What is APoE, and should you get tested?

There are a host of genes that have become somewhat famous in the health optimisation and longevity space of late. One being APOE.
Today, practitioner Mark sheds some light on this gene.
What is APOE? APOE is a gene that instructs how our body metabolises fatty acids. It comes in three variations either: APOE 2 (Farmer phenotype), APOE 3, APOE 4 (Hunter gatherer phenotype) and we all get a combination of two of these, one from each of our parents.
What does APOE actually do? Whilst APOE 2 is beneficial, APOE 3 is neutral and the most common gene. It is APOE 4 that is known for its correlation with an increased risk of developing Alzheimer's disease.
Some research suggests that APOE4 is the strongest risk factor gene for Alzheimer’s disease, although inheriting APOE4 does not mean a person will definitely develop the disease. The reason APOE4 increases Alzheimer’s risk is not well understood, although recent studies suggest that problems with brain cells’ ability to process fatty acids may play a key role in Alzheimer’s and related diseases.
The APOE genes are responsible for how our body manages fatty acids in the body, primarily what it does with saturated, omega 3s and polyunsaturated fatty acids.
If it's in my genes, can I do anything about it?
Yes! Your genes are not your destiny, and can be used to dial up motivation on optimising your blood lipids (aka fatty acids) through lifestyle interventions.
When we know what your APOE status is, we can test and check your current saturated fat, Omega 3 and polyunsaturated fat balance and as needed, support you with dietary and lifestyle interventions as part of your health optimisation strategy.
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