Experiment 20 A: Effect of drugs on BP & Heart Rate

Epi:It stimulates the alpha and beta adrenergic receptors. Conventional doses will increase the BP followed by a short fall before reaching the basal level (biphasic response due to alpha and beta receptor responses). The heart rate decreases due to vagal reflex.
NE: It stimulates mainly the alpha and beta1 receptors. The heart rate is generally reduced due to vagal reflex in response to increased BP.
Iso: It is a potent, non- selective beta adrenergic stimulant. It increases the systolic BP , but decreases the diastolic BP. Because the decrease is more pronounced than the increase, the mean arterial pressure typically falls.
Ach: Acetylcholine (ACh) leads to a sharp a fall in BP which returns to basal level quickly.