Introduction to Retinoids in Dermatology - Agents, Mechanism of Actions, Uses, Side-effects
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- Опубликовано: 10 фев 2025
- Hi. With this video, we will introduce ourselves to Vitamin A analogues and Retinoids; and their use in Dermatology, and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.
Introduction - 02:39
History - 05:03
Vitamin A - 07:31
Pharmacology: Retinoids - 11:42
Classification of Retinoids - 14:52
Mechanism of Action: Transport - 17:29
Mechanism of Action: Receptors- 21:36
Mechanism of Action: Decreased processes - 28:52
Mechanism of Action: Increased processes - 32:56
Mechanism of Action: Additional mechanisms - 34:58
Embryogenesis - 39:32
Recap of Retinoid Physiology - 41:27
Uses - 43:56
Uses: Psoriasis - 45:38
Uses: Acne - 48:09
Uses: CTCL, MF, Sezary Syndrome - 49:43
Adverse Events - 50:15
Teratogenicity - 52:54
Lipidaemia - 56:23
Depression - 58:19
Bone effects - 59:37
Eye - 01:00:57
Other adverse effects - 01:01:57
Drug Interactions - 01:04:26
Monitoring - 01:06:30
Further Reading - 01:08:44
End - 01:10:52
Good articles on Retinoids:
1. Chapter 22 - Systemic Retinoids. In: Comprehensive Dermatologic Drug Therapy, 4ed. Pg-245, Wolverton SE, Wu JJ. ISBN: 978-0-323-61211-1
2. Khalil S, Bardawil T, Stephan C, Darwiche N, Abbas O, Kibbi AG, Nemer G, Kurban M. Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects. J Dermatolog Treat. 2017 Dec;28(8):684-696. doi: 10.1080/09546634.2017.1309349. Epub 2017 Apr 2. PMID: 28318351.
3. Vieira AV, Schneider WJ, Vieira PM. Retinoids: transport, metabolism, and mechanisms of action. J Endocrinol. 1995 Aug;146(2):201-7. doi: 10.1677/joe.0.1460201. PMID: 7561630.
4. Jin Y, Teh SS, Lau HLN, Xiao J, Mah SH. Retinoids as anti-cancer agents and their mechanisms of action. Am J Cancer Res. 2022 Mar 15;12(3):938-960. PMID: 35411232; PMCID: PMC8984900.
5. Orfanos CE, Zouboulis CC, Almond-Roesler B, Geilen CC. Current use and future potential role of retinoids in dermatology. Drugs. 1997 Mar;53(3):358-88. doi: 10.2165/00003495-199753030-00003. PMID: 9074840.
6. Wolf JE Jr. Potential anti-inflammatory effects of topical retinoids and retinoid analogues. Adv Ther. 2002 May-Jun;19(3):109-18. doi: 10.1007/BF02850266. PMID: 12201351. 
Развлечения
Alitretinoin is a first generation retinoid according to new Rooks (seems to be incorrectly given in Wolverton)
Yes, you are correct. It has now been corrected as a 1st generation retinoid. Thank you for pointing it out. :D. I shall pin this comment so others may see this and correct. Thank you once again. :)
Your lectures makes learning drugs easy sir🙌
You are so kind! Thank you! I am glad you are finding these videos helpful. There are more to come. Keep watching 😄
Very informative video sir, request videos on nutrition deficiency and ageing of skin and its management.
Thank you sir
Hi, thank you for your suggestion 😊. These are very interesting topics. I will surely make videos on these topics. Would you suggest some good nutritional deficiencies that we should discuss?
Thank you very much sir 🙏🏻
Most welcome 😁 keep watching
🙌🙌
Thank you 😊
Very well explained sir....
A question...why platelet count to be done ( since they cause neutropenia..we do CBC...why platelets)
Also why RFT are to be done
Thank you sir
That's a good doubt. Retinoids are known to cause thrombocytopenia. There are multiple articles on this, even in acne patients. Interstitial nephritis has been reported. But RFT is just to have the complete evaluation of the patient.
Hydroxychloroquine drug pr lacture Sir
Thanks for the suggestion. I have added it to the suggestion list. 😊