Dorsal Ventral Polarity Generation in Drosophila | Gurken-Torpedo Pathway

The nucleus of the oocyte travels to what will become the dorsal side of the embryo. The gurken genes of the oocyte synthesize mRNA that becomes localized between the oocyte nucleus and the cell membrane, where it is translated into Gurken protein. The Gurken signal is received by the Torpedo receptor protein made by the follicle cells Given the short diffusibility of the signal, only the follicle cells closest to the oocyte nucleus (i.e., the dorsal follicle cells) receive the Gurken signal, which causes the
follicle cells to take on a characteristic dorsal follicle morphology and inhibits the synthesis of Pipe protein. Therefore, Pipe protein
is made only by the ventral follicle cells. The ventral region, at a slightly later stage of development. Sulfated proteins on the ventral region of the vitelline envelope recruit Gastrulation-defective (GD), which in turn complexes with other proteins, initiating a cascade that results in the cleaved Spätzle protein binding to the Toll recep- tor. The resulting cascade ventralizes the cell.
Source : Gilbert Developmental Biology

[@tanmoythetraveller6159]

I watch your videos in occasions from 2019 and this is my first comment.
I had passed Masters in 2012. When I read the topic back in 2017 there was no one to guide me. And I understood this dificult topic by myself reading Gilbert dev bio book.
These days the animated illustrations are very helpful for students and it's totally free. I can't understand why the views are so less

[@hussainbiology]

Thanks Tanmoy for appreciation..... At my time i too had no on to guide or help me ......That being the reason i put out everything out there without any paid subscription. ( and only u could know how much it takes to make these difficult topics into these simple illustrations ).
Thanks again....

[@edthoreum7625]

Students are fortunate today with great visuals and tons of info.

[@phantomgamingignt6275]

Most underrated educational channel 🥰🥰

[@hussainbiology]

Means a lot buddy... ❤️ Thanks for appreciation

[@nehabaid7764]

Crazy how such multiple steps clarified and got to create such a clear picture in my head in freakn 5 minutes 🥳

[@hussainbiology]

thanks for appreciation..Glad it helps

[@Dhanush-s9l]

Hats off to your efforts 💫

[@hussainbiology]

Thank you so much 😀

[@rutujapatil4998]

Thank you ❤️

[@michaeleisenberg7867]

Beautiful animations, Shabir! 📽️🎞️📺
The oocyte is very busy🏃🤸🏋️🤹🌋.
👏👏👏

[@hussainbiology]

Thanks Doc....
Yeah Oocyte is always busy....

[@aathira4491]

You are highly talented …sir…clear animation with beautiful explanation…..Thank you sir….❤…

[@hussainbiology]

thanks for appreciation..Glad it helps

[@user-gi3qq1cb1z]

Wonderful fantastic diagrams and explabation❤❤❤❤

[@hussainbiology]

thanks for appreciation....

[@cat-di3wd]

Sir please do video about anterior posterior polarity

[@aniketdas7803]

Extremely helpful.
Love from India 🇮🇳

[@hussainbiology]

Thanks Aniket for appreciation... Glad it helps

[@hussainbiology]

hum b khud India se he hai🙏

[@aniketdas7803]

@@hussainbiology wow that's great.
Free mai sabki madat karna to hum Indians ki khoon mai hai...❤️
You are doing great job, it's really help us(students).
Thank you for your such effort...🙏

[@Dhanush-s9l]

Please make more videos on developmental biology sir

[@hussainbiology]

surely

[@MakeMemoriesWithKilbils]

Please sir make video regularly....
Thank you so much for your great effort..

[@lavalara105]

I though the above mentioned topic was difficult to understand .. but after sawing your video it will be easy to study... need more videos in lifescience subject

[@hussainbiology]

thanks for appreciation...Glad it helps ✌️

[@bhuviyadav8094]

Thank you so much sir ☺️

[@ankithaankitha6019]

Well animation and simple Anderstand explainatiin

[@crissy6133]

It's really helpful to understand what's going on there, BIG thanks 🙏🏼👏🏽

[@maatimaati6671]

A very clearing illustration...
I hope you can add the expriments which prouve that....

[@sonalibalodhi.5015]

Thnku so much sir

[@hussainbiology]

most welcome

[@malikishfaq2978]

Awesome explanation

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@khadeejasalah776]

Tnku so much sir..you video help me a lot for my seminar

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@chaithrashreei3029]

The best video

[@lavalara105]

Amazing

[@izabellahubbard6791]

this video is soooooo helpful. thank you!

[@hussainbiology]

thanks for appreciation..Glad it helps

[@indianfamily920]

Very nice

[@Se7en_000]

Assalamualaikum brother...
Plz plz humble request can you cover up topic early development of drosophila plz

[@pavithramurugesan6208]

It was accurate 🙏👍

[@user-ki6bj5tt5j]

Could you please clarify why there is no gurken signaling on the ventral side? How can the nucleus distinguish ventral from dorsal and only produce gurken mRNA on the dorsal side? Thanks a lot!

[@mehwishnawaz6519]

👍

[@alhaeri1]

good stuff