Polyol Pathway & Diabetes | The Role of Polyol Pathway in Diabetes Pathogenesis
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- Опубликовано: 14 фев 2017
- Polyol Pathway and Role in Diabetes Pathogenesis lesson.
What is the purpose of the Polyol (Sorbitol-Aldose Reductase) Pathway, and what is the role of the polyol pathway in diabetes pathogenesis? Here, I explain what the actual function of the polyol pathway is and that during diabetes, I explain how the polyol pathway can lead to diabetic retinopathy, diabetic nephropathy and diabetic neuropathy.
JJ
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JJ
This is amazing information, thanks!!! Between the video and the comments, I learned that kidney, retina, and nerve cells are insulin-independent, so insufficient insulin/insulin resistance will not prevent excess glucose from entering those cells. Glucose is converted to sorbitol when glucose concentrations are high, so sorbitol will be created in those cells when blood glucose is high. Typically, the sorbitol is then converted to fructose by sorbitol dehydrogenase, but kidney cells, the retina and lens of the eye, and nerve cells have low levels of sorbitol dehydrogenase, so sorbitol levels will increase. With uncontrolled diabetes, a condition of high blood glucose, excess glucose will enter kidney cells, retina/lens of the eye, and nerve cells, convert to sorbitol and get stuck in that form. Excess sorbitol is damaging due to its significant osmotic effect, so this leads to diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy.
Thanks
I finally got the connection between Sorbitol pathway and DM complications, thanks!!!
Why can't my teachers in med school be as clear as you? Thank you so much
I know right 😫
Cool - always love the connection between biochemistry and clinical medicine!!!!
That's a very helpful video, my college professor spent half an hour explaining this and I couldn't understand anything he said. Thanks so much,sir!
That was a great video! Thank you so much for being so clear! ^^
Nice video, I use Libre and Blucon and love them to track my blood glucose values. The alarms are nice and are loud enough to wake me up. You can adjust your BG ranges to whatever you want. The best part of blucon is I can calibrate it for higher accuracy!
Simple , clear, easy launguage , 🙏 thnkz 😘😘😘😘😘😘😘😘😘😘😘
Thank you, you made that so easy to understand
What an amazing explanation, thank you so much
Great video. Simple and concise.
Great video, completes the puzzle.
This video is perfect thank you
Simple and clear. Thanls a ton.
Thanx for uploading this video.
Real shit man, thanks.
Thanks sir!!!! you explained well !!!! ✨💕
WOWWW! Many thanks! amazing video as always
Glad you liked it!
Thanks for this
Very clear
Glad it was helpful!
As a diabetic type 2 with retinopathy undergoing treatment ( 6 times anti vegf injections ) I am very surpised to discover right now , that my sweetener can be the culprit for my condition, for it sorbitol content! Thar could be the reason for my retinopathy being so persistent to present date even with ha1c in the middle 5. Hpe that with no sorbitol on my foods, the condition could improve.
so helpful❤️
Thank you so much ♥️👏
thank you so much....
thank you so much .
thank you very much
I see now how cellular production of sorbitol can cause problems. My question now is if there is any health issues with using sorbitol as a sweetener? Thanks in advance for any input.
Thank you ♥️
THANK YOU
thanks!!!
thanks alot
God loves you and he wants to save everyone 🙏🏾❤️
Nice man! Could you please recommend a really trustful reference, like for an investigation pls!! thxs
Thankyou
THANKYOU!
You are very welcome :)
thank u sir
thank u so much
You're very welcome :)
thanks man
No problem! Hope you liked it :)
Does sorbitol damage the cell by hypertrophy? , I mean when it accumulate does it also absorb fluid into the cell then cause hypertrophy or rapture of the cell occurs ?
wow sir
Beauty!
Cool
Hello, can we use sorbitol as a source of energy?
There is a mistake in the first figure. Aldose reductase only takes aldose form (aldehyde linear) not pyranose form as a substrate.
I love you
🙏
Isn't the whole problem with diabetes that the insulin receptors don't work so glucose isn't getting into the tissues in the first place? If so, why do we care about this if glucose isn't getting into the tissues?
Well did u get your answer? If yes then pls help me as well. Btw good thought process
I think thesw complications happen after 20 to 30yrs of diabetes even when controlled bc a diabetic has more blood sugar than a normal person even when hes on medication which is basically faciliating transport of glucose to cells and lowering blood sugar.
@@samiksha8397 Thanks. I found the answer:
"While most cells require the action of insulin for glucose to gain entry into the cell, the cells of the retina, kidney, and nervous tissues are insulin-independent, so glucose moves freely across the cell membrane, regardless of the action of insulin. The cells will use glucose for energy as normal, and any glucose not used for energy will enter the polyol pathway. "
💯❤️💯
So this is the cause of my gout. High amount of glucose can turn into fructose. I'm already fructose overdose.