I just finished my Biophysics BS and I am studying for MCAT. I find your Videos very simple yet complete and helpful with all the necessary details! I appreciate your work!
My teacher didn't explain that much in class and I was struggling to understand but after watching this video,I got everything. Thank you very much Miss🙏🙏🙏
So dna dependent dna polymerase catalyse polymerisation only in one direction that is 5'to 3' .So one template strand or parental strand with the polarity 3'to 5' end the replication will be continuous while on the other template or parental strand with polarity 5'to 3' end the replication starts and the newly synthesized strand will be discontinuous so it will be like fragments so the dna ligase later will join the discontinuous strand.
How do you know when the question is asking about this, as opposed to transcription and translation in an exam question? Will it always explicitly say?
On a mark scheme where it asks how the separation of the 2 strands occurs it says condensation reaction between phosphate and deoxyribose catalysed by DNA polymerase, but here you've said that dna helicase breaks the hydrogen bonds in order to separate the strands so I'm confused
Hello mam u r amazing and your videos are very very amazing thanks for helping us . Mam can u please make videos on mathematical requirements of aqa as level biology
Hi Ayesha , Glad they are helping you. Here is my maths playlist so far. ruclips.net/p/PLOfYYgIrtVMgVDUYVjwoBKiN1PkInY9hL Let me know any maths skills not on there you would like.
Do you mean the Meselson & Stahl experiment? If so, the spec says.... Students should be able to evaluate the work of scientists in validating the Watson-Crick model of DNA replication. So yes, its on the spec here
Hey, im sorry if your next video answers my question, i haven't finished making my notes on this video so i've not moved onto the next video yet (last video of topic 1). But anyways, back when i was last learning this topic i remember coming across things such as 3 prime and 5 prime and leading and lagging strands, RNA primer, ligase, okazaki fragments. Do your videos cover everything we need to know or is it advised to use the text book on top of watching your videos? in other words if i watched every video+ playlist from topic 1 - topic 8, should everything in the exam be familiar to me or is there content/info which you skip for the purpose of making these videos shorter and more brief / for the purpose of not wanting to go into too much detail? Essentially what i mean to say is can i be ready to move on to past papers after having watched each and every one of your videos or will there still be gaps in my knowledge and things in the exam which may look alien to me? Thank you, sorry if i seem doubtful its just the fact that i've never come across anyone who's made DNA replication this simple to understand and now im wondering if its overly simplified and if i'm missing any key steps / knowledge! (also i don't want to sound lazy, im willing to go through other resources but im just hoping that your perfect videos are enough to cover all the content and then i can move onto practice papers opposed to going through a 700 page text book) and thank you for another great video :)
Hello, All the videos are the level of detail required for AQA A-level. I follow the specification closely when making them, plus having taught AQA for 10 years I know the exams and mark schemes. Tee details you mention about DNA replication were on the old specification and help to give a better picture, which is why they are often also in textbooks or teachers give this detail. You do not need this for AQA and if it did come up in an exam question it would be an application question which they would have to give you details on it. I hope that helps :D
@@MissEstruchBiology yeah that definitely helps 👌🏼 so if I was to learn the old spec details which could come up in the application questions, would that extra old spec knowledge help with the application questions and help make them easier to answer? Or would it just be better to do practise questions on this topic and learn from the mark scheme ? :D sorry hope this makes sense
It would help with the essay as it's going beyond the specification. For application questions the key is being fully confident on you knowledge and then lots of practise.
Remember be careful with anything electric as they could be harmful and or lethal to you and or other people and or start a fire along with causing other things. Remember be careful and stay safe.
I just finished my Biophysics BS and I am studying for MCAT. I find your Videos very simple yet complete and helpful with all the necessary details! I appreciate your work!
You're welcome 😊 So pleased they help you
My teacher didn't explain that much in class and I was struggling to understand but after watching this video,I got everything. Thank you very much Miss🙏🙏🙏
yay glad it helped
Miss Estruch you are a literal blessing on earth god bless you
So pleased my videos are helping
Can I just say I have never seen a teacher make it so simple to understand, thank you so much you have helped me so much.
aw thanks and I am so pleased it helped 😊
Hey what does the DNA polymerase bind to is it the 5’ or 3’ because some markschemes say it’s specific to 5’ others say 3’ I’m so confused 😭😭plz help
Did you ever find the answer to this?
@@l0v3ka no I realize that in the markschemes they always give the application questions from which u deduce which side it is
So dna dependent dna polymerase catalyse polymerisation only in one direction that is 5'to 3' .So one template strand or parental strand with the polarity 3'to 5' end the replication will be continuous while on the other template or parental strand with polarity 5'to 3' end the replication starts and the newly synthesized strand will be discontinuous so it will be like fragments so the dna ligase later will join the discontinuous strand.
I know this is late but the new strand is synthesized at the 5’ to 3’ direction with polymerase.
@@Hiii-w8v yeah lol I’ve done bio 🤣🤣
Thank you so much for the video, I’m doing home school for now and using google meet is absolute pain
You're welcome, hope the channel helps you 😊
I have a test tomorrow thank you so much ❤
How do you know when the question is asking about this, as opposed to transcription and translation in an exam question? Will it always explicitly say?
Thank you @Miss Estruch . The question is that, is this enough for A-level or detailed mechanism should be studied.
Hello,
Yes, this is based completely on the AQA specification guidelines.
yo I'm from India !!! This was such a a great help!!thankss
Hello! So pleased it was helpful 😊
@@MissEstruchBiology is there any video of you explaining lac operon?
Hi, I was just wondering is the phosphodiester bond mentioned in step 3 the same as a phosphodiester backbone?
The sugarphosphate backbone is the sugars (deoxyribose) and phosphates joined by the phosphodiester bonds.😊
hi miss , are u sure that we don't need to know about cistron, locus and alleles ? because on my A level book they mentioned about those
hello,
You do need to know locus and alleles. These are in another video.
On a mark scheme where it asks how the separation of the 2 strands occurs it says condensation reaction between phosphate and deoxyribose catalysed by DNA polymerase, but here you've said that dna helicase breaks the hydrogen bonds in order to separate the strands so I'm confused
what paper is this?
Hello mam u r amazing and your videos are very very amazing thanks for helping us . Mam can u please make videos on mathematical requirements of aqa as level biology
Hi Ayesha ,
Glad they are helping you.
Here is my maths playlist so far.
ruclips.net/p/PLOfYYgIrtVMgVDUYVjwoBKiN1PkInY9hL
Let me know any maths skills not on there you would like.
do we need to know the evidence for semi conservative replication for aqa spec. We were taught it in school but not in the spec.
Do you mean the Meselson & Stahl experiment?
If so, the spec says....
Students should be able to evaluate the work of scientists in validating the Watson-Crick model of DNA replication.
So yes, its on the spec here
@@MissEstruchBiology Yes that's what I mean do you have a video on that ? Thank you
@@evangelinroby3333 Hello,
Yes, here you go
ruclips.net/video/cY91hqbtzco/видео.html
I hope it helps :)
@@MissEstruchBiology Thankyou, your videos are so helpful I watch them for every topic
i have a homework question on the difference between conservative and semi conservative replication ?
Conservative theory suggests that when DNA replicates the two parental strands join back together and the two new daughter DNA strands join together.
@@MissEstruchBiology absolute life saver !!!! thankyou
Hey, im sorry if your next video answers my question, i haven't finished making my notes on this video so i've not moved onto the next video yet (last video of topic 1). But anyways, back when i was last learning this topic i remember coming across things such as 3 prime and 5 prime and leading and lagging strands, RNA primer, ligase, okazaki fragments.
Do your videos cover everything we need to know or is it advised to use the text book on top of watching your videos?
in other words if i watched every video+ playlist from topic 1 - topic 8, should everything in the exam be familiar to me or is there content/info which you skip for the purpose of making these videos shorter and more brief / for the purpose of not wanting to go into too much detail?
Essentially what i mean to say is can i be ready to move on to past papers after having watched each and every one of your videos or will there still be gaps in my knowledge and things in the exam which may look alien to me? Thank you, sorry if i seem doubtful its just the fact that i've never come across anyone who's made DNA replication this simple to understand and now im wondering if its overly simplified and if i'm missing any key steps / knowledge! (also i don't want to sound lazy, im willing to go through other resources but im just hoping that your perfect videos are enough to cover all the content and then i can move onto practice papers opposed to going through a 700 page text book)
and thank you for another great video :)
Hello,
All the videos are the level of detail required for AQA A-level. I follow the specification closely when making them, plus having taught AQA for 10 years I know the exams and mark schemes.
Tee details you mention about DNA replication were on the old specification and help to give a better picture, which is why they are often also in textbooks or teachers give this detail. You do not need this for AQA and if it did come up in an exam question it would be an application question which they would have to give you details on it.
I hope that helps :D
@@MissEstruchBiology yeah that definitely helps 👌🏼 so if I was to learn the old spec details which could come up in the application questions, would that extra old spec knowledge help with the application questions and help make them easier to answer?
Or would it just be better to do practise questions on this topic and learn from the mark scheme ? :D sorry hope this makes sense
It would help with the essay as it's going beyond the specification. For application questions the key is being fully confident on you knowledge and then lots of practise.
THANK YOU. your videos are extremely useful. I have one question about DNA polymerase, does it act in the 5' to 3' direction or the other way round?
Hello,
You're welcome 😊 Glad you like them.
Yes, It's 5' to 3' direction. If you are studying A levels you don't need to know this for AQA though.
@@MissEstruchBiology Is this still the case? My teacher taught us about 5' and 3', even though we are AQA
Thank for videos❤️
You are very welcome. Glad you like them!
Thanks very much
thank you
Thank you so much :)
you're welcome 😊
I have a test on Friday. Thank you❤😭
Good luck!!!
@@MissEstruchBiology omg you replied 🤭
Thankssssss
You're welcome :) I hope it helped you!
😍😍😙😙😙 I love you miss
Thank you!!!
what about ligase?????
you don't need to know that for AQA
ur missing a few key details like 5'3' or 3'5' direction and ligase
Hello
These aren't needed for AQA A level for DNA replication
@@MissEstruchBiology ah ok
cheers
Remember be careful with anything electric as they could be harmful and or lethal to you and or other people and or start a fire along with causing other things.
Remember be careful and stay safe.
Don't one of the parental strands act as a template?
In DNA replication, both strands act as a template.
In transcription in protein synthesis, only one of the parental strands acts as a template