Receptors: Signal Transduction and Phosphorylation Cascade

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  • Опубликовано: 18 ноя 2024

Комментарии • 132

  • @simontamang3076
    @simontamang3076 5 лет назад +127

    Best explanation someone has every given to me about cell signal...Thank you so much professor dave

  • @adamh.8823
    @adamh.8823 7 лет назад +172

    This stuff is too amazing. Does this not just blow peoples brains out of their heads?

  • @jmakinson
    @jmakinson 7 лет назад +41

    Thanks a heap! The entire first chapter in my Pharmacology text suddenly makes sense. Your video was the first domino and I am very appreciative. Keep up the great work.

  • @excel77115
    @excel77115 7 лет назад +16

    What a great help you are! You make the best videos for me! Visuals, language, in-depth enough explanations of the chemistry side as well, which helps with my understanding. There are many people out there making videos, but for me you're the best! :)

  • @liabduhliabduh2207
    @liabduhliabduh2207 6 лет назад +4

    Superb it couldn't be anymore better than this.

  • @brightbindim4907
    @brightbindim4907 3 года назад +2

    The tutorial is so helpful and easy to understand

  • @Avatarlifeplays
    @Avatarlifeplays 7 месяцев назад

    Thank you, Professsor Dave! I have learned a lot from watching your video. I am also a visual learner, so this was super useful, and I took notes as a listened and followed along.

  • @dkerrtty1220
    @dkerrtty1220 7 лет назад +7

    Thank you because I was doing some AP Biology learning (12th grader) and I was completely not understanding how phosphorylation was working.

    • @dkerrtty1220
      @dkerrtty1220 7 лет назад +1

      Now that I think about it, watching your channel could allow me to do well in college with my science classes

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  7 лет назад +3

      yeah yeah watch them all! i've got a lot of different stuff.

  • @midzymango4679
    @midzymango4679 2 года назад +1

    really saved my apbio grade thank u!!

  • @wfox6985
    @wfox6985 3 года назад +3

    Bro - your lecture was so good and helped so much. I am taking a psychopathopharmacology class and your lecture was a game changer for me. So basically, psychoactive drugs are just ligands that we hope illicit a favorable response. Would you say that is a correct way to look at it? Thanks!

  • @rdelong1210
    @rdelong1210 4 года назад +6

    Keep making these videos! They're so much help trying to put together this information. You make it actually make sense!!

  • @adamglustein8700
    @adamglustein8700 7 лет назад +7

    Thanks a lot for these videos, hands down the best explanations of all things science on RUclips. This video helped me a lot with my project on receptor related diseases (Grave's disease, hypercholesterolemia and the role of serotonin receptor malfunction in depression). Truly a lifesaver!

  • @hajiqasim448
    @hajiqasim448 4 года назад +1

    Simple explanation in you tube. thank you Dave

  • @teentony2181
    @teentony2181 7 лет назад +16

    Incredibly helpful, especially for visual learners!

  • @abhinavbachu5309
    @abhinavbachu5309 6 лет назад +10

    Thank you so much for this video!!! It really helped me out a ton!!!

  • @lyndapope7796
    @lyndapope7796 5 лет назад

    This video has helped solidify such a complex process thanks heaps

  • @adsilv7913
    @adsilv7913 7 лет назад +9

    Please make a video on Ras Pathway

  • @mariamklibadze
    @mariamklibadze 8 лет назад +16

    omg thanks a lot I couldn't get it before I watched it

  • @mitsunori222000
    @mitsunori222000 4 года назад +2

    Wish I'd discovered this before. Great channel, great explanations.

  • @embryophytelove
    @embryophytelove 6 лет назад +7

    This was great! Very helpful!

  • @SCIPROlearning
    @SCIPROlearning 3 года назад

    Excellent presentation

  • @gaganpreetsingh6238
    @gaganpreetsingh6238 4 года назад

    Omg professor Dave thank you.... this video made me understand so muck more better than my book and Professor.

  • @jellykin7161
    @jellykin7161 7 лет назад +9

    Slight correction at 2:00
    G protein coupled receptors already have a G protein before activation.

    • @anirudhsharma1706
      @anirudhsharma1706 3 месяца назад

      No its not true ig
      Can you share any link to proof .

  • @Acts--wn9zq
    @Acts--wn9zq 5 лет назад +1

    What an amazing design!

  • @hama8027
    @hama8027 3 года назад

    Thank you for this wonderful explanation

  • @darweeshhd5841
    @darweeshhd5841 5 лет назад

    I like this guy , very clearly explaining ....

  • @lottiehara3491
    @lottiehara3491 9 месяцев назад

    Well explained

  • @harisivanesh942
    @harisivanesh942 5 лет назад +1

    Super work professor

  • @bohanxu6125
    @bohanxu6125 Год назад

    3:04 I think such standard explanation of Phosphorylation cascade can be misleading. The Phosphorylation kinase are not "exchanging" Phosphate group, the activated Phosphorylation kinase would make APT to give up extra Phosphate group to yet-to-be-activated Phosphorylation kinase.
    The power of cascade is the chain reaction that amplify a signal from one Phosphorylation kinase to a huge amount of Phosphorylation kinase that can eventually bind with a lot of other proteins for some large scale cellular response. This amplification is a very non-trivial process. Typically you would image a few molecules can only cause a few reaction. However, a cascade is need for situation like how a camera can capture one photon and amplify it to a macroscopic effect like pixel changes on ones detector. (also like how g-protein can amplify a signal)
    By the way, I love Professor Dave's videos overall. They are very good. Also I can be wrong about Phosphorylation cascade. Biochemistry is not my field.

  • @FredsonTorres
    @FredsonTorres 8 лет назад +2

    Hi Professor Dave how are you doing? I am also a teacher (in Brazil) and I am thinking about doing something like your channel in portuguese. You are very inspiring! By the way, I got curious: what is your major? To which courses you give lectures to? Pharmacist guy here (Organic Chemistry PhD in progress here). Hugs from São Paulo, Brasil!

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  8 лет назад +7

      thanks for watching! i studied organic chemistry and that's what i used to lecture on, if you look up my organic chemistry tutorials those are the first things i created, and they are essentially just the lectures i used to give in class. good luck creating your own content!

    • @Drfocus123
      @Drfocus123 8 лет назад +1

      you are a great professor in organic chemistry thanks professor dave for all

  • @tismon112
    @tismon112 3 года назад +2

    You switched the "I's" between "ligand" and "diffuse"

  • @kaitlyndunn4571
    @kaitlyndunn4571 4 года назад

    Thank you Dr. Dave🥸👏👏👏

  • @sepsinareski889
    @sepsinareski889 6 лет назад +2

    thank for u explain.. can u explain about fatty acid signaling by GPR120 and GPR40? and how about lipid sensing mechanism.. ?

  • @noel5544
    @noel5544 2 года назад

    thank you professor dave

  • @Zetsuke4
    @Zetsuke4 5 лет назад

    Very nice! I really like your style

  • @muntahausman1744
    @muntahausman1744 3 года назад

    Thank you so much sir for this explanation!

  • @turboallen
    @turboallen 10 месяцев назад

    Fantastic video!

  • @priyadarshanishendage698
    @priyadarshanishendage698 4 года назад +1

    It is nice video sir thank you so much ....😍from india

  • @BenjaminDeutsch-xd1yh
    @BenjaminDeutsch-xd1yh 4 месяца назад

    Agreed, Best explanation

  • @shuqingyang6577
    @shuqingyang6577 6 лет назад +1

    I found it super useful!

  • @erickcruz2576
    @erickcruz2576 4 года назад

    Thank you Dave.

  • @viswaneedevisunnasee1878
    @viswaneedevisunnasee1878 3 года назад

    Amazing👏👏👏 Simple and beautifully explained. Thank you so much.

  • @krishnamurthy1086
    @krishnamurthy1086 4 года назад

    best teacher.

  • @PoojaSaini-cz5fu
    @PoojaSaini-cz5fu 3 года назад +1

    Thank you sir

  • @shinn-tyanwu4155
    @shinn-tyanwu4155 Год назад

    Outstanding

  • @soominlee376
    @soominlee376 Год назад +1

    Thanks a lot !

  • @Denise00700
    @Denise00700 2 года назад

    Very understandable! Thank you

  • @ALIKHAN-ge4cj
    @ALIKHAN-ge4cj 5 лет назад +1

    thanks Pro.

  • @crystalstob3740
    @crystalstob3740 2 года назад

    So helpful! Thank you!

  • @asmajaved424
    @asmajaved424 2 года назад

    Thank you so much.This was really helpful.Really appreciate your hard work.❤❤

  • @moemedimbakibazanisi224
    @moemedimbakibazanisi224 3 года назад

    Thank you

  • @curranadvani9725
    @curranadvani9725 3 года назад

    Professor Dave>>anyone else

  • @btchhangte4481
    @btchhangte4481 2 года назад

    Please explain Protein kinase receptor

  • @asox5229
    @asox5229 4 года назад

    Super helpful 🙏🙏 Thank you so much Professor Dave!

  • @kaustavbhattacharyya2217
    @kaustavbhattacharyya2217 4 года назад

    What is noise in signal transduction? Please explain me in detail.

  • @insight4052
    @insight4052 2 года назад +1

    Helpful 🎉

  • @gogomoh5909
    @gogomoh5909 6 лет назад +3

    Thanks a lot 💓

  • @jacksonharms8007
    @jacksonharms8007 2 года назад

    You are the goat man

  • @walarajab3052
    @walarajab3052 3 года назад

    Thanks

  • @aeiiea
    @aeiiea 2 года назад +1

    Superb

  • @himaniy6013
    @himaniy6013 5 лет назад

    Thnx alot...from🇮🇳

  • @jenroberts7267
    @jenroberts7267 3 года назад

    Thanks Professor Dave! Ps. I like the intro: "He knows a lot about the science stuff..." My sense of humour with all the facial expressions too. Haha!

  • @sphiwekaluwa8720
    @sphiwekaluwa8720 3 года назад

    Thanks sir so helpful

  • @herbertlaraordaz2136
    @herbertlaraordaz2136 5 лет назад

    Thanks, I enjoyed much.

  • @THUBBNC
    @THUBBNC 2 года назад +1

    Awesome!

  • @TBCS3000
    @TBCS3000 9 месяцев назад

    Can anyone know a movie about biology that you recommend?

  • @bangnikabang6501
    @bangnikabang6501 3 года назад

    awesome, thanks !

  • @negar1370
    @negar1370 2 года назад

    thanks a lot

  • @parfoisbaker
    @parfoisbaker 6 лет назад +1

    Thank you!!!

  • @ihanba
    @ihanba 5 лет назад

    Your delivery is grating, but this video was very informative and helpful. Thank you.

  • @goodsir2551
    @goodsir2551 8 лет назад +6

    Thanks for all the helpful videos and for being so awesome Professor Dave. Why are you so awesome though? It's simply not possible to be so awesome as you are. Are you an alien or something?

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  8 лет назад +9

      i've been practicing the art of awesome for many years, young padawan!

    • @adamh.8823
      @adamh.8823 7 лет назад +3

      Avoiding the real question I see... you are fooling no one.

    • @lilianignatius
      @lilianignatius 6 лет назад

      My thoughts exactly. You deserve more. Thanks Professor Dave!

  • @stevereyes861
    @stevereyes861 5 лет назад

    Thank you, you have explained it so well

  • @shandrajones6462
    @shandrajones6462 4 года назад +3

    Anybody here before the 2020 AP biology exam? 💀

  • @Jamez006
    @Jamez006 6 лет назад +1

    Awesome!

  • @naoh22000
    @naoh22000 2 года назад

    3:15 Are all ligand-receptor complexes absorbed into the cell? Or is it a rare case?

  • @louispasteur5053
    @louispasteur5053 6 лет назад +1

    Thanxxxx

  • @jasminehasan7084
    @jasminehasan7084 3 года назад

    I LOVE YOU SO MUCH

  • @Mina-Rofaeil
    @Mina-Rofaeil 5 лет назад

    Perfect

  • @oliviadittmar9719
    @oliviadittmar9719 4 года назад

    Thank you!!!!!!!

  • @muvafakiyefilanfalanhanm1412
    @muvafakiyefilanfalanhanm1412 6 лет назад +1

    you are jesus himself.. ur saving all of us god bless

  • @abdullahhelal5413
    @abdullahhelal5413 5 лет назад

    Nice!

  • @rouleit5131
    @rouleit5131 8 месяцев назад

    I worship you

  • @jagadishvemula2304
    @jagadishvemula2304 3 месяца назад

    TQ bro

  • @Girlnamedanne
    @Girlnamedanne 7 лет назад

    Does it frustrate the bajeebus out of you that profs of major unis are using your teachings in place of them lecturing? And yet, they get paid. I'm mad for you, but happy for me...because my brain receptors are finally understanding this stuff. Thank you.

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  7 лет назад +4

      but i get paid too! not very much right now, but in a couple years when the channel is bigger i'll be making much more than those teachers, and in completely passive income. so to the teachers who use my content, whether appropriately or not, i thank you!

    • @Girlnamedanne
      @Girlnamedanne 7 лет назад +1

      As a nursing student, toddler mom, and one whose dog is currently challenging my rent amount in the hospital for canine pancreatitis, it is a laughable amount, but please accept my meager monthly dolla-dolla bill toss into your guitar case, good sir. If there was a "Professor Dave pretends to be you and takes your exams for you" option, I'd probably figure out a way to make that happen, academic dishonesty aside. :)

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  7 лет назад

      woohoo thank you! every dollar counts!

    • @83rickyspanish51
      @83rickyspanish51 6 лет назад

      Anne Marie Miller I would have to say that it makes money for the universities and schools to keep the students coming back day after day instead of just comprising creating a way to just explain it cleverly and in an understandable form as this medicine all about money keep them coming back

  • @tahirtantary7438
    @tahirtantary7438 5 лет назад

    Nice bro

  • @FeraleHubbard
    @FeraleHubbard 12 дней назад

    You rock

  • @SCIPROlearning
    @SCIPROlearning 3 года назад

    👍 great

  • @54blueroses
    @54blueroses 6 лет назад

    in summary 05:16

  • @dimaabuelainain7670
    @dimaabuelainain7670 Год назад

    I liked the explanation but I don't like that you are reading from somewhere!! this makes me confused 😫😫

  • @trejosworld
    @trejosworld 2 года назад

    What

  • @Avatarlifeplays
    @Avatarlifeplays 7 месяцев назад

    2:42

  • @karebthedog
    @karebthedog 6 лет назад +2

    You're awesome. But maybe, like move your arms around and loosen up a little bit? Sorry the content is great but it just looks a bit awkward haha

  • @joymutheu7737
    @joymutheu7737 Месяц назад

    ❤❤

  • @kristineofori1331
    @kristineofori1331 6 лет назад

    When you close your eyes and listen he sounds like the guy from crash course :D

  • @bera9919
    @bera9919 2 года назад

    tıp için çok yüzeysel, beğenmedim

  • @patrickbush2531
    @patrickbush2531 5 лет назад

    his intro doesn’t match with his video personality

  • @anirbanmaitra6051
    @anirbanmaitra6051 3 месяца назад

    Very detailed! Thanks a ton

  • @bangnikabang6501
    @bangnikabang6501 3 года назад +1

    Thanks

  • @alimamstudying9462
    @alimamstudying9462 2 года назад

    Thank you

  • @bera9919
    @bera9919 2 года назад

    tıp için çok yüzeysel, beğenmedim