The nervous system, our hormones, the immune system, and our microbiome are the integrative mechanism of our incredible complex biology. Your explanations are superb. I´ve realized that integrating clinical practice, basic science, Pub Med, and incredible people like you explaining videos, are the most disruptive way of learning that I´ve found. People like you destroy the old method of teaching-learning. My most appreciated thank you. Gabriel from Buenos Aires
You seriously have THE BEST teaching videos online. Bar none. Thank you so much for everything that you do! You have saved so many students, and still counting. What a gift! You, sir, are a true hero.
Actually to be more specific, T cell receptor (TCR) and CD4 gylcoprotein are two separated components yet work closely together. TCR binds primarily to the antigen:MHC complex, but CD4, behaves as a co-stimulatory molecule binds to the side of MHC only, without any contact with the antigen. Hence, the full activation of T cells can occur.
U always get directly to my head :) thank u for ur step by step and categorizing ways of explaing things.. I have a rising question though, the difference in time of use for theses three types of antigen representing cells is where they r locted?
Hi Sir, thank you for the lesson! It is greatly appreciated! I have a question, MHC2 can only bind with the cleaved peptide of the pathogen, what if the pathogen is aggregated protein? Is it possible that the MHC2 can present a small aggregated motif (but not just sequence?) after the digestion of aggregated proteins?
I like your explanation it’s awesome... I need more videos takes about DCS specifically and their characteristics I interested in it. Thanks, in advance ❤
i have a question. When will the macrophage or dendritic cell work with oxygen radicals and destroy themselves? when will the WBC use exocytosis after phagocytosis?
What if a helper T lymphocyte directly comes in contact of a foreign antigen ?? Will it then also undergo differentiation to form cytotoxic, helper and memory t cells ??
A naive t helper will not be activated by just bumping into an antigen that matches it's TCR. It need to simultaneously be co-stimulated by other proteins as well as the mhc2
i have when APC engulf antigen the have to either phagocytosis them lysis them or take them to lymph node where the adaptive immunity can take care of theme Am i right ?
In the 4 months since posting this question, I took a histology class and you're right! Dendritic cells are part of the lymphoid lineage, and macrophages are part of the myeloid lineage.
i keep hearing that there is almost no understanding of autoimmunity. if our protein sequences are presented as antigens would it not create autoimmunity? so it seems to me there are likely parts of cells in the interstitial fluids that get picked up by APC's or maybe a pathogen or virus takes over a cell and overwrites its ID than our immune system couldn't know the difference. we should be looking closer at these ares for autoimmunity.
You have a gift for teaching us hard subjects and presenting them in a very simple way. You're just amazing. The best!!!!
The nervous system, our hormones, the immune system, and our microbiome are the integrative mechanism of our incredible complex biology. Your explanations are superb. I´ve realized that integrating clinical practice, basic science, Pub Med, and incredible people like you explaining videos, are the most disruptive way of learning that I´ve found. People like you destroy the old method of teaching-learning. My most appreciated thank you. Gabriel from Buenos Aires
Still saving lives 5 years on...
You seriously have THE BEST teaching videos online. Bar none. Thank you so much for everything that you do! You have saved so many students, and still counting. What a gift! You, sir, are a true hero.
I feel like I should give you my tuition money. I am definitely donating.
that right he really deserve it
Wow, you not only go in depth, but the way you talk enhances my focus. Thank you so much and bless you.
Very clear explanation. I have enjoyed listening to you because you speak so clearly and make it so much easier to understand. Thank you so much.
Patricia Vickers me too ❤️
me too
I don't usually comment on these type of videos, but, really great explanation.
+kwhatofit thanks appreciate that
Actually to be more specific, T cell receptor (TCR) and CD4 gylcoprotein are two separated components yet work closely together. TCR binds primarily to the antigen:MHC complex, but CD4, behaves as a co-stimulatory molecule binds to the side of MHC only, without any contact with the antigen. Hence, the full activation of T cells can occur.
great explanation you earn it
Immunology for dummies like me, easily understood and life-saving! Thanks big time!
ur incredible u saved my life!!!
I have a Microbiology final coming up and you SAVED MY LIFE, THANK YOU!
however this video is closer to immunology than microbiology I mean he focused on mostly immunological side of processes
Ruhid Yusifov Oh well it was exactly what we were learning in micro!
The best instructor ever!
I definitely will be donating you deserve it. the best lecturer of biology. I understand more than when am in class
amazing as always. yet another topic that you absolutely crush
Whenever I have a topic in university that I can't understand,I come directly to your vedios.Thanks a lot
we really appreciate your clear language
Thank you! You are a fantastic teacher. Learning immunology is actually fun thanks to your explanations and beautiful diagrams.
you have a great talent for explaining things, thanks so much. I'll be donating soon
you hit the nail on the head. Bravo
Thank you so much. You help me more than my so many teachers do
What a Legend this guy!
The best class on this topic😍
all your video are very well explained,you make micrbiology very easy.Thank you so much.
you are the best tutor explaining the immune system
Professor of all subjects
your're the best , seriously THE BEST .
Thanks alot ur lectures saved my life
Excellent work 👏🏻
Great lectures, with incredible animated texts.. Good job
Donated my friend thank you for all of these videos
Thanks a lot of explaining microphages ..
ya i agree you explain this well i have seen videos that try to explain it like you do but end up confusing themselves
hofmeister15 lol thanks! glad to hear that!
0.75 playback speed makes it so much easier to follow
Thank you soooooo much. You rescue me!!!
What a great lecture from great man . God bless you sir
Thank you so much for the video! Your explanation was outstanding!
I love this guy's talking pattern
you are just AMAZING
U always get directly to my head :) thank u for ur step by step and categorizing ways of explaing things..
I have a rising question though,
the difference in time of use for theses three types of antigen representing cells is where they r locted?
Amazing video!!!
This is great!! Thank you so much!!!!! You're a great teacher!
you sir are a God. UBC needs to sponsor you
16:11 for clear picture! :) Thank you AK Lectures!!
Thank you so much for this video!
Thank you. Explained very well
excellent lecture...as always
Gold! Puuuuure gold. Thank you!
Wow, It's very clear. Thank you so much for the explanation!
Sir you are great .I really have a great respect for u becoz u make hard topics so easy to understand . Truly a great teacher 💓💓💓
Great explanation. Well done! Thank you!
CD4 is a cofactor of TCR, which binds to MHCII-Ag
Amazing ! Thank you
Amazing lecture. Thanks a lot sir !!!
very nice lecture sir its solve all my quires
Oh my god you are soooooooo good ! now i finally get it ,,thank you so much
Wow! Well explained :))
amazing explanation thank you so much
Thank you so much 🙏🙏🙏
Hi Sir, thank you for the lesson! It is greatly appreciated! I have a question, MHC2 can only bind with the cleaved peptide of the pathogen, what if the pathogen is aggregated protein? Is it possible that the MHC2 can present a small aggregated motif (but not just sequence?) after the digestion of aggregated proteins?
Amazing video
this is fantastic
i have questions:
How these types of cells interact with each other in innate immunity and adaptive immunity?
Thank you very much ^^
you are the best!!!!!!!
I like your explanation it’s awesome... I need more videos takes about DCS specifically and their characteristics I interested in it. Thanks, in advance ❤
thanx so much doctor
Dude you are the bomb
Hello! thank you very much for the vide, very helpful. However I have a question, where do the LT and the macrophage meet?
I love you guys
Thank you!
fantastic
i have a question. When will the macrophage or dendritic cell work with oxygen radicals and destroy themselves? when will the WBC use exocytosis after phagocytosis?
What if a helper T lymphocyte directly comes in contact of a foreign antigen ??
Will it then also undergo differentiation to form cytotoxic, helper and memory t cells ??
A naive t helper will not be activated by just bumping into an antigen that matches it's TCR. It need to simultaneously be co-stimulated by other proteins as well as the mhc2
👌👏 so AmAzing
thank you!
thank uuu so mch😘
I was really worried about this topic of dentric cell bt now I feel its really easy 😘
thank u so mch
preciate ya stay blessed
i have when APC engulf antigen the have to either phagocytosis them lysis them or take them to lymph node where the adaptive immunity can take care of theme
Am i right ?
+Saad Alosemi essentially, yes!
your awesome!!!
Great!! thank U so much man
Thanku
So B lymphocytes play a role in both humoral and cell-mediated immunity no?
Now i understand - antigen is your lovely word :) and you don't like patterns (
+Eva Gold It is indeed Eva :-D
We want a special lesson on DCs
Thank you :)
awesome
Thank youuu sooo muchh
8:32 the voice crack😄
can you do a video on cross presentation by MHC class I? I don't understand it at all!!
THANK YOUU!!!!!!!!!
Do B cells activate before T cells? Or is it the other way round? Or can it depend?
Ben Taylor They activated together by antigen
Wow a fuc**ng master!!!! Holy Cow!!!!
I get it, but if they all do the same thing, what makes them differ?
You da man!
Anybody body knows?
Which book sir Ak follows?
Hi Andrey, what differentiates macrophages from dendritic cells?
the form, where they are in our body and probably also some embryo stuff I am not good at :D a histology book could help you
In the 4 months since posting this question, I took a histology class and you're right! Dendritic cells are part of the lymphoid lineage, and macrophages are part of the myeloid lineage.
If we wash our hands again and again with sanitizer ,will our dentrtic cells get killed?
helpful
i keep hearing that there is almost no understanding of autoimmunity. if our protein sequences are presented as antigens would it not create autoimmunity? so it seems to me there are likely parts of cells in the interstitial fluids that get picked up by APC's or maybe a pathogen or virus takes over a cell and overwrites its ID than our immune system couldn't know the difference. we should be looking closer at these ares for autoimmunity.
My Nigga macrophages, got my back