I’ve been using topical finasteride 0.1 with 10% minoxidil, took a while for it to work. Around 2 years, but I’m finally starting to see progress. This was with derma stamping too
If you have the hair that you do I strongly recommend seeing how low you can reduce the dose and frequency and be happy. Especially since you indicated that you had side effects with oral finasteride. Side effects can sneak up on you especially as you get older and you might think it's just normal with part of aging but perhaps a portion of it is due to taking mote medication than needed
You also did take oral Minoxidil parallel to topical Dut, so you can't contribute the good results (increase in thickness of your hair) solely to topical Dut because you can't separate the effects.
Good question. Going off labels at least, both Finasteride and Dutasteride list persistent ED as a potential side effect on their official pamphlets. That much is 100% confirmed. My speculation: since they are both functionally the same drug. Pfs should be just as likely with dutasteride. Unless there's something in Finasterides metabolites that causes the problem. Or more. I got a few more theories I hope to see tested over time, lol.
I just got a hair transplant about 6 months ago but I never used finasteride or minoxidil because of not risking the side effects. But I wanted to give it a try and use their xyon Topical Finasteride and Minoxidil. Any thoughts on that product?
there is 1 thing that confuses me.. some of the drug will likely go systemic and the half life is incredibly long, you'd likely end up getting about the same serum DHT suppression as fin no matter how much you use it per week right? This is why we need more studies. I'm looking for an alternative to fin since i got mild sides from it, but they're reduced to almost nothing micro dosing topical. It still seems to be effective for my situation but an alternative with less sides would be ideal.
@@HairTransplantNetworkI get my Dutasteride through HAPPY HEAD for about $60/MO here in the states. I take .5mg daily. I was thinking about topical Dutasteride, BUT wondering if it would do me any good since I’m on the oral version. I figured the topical would maybe target the SCALP DHT a bit more? There’s serum DHT and scalp DHT. Idk lol.
What is the the correct dosage you use when using 2 pomp’s daily? And please let us now you’re serum dht I think lot of people would like to now if it go systematic.
The 500 dalton rule is hardly a rule. Here’s a good article. It depends on other factors. The vehicle also makes a big difference in penetration. The dalton rule says that under 500 allows for deep penetration. The dermal papillae is located at the upper most layer of the dermis. Which is in the middle, right below the epidermis (top of skin). That means that Dutasteride doesn’t need to penetrate systemically to reach the hair follicle androgen receptors and sebaceous glands. I would argue that this makes dutasteride superior over finasteride. It can reach the targeted area with minimal systemic absorption. But regardless, it does penetrate. It has a 528 dalton size, which means is just over the threshold. Topicals under 600 dalton penetrate. Furthermore, the drugs delivery system plays a big role. Lipid-based nanotechnology like siloxysystem increases the absorption into the dermis. Read this: skinactives.com/blog/understanding-skin-absorption-and-molecular-size/
Hi Melvin great, informative and objective video as always. This is just my personal opinion but it wouldn't be worth the effort for me. You can clearly see an improvement but I don't think it's so breathtaking that it would be worth it, especially when you consider the price and the possible side effects that could still occur years later even if you didn't have any to begin with.
That’s fair, I think it’s a good alternative for those who cant take oral medication. But if you can tolerate oral then definitely stick with that, doing nothing is never a bad choice either. But I wouldn’t suggest getting a hair transplant without medication.
@@HairTransplantNetwork Unfortunately, this ship has sailed for me. I can't tolerate DHT blockers and the topical stuff can only be obtained in my country via extreme detours that are also not legal. I already had my HT with 3000 grafts and my doctor says I can have another 3000 without any problems. I just have to hope that it won't get much worse for me, luckily I'm already 35 and "only" a Norwood 3. I also went to a doctor who is highly recommended on the Hair Restoration Network and she never said anyting about medication. So i hope for the best.
Melvin I recently had my 3rd prp with dutasterside mesotherapy and I notice a big improvement in my hair what are yur thoughts on dutasterside mesotherapy ?
@@michaels999 hey what’s up man ya so I had this done at HMR in TJ Mexico it’s legit and works they do the prp with dutasterside both are injections into the scalp and my hair changed dramatically I’m going back in October u definitely should do it
Hi Melvin, what do you think of using topical dutasteride while your partner is pregnant and then any ongoing risk of inadvertent exposure to the child later? Thanks.
Thanks Melvin, just means being off a DHT blocker treatment for a long time obviously. I guess I'll just have to rely on minoxodil during that time but makes sense to play it safe.
@@HairTransplantNetworkYou would get off of dutasteride during all the duration of the pregnancy right? But how long would you already stop the treatment before conceiving ?
Hey. I was taking topical Dutasteride with my wife's 2 pregnancies and there was no negative impact. We were just cautious and I would apply in the morning and have a shower before bed.@@Poupipoupi-bw2bl
When I first tried finasteride years ago I got side effects. I again started taking it half a year ago and it caused no side effects this time around. I think psychology can play a role. Especially when you're trying a non-FDA approved product like this with high concentrations of Dutasteride, instead of relying on side effects it would have been more prudent to get bloodwork done to measure DHT levels in the body pre and post starting the regimen.
I agree finasteride side effects can be nocebo. In my case, the only reason I discovered it was finasteride was because I went to a doctor because I had no idea what was going on with me. He asked if I was taking meds and I told him fin. This was back in 07. I didn’t even research the sides of the drug I just took it. So definitely wasn’t nocebo.
@@HairTransplantNetworkI know what you mean Melvin. But if finasteride gave you side effects why do you take dutasteride which is more potent that finasteride ? Plus, you were Norwood 6 before your HT journey so it's really worth using a product that is much powerful than fin ?
@@HairTransplantNetworkIt's difficult to get Minoxidil in Europe? Who told you that? It's easier than getting fresh bread here in Spain, and I think most countries in Europe sell it in Pharmacies.
Same in italy is about 5 euros oral and 50 topical, avodart is 20 euros lol off label costs almost nothing… soon they will cost more because more people will be asking for it
Yes, I tested my levels at the beginning. I haven’t retested them. I will though for sure. @alejandro, I put the link of the thread on the forum where patients have tested their DHT levels.
@@HairTransplantNetwork it would be extremely important to check your DHT levels as it would allow us to see if in 6 months of treatment with topical Dutasteride your DHT levels have gone down, and to what extent.
@@HairTransplantNetworkIt's a great improvement, ignore him. I'm just starting on a combination of DUT once a week with DUT mesotherapy every two months. Also taking 0,5 oral Minoxidil along with topical, so hoping for some decent results!
My actual concerns are having the medicine being on the scalp all day and potentially cross contaminating onto my daughter and wife however i would just use it the days I work and in the am and take a shower when i get home. But with that said i do come into contact with people at work
@@DEBO5 pretty bold statement saying it would have zero effect when they warn people that females shouldn't handle dutasteride pills. You know that topical solutions also have a higher concentration of the medicine than oral pills too.
@@Chanmantroop10 we're on two different wavelengths. I don't expect to out dad someone when Im not a dad myself lol. I understand your worry but you having dutasteride on your hair wouldnt pass to your wife and kids unless they rubbed your head and then sucked on their fingers.
@@DEBO5 yes and you clearly don't have kids as when you're playing with them their hands are all over you and in your hair. Piggy back rides. Them seated on your shoulders with their hands on your head etc. As for the wife sharing the same bed as you, having the topical rub into the pillow case and bed sheets is pretty much guaranteed. Then you're wife's face getting onto the contaminated sheets etc. The topical xyon dutasteride leaflet actual warns about this and tells you to apply it in the morning and not at night
Discount code is HRN
Looking great Mel and your openness is to be really applauded..
🙏
Looks awesome. You can definitely see a difference in your hair thickness. Thanks for sharing your results.
Thank you
*It's expensive...130 a month?...wow!*
Can you do microneedling and then apply the product you use like the dutasteride
I’ve been using topical finasteride 0.1 with 10% minoxidil, took a while for it to work. Around 2 years, but I’m finally starting to see progress. This was with derma stamping too
Did it restored your hair or it stopped hair fall? And within these two years, did it stopped your hair loss in the begging or it took some time
How can I mixed my oral avodart to liquid minoxidil.
If you have the hair that you do I strongly recommend seeing how low you can reduce the dose and frequency and be happy. Especially since you indicated that you had side effects with oral finasteride. Side effects can sneak up on you especially as you get older and you might think it's just normal with part of aging but perhaps a portion of it is due to taking mote medication than needed
So far things have been good in that department. If I experience some sides I will def lower the frequency.
You also did take oral Minoxidil parallel to topical Dut, so you can't contribute the good results (increase in thickness of your hair) solely to topical Dut because you can't separate the effects.
I did not. I used oral minoxidil 6 months prior to taking topical dutasteride.
@@HairTransplantNetwork But minox can take time to work oral or topical so he is correcto.
Can i mix crushed dutas tablet into minoxidil solution will it effective?
No
Is there such thing as post dutasteride syndrome? Weird that there is so much talk about Fin but not muchfor Dut
Good question. Going off labels at least, both Finasteride and Dutasteride list persistent ED as a potential side effect on their official pamphlets. That much is 100% confirmed.
My speculation: since they are both functionally the same drug. Pfs should be just as likely with dutasteride. Unless there's something in Finasterides metabolites that causes the problem. Or more. I got a few more theories I hope to see tested over time, lol.
Hey Melvin, Is there any update
on Hair cloning by Dr Farjo???
I can reach out to him, although there hasn’t been any updates
Can you use topical minoxidil in addition to the topical dut?
Yes you can
I just got a hair transplant about 6 months ago but I never used finasteride or minoxidil because of not risking the side effects. But I wanted to give it a try and use their xyon Topical Finasteride and Minoxidil. Any thoughts on that product?
there is 1 thing that confuses me.. some of the drug will likely go systemic and the half life is incredibly long, you'd likely end up getting about the same serum DHT suppression as fin no matter how much you use it per week right? This is why we need more studies. I'm looking for an alternative to fin since i got mild sides from it, but they're reduced to almost nothing micro dosing topical. It still seems to be effective for my situation but an alternative with less sides would be ideal.
Medical wellness center will prescribe Avodart(dutasteride) online, and send it to any pharmacy you want. Really cheap too
I believe there was an increase in the US, how much do you pay? Are you in the US?
@@HairTransplantNetworkI get my Dutasteride through HAPPY HEAD for about $60/MO here in the states. I take .5mg daily. I was thinking about topical Dutasteride, BUT wondering if it would do me any good since I’m on the oral version. I figured the topical would maybe target the SCALP DHT a bit more? There’s serum DHT and scalp DHT. Idk lol.
What is the the correct dosage you use when using 2 pomp’s daily? And please let us now you’re serum dht I think lot of people would like to now if it go systematic.
I have has some great results using this products s well with no side effects!
That’s great 🙏
Norwood 4 reversal possible with topical duta ?
Did u felt side effect with topical duta?
Depends if you’re a hyper responder
How much do you apply?
Two pumps
How much
Im skeptical of topical dutasteride based on the 500 dalton rule… feel like most of it cant penetrate the skin
The 500 dalton rule is hardly a rule. Here’s a good article. It depends on other factors. The vehicle also makes a big difference in penetration. The dalton rule says that under 500 allows for deep penetration. The dermal papillae is located at the upper most layer of the dermis. Which is in the middle, right below the epidermis (top of skin).
That means that Dutasteride doesn’t need to penetrate systemically to reach the hair follicle androgen receptors and sebaceous glands. I would argue that this makes dutasteride superior over finasteride. It can reach the targeted area with minimal systemic absorption.
But regardless, it does penetrate. It has a 528 dalton size, which means is just over the threshold. Topicals under 600 dalton penetrate.
Furthermore, the drugs delivery system plays a big role. Lipid-based nanotechnology like siloxysystem increases the absorption into the dermis.
Read this:
skinactives.com/blog/understanding-skin-absorption-and-molecular-size/
Hi Melvin. What is the best and safest dosage for topical dutasteride ?
It depends on the topical.
@@HairTransplantNetworkwhy is everyone saying topical dutastride can't be absorbed? Everyone is saying that on Reddit
@@kerry2921 That's not true. There are guys who have posted there DHT levels on HRN and it does absorb. Just at a lower rate.
@@HairTransplantNetworkwhat is hrn?
@@kerry2921
Hair Restoration Network
The Result looks almost perfekt , very nice.
Thank you
Is there anyway we can connect with you for more info ?
Sure, email me service@hairtransplantnetwork.com
Bro haw can i get sublingual menoxdil
You probably need to get it compounded at a pharmacy
Hi Melvin great, informative and objective video as always.
This is just my personal opinion but it wouldn't be worth the effort for me.
You can clearly see an improvement but I don't think it's so breathtaking that it would be worth it, especially when you consider the price and the possible side effects that could still occur years later even if you didn't have any to begin with.
That’s fair, I think it’s a good alternative for those who cant take oral medication. But if you can tolerate oral then definitely stick with that, doing nothing is never a bad choice either. But I wouldn’t suggest getting a hair transplant without medication.
@@HairTransplantNetwork Unfortunately, this ship has sailed for me. I can't tolerate DHT blockers and the topical stuff can only be obtained in my country via extreme detours that are also not legal.
I already had my HT with 3000 grafts and my doctor says I can have another 3000 without any problems.
I just have to hope that it won't get much worse for me, luckily I'm already 35 and "only" a Norwood 3.
I also went to a doctor who is highly recommended on the Hair Restoration Network and she never said anyting about medication.
So i hope for the best.
Anyway to work around the expensive topical versions? :x
Oral version is usually cheaper
yeah but the absorption and side effects are potentially about x100 more likely to happen isn't it ?@@HairTransplantNetwork
Bro you gotta weigh whats more important money, your hair, or your sex life
Do you know when they planning on selling in EU?
Hopefully soon
Melvin I recently had my 3rd prp with dutasterside mesotherapy and I notice a big improvement in my hair what are yur thoughts on dutasterside mesotherapy ?
I’ve seen enough evidence to see it works
Where did you get this done? I’ve heard very good things about it much better than just Prp alone
@@michaels999 hey what’s up man ya so I had this done at HMR in TJ Mexico it’s legit and works they do the prp with dutasterside both are injections into the scalp and my hair changed dramatically I’m going back in October u definitely should do it
Hi Melvin, what do you think of using topical dutasteride while your partner is pregnant and then any ongoing risk of inadvertent exposure to the child later? Thanks.
I would not recommend it. I would get off of topical dutasteride until the birth.
Thanks Melvin, just means being off a DHT blocker treatment for a long time obviously. I guess I'll just have to rely on minoxodil during that time but makes sense to play it safe.
@@HairTransplantNetworkYou would get off of dutasteride during all the duration of the pregnancy right? But how long would you already stop the treatment before conceiving ?
Hey. I was taking topical Dutasteride with my wife's 2 pregnancies and there was no negative impact. We were just cautious and I would apply in the morning and have a shower before bed.@@Poupipoupi-bw2bl
What about libido?
My libido is fine
@@HairTransplantNetwork why dermatologist not prescribing often
I m in stage 4 norwood does topical redensyl saw palmetto work?
Day and night difference Melvin. So happy for you re: the results and equally important no side effects! 👌 Thanks for sharing! 🙏
Thanks Adrian 🙏
When I first tried finasteride years ago I got side effects. I again started taking it half a year ago and it caused no side effects this time around. I think psychology can play a role.
Especially when you're trying a non-FDA approved product like this with high concentrations of Dutasteride, instead of relying on side effects it would have been more prudent to get bloodwork done to measure DHT levels in the body pre and post starting the regimen.
I agree finasteride side effects can be nocebo. In my case, the only reason I discovered it was finasteride was because I went to a doctor because I had no idea what was going on with me. He asked if I was taking meds and I told him fin. This was back in 07. I didn’t even research the sides of the drug I just took it. So definitely wasn’t nocebo.
@@HairTransplantNetworkI know what you mean Melvin. But if finasteride gave you side effects why do you take dutasteride which is more potent that finasteride ? Plus, you were Norwood 6 before your HT journey so it's really worth using a product that is much powerful than fin ?
What kind of side effects did he notice mel?
Results at 4:17
I live in Europe. 22 euros for 3 month supply of Avodart. They are gouging you americans.
Indeed, it’s a trade off though. We pay nothing for minoxidil and it’s difficult to get in Europe. $800 per month is absurd for Avodart.
@@HairTransplantNetworkIt's difficult to get Minoxidil in Europe? Who told you that? It's easier than getting fresh bread here in Spain, and I think most countries in Europe sell it in Pharmacies.
Same in italy is about 5 euros oral and 50 topical, avodart is 20 euros lol off label costs almost nothing… soon they will cost more because more people will be asking for it
Hello Melvin. Have you tested your DHT levels throughout your treatment with topical Dutasteride ??
No he didn't. None of these guys who promote topicals from companies like Xyon ever ever do bloodwork before and after for whatever reason
Yes, I tested my levels at the beginning. I haven’t retested them. I will though for sure.
@alejandro, I put the link of the thread on the forum where patients have tested their DHT levels.
@@HairTransplantNetwork it would be extremely important to check your DHT levels as it would allow us to see if in 6 months of treatment with topical Dutasteride your DHT levels have gone down, and to what extent.
So your dht levels actually went down? I don't see that link you're talking about
Where i can buy It?
Haw can i get ?
Link in description
www.xyonhealth.com/hrn/?
not a big difference at all
That’s fair.
No, we can see the difference bro
Stop being jealous 😂 huge improvement
#Rocky You crazy as hell. Watch the video again. It didnt completely restore the hair in the center area, but it did thicken the hair around the area.
@@HairTransplantNetworkIt's a great improvement, ignore him. I'm just starting on a combination of DUT once a week with DUT mesotherapy every two months. Also taking 0,5 oral Minoxidil along with topical, so hoping for some decent results!
My actual concerns are having the medicine being on the scalp all day and potentially cross contaminating onto my daughter and wife however i would just use it the days I work and in the am and take a shower when i get home. But with that said i do come into contact with people at work
It’s not that serious that would be such a negligible amount that you would potentially be passing on it would have 0 effect on your family.
@@DEBO5 pretty bold statement saying it would have zero effect when they warn people that females shouldn't handle dutasteride pills. You know that topical solutions also have a higher concentration of the medicine than oral pills too.
@@Chanmantroop10 we're on two different wavelengths. I don't expect to out dad someone when Im not a dad myself lol. I understand your worry but you having dutasteride on your hair wouldnt pass to your wife and kids unless they rubbed your head and then sucked on their fingers.
@@DEBO5 yes and you clearly don't have kids as when you're playing with them their hands are all over you and in your hair. Piggy back rides. Them seated on your shoulders with their hands on your head etc.
As for the wife sharing the same bed as you, having the topical rub into the pillow case and bed sheets is pretty much guaranteed. Then you're wife's face getting onto the contaminated sheets etc. The topical xyon dutasteride leaflet actual warns about this and tells you to apply it in the morning and not at night
What dose is safe and effective to use dutastride??
0.5mg every other day try and see if u get any sides if not try every day 0.5mg
Dosage needs to be titrated to effects and side effects