Making Benzocaine (Revisiting!)
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- Опубликовано: 11 дек 2015
- This is a revisit of when I make benzocaine like a year ago. I was appalled at how unenthusiastic I was and how sloppy my video was.
The next thing that I put my money to is a proper vacuum pump. My current one smokes after running for 30 seconds. When I get a better pump, I will be able to do some proper vacuum distillations.
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Nile talks about lab safety: • Chemistry is dangerous. 
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The original title was "How to make 90K real fast and leave town"
lol i read a story in my local paper about some drug dealer getting ripped off some guy managed to sell him a breeze block taped up with an hole in the corner which had a tiny bit of coke he tested in it, and he bought it lol the funniest part is the police intercepted the deal and he also went to prison lol.
@@txttxt7482 i'm glad the scammer also got nailed, people pulling scams like that in the "drug industry" likely gets people shot
I came here because I was looking to buy an industrial press and then it said: «people who buy this also buys: Benzocaine» and I was like «yeah these motherfuckers are making fake coke or they are cutting coke with benzocaine and pressing it somehow» 😂😂
Idk much about the street but when I see a press and white substance I know enough 😂😂
Haha you know that!!
"This leaves your nerve cells sad and alone"
Dying XD
+W4t3rf1r3 haha, you are the first person to acknowledge my attempt at comedy
I too caught this. Drug users are sad and alone, that's what I got from it. Thumbs up for education!!
OligoST snoop dog isint sad and alone
@@NileRed You are hilarious ! I love your comedy!!
@@NileRed The start of a dangerous comedian kingpin
this guy is definitely on some sort of list
***** just cause you have a degree in chemistry doesn't mean you're not on some sort of list
***** dude chill, stop taking everything so seriously
Yeah. Dean's List, maybe.
Hehe, thanks for the tip Ality
Danny Carbona best...comment...today!
you sir, have been awarded an internet medal! 🖒
"I should note that it's probably not the best idea, to store a white powder that can numb you, in a plastic bag."
LMAO..
I know right like NO ONE has ever done that before 😂😂😂
ha ha ha, white powder that numbs you in a plastic bag. very entertaining videos.
It's actually used to cut cocaine really often, most street cocaine contains benzocaine
You must have missed the part where he said it can be lethal because it's poisonous
@@OligoST Oh yeah - and cocaine isn't? Sola dosis facit venenum.
Robert Paul Guidry
You can ask if you can make a video showing how pure cocaine powder is transformed into water or liquid using a simple chemistry method and also how to turn water or liquid cocaine back into pure cocaine powder Please some one can explain how to do it more or less simply important was clear thanks
@@OligoST yea of you overdose duh
I really love this channel. I'm a chemist as well, and it's fascinating to see syntheses and protocols that I have not had the occasion to do myself carried out on video . I would like to make one suggestion if I may. You don't have to cut down explanations to the absolute bare minimum. People that watch RUclips videos on organic synthesis are hungry for knowledge and they have a genuine desire to learn as much as possible. I think that your audience might appreciate it if you went into a little more detail on the hows and whys of the reactions. Not saying you do a bad job of it now and it certainly doesn't keep me from recommending your channel to other chemistry loving friends. It's just a thought.
Michael really a chemist?
Hey Michael would benzocaine powder 99% be a viable numbing agent because normal tattoo numbing creams aren't strong enough for me. And are there any health risk.
Hello can me speak u
Mix a bit in with the cream. Topical applications are quite safe. You could just man up and take the pain ;-)
This is also used as a filler partly in cocaine so when they cut it with something inert it will still numb the gums giving the appearance of higher end coke.
So glad I don't do coke
@@OligoST well you wouldn't be doing coke then, you'd be doing benzocaine
@@OriginalCatfish42 jajaja original
Benzocaine don't cook the way coke does it's more like sand instead of a hard crack rock. So if the person that got the coke that was stepped on to make there own crack they'd find out fast and flip out on ya! Ppl get beat up or shot wen they step on it but if they only snort it they may not know the difference especially if they aren't used to doing coke often or it's there first time! Know your audience lmfao. Ijs
Michelle Perrish yeah it grinds my gears when a friend calls and says he’s got good coke and it ends up being cut to shit😡
Great video, really helped me for my IB Chemistry class. Loved how clear all the explanations are and how you take into account safety precautions and concentrations to shift the equilibrium towards products. I will reproduce it for my internal assesment. Overall, excellent tutorial.
Thanks for posting this, I wouldn't have thought to look for benzocaine synthesis.
I carried out the process outlined to create benzocaine for crystal growing. It worked very well!.
Best chemical synthesis channels: Nurd Rage, chemical myst, uc235, and now.... Nile Red.
"Ignorant masses", I think that's a bit harsh. I actually started watching Nurd Rage when I knew very little about chemistry and it really got me more interested in the subject; even if it was on a very shallow level. At the time I would have been considered part of the masses--attracted to the flashy ka-booms in the videos. But now I've completed a bachelors degree in chemistry and am on my way to a PhD in chemistry. I definitely see what you're saying, but maybe there's value in impractical reactions if it will generate a greater interest in science (the world could always use more scientists!). Oh and Doug's Lab is good too.
I'd like to add 2 more: Tyler Dewitt - A great source for people learning about chemistry. (makes it really easy to understand)
and Cody's lab - although I don't like watching him as much, he shows you can do a fair bit without a professional lab setup. (so maybe he doesn't belong in a 'Best' channel lineup..)
Listening to you I figure out you are much more ignorant than most of us involved in this videos or chem. lovers
Much love for Doug's Lab. He's just so darn enthusiastic!
One thing to be aware of with molecular sieves is that they are slightly basic. This means that (in this type of reaction) if you add conc. sulfuric acid to them, they will be fairly likely to decompose to an amorphous sludge. They should still work (perhaps to a lesser degree, but i'm not certain) but it would involve a few additional filtration steps to remove the sieve powder.
On a related note, don't do what I did and try to store your beautiful clean glacial acetic acid over 4A sieves.
"I should note. That its probably not the best idea to store a white powder that can numb you in a plastic bag." I'm dead😂😂
Also you can use a Dean Stark or a Soxhlet extractor packed with 4Ams (or 3Ams) to remove the water from the azeotrope and return anhyd solvent to push the equilibrium. However the rxn time will be increased as sieves aren't fast at absorbing H2O.
Can u turn this into cocaine?
No u cannot!
Well than Nile I do believe we must part ways now.
i had to just do a read up on words so here's the information for the random denizens of the interwebs i don't know
the word cocaine comes from coca + ine (coca from cuca which was a group of people)...... so this information was lost i guess when cocaine becomes co-cane
the substance was important due to the hunt for anaesthetics, before this point we could get them drunk or dope them on morphine
the subsequent anaesthetics therefore inhert the "cane" part of the word, procane (branded novacane)..... they seem to bear some similarity (the ring and the double oxygen bond, the presence of nitrogen).... they have all therefore been categorised as amino-esters
so in conclusion to this science, maybe you should try snorting some and seeing if you like it, it may have a similar effect to cocaine
@@DarkShroom do u really think benzocaine snorted would do anything? If its a local anesthetic then wouldn't it just make ur nasal cavities numb.
@@yui_bernz you can mix it with meth and make fake cocaine
AutisticGHOSTdog try caffeine crystals plus lidocaine it produces id say 75% the same effect you just need to add some mdma or ketamine and youre all set to make big dough lmao
@@SuperDragler where to get caffeine crystals and lidocaine?
LOVE YOUR VIDEOS
i literally check my notifications everyday to see if there's any upload from you :D
+Shivam Bhatt :)
+Shivam Bhatt me to every day i check
Would there be a risk of molecular sieves interfering with the reaction at all? I.e. could you put the sieves in a dean stark trap if there were any such danger?
Thank you for the videos !! very interesting ! keep on !
How are Methyl Diethylamide or ethyl groups considered hydrophilic? If anything both ends of the caines shown would be hydrophobic and the center ester/amide would be the hydrophilic one. I imagine this would cause quite a weird confirmational change.
I think the intro part with the explanation was great!
Thoroughly enjoyed this mate. Where was you when I was back in school. 🖖 Keep up good work
I did esterification my first year of chemistry but we didn't have 60-90 minutes for the reaction to take place. We also forgot to add the concentrated sulfuric acid as the catalyst. The reaction didn't go as planned but I learned a lot about esterification from watching your video, thank you!
How did you forget to add sulfuric acid lol
have to say i just starting watch your vids, and I really like you informative way of describing thing, as I am no chemist at all.
I just did this with about a 76% yield. That's even after I had a foaming accident that lost several grams of product.
I used a soxhlet extractor with molecular sieves to get the water out of the alcohol as it was refluxing.
I used 40g (~0.292 mol) of PABA and about 250 ml ethanol, 15 cc of 98% sulfuric, and let it reflux for 2 hours.
Then I added it to a saturated solution of sodium bicarbonate. I got too happy with the pipette, though, and that's when it foamed over.
Washed it a couple times with distilled water, vacuum filtered it, and let it dry for 2 days in a sunny window.
When it was nice and dry, it yielded 36.53g (~0.221 mol)
My pick for the next video is clean sulphuric acid drain cleaner and really keen to see synthesis of nitrous oxide very soon. Keep up the awesome videos!!!
With partially reacted H2SO4, wouldn't you get some CaSO4 with your bicarbonate solution that then precipitates with the benzocaine?
+Nile Red How do you find that cold-finger condenser for reflux? Better than a Liebig?
Hot tip for higher yield... Reflux through a soxhlet extractor that is filled with 3A sieves, to remove water that shows up during the reaction. I'm averaging 86% of theoretical.
How strong does the acid need to be? Thank you in advance for any answer i know its an old video
That biochem explanation was great!
It being reasonably pure, it would be pretty safe to try, right?
I'm curious as to whether or not it works.
And are you going to store it 4ever and never use it again or eventually convert it to something else?
Wouldn't slowly neutralizing hurt your yield? As you would be removing reactants from the equilibrium. Or would this not matter due to the neutralization of the sulfuric acid, it being the catalyst?
+Chase Wilbur Technically it shouldn't because like you said, the sulfuric acid would be first to be neutralized and it is the catalyst for the backwards reaction. I would say though, that I wouldn't be surprised if some was lost.
could you not use magnesium sulphate pearls at some point within the apparatus to absorb the water vapour during relux?
"because you love me", of course you know I do. You and I have chemistry lol
just an amazing chemestry channel
can you use magnesium sulfate as a desecant or it will just disolve into the water etanol solution?
Would the water washing of the beaker potentially form a small amount of PABA as you filtered everything?
how would i make numbing cream out of this powder? could i just add water to it? or maybe glycerin?thank you.. i need it for a tattoo
Can you use Ammonia or NaOH solution to neutralize the pH?
You are very interesting and i love to watch all your videos.
Thank you❤
3:03 I very much enjoyed your explanation.
Would adding more sulfuric acid produce a better yield? Also, how do you know if you have your product at then end- is there a test you would recommend to identify esters or this molecule specificly?
The acid is just the catalyst. You could use less, but the reaction would take longer. Use more, and it won't speed things along very much. The yield would be roughly the same.
To increase yield, you can pull out the water to keep the reaction from reversing. (but the reagents are relatively cheap, so why spend too much time and effort?)
With reactions like this, the "end" is pretty much a judgment call.
Nice and simple procedure. Do you just use a recrystalizing dish as an oil bath?
Could the H2SO4 be added via the reflux condenser?
That way the solution would stay non-viscous, allowing the stir bar to stir.
=> No manual mixing required.
And since we're already heating the solution, heat from H2SO4 addition would be less of an issue.
how can we make essential oils like apple scent or perfumes we use in detergents ?
i would like to see a video about acetone synthesis
One quick question... at 1:11 the diagram shows benzocaine and lidocaine, but on the hydrophilic end of benzocaine there are no polar bonds, and there are polar bonds on the lipophilic end of the molecule, how does that work? Surely for something to be hydrophilic it needs polarity and equally so for lipophilic it has to be non-polar? Bit confused :S
A stupid question, but how did you calculate the yield? could you tell me step by step?
Interesting video. Now, is there a practical application? Would you mix it into maybe Vaseline to make a topical numbing agent? Maybe an ointment or cream for hemorrhoids? Maybe dissolve in some liquid to spray on for sunburn? In what ways would you NOT want to apply, (besides internally of course).
Where in the name of Bob did you get that condenser I have to get one I've never seen a condenser like that in my life and I've worked in labs after 9 for 35 years!
I love googling a random thought and being directed to a Nile video
Did you add the molecular sieves?
What type of condenser is that?
Have you attempted to redirect the forward reaction towards bupivicaine?
So would this be dissolved in water and injected in the local area?
1:40 cool, wonderful to hear about the stuff I just used on my gums
Where can i get all those things he used to make this? Are they possible to get for normal people and where?
Dá para fazer a reação com solução de bateria (ácido cloridrico com concentração baixa)?
This might be a dumb question but if benzocaine has an hydrophilic end why can you wash it by using water?(the same with the lidocaine one). Like i get that the salt form is hydrophilic but is'nt he clearly refering to the "pure" form? Thanks in advance
In the first benzocaine video you mentioned showing how to make it absorb through the skin, did that ever happen?
hey dude, just to get this straight, concentrated sulfuric acid MUST be 99% or can go lower like 30% ?
This was really cool!
Can someone explain how the freebase benzocaine precipitates out when the ph hits 8?
You can take pure life oral anesthetic with benzocaine and put cold water in it strain it off and you'll have benzocaine but still some by product left, can you use some type of ethanol to clean out the rest?
I'm curious, couldn't you use molecular sieves as a drying agent?
"Explain as little as information as possible" goes on to explain how nerve cells work. It's hard to catch the dry and sarcasm in these videos but when you do it's hilarious.
Wouldn't molecualar sieves decay in an acid solution like this though?
Can you use anhydrous methanol instead of ethanol?
Why do local anesthetics only prevent the communication of certain stimulai for only sensory nerves?
birch extract sounds amazing
Is both the sulphuric and ethanol 100%?
What do you plan to use the benzocaine for? Out of curiosity.
Can this be put on burns and cuts?
Blistex "kanka" for lip/mouth sores has benzocaine 20% as the main and active ingredient, but when it comes in contact with water, a sap-like substrate forms. Would this still be a good candidate for the process?
+J Alvi If you'd like to extract benzocaine from OTC products choices like Maximum Strength Oragel are a good option as they have similar strength and fewer additives than the Blistex product, mostly PEG. I've misplaced my detailed lab notes, but the simplest method is to use benzocaine's temperature-dependent solubility in water.
Roughly: Mix 0.5mL oragel into 15mL cool distilled water, centrifuge/settle and pour off the liquid (a mix of water, PEG, sucralose, and flavoring, all of which dissolve well in cool water. Not sure what temp is best for 'cool' here, as cold as possible while still diluting away the PEG). Add 15mL distilled water and heat in water bath to ~98C. While maintaining temp, add sufficient distilled water to completely dissolve the bead of molten benzocaine that forms. Cool to ~5C, crystals will precipitate. Filter.
The resulting benzocaine crystal should be quite pure. It's great for growing crystals via either slow cooling or evaporation. Makes nice feathery white crystals. Yield is fairly economical, benzocaine solubility in very cold water is about 0.4g/L, so only about 15 mg or less is lost each time water and crystal are separated.
Fascinating. It would be great to get this 100% pure for practical use for pain relief eg. root abscess or sore throat (while waiting for proper treatment of course).
It literally is. Not 100% though.
+Nile Red would it be possible to isolate barium from Barium nitrate using a solution of barium nitrate and copper than heat it on a hotplate
+Riley Crocker Off the top of my head, i have no idea. I have never really dabbled with barium salts.
Feeling _unenthusiastic_ and _sloppy_ when making bags of anesthetic?
Well, I never! ;-)
Great stuff as usual. Thank you.
I am sub-layman level, interested in everything, fascinated.
Lol
How that paper clip is making the solution to stir?
If you're still hunting for a Dean-Stark Apparatus, you can totally get by MacGyvering one out of a Claison/Distillation Head and a stopper with a keck clip.
Now that recreational cannabis is legal in the US and Canada could you do a synthesis of THC from olivatol and pulegone or a terpene extract or synthesis?
Couldnt you use a soxhlet packed with calcium chloride to get the water out of the reaction?
I can boil it without condenser ?
Would you ever be willing to teach anyone how to do some of these experiments?
Can you use a different acid?
Hi, don't you think that the Ethylgroup on Benzocain is Hydrophobic? ;) 0:36
Benzocaine is pretty much insoluable in Water
hey i’m new to this level of chemistry so help me out a little but are you referring to the C2H5 bonds on benzocaine as an ethyl radical? cause a true ethyl group would be C2H6 right? sorry i’m 5 years late hahah just confused and if ur still here i’d appreciate the clarity
At :39 it says the ethyl group on benzocaine is the hydrophilic part? How is that
+The Herb It was a poor choice on my part.
Can someone tell me what kinda equipment i need? Like how is his thing stirring without him touching it. Also do these flasks have certain names? Thanks in advance
Fuckk Face
Here's some googling material to help you out, mate
-Test tubes
-Test vials
-Watch glass
-Glass stir rod
-Metal spatula
-Beakers
-Round bottom flask
-Separator Funnel
-Elmer's Flask
-Hot plate/Stir plate (the one you asked about)
Please publish the phosphorus tribromide synthesis and film the production of vanillylamine.
Do you plan to make a video of the bromation of alkohols with your produced phosphorus tribromide?
Is it safe to buy chemicals of websites like ebay?
And next up on Nile Red, 2-(3-fluorophenyl)-3-methylmorpholine) synth.
Lol jk. Great video Nile, looking forward to your video about cleaning Mercury. :)
Or maybe (RS)1(Benzo[d] [1,3]dioxol-5-yl)-N-methylpropan-2-amine? That would be pretty cool :)
Doubt it haha. :P
Different time or dimension.. Everyone's getting along... I notice nothing but hate nowadays.
Hello Nile Red, grat video.
Although unfortunately OTC PABA is very expensive here and full of fillers. Do you have a video or any instructions about the synthesis of PABA?
Best regards
+Nitrato ... making paba is not the easiest and it would be a pretty roundabout method. You can either extract it from pills or buy it online like i did.
+Nile Red thank you for reply Nile Red. I will try another chemical store sources then.
beautiful video.
Are you using a base to precipitate the Benzocaine out of solution? So this is what freebasing means?
Where do you get PABA?
What do/did you study? thanks for the biochem intro. Im glad you dont hold back on your wisdom :)
0:40 why is the methyl group on benzocaine hydrophilic?? It's not that polar, is it?!
Was für eine Temperatur hast du gewählt?
Can diethylamide or ethyl groups be really considered as hydrophilic?
+piranha031091 I would consider the amine functionality of the Lidocaine hydrophilic. The ethyl group though is definitely not hydrophilic.
As I'm watching this, I had to put a little on my tongue that I made about two years ago the exact same way. (hell of a toothache remedy) I used sodium hydroxide instead of sodium bicarbonate to bring the benzocaine out of solution.
Thanks for the video and information.
God Bless
7:55 I decanted off to a nice broken beaker, yep, a nice broken beaker...
This kind of flask, What kind of temperatures can it stand?