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Krebs Cylcle Trick How to remember krebs cycle FOREVER!!
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- Опубликовано: 1 май 2018
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KREBS CYCLE (called after Hans Krebs) is a part of cellular respiration. Its other names are the citric acid cycle, and the tricarboxylic acid cycle (TCA cycle).
It is the series of chemical reactions used by all aerobic organisms to generate energy. It is important to many biochemical pathways. This suggests that it was one of the earliest parts of cellular metabolism to evolve.
The Krebs cycle comes after the link reaction and provides the hydrogen and electrons needed for the electron transport chain. It takes place inside mitochondria.
The TCA cycle plays a central role in the breakdown, or catabolism, of organic fuel molecules-i.e., glucose and some other sugars, fatty acids, and some amino acids. Before these rather large molecules can enter the TCA cycle they must be degraded into a two-carbon compound called acetyl coenzyme A (acetyl CoA). Once fed into the TCA cycle, acetyl CoA is converted into carbon dioxide and energy.
The TCA cycle consists of eight steps catalyzed by eight different enzymes (see Figure). The cycle is initiated when acetyl CoA reacts with the compound oxaloacetate to form citrate and to release coenzyme A (CoA-SH). Then, in a succession of reactions, (2) citrate is rearranged to form isocitrate; isocitrate loses a molecule of carbon dioxide and then undergoes oxidation to form alpha-ketoglutarate; alpha-ketoglutarate loses a molecule of carbon dioxide and is oxidized to form succinyl CoA; succinyl CoA is enzymatically converted to succinate; succinate is oxidized to fumarate; fumarate is hydrated to produce malate; and, to end the cycle, malate is oxidized to oxaloacetate. Each complete turn of the cycle results in the regeneration of oxaloacetate and the formation of two molecules of carbon dioxide.
Energy is produced in a number of steps in this cycle of reactions. In step 5, one molecule of adenosine triphosphate (ATP), the molecule that powers most cellular functions, is produced. Most of the energy obtained from the TCA cycle, however, is captured by the compounds nicotinamide adenine dinucleotide (NAD+) and flavin adenine dinucleotide (FAD) and converted later to ATP. Energy transfers occur through the relay of electrons from one substance to another, a process carried out through the chemical reactions known as oxidation and reduction, or redox reactions. (Oxidation involves the loss of electrons from a substance and reduction the addition of electrons.) For each turn of the TCA cycle, three molecules of NAD+ are reduced to NADH and one molecule of FAD is reduced to FADH2. These molecules then transfer their energy to the electron transport chain, a pathway that is part of the third stage of cellular respiration. The electron transport chain in turn releases energy so that it can be converted to ATP through the process of oxidative phosphorylation.
The German-born British biochemist Sir Hans Adolf Krebs proposed this cycle, which he called the citric acid cycle, in 1937. For his work he received the 1953 Nobel Prize in Physiology or Medicine. Although Krebs elucidated most of the reactions in this pathway, there were some gaps in his design. The discovery of coenzyme A in 1945 by Fritz Lipmann and Nathan Kaplan allowed researchers to work out the cycle of reactions as it is known today.
I've ditched all my lecture notes as they make no sense, my tutors at University do not know how to teach things in a way I can understand. This RUclips channel is an absolute Godsend, whoever creates the content for this channel is a genius!! Thankyou so much for helping me through my Biomed degree!!
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MEDSimplified I had my Metabolism exam on Tuesday and thanks to your channel I came out of it feeling really happy, I know I've passed! I can't thank you enough ❤️
Same to you. I don't understand anything from my University class lecture. We call our teacher "Robot Sir", because nobody understand his lesson.
This was me for months!! I even hated the fact that I spent money on my textbook coz I rarely used it
Really
i missed my lectures and everybody said that i will never understand krebs cycle and then i found this video and now i know more than them...
This same thing happened with me and my teacher refused to explain it to me 😢
@@ananyaghosh3339what a useless teacher
Ikr? Lol
Acha Batana zra phir citrate into isocitrate Sirf arrangements change huyi toh CO2 kahan sa bni NAD kahan sa aya ????????
@@LaibaNoor010Is step ma CO2 release ni hogi
Next step ma jab isocitrate a-ketoglutarate ma change hoga tab C02 release hogi or NADH b
Is step ma 6C compound (isocotrate) 5C compond ma change huva ha is liya 1 carbon as CO2 release ho gi or jo electrons release ho gay unhay NAD+ accept kar lay ga or NADH ma chnage ho jay ga
Hope this helps
7 minutes of your video explained this better than a textbook, a PowerPoint, and a 90 min lecture on the subject. Thank you SO much!
good stuff!
Also note: if you compare the two mnemonics side-by-side and skip Aconitase, every enzyme lines up with the intermediate it is named for.
C | S : Citrate Synthase
_ | A : Aconitase
I | D, : Isocitrate Dehydrogenase
K | D : alpha-Ketoglutarate Dehydrogenase
S | S : Succinyl CoA Synthase
S | D : Succinate Dehydrogenase
F | F : Fumarase
M, | D! : Malate Dehydrogenase
O? | _ :
I changed the second one to "SAD Devil Sipping Down Five Drinks" made more sense to combine first 3 letters together. Thanks for the video !!
I was struggling for the longest time to understand the Krebs cycle and this video just made it all crystal clear. Thank you!!
I've spent the last 2 hours watching lectures trying to understand what you just said in 5 minutes. Thank you for your videos!!
“Can I Keep Selling Substances For Money Officer” helped me totally answer a question on a test today! 👍🏻 thanks!
Wtf
I'm learning this right now to prepare for my PCAT and it looked terrifying at first but because of you MEDSimplified I feel like I can memorize it. Thank you and God bless please continue to help future students ♥
The use of mnemonic aids is very helpful. Dr. Krebs has always been one of my Science heroes. I'll recommend your video to students. Thanks.
I have a test this morning, Krebs cycle has been a big thing to me but you made it easy
You saved me, thank you🙏
I have an exam in 6 days and so far nothing has helped me. Thank you so much for making this vid, you are a life saver!
watched this video for my IB exams 2 years ago now I'm back from my biochem lectures and you just never seem to fail in explaining this so simply!!!!
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That’s my Life bro I just hate the thick books... I don’t read them at all just watch ytb videos then I’m done learing and have good marks🤩 I don’t how I could pass without this here
Hey! you are really amazing at teaching . I've watched your videos and I know it is really difficult to edit the videos in such a way that people understand . I've tried to make education videos but they are not up to the mark . you are my inspiration and I watch your videos to get an idea how to make people understand . just wanted to tell you . thank you so much ❤️
Thankk you. Your words nd appreciation means so much to me😁
The enzyme that converts succinyl-CoA to succinate is succinyl-CoA synthetase, not succinyl-CoA synthase. Synthetase means that ATP is generated
seriously, you have no idea how grateful I am for this video. thank you
I love u man. Making complicated objects simple!
never in my life thought kerb cycle can be easy
you made it. thanks bro
its really amazing....I have learnt it only within 15 min..God bless u..😊
brother i cant thankyou in word. you are literally god for me
Sir ur explanation was awesome I'm able to understand the Krebs cycle now
Amazing! I memorized the whole thing by just watching the video once!!
I've an exam this weekend and i hate biochemistry but this just saved my exam. thank you so much!!
This video is unvelievably helpful. Thank you so much!
Thank u so much.... I was beating my head against the wall to remember it bt all in vain. Finally your video helped me to remember it in a min.... Loved it.... 😇😇😇
thank you, I have a biochemistry test this Friday which I am ABSOLUTELY dreading. This video explains the Krebs cycle so well, Thank you!!!
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"So at disco, devil sipped down five drinks!"
Thaaank youu soooooo much Sir... Yesterday was my exam and I was so stressed but for you I have written my exam well 😄.. I am fully satisfied.. thaaank youu
Being a medico
I can say its the best video on yt for this topic but only for +2 students.....for higher studies....even this cycle is not complete ( cis-aconitate and succinate thiokinase absent)
Right
Oh my goodness! You are amazing! This was the BEST way to remember~ and study for my exam! Thank you so much!! I have watched so many- why couldn't I have watched this first!! Thank you!!
This is so far the best video on krebs cycle, thank you very muchhh
Thankk you so much for Appreciating 😅😅
Algorithm is either next level or has a scary amount of insight into my life. I needed this.
I have an exam tomorrow and you're saving my life here
The tips for memorization was so helpful!
OMMMGGGGGG I had metabolic biochemistry exams 2 days ago and was struggling with this cycle why this appear now in my recommendation while i needed it 2 days ago .... TALK ABOUT BAD LUCK
Saved my life. THANKYOOOOOU! 😭😭💕💕💕
I didn't understand at the time of lecture but u r awesome thank u
Have managed to write a citric cycle today, thankyou so much for your simple teaching
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You are welcome 🙃🙃Thanks a lot for Appreciating 😄
Yesss hopefully it'll help me on my biochem oral exams!
Sir it is really excellent shortcut which will not found anywhere but you have thiss👏👏👏👏👏
thanks for the video man
did help a lot. i have my final exam tomorrow i hope i remember this
You are very welcome man!
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OMG, learning the Kreb's cycle was so easi with this video and the one before. Thank you!!!
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A million thanks to you! I feel I know something about the kreb-cycle
Very helpful. Very well explained.
I just realised that I can actually learn Kreb's cycle. I had already given up
Thank you so much 🥰
Brilliant and amazing, It enabled me to memorize them ASAP.
You are most welcome. And thanks for your feedback
wow I have never watched any video which is this good .. big ups to you guys🎉🤗
I just started my MSc and we're first covering the basic principles of biology, I saw the Krebs cycle and immediately came here for a recap. Text books always complicate key concepts!
loved the methodology nd great concepts.....keep it up😁.....I m being helped by this channel💞Thanks
Brilliant! Thank you so much for taking the time to create this useful content!
thank you so much for the video...now im able to remember krebs cycle easily........life saver video
The best video to understand Krebs cycle Everrrr...Thankyou
Life saving lecture ❤️❤️❤️
Thank u very much may Allah bless u i was worry for my presentation that about krebcycle but when i watch this video everything become well nd i understand well Thnk u Dr
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I can’t thank you enough for this video
You are so smart and your video has delivered the information easily!
Thanks a lot
I've got a final this weekend..
Came just in time
😄
I am glad i was able to help!
I have test in tomorrow thak uh so much sir agar apka video nai dekhti toh mai toh yeh que skip krne wali thi pr aab ache se ata he ✨💯🤟
You saved me in my Biochem exam. Thankies !!
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Thank u so much sir i have learned in just 10 mins after seeing this video this video make me a very helpful i confused a lot but now watching this video it makes me a very helpful thank u so much sir for explaining a typical answer in a easy manner tq
Thanks a lot for Appreciating 😄
Very well explained it & simplified properly.. Thanks😊keep it up👍
Today i came to know that ki tallent kis kis roop me nazar aati hain.apka talent is video ne batadiya insallah what a explaination
WHOAAAAAH. This made things simpler for me 😳. Amazing!
Quick Catch, the enzyme used to convert Succinyl-CoA to Succinate is not Succinyl-CoA synthase, it is technically Succinyl-CoA Synthetase. The difference being that Synthase does NOT require the use of ENERGY. Whereas, synTHEtase does which is the conversion of GDP to GTP as mentioned. Other than that dope video.
This has resulted helpful for me... I jzt love this video since i was not able to remember this but now i m perfectly doing this..... Tysm😘😘😘😘😘😘
I wish all the best things for you all your videos are so helpful
Thank u sir🤝🤝 very useful video nd helpful my studies
God bless u 🙌🙌🙌
Kai Dino se Mai ese padh raha tha pr yaad nahi ho raha tha, ab Sala poora samajh mein aa gaya, very very thanks sir ji
Well done on this video and the other detailed video.
Have a big exam in a few weeks.
This helps a lot! Thank you!
I am glad i was able to help! 😊😊😊
I just discovered
the CURE for my INSOMNIA!
THANKS!
this video was extremely helpful ....thank you
to remember when FADH is produced think, FADH with Fumarate, both start with F!!
There is an correction in the video in steps: 1.citrate ~ 2.Isocitrate ~ 3a.𝚘𝚡𝚊𝚕𝚘𝚜𝚞𝚌𝚌𝚒𝚗𝚊𝚝𝚎 ~ 3b.alphaketoglutarate~ 4. Succiny Coa ~5. Succinate ~ 6. Fumarate ~ 7. Malate
~ 8. Oxaloacetate
Note: you might be confused in no. Of steps so its 3a and 3b becoz together its called oxidative decarboxylation and conducted by same enzymes.
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Thank you for the great video!! Small correction: The enzyme is Succinyl coA Synthetase (not Synthase)
synthetase and synthase are interchangeable (same thing).
fariborz607 sythetase- utilizes ATP
Synthases- do not
You literally saved my life!!
Wow, it's an atrocity that I'm only finding this now. Thank you so much!
Thanks a bunch, your video was really helpful ☺️.
I was trying to make my own up and couldnt. This is a fantastic way, already able to draw it by memory.
Glad I could help!
Very helpful 🤗 I am very grateful for this video
This video is really helpful!! Thank u 🤗
i wish i searched this video before it was one day before my biochemistry exam, but this an excellent lesson!
That was amazing, thank you
thank you so much
please continue adding more videos
Its very hard for me
But u made very easy this cycle
So thank u so much sir
Thank you sir u make this cycle very easy to understand 😊
My Trick:
Oh
Citric
Acid
Is
Of
Course
Silly
Stupid
Funny
Molecule
Water in
Water out
Water in
Nadu(NADH2)
cotu(CO2)
naducotu(both)
Gatti(GTP)
FADU(FADH2)
Tamil(h2o)
Nadu
Wow
well explained and great teaching
This is very very very helpful for me to cram for my exams in one night
Frrrr XDD
very helpful, u helped a med student from moi university
This is very cool. I taught HS AP Biology for years and wish I had this to share back then. Very well done!
Good work sir ji 👍👍