Scientist Stories: George Church, The Future of the Genome Editing Revolution
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- Опубликовано: 25 авг 2024
- George leads Synthetic Biology at the Wyss Institute, where he oversees the directed evolution of molecules, polymers, and whole genomes to create new tools with applications in regenerative medicine and bio-production of chemicals. Among his recent work at the Wyss is development of a technology for synthesizing whole genes, and engineering whole genomes, far faster, more accurate, and less costly than current methods. George is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence (the human pathogen, H. pylori). He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers. His many innovations have been the basis for a number of companies including Editas (Gene therapy); Gen9bio (Synthetic DNA); and Veritas Genetics (full human genome sequencing).
George is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT). He is Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science. He has received numerous awards including the 2011 Bower Award and Prize for Achievement in Science from the Franklin Institute and election to the National Academy of Sciences and Engineering.
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1:07:00 wow, what a great answer on such a sensitive ethical topic
i have thought George Church and Robert Malone are clones Who's on first?
What strikes is that while Jeniffer Doudna fans are portraying George Church as "trigger happy" transhumanist. He's in fact very reasonable and far from being blind to ethics (his speech speech to: parents, teachers don't treat kids like commodities). He's just saying just like James Watson:
Lets broadly discuss ethics but don't draw dogmatic red lines, reason and scientific methodology not religious warrants or fears of American public like in the case of proclaiming Germ Line "crime".
We already know that it's possible, easy and safe to produce healthy Crispr babies whereas doing somatic gene therapy because someone wants it for fun (as Profesor George Church said) can have far more badly than editing embryos which in worst cases just Will be rejected or aborted after performing deep Sequencing.
While editing brains will never be reasonably possible:
Scientists like Robert Plomin already have rigorously documented how incredibly polygenic and pleiotropic neurology related genetic mechanisms are... add to this so many cells, together with their communication pathways and cancerogenesis...
Designing brains of future babies in a single cell will be hard enough but ultimately possible in the coming decades.
I don't treat seriously neither of these far fetched imaginary scenaurios but I think that this is funny that while fear of GAT-ACA (Threonine-Asparaginic Acid) is so deeply rooted in religious and certainly American mind., but few people seem to think about "Bornes Identity" or that (I don't remeber tittle) Bond movie with Icarus, Cuba,North Korea and that "change your genome" maniac.
Honestly if SF crazyness of whole body gene therapy can met somehow reality it will probably become reality as a kind of stealth weapon used to create deadly cáncer viruses pandemics or when tech will become advance enough : stealth killing of political opponents by introducing virus designed to match genome of only one person... introduce one, deadly and almost impossible to detect change in his/her genome that will cause natural looking death.
But I am an long term optimist.
It's not technology that's dangerous it's lack of control and reason and nothing deprives us from reason more than religious creationist fundamentalism.
@@jimmyjasi- what makes you think it has not already been done
"many people get their genome for free" ....If it s free, it s because you are the product
@@jimmyjasi-what about human rights? Something developed outside of a woman's womb, as God intended, is simply not human. The rights reserved for humans would, therefore, not apply. It's ungodly and, in fact, satanic. Should we now start telling people homunculus are acceptable, too?
@@deeaimeteeyes, read the fine print. There is no pretense of privacy when one sends off their sample to be analyzed.
When was this recorded, when did this talk take place?
Jan 2017
@@rtnjo6936Glory to He Jiankui! He and George Church should both earn a Nobel by the end of decade!
@@rtnjo6936@rtnjo6936 What strikes is that while Jeniffer Doudna fans are portraying George Church as "trigger happy" transhumanist. He's in fact very reasonable and far from being blind to ethics (his speech speech to: parents, teachers don't treat kids like commodities). He's just saying just like James Watson:
Lets broadly discuss ethics but don't draw dogmatic red lines, reason and scientific methodology not religious warrants or fears of American public like in the case of proclaiming Germ Line "crime".
We already know that it's possible, easy and safe to produce healthy Crispr babies whereas doing somatic gene therapy because someone wants it for fun (as Profesor George Church said) can have far more badly than editing embryos which in worst cases just Will be rejected or aborted after performing deep Sequencing.
While editing brains will never be reasonably possible:
Scientists like Robert Plomin already have rigorously documented how incredibly polygenic and pleiotropic neurology related genetic mechanisms are... add to this so many cells and cancerogenesis...
Designing brains of future babies in a single cell will be hard enough but ultimately possible in the coming decades.
I don't treat seriously neither of these far fetched imaginary scenaurios but I think that this is funny that while fear of GAT-ACA (Threonine-Asparaginic Acid) is so deeply rooted in religious and certainly American mind., but few people seem to think about "Bornes Identity" or that (I don't remeber tittle) Bond movie with Icarus, Cuba,North Korea and that "change your genome" maniac.
Honestly if SF crazyness of whole body gene therapy can met somehow reality it will probably be as a kind of stealth weapon used to create deadly cáncer viruses pandemics or when tech will become advance enough : stealth killing of political opponents by introducing virus designed to match genome of only one person... introduce one, deadly and almost impossible to detect change in his/her genome that will cause natural looking death.
But I am an long term optimist.
It's not technology that's dangerous it's lack of control and reason and nothing deprives us from reason more than religious creationist fundamentalism.
@@jimmyjasi- you do know that the Nobel is like a stint on Saturday night live, a gold star on the Hollywood walk of Fame and an Emmy- it means you're in deep. See nobody gets a Nobel peace prize, unless they're major players in the beast system- on board with pedo's, trafficking, new world order, which essentially means they're satanists, or may as well be, because they're Godless and on a fast track to hell
TLDR
We are talking about cholesterol uptake ,in what appears a hiarchy error in incomplete understanding in the singularity between charge ,circuit shut off enzymes and EU THAT WEAPONIZED everything ,now rejecting gmo.
What I dont get, is why is there not more research going into things like this. Like the writing digital data onto DNA thing. . . why have I never heard about that before until just now, it seems like something that is pretty important...
Does Nebula safeguard information?
E.T
So has George got the enhanced Eye of Oden? My own pet name.
Lovely how Jennifer Doudna introduced George Church at the beginning. When a Nobel prize winner has that kind of respect for you, you must be really cool
Ahh, the 4 codes of quantum that were sure?
Frankenstein abomination’s
Evil says one thing "I am good"