Wow you just explained this so well thank you. I've been looking for this kind of information all over the Internet and you're the first source that I've found that isn't opinion based and biased. I never comment on videos but I'm currently on vyvanse so my brain feels like writing a paragraph over the information it just absorbed.
I don't get why people complain about how he explains in the comment section. I listened to his video at 2.0x speed while working on something else, and it was very easy to understand and straight-forward. Very well explained.
Adderall vs Vyvanse @ 10:00 answer starts(listen to whole thing if you are not from medical background) , once you understand that Adderall is mixed( Levo & Dextro) amphetamine , while Dexedrine is Dextro-amphatmine Vyvanse is Lysine + Dexedrine is Just one . NOTE: You can't snort as you need stomach enzyme acidity to break Lysine -Dextraamphamine bond. I am sure people will find way to abuse anything. If you can take more than prescribed medications, and if you take them enough, you are abusing it at the cost of downregulating the dopamine receptors, and going on dangerous addiction path. Good Videos.
Hydrolyzing Vyvanse (lisdexamfetamine) was ORIGINALLY believed to take place in the stomach as an acid-catalyzed acyl substitution, so I don't blame you. However, Vyvanse is mostly absorbed intact from the small intestine. It is hydrolyzed by esterase enzymes in blood. Snorting Vyvanse probably does not work because it is positively charged and cannot cross the mucus membranes of the nose. Injecting Vyvanse has been shown to get you high, in pioneering research done by kids at your local Emergency Department.
It 2022, in March, and I just found this video but it is still so helpful for me. Thank you! I have had the worst time trying to get my ADD medication dialed in because I have the absolute most uneducated people in the area of ADD/ADHD medication‘s, prescribing my Vyvanse. ADHD medication do not take weeks or months to dial-in. They’re not Anna depressants or something, they don’t take forever and a day to start seeing if it works for you or not. It takes literally, 5 to 6 days to know if you are on the correct dosage and the right set up. Meaning, you shouldn’t have to keep increasing your medication because it stops working, which is my current problem. Instead, Dr. Parker says in another video, who specializes in us, you need an afternoon dose that’s a short acting to carry you through for the rest of the day. But since I have to be my own advocate and my own educator, these videos are what help me when I have to go in for another prescription (as by law, schedule 2 medications, they can only give you 3 months at a time and they’re 3 separate individual prescriptions, not refills.), and explain it to them with all the information/knowledge I have gathered on my own, in hopes that they won’t argue with me and treat me like I’m a drug seeking addict. It is awful to be treated like a pill head because everyone else ruined it for people like me, who actually do have ADD.
My doc put me on vyvanse cause adder all made me so anxious and paranoid and now I know why she did that. I always thought these drugs were all the same. I don't feel no physical side effects like I use too and no wonder I can't use vyvanse in the gym also. Aderall worked like a charm there . Thanks for this info . Helped a lot
With Vyvanse, release begins from the small intestine, the l-lysine gets cleaved off by stomach ph, and releases the dextroamphetamine. (making it strictly biologically activated.) Levoamphetamine effects the PNS nervous system indirectly effecting nor-epirnephrine.
Can someone please explain to me the difference with Vyvanse and Adderall and meth and speed? I always get into this argument and i am tired of getting called a meth head!
Adderall/l-amphetamine really helps my mood for some reason while vyvanse/d-amp is solely a focusing tool. Adderall fully cured my bipolar problem for ~8 months'ish so far. Amazing time we live in.
Same here. I need the L amphetamine for more full coverage dopamine boost. Just pure amphetamine (Dexedrine), doesn’t have any mood elevation component, and no body stimulation. Not bad, but I def prefer a mix salt treatment
TLDR; Adderall takes immediate effect and requires multiple doses, Vyvanse takes approximately an hour to kick in and lasts longer; only requires one dose a day. Vyvanse (most likely) does not work properly or at least as effectively if snorted. Vyvanse is approximately $300 (as someone that has been prescribed a daily dose of Vyvanse, I can confirm this. In my experience, the price does not change based on the mg dosage.) The medications are very similar but, again in my experience and own research, have different side effects. From what I have asked two different doctors, Vyvanse is far more natural and safe than Adderall. Adderall is also far cheaper than Vyvanse (probably due to the whole patent thing) and, according to the person in this video can range from $10-$70, depending on where you're from. It is vital in my opinion to note that (at least in Canada) if you visit your psychiatrist, s/he can give you little prescription cards (no idea what they are actually called, sorry!) that you can give to the pharmascist whenever you are due for a prescription refill (they may not allow you to get a refill if it is more than something like 24-48 hours before necessary as they don't want to risk any possible prescription abuse on your part) and it is far cheaper that way. I believe it's something like $50-something for it in that way. (Only been on it a few months and my father is the one that keeps the cards on him and does refills so I don't know anything about it besides that, sorry!)
Donivan Reis Vyvanse is dextroamphetamine bonded to an amino acid. In the blood this bond is broken leaving dextroamphetamine. It would be like the difference between an orange that is peeled and one that is not. It is one way to repatent a drug, since now it is technically a new compound. It would be as if you had a patent for peeled oranges and that expired. You would then patent the unpeeled oranges, since technically it is different compound, and continue to sell it for the patented price. They are both oranges and the same thing. Dextroamphetamine is peeled, Vyvanse is not.
Make a video on DMAA and how it compares in effects and in molecular structure to Adderall, Vyvanse(dextroamphetamine), and Ritalin. Dmaa is or was a big thing in pre workout supplements. Im curious if its effects on cognition are similar to dextroamphetamine or adderall cuz it can still be gotten online for cheap wit no script as a "reaearch chemical" like $15 for 1 gram
The best explanation I've seen online. And you confirmed my own conclusions about the increased ethicasy of dextroamphetamine compared to the racemic mixture. Who wants increased levels of norepinephrine when they're trying to focus?? I also like how you rightfully attributed this fuckup to the pharmaceutical industry and the patent process without dwelling on the politics and getting up in arms which would have been off topic. Great video, well done mate.
I don't think you can snort it. from what I know about digestion, protein breakdown takes place in the stomach and then continued in the small intestine by proteases. isn't this the case?
I've personally taken both but I was only on Vyvanse for ADHD for a couple months in the first semester of my senior year in fall 2010. The doctor took me off of it because my social worker at school and my therapist at the time thought it was causing me to act up. However, Adderall and later concerta also did the same thing, but although not quite as much. I think I was able to sleep a little more easily on Vyvanse though, and didn't perform quite as well academically on it compared to the regular Adderall concerta. However on Vyvanse I had less tics compared to when I was on the other. I also had a dual diagnosis of bipolar and also took risperdal for it from 2003 to 2012. Some years later ASD was officially diagnosed and bipolar was dropped and I no longer take ADHD meds.
This man is quite intelligent. Thanks for your exquisite explanation. One of the better ones I’ve ever seen on RUclips over the course of the last 12 years. You have the potential to become a full time youtuber if you had the interest. I digress, I learned a lot from you today. Will be consider asking my doctor for a switch off Adderall to something that wears off sooner than 12+ hours
having experience with the adhd-meds, including ritalin/concerta, i prefer vyvanse. i like the slower gradual onset. adderall was good but due to the various salts and metabolism rate i found the onset a bit jerky. dexedrine was fast but it also has a lot more abuse potential (sniffing & injection) which is my understanding as to why it's not as prescribed. ritalin was too short lived whereas concerta wasn't, although with that i was clenching/grinding my teeth. btw - i'm coming at this from a therapeutic perspective, not someone whose used these recreationally. fortunately where i am in canada i don't pay a cent for any of these :D
On Concerta was it effective for you. I’m taking adderall but I feel like my metabolism runs through it quick so it doesn’t feel as effective but so did the XR version
Thank you! It was tremendously helpful! I am not a chemist, but I have learned about different antidepressants and ADHD medication enough to understand your explanation very clearly.
Do you know if Dexamfetamine Sulphate is another term for Dextroamphetamine? If same/different do you know what the equivalent dose of Dex-Add would be? Great video, you covered everything so clearly
I think that although you are factually correct in saying that there is technically no difference between the 2 base compounds, the inhibitor has some positive aspects that help make the drug a lot more sustainable for certain patients. Since the drug requires protein and amino acids from food for it to work, it forces you to keep up with your nutrition giving you an incentive to eat as apposed to adderall which can have a greater negative effect on your appetite. This helps to extend it's effectiveness and provide a more consistent, level feeling of focus which is preferable to the distracting peaks and crashes of other versions. It also makes it easier to come off of since it seems to stay active for a while after you stop taking it so the come down is less pronounced and it doesn't give you the same "I need to eat everything" crash that adderall does.
Hi! Not sure if you will ever see this, but I'm curious about something and would appreciate your feedback. I took vyvanse for several years and it worked very well for me but recently stopped working. I suddenly had horrible side effects ("physical" anxiety, lack of focus, restlessness, repetitive fidgets/ weird muscle movements, intrusive thoughts, etc). I am now on adderall and I feel less anxious, less restless, and more focused. Considering what you explained about the two drugs, I cant imagine why this would be the case if the l-isomer is the one that increases physiological symptoms of anxiety. Any ideas? Thanks for the honest video, your content is valuable.
Hi, I know this is an old comment but maybe I can contribute. I should preface by saying I am not a psychiatrist or a pharmacist, so take this with a grain of salt (haha pun). If the dosage of adderall and vyvanse are approximately the same then you are actually receiving more dextroamphetamine by taking vyvanse due to only 75% of adderall being that compound. However it is unlikely that your dosages over time were exactly the same, so I’d have to know what they were to comment more on that. The other thing that I personally felt was neglected in this video is that the release time of each compound matters a lot in terms of the effects. The faster the release happens the more of a “high” one gets, for example when someone snorts adderall at a college party. Vyvanse, due to its extra step, has a much slower release time and this means that the therapeutic effect tends to be more stable over time as opposed to adderall, at least in general. Finally, the way each one is metabolized is heavily impacted by an individual’s physiology. My Dr even told me that I should not drink lots of orange juice as it could affect my stomach’s pH and allow less of the dose into my system! Having a relatively “inert” version of the compound prior to it entering the blood could have a large effect depending on an individual’s digestion.
+My Balloon Guy Sorry about that, I originally made this as answer to someone who was a chemistry student. I honestly never expected that so many people would watch it. Most of my videos have less than 50 views. What I will do is make a new channel devoted strictly to medicine and healthcare and try to make it as concise and understandable as possible. I made a test video, different type of drug, but if you have a minute check out and let me know how you like the format. If you think its good I'll remake this one in that style.
@@14thSun mate,i bought a tub of 28 X 30mg Vyvanse made by Shire Pharmaceuticals. Ive never took these before,i live in the UK where we just have Dexedrine 5mg tabs,i took 5 of these last night,fuck me i was euphoric and chemically close to God. There great,but 28 cost me nearly $190
Thank you so much for this as someone with ADHD who wants to know WHAT IS HAPPENING and WHY THIS AND NOT THAT and so many other things, thank you so much. My need to know has been sated.
To my knowledge, levoamphetamine was never approved or marketed in the US. I could check the FDA website, but making it enantiopure costs money and I have never heard of a motive. In contrast, levomethamphetamine is called levmetamfetamine and is marketed for nasal congestion.
Thank you for the explanation. I actually learned a lot. I wanted to know if I should switch from Adderall to Vyvanse for my ADD and it looks like Adderall generic is just as fine.
Hi! I have a question, even if the video if somehow old, but I have a question I can´t find a straight answer for, and u said u had researched the topic... Do you have any idea about how can Dexadrine cause more physical side effects than Adderall for some people? It doesn´t seem to make sense. Both the little chemistry I know from college and the "research" I have been doing this past year support exactly what your video says, that it is the Levo the one that causes most of the side effects( heart punding, insomnia, etc...) but still I know Dex has worse effect on those areas than Adderall for a bunch of us...Do you have any idea of how or why that may be 0.0? I haven´t manage to get any straight answer besides "everyone reacts differently", but this sounds like a very weird kind of different, when one isomer has an effect it just shoudn´t have at all... So I´d appreciate your thoughts on it Thanks!
ok, so now that adderall IR as well as XR is available in generic forms, WHY do doctors still prescribe 'mixed amphetamine salts' aka generic adderall when dextroamphetamine (dexedrine) is really the only useful molecule? Would it be reasonable to bring this up to my doctor and request just generic dextroamphetime? Also, I recently came across another ADHD drug called Evekeo™ which is 50/50 levoamphetamine/dextroamphetamine. Seems like they're reinventing the wheel. What do you think???
Have you ever seen street Amphetamine being made? It's unhygienic,it's explosive environment,it's rotting people's stomach linings and there teeth. I paid $189 for a tub of 28 Vyvanse capsules yesterday,only 30mg capsules,but I can definitely say hand on heart Vyvanse is very euphoric feeling. Plus it's clean and won't ruin your teeth. Dexedrine (Dexamphetamine sulphate 5mg tablets Vyvanse capsules 30mgs Adderall 30mg capsules. Dexedrine is very affective in stopping people use street Amphetamine and get them of dangerous unhygienic Amphetamine,which rots the users the teeth,and lining, psychiatrists for the majority do not agree with prescribed Amphetamine to stop illicit use of Amphetamine made in a bath,with more adulterants than Amphetamine. Fact. Portugal legalised drugs and look ,drugs are taxed,and regulated,crime rate has fallen by 52% ,no drug dealers making money of people's misery. It's safe,it's taxed,less people are dying due to poor quality drugs,look at Alcohol the most problematic and addictive substance available without prescription and people die daily due to Alcohol .
@@Yippeekiyaymummy Sometimes a certain drug might not be right for you which is why you should bring it up to the Doctor prescribing them so you can try other medications. But as someone else said, its not a magic pill, you also need to work for it
I was prescribed adderall XR. I am 51 years old.. I’m on week one. I started at on 5mg, no effect. I’m up to 20mg, I haven’t noticed anything. My focus hasn’t improved. I still have an appetite. Is this normal?
Amazing and clear review, thank you! I have a question regarding statements made 03:00-03:25. Specifically you mentioned that the levoamphetamine in Adderall, releases or somehow effects the norepinephrine which I assume is a positive and necessary process, helping the dopamine get transported or attached to the receptors...? Would the absence of levoamph... in for example Vyvanse or Dexedrine have a negative impact on the norepinephrine release and therefor affect the dopamine negativley(in terms of absorbtion/transport/attachment)? Or does dexoamph... also take care for this norepineph... release and fully or to some degree? I am above all assuming norepinephrine release is positive...(maybe that is not the case?).
+Aname No it has nothing to do with dopamine release. It was added to extend the patent, since now it is technically a new compound. If anything it is detriment to concentration as it activates the sympathetic nervous system, which prepares the body for action, which in turn makes it more difficult for one to sit still. In England, where the company that makes Adderall is from, they never approved it, because for study purposes it is less effective than dextroamphetamine for the reason stated above, therefore they did not approve it because it would be a waste of billions of dollars. It was developed for the sole purpose to replace the money they were going to lose when the patent of Dexerdine (dextroamphetamine XR) expired.
Appreciate the video immensely! Just switched back to adderall from vyvanse. I felt as if the half life of the drug made it harder for me to sleep than adderall, which makes sense now.
so I've been on Vyvanse since 2012 and it's now 2017 and I really want to change things up and I did the other day! got prescribed dexedrine 30mg IR. but supposedly the pharmacy I'm at won't support it or maybe there is an insurance problem.... Any tips?
Wow, so helpful. I'd love to hear this excellent presentation style on comparing dextroamphetamine and methylphenidate. Also this is gonna save people a lot of money.
this was an excellent video i can not praise it more i now have a complete understanding of vyvance and adderal! i have been looking online and starting to learn it now i get it. thank you kind sir
Evekeo is racemic amphetamine and it was launched in the US recently at high price. Benzedrine was the ORIGINAL commercial formulation of racemic amphetamine, I believe Benzedrine launched in the 1930s as an inhaler and as a pill in the early 1950s. Benzedrine was then replaced by the enantiopure Dexedrine, made by Smith-Klein French (SKF), which has since changed its name.
I will never ever understand why Anti-depressive meds did not help me Lexapro, Zoloft I couldn’t sleep at night but Dexidrine makes me feel so alive and I can actually sleep at night!!
Thank you very much for this explanation. I've been taking adderall IR for about 4 years now and was wondering what the difference was between the three. You have cleared this up. You earned my like.
I tried vyvanse and it didn’t do much except for help me stop being so much of a scatter brain. But on adderall I was sooo focused, happier, and SUPER confident. Also I wasn’t hungry on both which is a plus because I have a binge eating disorder. But tbh I prefer adderall because I can actually tell a mental difference.
Lmaoook the next video in my recommendation is the exact same question “adderall vs vyvanse” and it’s 3minutes long, I’m going to guess in that video he is not on either substance.
Zenzedi is exactly the same as Dexedrine and somehow it looks like it got a patent. I am not a lawyer, it may be a "branded generic" similar to Methylin, which is generic (non-patented) Ritalin, trade name methylphenidate, with a special trademarked name - specifically, Methylin.
hi I have really bad ADD not ADHD then agian my thoughts might be hyper, i was do you think modafinil or Vyvanse would be a better opetion, i have brain fog and im tired alot but the main thing is i lose shit all the time and I HATE to work and pay attention to tasks that dont interest me. Thank you sir love your vids
+Person Person It sucks, maybe I will try Vyvanse but I am not sure if the insurance will cover it...wow the typos in my message up above, I must have had a few beers in me lol
That sucks, maybe you should up it to 70? I wonder why so many prefer it to adderall, I know its just dex with a ceiling, I used to be on 10 mg ritalin, that was a long time ago
Yes hello dextroamphetaine- is it otc available? How is dex. Modified to become effective? Also could one supplement the amino L To create the same effect?
So in short, what is the difference between the two..? Just that I can’t snort Vyvanse over adderall? Adderall xr is the same as vyvanse. Basically, if you get a tablet you can crush it’s going to hit you faster whether you snort it or not
Great video. BTW, interesting pharmacology, but the bigger and more muscular you are (more lean mass), the longer Vyvanse will last. The reason is because more blood volume means the drug disperses into more blood, and your body only makes a certain amount of the enzymes to activate it. I found studies on PubMed about this. Vyvanse is a lot better than Adderall, at least in my case. Frankly, I think the only real downside of Vyvanse is it can last sometime too LONG! I take it with Intuniv (guanfacine) which HUGELY help extend it even more. Great combo. Good video.
It all comes down to "The Bottom Line". The reason why Vyvanse is around today (just like adderall before it) had nothing to do with "discovering" a new and "better" way to help treat symptoms of ADD or ADHD so as to help people, no no no. it's only around because the pharmaceutical industry, as a whole, is a business, and any For-Profit (Business) Organizations will tell you that they exist primarily to generate a profit, that is, to take in more money than it spends. He explains that very well throughout the video. I put together a breakdown of the video where he (if you read between the lines) talks about the fact that profit is the goal with big pharma rather than than helping people live better lives.(4:43 - 5:20, 6:36 - 8:27, 11:42 - 12:01, 13:21- 13:44, 14:11 - 14:14 /14:23 - 14:48, 15:58 -16:08 ). Just like in politics and private/for-profit prisons... we need to take money out of our (the U.S.) healthcare system. P.S.This was and very good, thorough and informative video BTW man. Thanks for making it. Jam on!
wow that was so helpful man. PERFECT EXPLANATION. I'm in AUS and this drug just came in the market, will be getting 70mg Vyvanse for $32 as we have PBS (Pharmaceutical Benefits scheme) along with my normal 5mg Dex amphetamine IR for ADD. thanks again mate
i have lots of d-amphetamine and vvynese and hate them as they hurt my heart. then i got long acting types = extended release ... and they are so strong and hard on heart palpitations and attitude is bitchy ...
Why is it that Psychiatrists do not do brain scans for each person with ADHD so they can know what stimulant is perfect for the patient? All they do is a small questionair.
Thagros The Amen Clinics do spec scans but it's very expensive. My personal opinion why most psychiatrists don't do spec scans, they make more money not knowing exactly what is wrong with their patient's then the can guinea pigging them on a ton of scripts.
At first, I thought someone had surreptitiously recorded one of my ES.S10 lectures and this guy was lip-syncing. Then he said "Dexa-DRYAN" and my ears started to bleed.
Been prescribed both, sometimes at the same time. 1-75mg (orange/blue) capsule of Vyvance in the morning, & 3-30mg tabs of Adderall taken throughout the day. Being said, Shire’s original product Adderall (Amphetamine Salts) is far superior to Shires new gimmick Vyvance.
![Noob To Max With DRAGON REWORK In Blox Fruits [FULL MOVIE]](http://i.ytimg.com/vi/LnBMOinoOvA/mqdefault.jpg)
I need adderrall to keep up with this dude
So far all the N. American reviews are too fast and talk crazy! I need something too :)
Im watching this with 3x speed
lol you kidding? i had to pause the video to tell you i'm watching this at 1.25x speed 😂
He needs it , moving away from the camera and
@@arrekesu6384 RUclips only goes up to 2x
I love a man who knows his orgo and can casually whip out a molecular set in conversation
lol
Lolz
@oneeze you just going to ignore your soulmate over here or..
Sexy AF
Yeah idk what it is, but he's strangely attractive
Thank goodness someone explaining with actual science. The second I heard "organic chemistry" I knew this guy knew his stuff.
Wow you just explained this so well thank you. I've been looking for this kind of information all over the Internet and you're the first source that I've found that isn't opinion based and biased. I never comment on videos but I'm currently on vyvanse so my brain feels like writing a paragraph over the information it just absorbed.
I don't get why people complain about how he explains in the comment section. I listened to his video at 2.0x speed while working on something else, and it was very easy to understand and straight-forward. Very well explained.
Either you’re on the drugs or you don’t have ADHD or you’re far too interested. Go away
Same had to speed it up to understand
You are great for those of us who do understand and deal with theses substances. Please keep up your good work. Thanks.
Explaining 30 seconds worth of information in 15 minutes... I love speed.
Right. Tweak infused delivery.....😜
Adderall vs Vyvanse @ 10:00 answer starts(listen to whole thing if you are not from medical background) , once you understand that Adderall is mixed( Levo & Dextro) amphetamine , while Dexedrine is Dextro-amphatmine Vyvanse is Lysine + Dexedrine is Just one . NOTE: You can't snort as you need stomach enzyme acidity to break Lysine -Dextraamphamine bond. I am sure people will find way to abuse anything. If you can take more than prescribed medications, and if you take them enough, you are abusing it at the cost of downregulating the dopamine receptors, and going on dangerous addiction path. Good Videos.
Hydrolyzing Vyvanse (lisdexamfetamine) was ORIGINALLY believed to take place in the stomach as an acid-catalyzed acyl substitution, so I don't blame you. However, Vyvanse is mostly absorbed intact from the small intestine. It is hydrolyzed by esterase enzymes in blood. Snorting Vyvanse probably does not work because it is positively charged and cannot cross the mucus membranes of the nose. Injecting Vyvanse has been shown to get you high, in pioneering research done by kids at your local Emergency Department.
True thank you.
As a person with ADHD I really appreciate your video!
You are welcome!
It 2022, in March, and I just found this video but it is still so helpful for me. Thank you! I have had the worst time trying to get my ADD medication dialed in because I have the absolute most uneducated people in the area of ADD/ADHD medication‘s, prescribing my Vyvanse. ADHD medication do not take weeks or months to dial-in. They’re not Anna depressants or something, they don’t take forever and a day to start seeing if it works for you or not. It takes literally, 5 to 6 days to know if you are on the correct dosage and the right set up. Meaning, you shouldn’t have to keep increasing your medication because it stops working, which is my current problem. Instead, Dr. Parker says in another video, who specializes in us, you need an afternoon dose that’s a short acting to carry you through for the rest of the day. But since I have to be my own advocate and my own educator, these videos are what help me when I have to go in for another prescription (as by law, schedule 2 medications, they can only give you 3 months at a time and they’re 3 separate individual prescriptions, not refills.), and explain it to them with all the information/knowledge I have gathered on my own, in hopes that they won’t argue with me and treat me like I’m a drug seeking addict. It is awful to be treated like a pill head because everyone else ruined it for people like me, who actually do have ADD.
💯 customer profiling. People who abuse these meds make it hard for those who need it.
My doc put me on vyvanse cause adder all made me so anxious and paranoid and now I know why she did that. I always thought these drugs were all the same. I don't feel no physical side effects like I use too and no wonder I can't use vyvanse in the gym also. Aderall worked like a charm there . Thanks for this info . Helped a lot
With Vyvanse, release begins from the small intestine, the l-lysine gets cleaved off by stomach ph, and releases the dextroamphetamine. (making it strictly biologically activated.) Levoamphetamine effects the PNS nervous system indirectly effecting nor-epirnephrine.
❤❤ this stuff
You sounded so smart... And then you used effects as a verb 😞
*thoughts on dexedrine** "i can put a right handed glove on my left hand. " " look i can flip inside out" " whos glove is this ?"
Same
Can someone please explain to me the difference with Vyvanse and Adderall and meth and speed? I always get into this argument and i am tired of getting called a meth head!
Adderall/l-amphetamine really helps my mood for some reason while vyvanse/d-amp is solely a focusing tool. Adderall fully cured my bipolar problem for ~8 months'ish so far. Amazing time we live in.
Of course, but the withdrawal your bipolar would be worse probably
How are you doing now
Same here. I need the L amphetamine for more full coverage dopamine boost.
Just pure amphetamine (Dexedrine), doesn’t have any mood elevation component, and no body stimulation. Not bad, but I def prefer a mix salt treatment
With that visual explanation and all the details, I think you are the best of all I found on youtube! Thank you
TLDR;
Adderall takes immediate effect and requires multiple doses, Vyvanse takes approximately an hour to kick in and lasts longer; only requires one dose a day. Vyvanse (most likely) does not work properly or at least as effectively if snorted. Vyvanse is approximately $300 (as someone that has been prescribed a daily dose of Vyvanse, I can confirm this. In my experience, the price does not change based on the mg dosage.) The medications are very similar but, again in my experience and own research, have different side effects. From what I have asked two different doctors, Vyvanse is far more natural and safe than Adderall. Adderall is also far cheaper than Vyvanse (probably due to the whole patent thing) and, according to the person in this video can range from $10-$70, depending on where you're from. It is vital in my opinion to note that (at least in Canada) if you visit your psychiatrist, s/he can give you little prescription cards (no idea what they are actually called, sorry!) that you can give to the pharmascist whenever you are due for a prescription refill (they may not allow you to get a refill if it is more than something like 24-48 hours before necessary as they don't want to risk any possible prescription abuse on your part) and it is far cheaper that way. I believe it's something like $50-something for it in that way. (Only been on it a few months and my father is the one that keeps the cards on him and does refills so I don't know anything about it besides that, sorry!)
Wow, I only pay 20.00 a month for mine. Couldn't imagine 300.00
Wrong.. Adderall takes hour to kick in..it and er
@@geraldyoung8753
20.00 a month here too. I think it's a matter of insurance.
My vyvanse 250.00 I got a 90.00 discount card from my psychiatrist.
Vyvanse 40 mgs takes only 15 mins to kick in
You said Vyvanse is dextroamphetamine. I was under the impression it was lisdexamfetamine.
Donivan Reis Vyvanse is dextroamphetamine bonded to an amino acid. In the blood this bond is broken leaving dextroamphetamine.
It would be like the difference between an orange that is peeled and one that is not. It is one way to repatent a drug, since now it is technically a new compound.
It would be as if you had a patent for peeled oranges and that expired. You would then patent the unpeeled oranges, since technically it is different compound, and continue to sell it for the patented price.
They are both oranges and the same thing. Dextroamphetamine is peeled, Vyvanse is not.
ONEEZE It's a prodrug, correct? as Codeine is a prodrug for morphine and it's other metabolites?
The amino acid lysine is attached to dextro-amphetamine really for the sake of having a new Patent and profitable drug
I LOVE this explanation is WAYyy more clear than any other reviews. Thank you Sir!
Make a video on DMAA and how it compares in effects and in molecular structure to Adderall, Vyvanse(dextroamphetamine), and Ritalin. Dmaa is or was a big thing in pre workout supplements. Im curious if its effects on cognition are similar to dextroamphetamine or adderall cuz it can still be gotten online for cheap wit no script as a "reaearch chemical" like $15 for 1 gram
The best explanation I've seen online. And you confirmed my own conclusions about the increased ethicasy of dextroamphetamine compared to the racemic mixture. Who wants increased levels of norepinephrine when they're trying to focus?? I also like how you rightfully attributed this fuckup to the pharmaceutical industry and the patent process without dwelling on the politics and getting up in arms which would have been off topic. Great video, well done mate.
I don't think you can snort it. from what I know about digestion, protein breakdown takes place in the stomach and then continued in the small intestine by proteases. isn't this the case?
Hey man. You should be a chemistry teacher or something. You really help me out and understanding what you said. Thank you again.
I've personally taken both but I was only on Vyvanse for ADHD for a couple months in the first semester of my senior year in fall 2010. The doctor took me off of it because my social worker at school and my therapist at the time thought it was causing me to act up. However, Adderall and later concerta also did the same thing, but although not quite as much. I think I was able to sleep a little more easily on Vyvanse though, and didn't perform quite as well academically on it compared to the regular Adderall concerta. However on Vyvanse I had less tics compared to when I was on the other. I also had a dual diagnosis of bipolar and also took risperdal for it from 2003 to 2012. Some years later ASD was officially diagnosed and bipolar was dropped and I no longer take ADHD meds.
This man is quite intelligent. Thanks for your exquisite explanation. One of the better ones I’ve ever seen on RUclips over the course of the last 12 years. You have the potential to become a full time youtuber if you had the interest.
I digress, I learned a lot from you today. Will be consider asking my doctor for a switch off Adderall to something that wears off sooner than 12+ hours
having experience with the adhd-meds, including ritalin/concerta, i prefer vyvanse. i like the slower gradual onset. adderall was good but due to the various salts and metabolism rate i found the onset a bit jerky. dexedrine was fast but it also has a lot more abuse potential (sniffing & injection) which is my understanding as to why it's not as prescribed. ritalin was too short lived whereas concerta wasn't, although with that i was clenching/grinding my teeth. btw - i'm coming at this from a therapeutic perspective, not someone whose used these recreationally. fortunately where i am in canada i don't pay a cent for any of these :D
On Concerta was it effective for you. I’m taking adderall but I feel like my metabolism runs through it quick so it doesn’t feel as effective but so did the XR version
Anna Fisher Thank you I keep trying Adderall or Ritalin
Technically you do pay for those, just in the form of a lot more tax
@@SanjacPr0ductions I don't pay taxes
@@Fitheach81 yet
this should be titled The chemical breakdown of these drugs,,,
Thank you! It was tremendously helpful! I am not a chemist, but I have learned about different antidepressants and ADHD medication enough to understand your explanation very clearly.
Do you know if Dexamfetamine Sulphate is another term for Dextroamphetamine? If same/different do you know what the equivalent dose of Dex-Add would be?
Great video, you covered everything so clearly
Allegra Van Zuylen yes dex sulfate is the same as Dexedrine
I think that although you are factually correct in saying that there is technically no difference between the 2 base compounds, the inhibitor has some positive aspects that help make the drug a lot more sustainable for certain patients. Since the drug requires protein and amino acids from food for it to work, it forces you to keep up with your nutrition giving you an incentive to eat as apposed to adderall which can have a greater negative effect on your appetite. This helps to extend it's effectiveness and provide a more consistent, level feeling of focus which is preferable to the distracting peaks and crashes of other versions. It also makes it easier to come off of since it seems to stay active for a while after you stop taking it so the come down is less pronounced and it doesn't give you the same "I need to eat everything" crash that adderall does.
Hi! Not sure if you will ever see this, but I'm curious about something and would appreciate your feedback. I took vyvanse for several years and it worked very well for me but recently stopped working. I suddenly had horrible side effects ("physical" anxiety, lack of focus, restlessness, repetitive fidgets/ weird muscle movements, intrusive thoughts, etc). I am now on adderall and I feel less anxious, less restless, and more focused. Considering what you explained about the two drugs, I cant imagine why this would be the case if the l-isomer is the one that increases physiological symptoms of anxiety. Any ideas?
Thanks for the honest video, your content is valuable.
Hi, I know this is an old comment but maybe I can contribute.
I should preface by saying I am not a psychiatrist or a pharmacist, so take this with a grain of salt (haha pun).
If the dosage of adderall and vyvanse are approximately the same then you are actually receiving more dextroamphetamine by taking vyvanse due to only 75% of adderall being that compound. However it is unlikely that your dosages over time were exactly the same, so I’d have to know what they were to comment more on that.
The other thing that I personally felt was neglected in this video is that the release time of each compound matters a lot in terms of the effects. The faster the release happens the more of a “high” one gets, for example when someone snorts adderall at a college party. Vyvanse, due to its extra step, has a much slower release time and this means that the therapeutic effect tends to be more stable over time as opposed to adderall, at least in general.
Finally, the way each one is metabolized is heavily impacted by an individual’s physiology. My Dr even told me that I should not drink lots of orange juice as it could affect my stomach’s pH and allow less of the dose into my system! Having a relatively “inert” version of the compound prior to it entering the blood could have a large effect depending on an individual’s digestion.
some of us have no idea what you're talking about, "as you probably know"
+My Balloon Guy Sorry about that, I originally made this as answer to someone who was a chemistry student. I honestly never expected that so many people would watch it. Most of my videos have less than 50 views.
What I will do is make a new channel devoted strictly to medicine and healthcare and try to make it as concise and understandable as possible.
I made a test video, different type of drug, but if you have a minute check out and let me know how you like the format. If you think its good I'll remake this one in that style.
+ONEEZE you did a good job, but nowadays people definitely do more research on what kind of drugs their doctor prescribes to them.
+My Balloon Guy Sorry I meant to put a link,
ruclips.net/video/Sm2EdoGSolo/видео.html
ONEEZE what are the long term effects of vyvanse?
@@14thSun mate,i bought a tub of 28 X 30mg Vyvanse made by Shire Pharmaceuticals. Ive never took these before,i live in the UK where we just have Dexedrine 5mg tabs,i took 5 of these last night,fuck me i was euphoric and chemically close to God. There great,but 28 cost me nearly $190
Thank you so much for this as someone with ADHD who wants to know WHAT IS HAPPENING and WHY THIS AND NOT THAT and so many other things, thank you so much. My need to know has been sated.
To my knowledge, levoamphetamine was never approved or marketed in the US. I could check the FDA website, but making it enantiopure costs money and I have never heard of a motive. In contrast, levomethamphetamine is called levmetamfetamine and is marketed for nasal congestion.
Thank you for the explanation. I actually learned a lot. I wanted to know if I should switch from Adderall to Vyvanse for my ADD and it looks like Adderall generic is just as fine.
This is an amazing video. thank you so very much. Honestly one of the best youtubers I have seen in a while that isn't comedy related.
Hi!
I have a question, even if the video if somehow old, but I have a question I can´t find a straight answer for, and u said u had researched the topic...
Do you have any idea about how can Dexadrine cause more physical side effects than Adderall for some people? It doesn´t seem to make sense. Both the little chemistry I know from college and the "research" I have been doing this past year support exactly what your video says, that it is the Levo the one that causes most of the side effects( heart punding, insomnia, etc...) but still I know Dex has worse effect on those areas than Adderall for a bunch of us...Do you have any idea of how or why that may be 0.0?
I haven´t manage to get any straight answer besides "everyone reacts differently", but this sounds like a very weird kind of different, when one isomer has an effect it just shoudn´t have at all... So I´d appreciate your thoughts on it
Thanks!
Can you make a video about lexapro and other popular antidepressants
hands down one of the best videos i have found for these medications. granted it helpd to have a higher knowledge on the subjects, still very handy.
Glad you like it. Thanks!
ok, so now that adderall IR as well as XR is available in generic forms, WHY do doctors still prescribe 'mixed amphetamine salts' aka generic adderall when dextroamphetamine (dexedrine) is really the only useful molecule? Would it be reasonable to bring this up to my doctor and request just generic dextroamphetime?
Also, I recently came across another ADHD drug called Evekeo™ which is 50/50 levoamphetamine/dextroamphetamine. Seems like they're reinventing the wheel. What do you think???
Joey Zee Dexedrine isn’t stocked as much in pharmacies, it can be harder to find than generic Adderall. My pharmacy had to special order it.
Have you ever seen street Amphetamine being made? It's unhygienic,it's explosive environment,it's rotting people's stomach linings and there teeth. I paid $189 for a tub of 28 Vyvanse capsules yesterday,only 30mg capsules,but I can definitely say hand on heart Vyvanse is very euphoric feeling. Plus it's clean and won't ruin your teeth.
Dexedrine (Dexamphetamine sulphate 5mg tablets
Vyvanse capsules 30mgs
Adderall 30mg capsules. Dexedrine is very affective in stopping people use street Amphetamine and get them of dangerous unhygienic Amphetamine,which rots the users the teeth,and lining, psychiatrists for the majority do not agree with prescribed Amphetamine to stop illicit use of Amphetamine made in a bath,with more adulterants than Amphetamine. Fact. Portugal legalised drugs and look ,drugs are taxed,and regulated,crime rate has fallen by 52% ,no drug dealers making money of people's misery. It's safe,it's taxed,less people are dying due to poor quality drugs,look at Alcohol the most problematic and addictive substance available without prescription and people die daily due to Alcohol .
Can you possibly explain why I haven’t seen an improvement in focus on 30mg and 40mg of Vyvanse?
Thanks.
Dose to high you goof
Wouldn’t I exhibit all kinds of side effects if the dose was too high?
30mg didn’t do anything for my ADHD, nor has 40mg :(
Jake F Bruh because you have to learn ist just helps you it isnt Magic
@@Yippeekiyaymummy
Sometimes a certain drug might not be right for you which is why you should bring it up to the Doctor prescribing them so you can try other medications. But as someone else said, its not a magic pill, you also need to work for it
I was prescribed adderall XR.
I am 51 years old..
I’m on week one. I started at on 5mg, no effect.
I’m up to 20mg, I haven’t noticed anything.
My focus hasn’t improved. I still have an appetite.
Is this normal?
An Amazing Teacher Explained so Perfectly. I'm also on Vyvanse and Prozac
Thanks!
Why the Prozac tho? Are you ADHD comorbid with depression or have OCD or anxiety issues?
Idk why but u remind me of Evan peters
princess angeee
lol maybe the hair style
Thank you soooooooo much for this video!!!!! Sadly, they don't tell you about this kind of stuff...So again thanks! Glad I found your channel
Why tf is every other video on my timeline about Adderall vs vyvanse
my vyvanse just kicked in > > > TALK TO THE HAND!!!
Thanks for this beautiful video,my questione is,are there sode effects from vyvanse?please help me
Yes duh
mY DOC just prescribed my Vivian and I had no idea what it was. This was insanely helpful!
Amazing and clear review, thank you! I have a question regarding statements made 03:00-03:25. Specifically you mentioned that the levoamphetamine in Adderall, releases or somehow effects the norepinephrine which I assume is a positive and necessary process, helping the dopamine get transported or attached to the receptors...?
Would the absence of levoamph... in for example Vyvanse or Dexedrine have a negative impact on the norepinephrine release and therefor affect the dopamine negativley(in terms of absorbtion/transport/attachment)?
Or does dexoamph... also take care for this norepineph... release and fully or to some degree?
I am above all assuming norepinephrine release is positive...(maybe that is not the case?).
+Aname No it has nothing to do with dopamine release. It was added to extend the patent, since now it is technically a new compound. If anything it is detriment to concentration as it activates the sympathetic nervous system, which prepares the body for action, which in turn makes it more difficult for one to sit still.
In England, where the company that makes Adderall is from, they never approved it, because for study purposes it is less effective than dextroamphetamine for the reason stated above, therefore they did not approve it because it would be a waste of billions of dollars. It was developed for the sole purpose to replace the money they were going to lose when the patent of Dexerdine (dextroamphetamine XR) expired.
Is this sons of Apollo ?
What is difrent betwen concerta or adderal or modafinal
I think not all doctors know this. I was looking for somebody talking about this vyvanse half life. Thank you.
Appreciate the video immensely! Just switched back to adderall from vyvanse. I felt as if the half life of the drug made it harder for me to sleep than adderall, which makes sense now.
so I've been on Vyvanse since 2012 and it's now 2017 and I really want to change things up and I did the other day! got prescribed dexedrine 30mg IR. but supposedly the pharmacy I'm at won't support it or maybe there is an insurance problem.... Any tips?
Wow, so helpful. I'd love to hear this excellent presentation style on comparing dextroamphetamine and methylphenidate. Also this is gonna save people a lot of money.
@oneeze does vyvanse show up as methamphetamine on a urine drug test? 🙏 please respond asa you can
this was an excellent video i can not praise it more i now have a complete understanding of vyvance and adderal! i have been looking online and starting to learn it now i get it. thank you kind sir
You are welcome!
Evekeo is racemic amphetamine and it was launched in the US recently at high price. Benzedrine was the ORIGINAL commercial formulation of racemic amphetamine, I believe Benzedrine launched in the 1930s as an inhaler and as a pill in the early 1950s. Benzedrine was then replaced by the enantiopure Dexedrine, made by Smith-Klein French (SKF), which has since changed its name.
I will never ever understand why Anti-depressive meds did not help me Lexapro, Zoloft I couldn’t sleep at night but Dexidrine makes me feel so alive and I can actually sleep at night!!
I would take my dose in AM and fall nicely asleep
TIMING is what counts a lot on these types of medications becoming more legal than ever.
you forget though Adderrall isn't prescribed for only ADD disabilities. Its can treat Narcolepsoy disorders an other orders.
This guy is smart as hell
so, vyvanse is better?
Juhn yong jin yes
Thank you very much for this explanation. I've been taking adderall IR for about 4 years now and was wondering what the difference was between the three. You have cleared this up. You earned my like.
I tried vyvanse and it didn’t do much except for help me stop being so much of a scatter brain. But on adderall I was sooo focused, happier, and SUPER confident. Also I wasn’t hungry on both which is a plus because I have a binge eating disorder. But tbh I prefer adderall because I can actually tell a mental difference.
So you say Adderall is better alround than VYVANSE, THANKS FOR TELLING ME,AS IVE NEVER HAD ADDERALL .
Spitters are Quitters is that sarcasm
@@Lavendermoonmedia sorry?
Why is Pervitin not made anymore and prescribed for ADHD?
It is. Its just not used very often.
Lmaoook the next video in my recommendation is the exact same question “adderall vs vyvanse” and it’s 3minutes long, I’m going to guess in that video he is not on either substance.
Lollll but this guy is cooler
Zenzedi is exactly the same as Dexedrine and somehow it looks like it got a patent. I am not a lawyer, it may be a "branded generic" similar to Methylin, which is generic (non-patented) Ritalin, trade name methylphenidate, with a special trademarked name - specifically, Methylin.
hi I have really bad ADD not ADHD then agian my thoughts might be hyper, i was do you think modafinil or Vyvanse would be a better opetion, i have brain fog and im tired alot but the main thing is i lose shit all the time and I HATE to work and pay attention to tasks that dont interest me. Thank you sir love your vids
+Tom Thomas i am sleepy alot not sure if i want to tell them that or they might screw me
We have basically the same ADD......
+Person Person It sucks, maybe I will try Vyvanse but I am not sure if the insurance will cover it...wow the typos in my message up above, I must have had a few beers in me lol
Tom Thomas i currently take a daily 50mg dose of vyvanse. its meh
That sucks, maybe you should up it to 70? I wonder why so many prefer it to adderall, I know its just dex with a ceiling, I used to be on 10 mg ritalin, that was a long time ago
That was amazing, thank you 😌
Just beautiful. Thank you
Thanks for clearing that up.............................???????????????????????????????????
How long does it take to get addicted to Addeall?
didn't really expect a good video (no offense) but you did a great job explaining my friend
+Alex Youknow No offense taken, glad to be of assistance.
Thank you just been put on elvanse UK prob iis vvanse feel a lot better after your explanation cheers
Yes hello dextroamphetaine- is it otc available? How is dex. Modified to become effective? Also could one supplement the amino L
To create the same effect?
great video man, thanks!
So in short, what is the difference between the two..? Just that I can’t snort Vyvanse over adderall? Adderall xr is the same as vyvanse. Basically, if you get a tablet you can crush it’s going to hit you faster whether you snort it or not
Best, most concise explanation I've heard comparing these drugs.
Great video. BTW, interesting pharmacology, but the bigger and more muscular you are (more lean mass), the longer Vyvanse will last. The reason is because more blood volume means the drug disperses into more blood, and your body only makes a certain amount of the enzymes to activate it. I found studies on PubMed about this. Vyvanse is a lot better than Adderall, at least in my case.
Frankly, I think the only real downside of Vyvanse is it can last sometime too LONG! I take it with Intuniv (guanfacine) which HUGELY help extend it even more. Great combo. Good video.
Awesome video thanks a lot
Dude you are incredible your parents should be extremely proud of you 👏
Why didn’t they just renew their patents?
It all comes down to "The Bottom Line". The reason why Vyvanse is around today (just like adderall before it) had nothing to do with "discovering" a new and "better" way to help treat symptoms of ADD or ADHD so as to help people, no no no. it's only around because the pharmaceutical industry, as a whole, is a business, and any For-Profit (Business) Organizations will tell you that they exist primarily to generate a profit, that is, to take in more money than it spends. He explains that very well throughout the video. I put together a breakdown of the video where he (if you read between the lines) talks about the fact that profit is the goal with big pharma rather than than helping people live better lives.(4:43 - 5:20, 6:36 - 8:27, 11:42 - 12:01, 13:21- 13:44, 14:11 - 14:14 /14:23 - 14:48, 15:58 -16:08 ). Just like in politics and private/for-profit prisons... we need to take money out of our (the U.S.) healthcare system.
P.S.This was and very good, thorough and informative video BTW man. Thanks for making it. Jam on!
So glad i found this gem
Great job explaining the differences between this two popular drugs
Best explanation of differences I have found so far. 👌
thank you for the talk! been searching for answers,,,,you explained it perfect......thanks!!!!
wow that was so helpful man.
PERFECT EXPLANATION.
I'm in AUS and this drug just came in the market, will be getting 70mg Vyvanse for $32 as we have PBS (Pharmaceutical Benefits scheme) along with my normal 5mg Dex amphetamine IR for ADD.
thanks again mate
Thanks you for this helpful video!!!!!
i have lots of d-amphetamine and vvynese and hate them as they hurt my heart. then i got long acting types = extended release ... and they are so strong and hard on heart palpitations and attitude is bitchy ...
thank you for explaining this.
Why is it that Psychiatrists do not do brain scans for each person with ADHD so they can know what stimulant is perfect for the patient? All they do is a small questionair.
Holy shit that would be so expensive lol
Better have good insurance
Stalkerx13
It's called a spec scan from
The Amen clinic
The technology/technique doesn't exist yet. It's coming in the next 3-5 years according to some researchers.
Thagros
The Amen Clinics do spec scans but it's very expensive.
My personal opinion why most psychiatrists don't do spec scans,
they make more money not knowing exactly what is wrong with their patient's
then the can guinea pigging them on a ton of scripts.
Did you make that art work in the back
THAT was the BEST explanation i EVER heard in my LIFE!!!!
At first, I thought someone had surreptitiously recorded one of my ES.S10 lectures and this guy was lip-syncing. Then he said "Dexa-DRYAN" and my ears started to bleed.
I would like to talk to you. We can discuss Evergreening, the name of this patent prolongation trick, and the class I used to teach.
LOL
Excellent excellent explanation. This was the best video ever! Thank you so much
Been prescribed both, sometimes at the same time. 1-75mg (orange/blue) capsule of Vyvance in the morning, & 3-30mg tabs of Adderall taken throughout the day. Being said, Shire’s original product Adderall (Amphetamine Salts) is far superior to Shires new gimmick Vyvance.
This guys showing every tell tale sign of being lit af on amphetamine