal- sifeh - DYE - ol, cal - seh - TRI - ol
How do you say Die or Triple? You must be fun
Punjabi vich daso
Dribble Dribble Dribble, tuck in shirt, give to my friend. Spin on finger, two rotations, dream about window. Put away basketball, go to work in cal-cium mine!
Yr recommendation is outdated
Who cares
Thank you