Transposons | Structure and Evolution | Part 2 | Pnkj Verma Sir

#Biomania
#PnkjVerma
#TransposonsStructureAndEvolution
Prions are misfolded proteins with the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals.[3] It is not known what causes the normal protein to misfold, but the abnormal three-dimensional structure is suspected of conferring infectious properties, collapsing nearby protein molecules into the same shape. The word prion derives from "proteinaceous infectious particle".[4][5][6] The hypothesized role of a protein as an infectious agent stands in contrast to all other known infectious agents such as viruses, bacteria, fungiand parasites, all of which contain nucleic acids(DNA, RNA or both).
Recently it has been proposed that the emergence of the prion protein founder gene was based on two genomic rearrangements that occurred hundreds of millions of years ago [31]. The first event occurred within the N-terminal ectodomain of a ZIP predecessor gene, when metazoans first emerged on the planet. As a consequence of this rearrangement a cysteine-flanked core (CFC) region was generated within this ectodomain. The second event, which allowed the creation of the prion protein founder gene to be traced back, occurred approximately a half-billion years ago (around the Cambrian explosion). This later event resulted in the apparent genomic retro-insertion of a spliced and C-terminally truncated ZIP gene transcript, indicating that the prion protein founder gene is equivalent to a retrogene [32].
An earlier investigation using a quantitative interactome analysis identified ZIP6 and ZIP10 as potential molecular interactors of PrP at the cell surface, revealing that the known prion proteins are structurally related to an extracellular domain of ZIP6 and ZIP10 [33]. Similarly, other authors using interactome analyses have identified multiple interactions between PrPC and other molecules, like the neural cell adhesion molecule (NCAM) [34], the laminin receptor precursor [35], Na/K ATPases [36] and protein disulfide isomerases (PDI) [37]. Together, these findings suggest that PrPC organizes its molecular environment by binding adhesion molecules, which in turn recognize oligomannose-bearing membrane proteins.

[@sanyat6792]

Thank you sir for such a simple and clear explanation😁

[@twinkle1548]

Wow sir may god will fullfill all your wishes💓💓👍👍👍😊😊👏👏

[@dhyanbhavsar-dn8yb]

Thanks a lot ...... amazing explanation.....keep it up ......🤝🏻

[@anjalisharma8918]

thanku sir for explaining in such a beautiful manner

[@Masooda_zafarullah]

Masha Allah.....bhut simple or bhut shaandar explanation tha ....mujhe to aapka video dekh hi SB yaad ho gyaaa .....tqqq so much

[@loveislife4978]

Thank you so much sir. Aaj hamara seminar presentation tha. Aur me ekdum se last moment me hi aapka video dekhke gayi thi. Aur hamare lecturer bhi Transposon evolution se hi questions puche the aur meine answer de diii. And I'm so happy now . Thank you so much sir

[@BiomaniaBiologyClasses]

Bless u beta

[@jyotigupta5754]

Very well explained sir I have watched both the parts and the concept of transposons is clear to me now
Sir one more request
Can you please make a video on replication in retroviruses
Sir it would be of great help
Thank you sir 💞

[@BiomaniaBiologyClasses]

i will try to cover it soon,,,but now i started immunology,,,so after completing this,,,then only I can upload yor video

[@iasparidhikumawat1929]

Thank u so much 💞 sir 💞💞💞💞💞✨💫✨💫🌍✨☺️☺️☺️☺️☺️ you are best ❣️✌️✌️✌️✌️✌️✌️✌️✌️✌️✌️

[@takini4918]

Best video 💯

[@burhanmuslim4223]

Well explained sir 👌👍

[@sekhar53]

Super explanation sir

[@divyanshitiwari4906]

Thanku so much

[@DannyDr3111]

🥰👌

[@lovelysharma3753]

Thank you so much

[@misbahhussain1021]

Vary 9c explanation sir

[@user-wg3ym5pg7c]

Finally 💯 after spending so many hours ..... finally this video helped me alot bacterial transposons🥲💯

[@smitaupadhyay6549]

Thnku so much... Such a great explanation... ❤

[@BiomaniaBiologyClasses]

wlcm Smita

[@jubinnautiyal808]

Thank you

[@mariagillani6016]

Amazing explanation

[@ShahzamanEntertainment]

❤

[@nextgeneration7925]

😃👌👏

[@nehajaiswal5684]

🙏🙏 thank you so much sir 🤗🤗🙏

[@PoojaMohan-mn5uv]

Tq sir

[@rajeevrao6853]

Nicely explain

[@kusumtanwar]

Such a helpful video.. 😄😄

[@BiomaniaBiologyClasses]

🤗

[@anchalyadav3061]

Thanku sir very well explain

[@Ismailkhan-nz7hk]

Thank u!

[@itsfairy2610]

Thanku sir..best lecture

[@BiomaniaBiologyClasses]

wlcm dear 🤗

[@harekrishnatalukdar9653]

Sir I would like to know what were the functions of transposons ,I mean why do they even existed before and what good they did by functioning before

[@pratimachalise8381]

Thank u soo much sir... 🇳🇵🇳🇵🇳🇵

[@BiomaniaBiologyClasses]

wlcm dear 🤗 Pratima

[@AartiKhatkar]

Thank u sir

[@rajeshwaripadhiyar5398]

Hello sir...plz make videos on restriction modification system

[@ayushipatel5326]

Thank you 😀

[@BiomaniaBiologyClasses]

thnx dear🤗

[@vikas-hc8bu]

😃💓🥰

[@devid2585]

Great lecture sir

[@aafrinparween8823]

Sir gall bladder ke bare btla saktye ho ky

[@rinchathakur4957]

Very nice explanation ! Thank you Sir

[@syedhayat7658]

Why the activity of transposan are cease in last many years ?and what is the specific reason behind this ?

[@BiomaniaBiologyClasses]

Evolution is the major reason,,,we are using only those parts that are required for the present climatic conditions.
And one more thing, Some scientific studies tells us the junk dna is not completely junk but we don't know their exact role in the body

[@adeebturk392]

IS3 is not an example of insertion sequence

[@techybomb8728]

Eukaryotic transposon

[@susmitachoudhary6984]

Sir pg k liye enf h kya ye matter

[@vinodkumar-sy6vw]

Sir inki pdf kaha per milegi

[@sonalipandey1975]

Msc me Itta likhne se marks milega?

[@anujjaiswal9354]

Genetic ke full class net ke liye provide kar de please

[@vinodkumar-sy6vw]

Telegram ki link send kar do na

[@mariagillani6016]

Thanku soo much

[@rajeevrao6853]

Nicely explain

[@BiomaniaBiologyClasses]

Thnx Rajeev🤗