Immunology wars: A billion antibodies
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- Опубликовано: 30 мар 2017
- Our bodies can create billions of antibodies to fight off billions of potential diseases. But how do our immune systems turn a limited number of genes into such an incredible diversity of antibody proteins?
You can find more on this topic at www.nature.com/milestones/anti...
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Channels producing videos like this should get recognized. This should be included in learning materials at schools. Students won't get bored watching this
I am overjealous of 2017 university students, having access to these shining jewels of infoscience!
this makes learning immunology so much easier for visual people
Amazing video! We need more of these types of videos on RUclips.
This channel actually needs more subs. One of the most respected scientific journals should at least. It would help even more considering the amount of brazen ignorance spread on RUclips about science and its recent discoveries. Awesome animations!
This video is priceless, and the animations are so well thought out, I can not thank you enough for this video that explained 300 pages in 3 minutes without missing anything
PLEASE WE NEED MORE MEDICAL VIDEOS
The animation and SFX were so cool I could barely pay attention in the scientific content of the video.
This was such a great job! 😁
Agreed....bright, shiny things get my attention. Good thing there is a stop, rewind, or play again.
Well done, Nature! We used this video in our Anatomy class, so interesting
This human body thing is sooooo damn complicated!
Awesome. props to all involved
Can you pls continue with the art style of like machines that was rly cool
Yes pls
i just found this channel and is now procrastinating on my physics final with biology-related videos..............STEM is beautiful
Oui, je suis d'accord avec vous. ;p
the explanations and animations in this video are amazing! thank you so much!!!
This is pure gold... amazing video guys...it inspires passion
Nice video I enjoyed and learned from it thanks I hope u ll make more videos like this
The most vivid and absolutely magnificent clip!
Damn! That's impressive information and representation. Love It
Now that's what I call a educational video. The best one I've seen in my life
Very entertaining and clear explanation, thanks a lot! :) Could watch it again and again
Love video's like this :)
Omg that was a best video of RUclips, thank you for créate the video. Ily
Amazing as usual Nature!
I would be really amazed to find an understandable video about how our bodies avoid auto immune responses. How they avoid B Cells to produce anti bodies that would bind to proteins typically exposed on the surface of our own cells?...
that was a badass video!
Thank you so much I really enjoyed this video
Great video Nature, please keep making more!
total thumbs up for this video
Thank you for this video. The information was good but I found the sound effects very distracting.
It so nice.. loved it really😍
excellent animation
amazing video!
This video is amazing!!!!!
I have watch an hour LECTURES and couldn't understand what happening until I watched this simple video
*Y* is the animation so good?
Neat!
Amazing!
Amazing ❤️
Love how cool rag enzyme is 😄
The sound is so mind frecing . It's coolll
great theme (theme of game) help to understand easy thank you
this video is so freaking cool
So cool animation... 😎👌👌
Rad vid and qute educative
Fantastic
Oh God, that explain of spontaneous remission in cancer and viral infection
How recombination activated gene (RAG) works as a gene shuffler & how this shuffling helps in formation of billions of different types of antibodies, all are explained! ❤️
Can I assume the autoimmune disease is happening to many people around the world due to RAG messing up, not doing its job properly perhaps? Am so curious ;p
what's that dope ending? anyone?
Niceeeeeeee👍👍👍 cool animation ❤️😎
The Nobel Prize winning discovery the narrator mentioned was in 1987. In 1987, Susumu Tonegawa won the Nobel Prize in Physiology or Medicine for his discovery of the generation of antibody diversity. This of course is what the video talks about.
great
Wow Rag looks cool😎
Barukh Attah ADON YESHUA HAMASHIACH, thank you for making me so wonderfully complex, your workmanship is marvelous ...... !
Mind blowed
The extro music is cool 😎😎😎
How did you calculate the numbers for antibody diversity?
I've read there are about 45 V variants buuut, as this video goes and as i understand it...
you multiply the number of variants to obtain possible combinations for the reorganization. That is, there's only 1 V segment (out of 130), 1 J seg (of 6) and 1 D (of 27) that can be joined, then you have vJ=786 (light chain, although she said 400, so idk) VJD=21060 (or 20K) possibilities. Then, for the H chain and L chain there are (400*20000)= 8000000 possible combinations.
PLUS, V and J have heptamers/nonamers -and the addition of up to 20 bases- that are recombinated, so (7+9+20)*4 bases=144*8M=over 1 billion of different antibodies can be produced
amazeballs
wow! this is so profissional
I wanted to know the name of the scientist who won a nobel prize
My GOD!
so basically our body just makes random sh*t and hopes it works
Can I assume the autoimmune disease is happening to many people around the world due to RAG messing up, not doing its job properly perhaps? Am so curious ;p Can anyone help on this please
The body tends to destroy t cells and b cells that target the body's own cells, sometimes these rogue cells escape persecution and cause havoc.
So we don’t need to swallow any medicine
I'm confused. If your antibodies can be that flexible, how come we still die from diseases?
JeffinBville Targeting microorganisms does not mean we can beat them all As stated in the video, we have the ability to recognize almost all possible antigens (known and unknown) but the immune system is more than only antibodies.
JeffinBville Infact its the other way around. Its a miracle that we can even survive one day. Patients with non functioning immune systems will die within days due to multiple infections. There are many tricky ways for these organisms to avoid the antibodies too. And lastly cause of diseases and death are not only microbes/cancers(yes antibodies kill numerous cancer cells at bud too)....but numerous other reasons. Our population on earth itself is a proof for the efficiency of antibodies!
It all depends on the disease really. There are disease-causing organisms that spread and proliferate so quickly that the immune system doesn't have enough time to react and retaliate. Other diseases are good with "stealth" and then spring outta nowhere and do massive amounts of damage before being fought back, but then it's too late. Then there are those who use our own immune system against us. It's really a game of cat and mouse.
Nab Z amazing 😎
Some diseases have a plan to come in like a wrecking ball, basically. take Ebola' for example, The virus targets the immune system so after the virus wiped out most of the immune system the immune system is so weakened the immune system tries to fire all of their weapons at once. (Note: That is how the internal and external bleeding is caused) so then after that the host dies.
Amazing video, thank you. 🧪
Does that mean that we are immune to every possible disease?
Glory to God. Our bodies are amazing !!!
Thanks nature video on making these gems!!
Studying PreMed Immunology right now!
Gode gedaan
Cool...🤓
I actually preferred the more serious editing style.
This style seems too playful and omits important details.
Great content nevertheless.
Sobhan Allah
Check out Kurzgesagt, they have a much more comprehensive and in-depth video on the immune system.
Кто после Топлеса? Кто такой любознательный источники прошерстил?
👍👍👍👍👍
I’m the only one in school who knows this and other things of immune system
Welp, that's a butt ton of Antibodies.
Yet we get sick by 🤒
What,10000000 antibodies?🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯
👌👌👌👍👍
Being great full to Dr osaye from all time till all time I hope you find what your heart desires just as you have put a smile on many of our faces with just your hands and herbal’s
More grace to you work doctor thanks so much for the medication,it did fight the (Els) and nailed it…
youtube should've delete despacito and promote this video
Rag = rap
🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯
Another sponsored video. This really hurts Nature's reputation- also key points that are easy to conceptually explain were skipped, like how we don't target our own cells, which is very inspiring compared to a 'numbers game' explanation. I guess it's not like the Cell RUclips channel.
Happyfeetr rawfds they can't focus on everything. i thought it was great! and if by sponsored you mean monetised.... literally everyone who can be monetised on RUclips is. free income!
Hi. It might reassure you to know that the sponsor has no input into the content of the animation; Nature is fully responsible for the content.
You are aware that Nature Publishing Group is a private company?
Great Video! (Jesimiel Millar Fernåndez) 1M957