Multiple Sclerosis Remyelination Trial Update: Metformin and Clemastine
HTML-код
- Опубликовано: 19 дек 2022
- In this video, Dr Will Brown (University of Cambridge) discusses the importance of myelin repair in multiple sclerosis and the current state of remyelination trials. He also provides an update on a current trial that is being conducted at The University of Cambridge, where they are investigating the effectiveness of metformin and clemastine to promote remyelination in people living with MS.
Learn more about MStranslate and follow us on our other platforms via the links below:
Website: mstranslate.co...
Facebook: / mstranslate
Twitter: / mstranslate
Instagram: / mstranslate
LinkedIn: / mstranslate 
Наука
![Multiple Sclerosis Diagnostic Criteria [Neurologist Explains]](http://i.ytimg.com/vi/Ixns85V95-Y/mqdefault.jpg)
![Multiple Sclerosis Diagnostic Criteria [Neurologist Explains]](/img/tr.png)
Good news, a good start. But the real issue with ms and other demyelination staff is neural damage caused of this. Remyelinate o damaged nerve is like insulating a damaged cable. Its not the same. So in my opinion research has to focus (also with remyelination) in neural repair. That would also help with many other diseases caused of neural damage.
Thanks for the comment. This is definitely another area that will be investigated in multiple sclerosis research. We need to make sure there is clear understanding that myelin repair won't help in cases where there is damage to the axon itself. However, there will likely still be large benefits to many people from an effective remyelination therapy. As always, the more avenues that we can look into to improve the quality of life for people living with MS, the better! Thanks again - Brett
I have SPMS and did HSCT in Moscow as in Canada my doctor said it wont help. It helped a lot. Now I need to regrow myelin sheeth. Combination of B12, Clemastin (2mg), and lions mane extract with daily use of UV. Diet change includes reduction of sugar by 80%. Improvment in EDSS within 2 weeks. I can cure it and I am just a biologist. I can even give you set up to findna remyelination that has 70% probability to do the research and trials on. Keep the money, I need cure
Are you suggestion htsc
@@keremreenergy4646 I would reccomend HSCT.
@@keremreenergy4646people may experience “remission” because of the chemotherapy but the stem cell portion is not of benefit.
Great news,our 47yr.old son has MS,since 2016!He suffers much as others who have this dreadful disease.Thank you for this positive report!Bless you!
I hope u succeed guys . Thanks for your efforts we look forward to it. From iran❤️
Thank you for the updates ❤🙏🏽🙏🏽❤️
what about PPMS. I'm done Hsct in Mexico 9 months ago and have worsened. I also worsened on Ocrevus which was all I was offered at Barlo in Toronto. I'll try humbler food portions and staying active. Thanks for your work good Dr. Will Brown.
My brother is 54 and down to use of one hand, can’t talk, chokes all of the time. We need to do something before it’s really too late. Maybe I’ll see if I can get some of this for my brother!
Has your brother looked into the Mollii suit? It's been a game changer for a lot of people with MS.
@@msagoo29 thank you. I think he is too far advanced for this device.
@@imbubaroots I honestly don't see much on the horizon for MS, apart from Nervgen in Canada who have NVG291, which is the one to watch. You have nothing to lose by giving Mollii a try, it can be hired for 3 months and help with Neuro plasticity. It can be used by those with secondary progressive MS and activate weak muscles. it works on a sensory level so can help with motor skills and balance. The other thing you can try with him is FES stimulation. You can apply neurostimulation electrodes on his legs and arms and run through a cycle of NMES. In my local Neuro rehab clinic in London, I've seen great results with this, and it can be done easily at home once a physio shows you how to use it.
Is this device available in Dublin Ireland?
Here you go:
Friends: I read a slew of the comments left; maybe I can help a bit from applied recent experience. Here We Go:
Opinion: Yes, Most of You are 100% Correct. Sure your average doctor cares, but They Just Don't Give A Flying Rip About You. Why..?
Answer: The System put Simply is Overloaded, It Sucks, and despite that fact;
..... Its Greedy and Money hungry; So Here Is What You Do:
You need to learn, how to ' Game The System..'
How To Do It:
1.) Realize: Every Disease Had A Beginning... Fact.
2.) Every Ending Had A Beginning.
3.) To Reverse Or Mitigate Your Disease and Disease Symptoms, Begin Thinking Back To That Point In Time, When You FIRST began to experience Symptoms.
4.) Believe It Or Not, Many Problems with Joint Inflammation, Difficulty Breathing, Neurological Dysfunction, and Feelings of Anxiety and even Dread, often happens because of something as simple as both, ' The Wrong Type of Diet, ..AND.., the way a myriad of Common Parasites - Do Attack The Gut, Your Lungs ( can't breathe well..) ...the way they got ME in 2013, plus The Brain and Central Nervous System, causing MS Symptoms, The Blood via Viruses; causing Lyme Disease, due to Ticks, Mosquitos, and more...
Seems They have been quietly plaguing Society in General for the last decade or so,
..but it does seem, that 'Nobody In The Medical Field ... Really Wants to Talk About It.'
What To Do:
Friends: Knowledge is power. Start by cleaning up your body and your diet. Begin by finding the diet you can work with that can effectively begin to heal your body.
Then: While You Pivot and Change Your Diet, Begin A Vigorous Parasite Cleanse.
Yes, - it may kinda suck; the way you feel like it's not working for about Two to Three Weeks, - but You'll Thank Yourself for having read my comment. You'll begin to slowly heal and return to near normal once again; and you'll be happy once again..
My best, MM JD CANDIDATE ,
PEACE ✌❤❤
PS: I'm hearing QUININE; a simple Malaria Drug from long ago, showed Efficacy in the Treatment of MS Patients in a study decades ago, and then the Study was either buried or Erased. PEACE ✌❤❤❤❤
excellent. why not include separate groups of PPMS and SSMS and SPMS? People are out there!
thank you
thanks and good luck :-) !
You definitely don't want people to get better! How many people's lives have been lost so far because of pharmaceutical companies? The year is 2024, there is still no stopping or repairing treatment, this cannot be justice. DO YOU HAVE NO CONSCIENCE OR CHARACTER? EVERYTHING IS MONEY!?😢
The problem is that it s still not yet "on the market". Years are passing and decades as well. It will be for the patients who aren’t in a critical MS. As my doctor says, often hopes but probably too late for the current patients.
Clemastine is available without a prescription. Metformin can be replaced with Berberine. Buy and act!
Thank you. There needs to be more emphasis put on educating people with MS on how to fast successfully, some neurologists will not recommend fasting to their patients but at the same time concede it helps people with MS-is it just a way of avoiding responsibility for initiating a big lifestyle change? It would also be great for biomarkers like VEP to be used by neurologists given how cheap EEG is now. I can personally do VEP tests myself at home on a screen or VR headset whenever I like(eeg hardware cost around $600 AUD) - it is something which no local neurologists would ever do for me.
Thanks for the comment. I think that we will see both of these areas start to develop over the coming years. The team at Cambridge are looking to run a fasting trial in the future, so this should help inform and educate about whether this is beneficial and the best approach to use. Similarly, in my discussions with them, they did talk a lot about how we are starting to learn so much about the best ways to conduct myelin repair trials, including the best ways to measure it (including VEP). We will continue to provide updates on all of these areas, as we know they are of great interest to the MS community, so please stay tuned! Thanks as always for your contribution - Brett
@@MStranslate1 Thanks for the response Brett. As I type this message I am using biofeedback(neurofeedback) to train my brain to facilitate functional repair in the areas riddled with lesions. They were independently picked up on a QEEG report without any prior knowledge of MRIs etc. I'm working on bringing VEP to people at home along with other functional tests with the help of NeuroTechX. Looking forward, not backwards, towards solutions for people with brain damage. Given substances involved in BDNF and neuroplasticity the future is bright. I want to congratulate you and the team at Cambridge for having the right intention in helping us people with MS.
@@MStranslate1 regarding fasting, my bets are on mTOR signalling-periodically cutting protein intake via fasting mimicking as suggested by Valter Longo. It might have an even better effect than ketosis/metformin.
@@MStranslate1 * How Sad it is,, to sit here, read comments suggesting Years for potential therapies and treatments, while Millions of people suffer, while medical researchers, who are not afflicted, get paid lavish salaries, spend many hours focusing on banking and finance, while offering little more than subtle platitudes of relief from a terrible auto-immune disease..
@@MStranslate1 I applied to be enrolled but am slightly over 50 so wasn't eligible. I am now experimenting combining clemastine (10mg pd) with fasting. The initial problem was finding the correct fasting model, as I lost nearly 10kg in 2 months. Now trying intermittent fasting with 2 meals pd pushed close together, and reduced carb intake. Once adjusted, I may move to the one meal per day model which I believe is proving successful for some.
- Is there a way to source the OTC clemastine more affordably (I currently import overpriced from Europe as its no longer available in the UK through conventional means)?
- I'd be interested in participating in your fasting trials so will keep a look a out, or please add me if you can?
Many thanks for the work you are doing, which is very much appreciated.
Is there an update here? Thanks for the video
I had no idea that myelination stops with age. That’s just another kick up the backside 😢 I have been taking clamastine on and off, and just recently I have managed to get metdormin. What’s interesting, my walking improved by taking 3 pills of clemastin and one of metformin once a day. I usually take them at night. I wish I knew more on how to administer this drugs together. Great update
It's on the market already ...clemastine ?
@@RobdeKlerk-qg6lcyes it’s available online at German pharmacy’s
Where can i get this medicine? I am based in South Africa. The medicine is not seen here in pharmacy.
@@EmekaOkafor-rq2ne I found the clemastine pills in Canada or Turkey … there are not cheap either 😔😥 but try Lions Mane instead; do some research on that. Might work better. I am currently taking lions mane, and if I stop my energy levels, my fatigue is bad. I’m hanging onto anything at the moment. This illness is cruel and hard to bare. Good luck ❤️
I would really like to join this trial but I only see it available in California and abroad. When can we expect for it to spread to more states?
What part of California is the trial?
can isotretinoin mimic effect of bexarotene since they are both oral retinoids?
Have there been any updates or revelations on the study of Metformin/Clemastine for myelin repair?
Help!😓
Thats a filthy disease i have relapsing remitting ms and if i did not have my wife an kids and did not know jehovah god i would be screaming non stop in pain😢😢
Thank you. How is the study progressing?
it will be wonderful if we can join you in this researh
Has this resulted yet?
I fast a lot, its called Universal credit diet
MStranslate will you be doing a video anytime soon about the drug Pipe-307 which from my understanding is already in trials. Its a remyelination drug.
What would be the suitable fasting period in lieu of metformin? Would 16/8 suffice? Thanks
Thanks for the question Isabella. Unfortunately, there is no way of answering your question at this stage. The fasting data that led to this study was only performed in an animal model. In those animal studies, they used an alternate day fasting approach (e.g. the mice only ate every second day). However, there is no indication that this is what should be pursued in people living with MS at the moment or that this approach would be successful. The team at Cambridge are looking at running an early stage trial looking at the potential for fasting to help repair myelin in people living with multiple sclerosis, so we will know more when that data becomes available. Thanks - Brett
@@MStranslate1 Thanks for taking the time to reply Brett. I’ll keep up with 16/8 fasting, tavegyl and cross my fingers Mavenclad Mike Tyson’s my MS 😉
@@isabellaprincess6890 I have yet to start intermittent fasting but I need too. I am 100lbs overweight due to several physical factors. Now I need a new knee. Have you had much success with fasting?
@@j.m.p8051 personally l feel my symptoms improve with fasting. I am trying to change my gut microbiome now to see if that helps with my MS also. I’m not sure about fasting for weight loss personally, my BMI is only 18.5 and l struggle to gain weight. I did try keto (eating under 50grams carbohydrates a day) and IF but it made me too skinny. If you want to loose weight and regulate your blood sugar levels, definitely try this combination. Dr Eric Berg has lots of videos on these topics. I wish you the best of luck.
Please advise how long will it take to release the new drug on the market across the world ?
took clemastine for four years with no effects.
What doses
Could this help repair the myelin sheath for people with CMT?
What is the criteria to enroll in the Metformin study?
Hi Chris, thanks for your interest. Some of the requirements for the trial, as per the Cambridge website, are: "The trial is being conducted in Cambridge. Participants will need to attend fairly frequently: at least 7 visits over a 38-week period are required. Participants should have relapsing-remitting multiple sclerosis, be aged between 25 and 50 years, able to walk for 100m (with no more than one walking aid), and should be taking a disease-modifying drug for their MS (beta-interferon, Copaxone, Tecfidera, Gilenya, Tysabri etc.). More information, as well as contact information for the trial coordinators, can be found at the following link: www-neurosciences.medschl.cam.ac.uk/jones-coles-group/ccmr2-a-trial-of-metormin-and-clemastine-as-remyelinating-drugs-in-ms/
@@MStranslate1 thank you for the reply. I wouldn’t qualify but am very excited to see where this goes!
👍
Too slow, too limited in scope, too few participants.
Thanks for the comment Anthony and we can certainly understand that sometimes the slow progress of research can be frustrating. Unfortunately, this is the nature of the process that must be followed. This initial trial, while small in scale, will help provide information about the safety and tolerability of the treatments, as well as give some early indications as to whether they are effective at promoting myelin repair in people living with relapsing-remitting multiple sclerosis. If the results are positive, then this will expand into a much larger trial. We'll continue to provide updates on this study and others in the area, so please stay tuned for those. Thanks - Brett
Totally normal. The phase 3 trial would be large.
no wonder no one signed up for this the number to gall is wrong and in the worst format for optic neuritus sufferers. C'mon sort it out doc!
Keep at it guys! Perhaps with a bit of luck, we may find the root cause so as to stop it before it starts.😁