Thanks for such incredible videos! Your videos on musculoskeletal physiology are BRILLIANT! I have a question. In the small intestine, after a high carb meal, shouldn’t the intestinal luminal concentration of glucose be higher than that in the intestinal cell (on the apical side)? Why do we need secondary active transport for glucose here? How is glucose travelling UP its concentration gradient here?
I have never come across information on a perticular case of high carb meal. But let's try to explore the possibilities based on what we know. The first possibility is that the glucose concentration in the lumen might not be getting higher than that in the cell despite the high-carb diet. The reason might be the dilution by other stuff present in food, water that we drink, and even saliva and gastrointestinal secretion. And second, even if the concentration gets higher, it is not a problem. See in simple words, it's like the cotransporter pulls the glocose uphill. For this, it exerts some force. If the glucose is already elevated (by higher concentration in the lumen), the cotransporter needs to exert less force, but it does not mean that the same cotransporter cannot pull the glucose any longer. Rather the higher concentration makes the work of the cotransporter easier. This question is like asking I have a robot that can carry 10 kg weight but I need to make him carry 2 kg only, how do I do that! Well, the robot that can carry 10 kg weight will carry 2 kg also. The problem arises when we need him to carry more than 10 kg weight. I hope you are getting what I mean to say. Again these are my intuitions. I don't remember it reading anywhere. I hope it helps.
@@NonstopNeuronThanks for the reply! I was just wondering if the intestinal luminal glucose concentration is higher than the intestinal cell after a high carb meal, glucose could have been transported to the inside of the cell by facilitated diffusion through the GLUTs, just like on the basal side.
This channel is the best for learning basics of medicine I have ever seen in You Tube. Thanks , Sir ! And I have a question : Na concentration in outside is higher than inside, so both chemical gradient and electrical gradient are same directions, if thus are equal in equilibrium potential for Na, which direstion Na moves? We say that no net move, but those two gradients are not different directions, they are same directions. In my mind in this situation Na must move to inside of cell.
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thanks
I recently came across your videos and am amazed by the pictorial explanations! Keep doing the good work.
Thank you! Will do!
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Thanks for such incredible videos! Your videos on musculoskeletal physiology are BRILLIANT!
I have a question. In the small intestine, after a high carb meal, shouldn’t the intestinal luminal concentration of glucose be higher than that in the intestinal cell (on the apical side)? Why do we need secondary active transport for glucose here? How is glucose travelling UP its concentration gradient here?
I have never come across information on a perticular case of high carb meal. But let's try to explore the possibilities based on what we know. The first possibility is that the glucose concentration in the lumen might not be getting higher than that in the cell despite the high-carb diet. The reason might be the dilution by other stuff present in food, water that we drink, and even saliva and gastrointestinal secretion. And second, even if the concentration gets higher, it is not a problem. See in simple words, it's like the cotransporter pulls the glocose uphill. For this, it exerts some force. If the glucose is already elevated (by higher concentration in the lumen), the cotransporter needs to exert less force, but it does not mean that the same cotransporter cannot pull the glucose any longer. Rather the higher concentration makes the work of the cotransporter easier. This question is like asking I have a robot that can carry 10 kg weight but I need to make him carry 2 kg only, how do I do that! Well, the robot that can carry 10 kg weight will carry 2 kg also. The problem arises when we need him to carry more than 10 kg weight. I hope you are getting what I mean to say. Again these are my intuitions. I don't remember it reading anywhere. I hope it helps.
@@NonstopNeuronThanks for the reply! I was just wondering if the intestinal luminal glucose concentration is higher than the intestinal cell after a high carb meal, glucose could have been transported to the inside of the cell by facilitated diffusion through the GLUTs, just like on the basal side.
This channel is the best for learning basics of medicine I have ever seen in You Tube. Thanks , Sir !
And I have a question : Na concentration in outside is higher than inside, so both chemical gradient and electrical gradient are same directions, if thus are equal in equilibrium potential for Na, which direstion Na moves? We say that no net move, but those two gradients are not different directions, they are same directions. In my mind in this situation Na must move to inside of cell.
Yes. Na moves inside. But this entrey of positive ions makes the inside of the cell positive which eventually stops the further Na entry.
Sir this video is not palying..?
It's playing fine for me.
Don't know sir still not palying, problem with this video only
Sir know it is playing , thank you
Upload the next video
Hi prashant, will upload next video this weekend. Thanks for comment.
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