Antibiotic Resistance is Way Worse than You Think...
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- Опубликовано: 17 сен 2024
- Uncover the alarming reality of antibiotic resistance and its historical context, from deadly pandemics to the groundbreaking discovery of penicillin. Explore potential solutions, including cutting-edge machine learning, offering hope for a resilient future.
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Crazy to think my great grandmother was born in the old world (pre-penicillin) and has lived long enough to see antibiotic resistance become a growing problem. She’ll be 102 in July
Yup I can relate
@@Jen39x feel u , my mothers aunt is 107! and still lives by herself, they have seen so much.
My mother was 100 last year. It is amazing the stories she tells us. She lived through The Depression, was a nurse during WW2, and worked her whole life until 70 in offices - so she saw massive changes there.
@@midnite_ramblerunfortunately mine is riddled with dementia and hasn’t been able to put a coherent thought together since she was probably 97. I did get to hear a lot of good stories as a kid, but not so much anymore.
My wife's Grandmother turned 100 on June 11th 2023. She passed away on Oct 26th, 2023. A war bride from England, her life was full and happy. She still had her own teeth!
Last year, I got a bacterial pneumonia. A doctor gave me antibiotics, but the disease didn't fully subside. I then saw a lung doctor who told me "Your doctor was sloppy: for the last 20 years or so, we've treated bacterial pneumonia with combining two antibiotics because it's resistant."
TB is currently resistant, so you have a cocktail of 6 drugs you take twice a day, for 6 months, because otherwise you will die. Even so half the patients stop taking it after a month, because "they feel well", so now when they rebound they need 12 drugs, and often then die.
There's a vaccine for pneumonia bacteria now
Oh my.
That's terrifying
Pneumo can be hard to isolate from sputum, so sometimes it takes a while to get the antibiotics right. I've never heard of just giving two antibiotics by default, but I guess it depends on where you are.
Conincidentally, everyone started vaccinating babies for pneumonia about 20 years ago.
I was watching dr. Dray (the Dermatologist) earlier today, and she discussed how one of the most troublesome things she often has to discuss with her patients is to *not* do anything -- and let the body and time recover on its own. The issue is, patients often expect their doctors to prescribe them medication (specifically antibiotics), and will most times be upset if the healthcare provider does not. Antibiotics are a miracle drug, but should only be used when absolutely necessary. Our society is dependent on instant conveniences that we ignore the dangers -- cost -- we ought to pay later on for aforementioned conveniences.
Thank you for making this video. I think it's not something everyone is aware of or is often discussed in schools enough
An example: people presenting to the doctor with a virus (e.g., influenza) and "demanding" antibiotics, which are useless in such cases. I see this often.
@mongo88now88 as a pediatric LPN, in our office I see the massive difference in severity of flu after antibiotics are started, usually for an ear infection that developes from the virus. I completely understand why adults/parents want antibiotics for their kids. So while I don't believe the antibiotic is helping with the virus, I DO believe that some symptoms of the flu is the start of a bacterial infection and those symptoms are lumped in with flu symptoms. (I hope this made sense.)
Yep. People want zero suffering or discomfort and that’s just not reasonable. Discomfort is good for us, we should get comfortable with more of it.
doesn't help that at some jobs you'll essentially get in trouble for being sick or get fired
I took antibiotics for years to deal with tooth infections rather then getting the teeth removed. I knew there was a risk of developing bacteria that would be immune to them. What I didn't know was that I could become allergic to Amoxicillin. No one told me that. Now I can't take any without breaking out into hives and nearly passing out.
My mom contracted MRSA while in the hospital. Unfortunately it was in her respiratory system. She was already fighting severe diverticulitis that had required 2 surgeries and the infection had become systemic. She had to be in the dark in ICU because of the drugs being used intravenously. We all had to wear masks with face shields, gowns, booties, gloves... it's a terrible, horrible thing and after 7 1/2 weeks of fighting, she passed away. Please be really careful. ❤
I'm so sorry that happened to you.
Rip mom
I am sorry about the loss of your mother 💔
Thank you for sharing the difficult passing of your mum. I'm sorry for your loss, and certainly hers.
So sorry for your loss. She was a fighter. 7 and 1/2 weeks. I can only assume pain. You should be proud. She obviously had wonderful people she wanted to stay with in her life to fight so hard for so long. RIP
I trained in plastic surgery at Johns Hopkins (the Johns Hopkins/University of Maryland Shock Trauma Program). We had a patient in the ICU. He was a soldier from deployment in Iraq. He had Acinetobacter spores on him, from the desert sands. The spores germinated into bacteria and became pan-resistant to all antibiotics, including Colistin. When Colistin won’t kill something, that is the definition of being f*ck3d. The patients on each side of his ICU room contracted the same Acinetobacter infection. All three died. Before they died we sealed off the ICU and moved all other patients somewhere else.
When it came to decontaminating the ICU, it took the applied physics department at Hopkins to literally create a robotic machine for the purpose. It sprayed an unbelievable dangerous peroxide on everything in the entire unit for over 24 hours. The cost of the decontamination alone was over $50 million. It worked.
It took the best of everyone-infectious disease, intensivists, epidemiologists, applied physicists, and more-to put their heads together at one of the greatest hospitals in the world to come up with this plan. There are only a few other hospitals capable of this expert mobilization. They pulled it off, but barely. I cannot put into words how close we came to not successfully decontaminating that unit without the Acinetobacter getting out of the unit. How it never got out of the unit I don’t know. It never showed up again in any patient.
But, I guarantee you it did get out on nurses and doctors, therapists and anyone else near. They were healthy. So they didn’t get sick. But it’s still out there. Those spores will never die in the world environment.
Most people will simply never understand how insanely scary this is. It will happen again, and it will eventually not be contained.
That's incredibly scary. I hope this gets pinned or gets to the top comments because that shows exactly how close we are to something really bad. It already exists, it just hasn't woken up yet.
That is quite terrifying.
More likely you made this up
@@majormarketing6552 copium
I'm not sure if you're a person of faith, but in the Old Testament, God instructed the Israelites to destroy a city (literally executing all of the inhabitants, except for those who hadn't engaged in sexual activity.) It's possible all of the inhabitants were infected with syphilis.
Another factor to bacteriophages that I'm pretty sure he missed is that 'phage resistant bacteria end up losing some of their antibiotic resistance in the process of developing resistance to the bacteriophage, so treatment could be as simple as pairing a bacteriophage with an accompanying antibiotic.
Yep, I remember doing a project about this in university. Essentially as the bacterium gets phage resistance, they lose antibiotic resistance, and vice versa.
Nature will find a way ... but yeah, this will give us a few years/decades and save countless lifes. But eventually, we will face something new, may be some nasty fungi?
That's really cool. Thank you for the info.
To go beyond that, we can, theoretically, develop bacteriophages to attack the very structures that that bacterium uses to protect itself against antibiotics. That way, it's a kind of damned if you do, damned if you don't scenario.
@@friedrichjunzt Luckily, it doesn't matter if fungi are antibiotic resistant, because they don't work on fungi anyway.
If it wasn't for penicillin I might have never been born. My grandpa was in the pacific theatre WW2 and got pinned down in shallow water behind rocks n coral on a kinda failed beach landing. A Japanese sniper bounced a bullet/shrapnel off a rock behind him and hit him in the leg, he was prone and bled into the salt water for hours before help got there. When he got to the doctors they were like, hey it looks pretty bad but we have this new experimental stuff called penicillin, its been working really good, wanna try it?
As always, soldiers used as guinea pigs to test the experimental stuff.
jesus christ that was the trickshot of the millenia
damn japanese snipers were insanely good
I took antibiotics for years to deal with tooth infections rather then getting the teeth removed. I knew there was a risk of developing bacteria that would be immune to them. What I didn't know was that I could become allergic to Amoxicillin. No one told me that. Now I can't take any without breaking out into hives and nearly passing out.
I would be dead if not for antibiotics. I got so many infections as a child, I wouldn't make it, I think. There were many people who died young in the past. Chopin, famous composer, perhaps one of the best ones, died due to tuberculosis of the lungs and larynx in his 30's.
thank you for making me realize that:
- i go through semi-regular (medically called for) antibiotic rounds.
- the last 2 times my gut/intestines seemed to recover remarkably well compared to the fi... oh no
good news: the good bacteria in my gut are now more resistant to antibiotics
bad news: they might teach their cousins the ropes..
My mother-in-law developed a Clostridium difficile (C.diff) infection in her gut. It's a notoriously difficult Gram-negative bacteria to treat, and only two antibiotics have been approved where we're at to treat it. The weaker one didn't work, so they put her on the stronger one. She was on it for YEARS and still getting recurrent infections even though she was in a nursing home and they were obligated to ensure that she got every dose. It got to a point, as the infections became more frequent again, where I had to ask her doctor what the risk was that her C.diff infection was becoming resistant. "Oh, no worry." Bull. Every time it surged and got knocked down, it had another chance to evolve and adapt against the drug that was always in her system anyway: that's a recipe for developing resistance.
I was also given a lot as a kid they dodnt end up curing me of pneumonia for months so my mom got a traditional Chinese herbalist and he cured me in weeks with whatever that horrid stuff was. Also same with tonsillitis and same later in my life after I had horrific side effects from super strong chemotherapy grade antibiotics they gave me for an ear infection even after it was banned but there's no way to alert doctors something has been banned. Christ. Whenever they have suggested antibiotics after that l ilsaid no. Cured my kids toe infection with manuka honey whcih they use as a last resort to good effects got rid of gum disease with oregano oil and staph on my skin with iodine. So many old weapons that still work.
You just cant win. Might as well not even try. Welcome to absurdism.
@@DeborahRosen99people don't realize how prominent it is in the health care field. If you receive enough antibiotics inside of a hospital to nuke your gut flora you're getting it. Not only is it incredibly hard to kill inside the body but you have to use bleach to kill it outside the body. Alcohol doesn't work like it does for BASICALLY EVERYTHING ELSE
@@StainsStainsStainsI think more and more people are feeling that way. And a society that's willing to throw it all away isn't a healthy society
I remember during my 16th birthday, I had turned out to be a staph infection on my legs. I went to a clinic and they gave me a script for penicillin, but my mom wisked me back home to see my primary, and they gave me a different antibiotic and tested some of the sores. Two weeks into a four week treatment, they told me that I was resistant to that antibiotic (which was crazy because the sores had been going away)
I got it from a beach. There had been a high bacterial levels, and we didn’t know about it until after I had gone swimming with scratched open bug bites.
I remember back in the 80s part of the problem was identified as being people given antibiotics when they didn't need them. Another problem was people not finishing their course of antibiotics therefore they were not killing them all and creating resistant bacteria. (many member of my extended family worked in medicine)
The giving antibiotics practice when not needed is very much alive and well in asia.
Definitely. We've brought a lot of this on ourselves.
In China, you have a sprained ankle. Antibiotics. You have a depression. Antibiotics. Basically, you see a doctor. Antibiotics. Often dangerously strong one's at that for some reason. (Quinolones) @@juslitor
@@juslitorantibiotics can be bought over the counter in many countries.
Patients not finishing their antibiotics is mindbogglingly common. So is taking the leftovers years later for something else entirely, unfortunately...
I still remember an older gentleman coming into our cardiologist office a few years ago for shortness of breath. During the exam he mentioned that some antibiotics he took before didn't alleviate the symptoms. Doc asked him who prescribed him the antibiotics, pretty confused as the cause for his short breath was very clearly not an infection which any halfway decent doctor should have recognised.
Patient just shrugged and said he still had some leftovers from an ear infection like 7 years ago.
A little off topic, but Simon reminds me of a Bond villain sitting in that chair. All he needs is a fluffy white cat on his lap.
Lol true I see it 😂😂😂😂
He did have a white space heater for a while.
Considering his disdain for dogs, it would have to be a cat.
Lol instead of Jaws, Simon is
BEARD 😂😂
@@noneofyourbusiness6496
*everyone has no idea what your saying*
My friend does this research as virologist. And his conclusion is that its going to come from either india or china, areas who dump massive ammounts of antibiotics in their population but the hygene standards are still so subpar that its creating more resistant diseases
Hell, one of them already released a pandemic.
Or USA? Or anywhere where antibiotics are taken for everything AND especially livestock. Livestock sounds scary because anyone can give antibiotics to their pigs without knowing how to use antibiotics. Then the excrement goes to water system or compost so yum.
@@ksoosk true but the zoological transfer of diseases is harder compared to human ones. Not saying it wont ever happen or cant, the likelyhood is more that it will be developed from human hosts before animal
@@jkee9760 There is horizontal gene transfer. As the video also remarks, in the water reservoirs non-humanborne and humanborne pathogen intermingle, and due to stress factor exchange genes. Species are much less clear in the microscopic world. Those bacteria can them make it in the water supplies and share their gift to others.
@@fluffy_tail4365 I guess so, I'm not a virologist and this was remarked by my friend like 6 years ago.
I just paused this video because, even though I've heard the phrase a million times, I was curious about the story that birthed the expression "sword of Damocles". So for anyone else curious:
Dionysius, king of Syracuse (in Sicily) was always worried. He had the finest foods, sweetest wines and most gorgeous women at his disposal but he seemed disinterested in all his finery. One day, his closest friend, Damocles, mocks the king for his constant sulking. So, annoyed, the king suggests that they swap places for a day, but while sitting in the throne Damocles was not allowed to get up and a sword would be hung above his head on a horsehair thread. He has his day as king but has little interest in all the finery he now has access to and is simply consumed with anxiety over the sword. When Dionysius returned the next morning Damocles practically threw the crown back at him and the king explained "when a king is crowned an invisible sword is hung above his head. Pirates, thieves, plotters and revolutionaries would cut the thread to steal the crown, hanging their own sword in the process" Damocles never mocked his friend nor wished for his crown ever again.
So now I finally understand, a "sword of Damocles" is the foreboding of an imposing event, imagined or real.
Cheers
For anyone else interested in a better told version of the story, See U in History/Mythology does a great video on it.
Thank you kind sir
I like this explanation the best: ruclips.net/video/LGzc0pIjHqw/видео.html
Thanks for your work mate in finding out and letting us know. I was in the same position (heard it a million times)
I contracted MRSA in 2009 while working EMS and have become septic twice almost died, had a septic joint infection in my ankle a few years ago had to get emergency surgery and a follow up surgery later that week due to reinfection. Got sent home with a central line and a months treatment of high level antibiotics... Killed the infection but still have MRSA so yeah really fun.
Its still in your joint? Why are they not trying to get rid of the last of it I'm so sorry
@@RustyShakleford1 MRSA colonizes your body it never leaves, it waits until you body is weak from illness, stress, or injury then does it's thing. My immune system is so messed up from it now it's ridiculous. It never goes away just a waiting game until the next round.
Whats crazy to me is here in the US we STILL give amtibiotics to combat teen acne. I got monocycline for couple years for acne from 2009-2011 when i was in high school.
Turned out im fructose and lactose intolerant and within a month of cutting all that out of my foods, my skin cleared up. My IBS symptoms went away. I stopped getting migraines. I slept WAY better.
This experience of every doctor telling me medical problems(IBS, acne, migraines) and advanced ways to treat it. When it was actually just my diet and exercise. Made me become an exercise scientist and now medical researcher. I hate the voodoo marketing BS around food but we really are what we eat and so many doctors, even GI doctors, look at it from a textbook manner vs a holistic manner.
And i get why. the system incentives are to move quick, prescribe and then access. The system and patient both want quick results and being mindful of foods(something most people interact with 3-5 times a day) can be tedious and puts a lot of the Onus on the patient being diligent and doctor educating vs doctor fixing everything.
Oh god yeah - my acne was caused by a hormone imbalance but my doctors refused to do anything with my hormones till I was 18. What did they do instead? Prescribe me antibiotics that did practically nothing for YEARS. Which was so pathetic because I switched doctors as an adult and he asked me to do some blood tests and prescribed me a hormone blocker. My acne cleared up so fucking fast, compared to almost ten fucking years of painful cystic acne and dermatologists prescribing me different antibiotics and topical creams that did jack shit.
@@ag8454 my high-school girlfriend was pizza face and wore 3lbs of makeup to cover it up.
Within 2 weeks of getting on birth control her acne was GONE. Acne use to stress her and her mom out so bad, after the birth control, her mom made jokes that "who knew her teenage daughter having sex would be a stress relief, not a stress maker"
-also im 30 now and I still think of how cool, loving, and supportive that family was. I strive to build my family like how the mom of my Ex built theirs. Its too bad i stared into the abyss as long as i did and let that relationship die.
Never be afraid to love those around deeply. Be the type of parent you wanna be.. When you see something good, take note and emulate. Never know how you'll effect others. I haven't spoken with Exs mom in 8years. I swear I think about the love, care, and support she showed me and her daughter least once a week.
So you stop eating fruits and drinking milk?
@@DAMfoxygrampa and anything with fructose added into it. Which in the US is a lot of things. Like no pop tarts for me. No keylime pie. No casseroles they're milk based. Etc etc
The acne was a byproduct of of my intolerances, I had massive gut distress everytime I had those things.
@@morsumbra9692 Yikes, sorry to hear that
This is why I don't take antibiotics unless I have a serious infection that won't end up going away on its own. I've only taken them twice and both times were due to severe wounds
Unfortunately, if you catch one of these antibiotic resistant infections, that won't make any difference. But I'm in the same boat.. I've only ever had 3 rounds of antibiotics in my life.
That's the ideal way to take them, though most resistance has stemmed from industrial misuse in animal farming :( the freely buy them without a prescription it would be much more chaotic, that's why it's insane to me that you can buy antibiotic ointment OTC in the USA
@@Jakey4000you can buy it because it's only topical and you can't get any beneficial effect from ingestion.
The much bigger issue is antimicrobial soap. You're telling me we'd live in a happier society if every cut on my hand that enviablely becomes infected due to my line of work just stayed infected and painful for weeks?
@@stevenutter3614 chill, weirdo. I'm not telling you anything.
I'm allergic to penicillin and derivatives, so I've always tried to avoid antibiotics if possible since I already have so few to choose from. I also have to second-guess my physician every time. When I tell them I'm allergic to penicillin they always think, I might get some pimples. No bruh, I can die from that, I'm not being unnecessarily complicated.
I can't take it either. I almost died from it as a child. I was always
extremely careful about sex partners. I also can't eat cheeses made
with it.
I've taken to always telling doctors the nature of my allergic response. That tends to make a doctor go 'oh. Let's give you something else, then'.
Nah yeah, I vomit repeatedly for days. I’d rather not do that lol
I react to Penicillin and Clarithromycin both not deadly but my fingers swell to truly uncomfortable sizes and I get the typical rash but that was after one time use so if the dose was high enough or I got repeated exposure it could develop into a deadly reaction. Most doctors are fine with that though I also try to avoid Erythromycin if possible because I get the full broadside of side effects (the shits and vomit) but I can take it if necessary. But I've found most Doctors are accommodating. I also don't need antibiotics very often thankfully
Allergies to penicillin killed my great grandmother not long after it was released into stores. My brother is also allergic
The thing about bacteriophage that makes me feel confident about them is that unlike stagnant antibiotics is that phages are arguably alive as such they are under the same biological rules that got us into antibacterial resistance bacteria - biological armrace. In essence, the as the bacteria adapts to the phages resistance the phages adapt more strategies to infect them
Thats a negative in my opinion. Studies have shown that bacteriophages already have the ability to influence our immune system (let me know if you want a link). It's not far fetched to suggest that once they run out of their bacteria to kill, they may mutate to infect probiotic bacteria, and with enough time, may be able to infect immune cells, or at the very least cause immune cells to go haywire.
I've talked to some of the scientists working with them. The problem is that they're adapting very strongly to that very specific line, and he wind up needing to have a huge bank of thousands and thousands of phages and getting a sample of the infection bacterium and testing which of them works against it before you can use them.
What's more interesting is it seems like there are certain phases that evolving resistance to them necessarily requires losing antibiotic resistance due to the mechanisms of resistance...
@@personzorz ah so like a combination of phages and antibiotic might be a different avenue could be the most realistic approach
@@personzorzbecause we have to sensitivity panels on bacterium for Abx already. Particularly with some the more awkward ones like Staph, Pseudomonas etc. Having a good Bank of phages could make that plenty viable. The difficulty then would be storage, transport and availability from panel results to application.
I shattered both legs in 2001. A resistant staff was introduced into my bone marrow during the surgeries to repair them. The damage from the wreck was horrific the damage from the lack of cleanliness in the operating room was DEVASTATING
I know here in the Netherlands: The use of antibiotics is only used as a last resource.
Our own bodies can do a lot by it self if you provide the right nutrients, or assist with common medications.
Assisting certain ailments, so the body can focus on what maters.
I have resistant bacteria in my bladder it’s colonized and many things have pushed it into my bloodstream and I have to have iv antibiotics for a week in the hospital then more at home until it’s clear. Happened 4 times in 2022. When I come in the er I tell them get my infectious disease dr on my case.
It’s not fun being disabled
I have PBS and chronic UTIs, I know how it feels to have to have to go in yet again like "Yeah, I know what this is already." In my experience the doctors always get super stuck up at that point but then act confused when it comes back and I was right. They never want to trust the disabled person who's been experiencing these problems for usually a long time.
online brand rheas holistic would be fun for you to check out.
Please ask your doctor to look into bacteriophages (Google it, it's not some sort of weird alternative therapy)
@@rocketterrier
I absolutely hate how doctors assume patients have no idea what ails them. Like to them apparently you HAVE to be in the dark about any medicinal knowledge because you’re not a doctor despite living first hand with whatever condition it is.
Especially given most of them are glorified pill pushers now a days anyway.
Yep, those are very likely resistant. But the phage therapy is resurfacing. We've used them for about a century, but they are trickier than antibiotics.
I've had a quick glance at a summary of studies and it looks like it works great. If you want to read for yourself: Phage Therapy in the Management of Urinary Tract Infections: A Comprehensive Systematic Review
One issue is that you can't make as much money from bacteriophages as with antibiotics, because you extract them from the environement and multiply them. That's not something you can patent. Maybe the way you do it, but we've been using them in the soviet states for ages. There's no "big" money to be made and it's difficult to get a licence for it because technically every different bacteriophage would require a new licence.
Just a tiny correction from a scientist: mutation don’t occur because of the antibiotic treatment. They occur spontaneously, but if they have a positive effect on the survival, for example because they help against the antibiotic, they will be kept.
Think about a zebra getting its stripes. The “horse” that is was before didn’t have these stripes. If the zebra lived in the artic, it wouldn’t benefit from stripes. If an organism mutated to have stripes, it would probably be eaten more easily, because it can be seen well in the snow. And of cause mutations can be bad under all conditions, for example if you are deaf as a zebra. Or you have an immune system weakness.
It’s the same for bacteria, just that one generation for them takes usually like 20 minutes, compared to us humans that take 20 years or longer. I hope my point is clear 😄
There is a metaphor used to explain this concept around 12mins in :)
@@terryenby2304 I don’t quite like the metaphor personally and it doesn’t make the point that clear neither in my opinion.
To sum it up bacteria aren’t fighting off the antibiotics, the antibiotics just don’t kill all the bacteria meaning the ones that do survive had a trait to make them survive that they than pass on
www.ncbi.nlm.nih.gov/pmc/articles/PMC7642495/#:~:text=Antibiotic%2Dinduced%20mutagenesis%20is%20one%20of%20many%20factors%20that%20influence,of%20antibiotic%20resistance%20remains%20unclear.
@@terryenby2304 That metaphor doesn't clear up the misunderstanding introduced 7 minutes into the video. It's simply not accurate to say that mutations are caused by a selection pressure.
I had an infection, but the doctors never made sure it was gone by the time the meds were out. I would let them know I didn't feel like it was completely gone away, and they would tell me they wanted my immune system to take care of the rest. Well, it keeps coming back and I have only ever gotten them to extend my dosage by once, by a week. It feels like they're making antibiotic resistant bacteria, and my body is the subject.
That qualifies as malpractice
Sue them, this should NOT happen.
You do know you can get a second oppinion from other doctors?
@@GusOfTheDorks you do know how insurance works? Or doesn't work to put it more accurately.
@@Fred_the_1996 pay for the lawyer and I will
I am absolutely excited for this episode as I am a medical laboratory scientist working in a high volume bacteriology laboratory running patient samples, and as such have a vested interest in AMR. In fact, for the practicum I need for the Master's in Public Health I'm pursuing, I intend to work with my lab's technical director on AMR trends in our large demographic.
It is nearly 2AM, so I will be listening to this on my way to work tomorrow. In the meantime, anyone here in the comments with questions should feel free to ask and I will answer whatever I am able.
Thank you for the info. Can u please provide me with your email ID. I have some serious concerns i want to discuss.. I won't trouble you much.
Thanks in advance
What trends are you seeing? What area of the world are you in?
I’m so sorry your mom is having to go through this. Sending healing & comforting thoughts her way. 😢😢
This is why I decided to do my PhD (in my final year woo!) in making a new antibacterial drug.
It's far from perfect and my final year is going to be making modifications to make is a better drug which gets into the body more effectively.
There is a silver lining, the biologist who does that side of things has shown that the bacteria he tested it on can't seem to become resistant to it. Not sure why, but it's promising.
While I doubt anything I make will be used in humans, I hope someone can carry on my work to the point of it at least getting tested in animals and maybe, getting a human trial. Statistically that's where it'll fail, but at least it gets a shot.
If it passes, well, I hope we can reduce antibiotic usage enough that my drug that'll be reserved for the most drug resistant infections hardly gets used.
I hope your research proves fruitful! I studied biotech in high school for trade school and i remember learning about antibiotic resistance and being scared that i know overprescription was happening by qualified adults whereas I, a humble 16 year old, was aware that viral infections need to be ruled out before antibiotic prescription. Now Im 25 and thinking of going back to school for neuroscience, but it sucks that patients need to deal with the consequences of careless doctors.
Congrats on your final year and thanks for helping humanity 🫡
Dope. Let me know if you need help on any level. ❤
@@yourfinalhiringagency3890congratulations! You’ve just volunteered to be the first in their human trial.
Ayyyee thanks for doing the hard work 😊
Pharmacist/ drug development researcher here….
Would love to hear about your research interests/molcules/ favorite carbon skeleton
My mom does research with drug resistant bacteria and says she always has to be on the lookout for another bacteria that only has one known antibiotic that works because if it somehow mutated with drug resistant bacteria and rendered the antibiotic useless, it could possibly be a world ending event.
@ivanschlotzky1378
70% of the European population died.
That was before the world was so interconnected allowing diseases to spread more easily. Look how fast Covid became an international problem.
Not world ending, world resetting for that pathogen to 100 years ago
@ivanschlotzky1378 today it's different. Would end the world as we know it. We saw how fast COVID spread. If that happened but with a more deadly disease, it could cause a serious issue. In fact, the pathogens required to do this probably already exist in labs.
@ivanschlotzky1378 the human experience of the world . And many many people didn't make it
@ivanschlotzky1378well it probably won’t end in the literal sense but the one we are accustomed to would change irrevocably 😊
I contracted cellulitis in 2018; a strain of MRSA was the culprit. Fortunately, I was able to be treated with the first antibiotic series they tried. I only had to spend one week in the hospital. Antibiotic resistance is a big deal. Having to try multiple antibiotics to find one that was effective could have made complications much worse, possibly fatal.
I currently have cellulitis, had it for about 18 months. It is just in the one area and hasn't spread, but it also won't go away.
@@midnite_rambler, that is unfortunate. The concern with cellulitis is that it usually spreads rapidly where it can then lead to sepsis.
I hope your physician can find an effective treatment for you.
Staph infections are no joke, I caught one on my arm last year from the gym and over the course of a week it took over my whole forearm, was so painful, swollen and I had a fever. Luckily it wasnt MRSA but my doctor went under the assumption that it was given the first round of 2 antibiotics didnt help and prescribed me a 3rd, cut it open and drained it and then it got better.
From what I’m told MRSA is not a thing you develop. All MRSA is, is a unidentifiable infection.
My sister had this.. it didn’t go away with several attempts.. but then they got it.. what’s weird too is her commune system was completely unalerted also until the antibiotics started working (and then cam in in full force poor thing) .. so the beggars had dodged detection there also.
I contracted MRSA in 2008 that got into my bloodstream while I was already fighting Sepsis, My life has NEVER been the same.
I'm sol sorry I know you pai. 2 year ago al not died from sepsis still have some infection left in my bone I'm bedridden in pain short of breath. The feeling of gasping for air still gives me ptsd. How are you doing? Praying for you
So you had multi-sepsis then?
My gf spent two months in the hospital due to a septic MRSA infection and the osteomyelitis it led to. Absolutely horrible.. good job on this Simon, hopefully it leads to something good being done.
In my microbiological classes we were advised that the best to clean our kitchen is with a clean rag (boiled in water is best) & cold water. Microbes need 6 things to survive; Food, Acidity, Time, Temperature, Oxygen, Moisture. We have limited ability to control/limit these in our kitchens but the easiest is food. Just cleaning surfaces with hot water is enough to heavily reduce & limit microbial growth & what microbes that do survive will develop no immunity to lack of food, will become the dominate microbe in your kitchen which you will develop a resistance to (tough luck for your guests lol) & limiting new microbes for taking hold. The best war on microbes is no war at all, just as they adapt, we too can adapt albeit slower.
Correction. Soap and hot water, not just water, is most effective.
@@dr.michaellittle5611 Soap does cut through grease & fat, very hot water does kill microbes both helping to clean surfaces better so you are correct. However as the surface cools down it will go through the ideal temperature that will promote microbe growth for a short while which is why we were told cold. To be honest the water temp doesn't really matter as long as you remove all food & dry the surface
@@TheFalconerNZ Soap is used to reduce surface tension and permit the facile removal of microbes. This why surgeons use hot water and soap to scrub before surgery.
Or just clean with iodine solution, if you dont mind the staining, aint no bacteria around that will develop resistance to iodine.
@@juslitorwhat about ethanol?
I am not a doctor by any means, but farmers sometimes (depending on what they're growing) try to avoid planting one type of crop each year to avoid letting specific diseases for the plants evolve. Maybe we can do the same by developing different kinds of antibiotic sets, and globally roulate the antibiotics in use. This might help making next generations of bacteria not resistant to one particular antibiotic anymore. The challenge of course is making sure everything is getting roulated correctly...
When places like China ignore even basic hygiene practices in their food chain, can you really expect them to use antibiotics intelligently?
That's a really smart idea! I think there may be a few obstacles, like some antibiotics only work on some bacteria, and some people have allergies, so there are some limits on what ones could be used and workarounds would need to be paired up thoughtfully in the rounds, but I do really love your idea!
It doesn't work that way sorry.
Smart idea and some studies imply that this way, we could irradicate antibiotic resistances in a few years. Unfortunately, we refused to wear masks during a once-in-a-lifetime pandemic because of stup... sorry, "political" reasons and "freedom". Telling people (worldwide!) not to use specific antibiotics for a year or so won't work for the same reasons Covid could kill millions and why Climate Change will wipe out hundrets of millions.
@@HondaMonkeyMan it does, but time needed might be a bit too long. Producing additional proteins inevitably requires additional resources. So resistant bacteria will be outgrown by their non-resistant siblings in normal conditions.
But population replacement will likely take multiple years of not ingesting antibiotics, which I assume is unlikely for most people using them.
One of the laws of nature is that the harder you try to kill something the more it strives to survive. Bacteria are no different.
Otoh the Dodo proves things can be genocided.
But this is a chicken and egg scenario, no? These bacteria must have existed before we tried to kill them, or they'd be dead. So logically if we never tried to kill them at all, they'd still be out there and still be reproducing.
So what benefit is it to us, to not even try? They'd be murdering us if we never discovered penicillin.
You can exterminate multicellular. But bacteria literally can guess the surviving set of scripts, and _share_ it between the other bacteria. Also, they sometimes adopt _viruses_ to do that.
Many things won’t but bacteria are notorious good at it.. it’s what they are made to do.
In December 2019 I was 31 years old and in a medical coma in the ICU for 10 days then spent another 17 days in the hospital after going into septic shock. At one point I had 2 IVs in my right arm and 1 in my left. This all happened from what my doctor and I thought was a simple uti. It spread into my kidneys and created 3 huge abscesses on my right one. Even vancomycin 3 hardly had any effect on this infection.
The pain was unbearable to the point of begging a nurse to put me out of my misery. To put it in perspective, I've given birth naturally 2 times and those were a breeze compared to the pain I experienced with this infection. The pain was similar tho. Like a deep, crampy feel. It also came in waves. I'd say it was like giving birth while also suffering from kidney stones and a stomach virus. Even with fentanyl, the pain was too much, so the medical coma was a welcomed relief.
Since then I was diagnosed with stage 4 ovarian cancer. I've had chemo, multiple surgeries and procedures. One surgery involved stopping a bleed on the outside of my lungs. It involved going through my ribs. Yet through all of this an antibiotic resistant infection was the worse thing Ive gone through.
Thats a sign of Great resilience
I live in the municipality of Chatham-Kent in southwestern Ontario Canada, where animal factories are driving, antibiotic resistance. Biohazard signs are popping up in front of the so-called, “farming“ operations. If you want to help stop, antibiotic resistance from killing people, then reject factory farmed meat.
Are the biohazard signs because of the feces or because they legitimately are aware that the antibiotics are causing dangerous resistance in their feces? I know one meat processing plant had to refuse meat with antibiotics because their workers were getting crazy deadly infections from small cuts from butchering all day
@@RustyShakleford1 the biohazard signs are there to dissuade people from exposing the horrors inflicted on the animals within the battery operations.
@@RustyShakleford1 The sad part is that on many of these animal factories fecal matter is often allowed to drain into lake Erie.
Coming from a pharmacy view point, I see quite a few of my community patients come out, and back into hospital after already being on a hefty antibiotic course that didn't work, especially vulnerable people i.e the people most vulnerable to covid. It's becoming more and more frequent, and no end is in sight since antibiotics aren't sexy drugs to invest in research for since they dont make killer profits like ozempic, though the damage long, and, or strong antibiotics can do long to renal function (kidneys ability to work) means quite a few people are dying from renal failure, like my grandfather in 2020. If we really want to get ahead of this we need governments around the world to collaborate on funding antibiotic research.
Also so many people don’t take them properly.
@@Dgnmuse yep, that's also very true. There's a good reason why I always write ***ANTIBIOTIC - COMPLETE WHOLE COURSE*** on antibiotic lables I write, though god knows if people actually do that
I choose to not use antibacterial cleaning supplies in my home and personal care, unless I don't have access to soap and water. I do have bleach based cleaners for some things like the toilet but that is it. A former workplace had 2 (of 4) who would wipe down everything with antibacterial wipes 3 times a day and use hand sanitizer in addition to washing their hands. Guess who never had a sick day and who caught something every two months or so.
Common sense cleaning and not overdoing the antibiotics goes a long way towards keeping the immune system working
Just use sodium hypochlorite and or hot water... bleach isn't antibacterial is it I don't think?
actually you should definitely use antibacterial cleaning supplies for your bathroom and kitchen. there sure is overuse, but don't be an idiot and keep the places you eat off or bathe in bacteria free.
What they said ⬆️
@@ivoivic2448 Soap, water, air drying (if you don't have or choose not to use heat drying like a dishwasher), and only using wood cutting boards are good enough. I am 68 years old and get a cold maybe every 2-3 years and have never had a food borne illness. The wood cutting boards have been proven to be a natural antibacterial as long as you wash them and let them dry at least 2 days after using them for meat. Again, common sense > chemicals.
Any vinegar or bleach or rubbing alcohol is fine. The actual products are $1.25 but if you want to spend an extra $5.00 for fragrances or "gel" consistencies, that's cool.
My daughter has been put on antibiotics 2 days ago and i literally googled all this a few hours ago and here you are in a better format for my drive home from the hospital. Dont stop contenting please 😁
had mrsa 2 times. treatment is always with me hospitalized with a drainage of the abscess and antibiotics every 2 hours on an IV pump changed out by a nurse. if you have an infection with a spreading hot red ring around it, please get it checked out. it needs to be treated no matter what.
you can draw with a pen or sharpie around it to see if it spreads
I took antibiotics for years to deal with tooth infections rather then getting the teeth removed. I knew there was a risk of developing bacteria that would be immune to them. What I didn't know was that I could become allergic to Amoxicillin. No one told me that. Now I can't take any without breaking out into hives and nearly passing out.
Bruh what...
So that's *YOUR* problem?
Is the infection gone or your tooth fixed?
that's insane that you took them so long. antibiotics can also destroy your intestinal flora.
@@devynkyng I took them for 4 months because I was misdiagnosed with a tooth infection that spread to my heart so I treated myself with 15grams of amoxicillin a day and 4 grams of keflex daily for over 3 months
I’m ridiculously prone to sinus infections. Ridiculously. I’ve had them last for 3 months. My mom and sister are the same. Im so prone that I no longer seek medical treatment beyond OTC medications for the symptoms because I feel it’s irresponsible and unethical for exactly this reason. It sucks, but it’s better than contributing to a superbug.
My mother used to have constant sinus infections. Turns out she has Chronic Immune Deficiency. She was always on antibiotics. These days she takes infusions every 6 weeks. Maybe sinus surgery might help? It helped my mom for a good while. Best of luck!
Edited for grammar
I got constant sinus infections, bronchitis, and even pneumonia when in lived in Florida. I moved to Chicago for school and it instantly cleared up. I would just get a bloody nose every now and then during the winter from the dry air. I’m not moving back.
Same here, I used to get them regularly as a kid after getting a cold. As an adult luckily they stopped but if I ever get one again I'm just going to let it run its course and only seek antibiotics if it doesnt clear up.
I've heard of this, it's terrifying, and I experienced the over-prescription first-hand ^^' general doc couldn't figure out my persistent cough and tried antibiotics before referring me to a lung doc who figured out.. some kind of rare form of (likely stress-induced) winter asthma, can't blame the general doc for missing _that_ of all things but I really wish we skipped the antibiotics step until proven necessary
I feel it, I've had doctors throw many seemingly unnecessary medications at me that only seem to make things worse instead of better
All they do is guess until they get it right.. I could do that and fuck myself far less.... Rarely ever go to the doctor for a reason
That's some good looking flagella!
BTW the idea that a viral infection doesn't need antibiotics is somewhat misleading. A viral infection can cause the immune system to hyper focus on viral antibodies and it allows opportunistic bacteria to divide unencumbered.
Great great great point it also alows us to divert energy from fighting bacteria in out digestive tract
Using antibiotics as a supplement for hygiene for livestock probably doesn't help.
The easiest way to manage your money is to take it one step at a time and not worry about being perfect😊
After meeting Mr James in the United States, my life changed completely. Yours can change too, it's just a matter of commitment and focus.
CRISPR and mRNA based antibiotic research is in it's infancy, but is incredibly promising.
Yeah, especially if you correct one dna strand. You soon discover, you have a chance of getting over 600 other diseases. Sounds like a winner.
Mrna should be shleved
MRNA treatments are probably going to be MASSIVELY unpopular because Big Pharma decided to lie to people and call it a v**cine.
Even if it is promising it's not going to catch on because people HATE being lied to and they know they that Big Pharma is willing to sell them genetic alteration treatments disguised as something else. Sickening.
My grandfather told me about this phenomenon back in like 2005. Interesting.
I remember this in a biology class in this same timeframe 2005. I remember hearing that antibiotic resistant bacteria was supposed to be a pandemic and the prediction was estimated to be in the same place as COVID-19 did from 2020-2023 plus kill the same amount of people COVID-19 did.
Yikes, just remembering that I was on Doxycycline, (antibiotic) for literally 4 years for acne, and only went off it because a blood test that showed I had a persistent infection we didn’t know about from somewhere.😅
i do a few doxycycline for acne prescriptions a day and i have no idea why they still do that.
I work as a lab tech dealing with bacterial resistance. many of the multi-billion dollar pharmaceutical companies only want 'high profit' molecules, i.e. 'antibody therapies'. I have talked to a few directors in an upstate NY company that said, "it's a problem, but for the future."
If that mind set continues with what I see in lab (severe resistance to aggressive medicines), we will need to be very diligent in our prescription of antibiotics.
Solid video, thank you!
When I was in college doing the Paramedic program (1995) I did my research project on communicable disease outbreaks. One thing I read in a book called the CCDM (Control of Communicable Disease in Man (now changed to Manual) was the possibility that 30 years many antibiotics would be far less effective. Even though technology is making progress, that book was too close for comfort.
Gee, there's not enough stuff out there to scare the shit outta me, let's see what Simon is up to today... oh God
It's been at least 2 days since my last existential crisis.
Thank you for making this video! As a Medical Laboratory Scientist, vancomycin resistant enterococcus is one of many antibiotic resistant organisms, and its terrifying. When the carpet bomb of antibiotics doesn't kill the bacteria responsible for your illness its pretty bad.
1: We over prescribe antibiotics without sensitivity testing of the pathogen responsible for the illness to determine the BEST antibiotic to be used. Blindly tossing broad spectrum antibiotics at every infection has brought us here.
2: Patient compliance in taking the entire dose thus allowing the pathogen (The more resistant surviving bacteria) to continue to infect the patient.
Be better physicians! Be better scientist! and be better patients!
I've just recently recovered from a chest infection, developing into pneumonia by Amoxicillin resistant Streptococcus pneumoniae. What I found surprising was they doctors want a sputum sample on the first occasion. If one had been provided, then the Doxycycline prescribed on the second occasion, could have not only been provided to me earlier, but it also wouldn't have exposed my microbiota to amoxicillin, thus spurring some exposure which could lead to future resistance, in an instance whereby Amoxicillin could previously be effective. Broad spectrum worked in this instance, but I do fear the future consequences of it.
I work in food microbiology so I don't actively test for antimicrobial resistance, but I take a heightened interest in it, and see increasing levels of it these days, especially with more KPC in E.coli, Klebsiella and even Acinetobacter. It's scary
Great episode! That's despite that there were a few issues. Like E. coli isn't typically a pathogen, some strains are, and some can be. And, about strains, a whole species doesn't change instantly, there can be differences within a species that are huge for us, like in pathogenicity and antibiotic resistance.
One aspect I think is important and interesting is that completely new antibiotics will only be used extremely restrictively to delay resistance development, and therefore not sell much, and to get their money back the pharmaceutical companies would have to charge astronomical sums for each treatment to get their money back, and that would limit their sales even further, creating a viscous circle of increased price and reduced sales, and the pharmaceutical companies already have a PR issue.
Another thing is travel, we travel around the world and transport strains that have increased resistance, we don't "just" breed and select very heavily for resistance, we also distribute the resistance, combining strains from all over the world, and the bacteria can then combine the genes that we select for. Remember, it takes just one individual "super-bacterium" to create a new "super-strain" as bacteria don't dilute their genome every generation as they reproduce by binary fission, but still can adapt their genomes by HGT.
Still, for youtube video, I think it was great!
I had some sort of bacterial tonsilitis, maybe strep, that just kept coming back after like 4 rounds of antibiotics seemingly clearing it up, and then ending up returning a month later. I knew antibiotic resistance was a problem, but I didn't realize I'd deal with it so soon. Luckily I haven't gotten it again since
I had strep for weeks and it's awful, all the antibiotics messed up my stomach for months as well which was the cherry on top. My tonsils are frequently inflamed. Next time you feel something funny in your throat use half hydrogen peroxide with half water to do gargles with every time you brush your teeth for a few days. It really helps.
As a nurse, there's been some long term patients that have stayed in hospitals for months on multi-IV antibiotics running. I think the longest was 13 weeks post op knee replacement. He was having PiperTaz 6 times a day and i think fluclox 4 times a day, so like (time of day 24hr clock): 0600, 0800, 1000, 1200, 1400, 1800, 1000, 2400, 0200, 0400. Trust me, you don't get sleep/rest in hospital. He finally went home but with a PICC line and baxter bottles (more IVAB at home) until dropping to oral tablets. Antibiotic resistance is hell!
I got a pretty painful UTI. The Urgent care clinic kept prescribing me different antibiotics because it kept coming back. It was like "lets try this one! Oh, didn't work? Let's try this one!" Continuously pumping me full of useless antibiotics until the fourth one finally worked when they finally tested the strain of UTI to see if they medication they were giving me was right, instead of just the generic.
I ended up hospitalised on IV specialist antibiotics due to bacteria being resistant to others. It started as a simple urine infection, by the next day it had spread to my one kidney. Dr gave me some antibiotics, sent the sample off for analysis and I didn't think about it. Until he rang me the next day, explaining that the bacteria was resistant to all but 3 antibiotics here in the UK, and only one of them is a tablet, the others are IV only. I swapped to the new antibiotic and it seemed to help, but then I relapsed and was rushed to hospital. I ended up spending 3 nights there, on different IV antibiotics and being tested and prodded constantly. I'm now on an antibacterial medication to stop a recurrence. Rather than taking antibiotics every day and risk more resistance from them, and more stomach issues for me, I take a tablet twice a day that makes the conditions in my body (specifically my wee) inhabitable for them to live. And so far it seems to be working. The tablets are awful but if it works I can't complain.
I’m a molecular biologist and my first ever lab course was to seed E.coli on an agar plate with ab. The idea was to showcase random mutation rate that gives resistance. 2 plates out of 20 got it and this was only overnight incubation.
I am deeply afraid we are doomed. My mom, regardless of what I say to her even with my degree, every time she gets a tickle in her throat or a cough she starts a self medicated antibiotic treatment which often only lasts 2-3 days. I’m literally awaiting the bad news one day… she gets sick more and more now as she ages and the recovery is slower and slower. It doesn’t help that her pharmacist and doctor friends either prescribe or outright ignore the requirements for selling antibiotics.
Thank you for spreading awareness! this is indeed one of the most difficult problems we face as doctors! just last month i finished treating a resistant bacterial infection in an elderly patient over the course of 2 months! luckily the patient survived! but not without complications! the sad thing is you do what you can with the resources available and yet you get screamed at by the patients relatives for not having a magical cure!
Last time I had antibiotics was for pneumonia. I just thought I had a bad chest, but no, it was pneumonia and I'd been ill for 10-14 days.
The doc said 'You're past the worst of it, but I'll give you AB's' and I was getting better within in 3-4 days.'
Problem was, that I got pneumonia during winter and breathing cold air felt like I had barbed wire in my chest!
Don't get pneumonia!
Antibiotics definitely help you feel better quickly. Still need to finish the entire course to completely eliminate the bacteria, but you're definitely feeling better quickly.
I just commented on some one else's comment about this.
I had pneumonia last year. Nearly killed me. Under 40 amateur triathlete, so I am not at risk in the sense of being out of shape. Take great care of myself. But it just dropped me dead. They were calling family type stuff. Both lungs completely covered after two weeks of failed otc antibiotics. Resistant to everything I was given. They had to use "last resort" medications via IV. I didn't feel better quick like normal antibiotics. I was released with my blood oxygen still high 80s low 90s. Still sick when released. It didn't feel right. Follow-up doctors from multiple specialties (I have crazy work health requirements, so I had to be checked out thoroughly) said my immune system never responded to it like it was a bacterial infection.
Negative for covid (5 tests), Flu A and B, a swab that supposedly tested for 25 different viruses was negative, negative for MRSA, Staff, legionaires, literally everything. Cough was not productive at all to test anything directly. Still a complete mystery.
I think my body just defeated whatever it was on its own, and I got lucky. To this day, I have no idea what happened. Took 9 months to be fully recovered.
Ever since I have been obsessed with things like resistance and disease as away to deal with I never got an answer. Videos like this are Iike Crack to me lol
ahhhh my daily dose of dread....thanks factboi
🤣
I like how Simon has both the sense to relate a lot of his content to things American viewers (the most numerous) but also adds British references too. Just like choosing to use an S.A.S reference rather than U.S Navy Seals for example 😊
tbf the SAS are just as popular and globally known as Navy Seals.
it is exactly as expected, I was at conference around 2000s were this was a recurrent topic, and not much has changed in how we use them - promoting resistance
I remember in med school every infectious disease doc talked about this with great concern because there are no current solutions
I wonder if the old antibiotics will start working again after a time, and how long that time would be. Like, bacteria won't need to defend against those antibiotics if they stop being used because they become so ineffective, so over time they may lose the ability to do so. Obviously it wouldn't happen fast enough to matter to us now, but I'm curious all the same.
Could happen. Bacteria don't get the resistance for free. Thicker cell walls for example can protect from some types of antibiotics but cost more calories to build up and maintain. So in an environment where the resistance is not needed those that do not have it (or lose it through mutation) will do better and replace resistant bacteria.
Pathology and hygiene should be a required class in high school
Scientists: "We need to develop more antibiotics or we could end up dying from a papercut.
Pharma Companies: "Not profitable enough, guess we all die, and F you!"
Thanks Simon,
This video was especially pertinant as I got Acinetobacter Baumanii from an operation 2 years ago.
I am now constantly on antibiotics, and not your regular ones, but super strong kill anything ones.
And still I keep getting infections because that bacteria mutates rapidly. But if I don't take them, I can get delirium from the constant utis.
Which means getting abusive and inappropriate treatment at the Hospital until the infection is under control again. So far that has happened three times.
I also have a massive leg wound and the infection gets in there and in the bone causing oozing, and highly intense pain. Again, only fixed when we can get the infection under control again.
It cannot be cured with any of our current treatments, and I can't afford anything experimental or new as it won't be subsidised. Luckily I live in Australia where health care is free or most likely I'd have died from it already.
What lovely timing. I'm currently fighting a bad bacterial infection on my right foot for the last 2 months. I've been to the doctors, and had IV antibiotics, as well as 2 more prescription antibiotics. I just took the last of the antibiotics last week, and my infection hasn't improved at all. I will be going back to the doctors tomorrow. This infection is really REALLY painful, to say the least. This is piss poor luck, because about a year ago I had a staph infection on my other foot that lasted 6 months. It finally took several days in the hospital and a lot of IV antibiotics to finally get it taken care of.
What type of antibiotics did they have you on? Ceftriaxone?
@@RustyShakleford1 I don't recall the IV antibiotic, but the 2 prescriptions were Doxycycline and Amoxicillin.
@@RustyShakleford1 I went back to the doctor 2 days ago. According to them, the infection is all but gone. However I have whats called a chronic non-healing wound. Supposed to be seeing a specialist this week to figure out why its not healing.
@@jeremybr2020 it's not healing because they misdiagnosed you and stopped antibiotics now they are delaying treatment prolonging ypur suffering nd hoping it heals by itself it's bs
@@jeremybr2020 chronic non healing wounds after and infection???? My as. There's still a bit of the infection left or necrotic tissue or bone that is hplding some live bacteria stopping the antibiotics from petetrating and stopping healing or delaying it
Yes, this is one of the primary threats to human existence presently. It deserves extraordinary funding to repair the problem.
Humans existed for hundreds of thousands of years before penicilin use.
We need Simon on Hot Ones. Assuming he even has the time with all the channels he runs.
Only Sean could ask all the questions we want to know, and Simon would handle the hot wings like a champ.
You think? I mean he could, but in my experience the British guests don't often seem to do well :P
I recently had a 2 month cold/cough. Went in to get checked for a possible chest infection and i was more or less told off by hospital staff for 'trying to get antibiotics and cause issues with infections in the future'. They sent me there to get tested. If i had an infection i wonder if they would have shouted at me anyway
Good. I’m glad they told you off.
@@sugasheeze why? The hospital ordered me to go in to get checked because im imunocompromised and had suspected pneumonia. Its common in my family we have lung issues. Idk why you are glad that they were rude and judgemental after ordering me to stay there
As a physician who had to moonlight working urgent care to survive in training, the number of uneducated people requesting unnecessary antibiotics is insane. We created this problem when we made healthcare a transactional system. Patients who come for the most benign things like a cold or sinus congestion expect a course of antibiotics. They will act like animals if you even try to argue against it. Why do you think z-packs don’t work anymore? Because every patient expected one from their PCP every time they got a cold. They’re not getting better from the antibiotics, their body is fighting off the cold but they see the antibiotics as the thing that helped them improve.
I've probably grown penicillin resistance..
Augmentin is seeming to not work on me and I'm just 21 and I'm scared and having sleepless nights and I've no clue what to do or how to feel..I've never been this scared in my whole entire life.. I'm crying and losing hope..
Listen, I’m not saying that us pumping antibiotics into the animals that we’re gonna eat is a reason why bacteriums are becoming immune to them however, I do have to say it would make a whole lot of sense.
some countries, like China for example, prescribe antibiotics for everything from the common cold to a broken bone. i'm not a medical professional, but they should probably stop doing that.
I had the most extreme soar throat I've ever experienced a few months back, it had me worried that I may dehydrate. Pieces of throat tissue came up after it was over when I coughed.
This is fascinating. I am currently writing my Bachelor's Thesis and we are researching a relatively new kind of antibiotic.
I survived a severe MRSA and was in hospital for many months. All I can say is that I'm glad the scars are not on my face.
So backstory. I have been getting tonsillitis ever since the 5th grade, so about over a decade now, I'm 23. And almost every year I get it. They have always prescribed me amoxicillin (an antibiotic) which is just the general treatment for tonsillitis. Well for this holiday season I got the worst case of tonsillitis I've ever had. At first they prescribed me a high dose of amoxicillin but there was no effect at all for almost 2 weeks. So I went back and they were surprised it hadn't worked. They ended up giving me a strong antibiotic shot in my bum and even then it didn't help much. So they prescribed me clindamycin, which is a very strong antibiotic supposedly. After being on 10 days of that it seemed to have done the trick. All I can say is I think I'm building a resistance to amoxicillin. RIP
Nice, I had tonsillitis every year from age 5 to 17, and ended up with Hodgkin's lymphoma as a side effect. Also wrecked my teeth, since my tonsils became a bacterial reservoir instead of a functional organ.
@@maniaclaugh Wow that is terrible. I feel empathy for you. I hope you're able to have them removed if you haven't done so already. Ik insurance can be tricky and it's sad that it's that way. I hope the best for you!
Started this comment once and the video ended, so had to find it again. Clindamycin is very strong, it cramped my feet so bad I couldn’t walk. Guess it dries the body up, not sure. But I had a bad case of strep.
I've been resistant to amoxicillin since I was a child and got over 40 ear infections.
The doctor didn't recommend a tonsillectomy?
Well I mean... What I fear is the only natural possible outcome.
See we invented swords, so we invented armour, we developed swords better, so armoured followed etc, towards the end a knights armour was so advanced that sword fighting was deemed absolutely useless and people instead fought to exhaustion and then were executed with a dagger. This continued until we invented the firearm and for a short period it was impossible to defend against until once again new armour development emerged.
What does this have to do with bacteria? Well just like us, bacteria is a living creature that wants to survive, so much like us, for every vaccine we invent, a new resistant version comes. The only way to defeat this is to outright end all bacteria as even good ones could evolve into bad ones if needed for its survival, much like some animals went from prey to hunter after a few thousand generations.
The issue here is thst qe cannot live without bacteria as they are much like all natural things, a part of an extremely precise ecosystem that we reply upon to exist in the first place.
This is all fine and dandy right now as I'm sure we amazing humans will find a way to defeat bad bacteria for millions of generations to come. There will always be an era of a "gun" that can't be protected against until we invent the needed "armour" for it and this cycle will continue for the foreseeable future, when bacteria invents their version of "gun" that defeats our "armour" of whatever currently is the best we have, currently thst being antibiotics, we will more than likely develop the next thing to keep us alive for another century.
So I'm not worried about things in my lifetime, I'm simply saying that this could end in disaster though, because we got tired of this endless battle so we invented the nuke, the weapon of all weapons to end it all. There is no armour, there is nothing stopping it, it just cannot be defeated. The only thing we could stop it with was reason and compassion in promising each other as humans to simply not use it given its guaranteed devastating effect no matter the protective measures.
What is my ultimate point then? Well what will we do when the bacterial equivalent of a "nuke" happens? Something so undefeatable we just CAN'T do anything medically? Unlike humans, bacteria lacs compassion, you cannot reason with bacteria to stop and coexist with us peacefully in a symbiotic relationship, it just acts on pure instinct to ensure its own survival, in other words billions of tiny humans all carrying their very own self defense nuke with absolutely no care or compassion, I wonder what that will bring.
But given the seemingly "endlessness" of perfect loops in most ecosystems, perhaps the bacteria will slow itself down to let us live, not from a logical or understanding standpoint, but more of a natural eco system standpoint, as in bacteria needing creatures as a host, that being us, so to ensure it's own survival it let's some hosts survive to ensure a place for the next generation of bacteria, much like us now healing tge nature we destroyed during the industrial revolution.
The only counter I have there though is that humans are already looking to repopulate to Mars, so what's stops bacteria from going... Idk lets say, "Screw humans, let's consume them all, we'll just evolve to live better in monkeys and we'll live inside them after!" in some weird unknowing self destructive manner.
I know this is just theoretical mumbojumbo with no real scientific basis, I'm just trying to speak my mind noticing patterns of attack and defense in nature. Hope it at least caught somebody's interest to stick reading to the end.
Have a nice day though if you read this far, why not end on some random positivity, it's the least one can do during these difficult times with all issues going on out there. ☺️
I have chronic sinusitis and growing up I was thrown antibiotics all the time! I’m on them for a sinus infection now but I dunno when I last took them. Now I always try massage and sinus rinses and my doctor tries steroids if it isn’t a full blown clear infection. Makes me a feel a little better that at least where I am theres less antibiotics being prescribed.
If you’re currently on antibiotics, it’s best to finish the entire course as prescribed. Stopping antibiotics early can cause antibiotic resistance too, not just their overuse.
God Damnit I got angry reading that post @@techneti_um
@@techneti_um I always do! Im just taking them less overall in my life
No, I genuinely believe that my strep throat every summer or two is the worst a bacterial infection has ever been on this earth for any mammal.
The machine learning sounds like a great solution, as a one size fits all approach caused a penicillin resistant wound infection in my case. I had a wound infection that responded well to penicillin. When I finished the antibiotics it was still a little pink, but I was assured it was irritation rather than infection and I didn’t need more antibiotics. Two days later it was gangrenous, and when I went back on the antibiotics they no longer worked, so I had to switch to a new one. I’m sure instances like this contribute to resistance, and if we can adapt our treatments to each patient it will be a great help
At some point bacteriophages will be our only hope
The problem with phages is that their use could only be very short term (say 2-3 days) and the same ones can never be used again in the same patient. This is because your immune system will make antibodies to them, which block binding to the bacterial receptors, making them ineffective. Its’s very much like what your immune system does when you’re given a vaccine of attenuated virus.
Having had Mac/MIA (a bug similar to TB, though supposedly not contagious) that cost me part of a lung, the version I had was resistant to antibiotics, and so that treatment failed, requiring the removal of a portion of my right lung followed by a series of infusions of a very very nasty antibiotic. Wasn't fun.
Can you do an episode on the Romanian orphanages during the Iron Curtin?
My mom caught MRSA from a hot spring one summer. Took months and months to treat it. Was actually terrifying that nothing worked for so long.
What was she treated with??
@@RustyShakleford1 it's been long enough that I don't remember off the top of my head but I'll ask if she does next time I see her.
@@Lythaera OK thanks wishing you and your moms all the best in life
Coworker had what sounded like a bad cold. He went to a clinic and they gave him broad spectrum antibiotics.
I told him that was a really bad practice and they shouldnt have done that. He told me they always do that.
used to work at a shitty urgent care and the amount of broad antibiotic pills and shots that were given for anything and everything astounded me. its a wonder if rocephin and amoxicillin work for anything anymore.
I don’t use antibiotics unless it’s a good infection. But years ago I caught a sliver from an outdoor picnic table and in 2 weeks my butt looked like a Kardashian implant. I had a MRSA infection and needed a 3 drug cocktail to beat it.
Speaking from experience, I almost lost a leg due to resistant e-coliforms (post surgical infection and 2 rounds of antibiotics before we cultured it). 2 surgical “cleanings” and a wound-vac later, I won the war. Not a fun time, haha.
I remember when I worked at an urgent care where it was never more clear to me why this will always be a problem with our current system.
"Everyone who walks through that door gets a script."
These are the exact words I heard the department supervisor say, and the medical director agreed with her because he was part owner of the company. It's not healthcare, it's a business. They really don't care about correct use. They care about making customers happy, and no ones happy spending money for a visit only to be told, "Just go home and get some rest. You'll feel better in a few days." They want a drug they can take that will make them think they'll feel better because they're taking a pill. It's a mess.
Greed is the root of a lot of problems these days.
"It's not healthcare, it's a business."
No, it's healthcare. Healthcare is a business. Healthcare does not magically bypass the laws of economics. This is incredibly important to know.
@@psyxypher3881Ask yourself, “When I was a child, did my mother give me healthcare?” Mother Teresa was a business woman?
Anticipation of antibiotic resistant bacteria is why I bought my first Rife machine many years ago... they can evolve to resist chemicals, but they can't evolve fast enough to change the frequencies they vibrate/resonate and go pufffff at being subjected to....
I remember a video about Soviet chemists using bacteria-killing viruses to clean hospitals, surgical incisions, equipment etc.
In agriculture antibiotics are given to animals to help them fatten up, not just to protect them. Gut bacteria consume a lot of calories, calories that can be used to make animals mature for slaughter faster. Farmers give antibiotics to animals to kill their gut flora so they'll get bigger faster
Exactly our immune system takes alot of calories just fighting our gut bacteria that enter
Keep going
The downfall of humanity is the use of antibiotics for animals and short antibiotics courses.
I’ve been on antibiotics for over a year through IV and oral. I was dying from an infection in 2018 and it went dormant. We found it a little over a year ago and I might be on them for the rest of my life if the surgeries and treatments don’t work.
Is it tb? What type of infection praying for you
Such bacterias are weak compared to normal ones, that's why they mostly encountered in hospitals. In the wild non-resistant bacterias are stronger and replace the resistant ones with time
7:43 Ohhhh, it's like selective breeding. This part cleared up some confusion for me.