SOREGATT: sequencing regorafenib & trifluridine/tipiracil in pre-treated mCRC

Chiara Cremolini, MD, PhD, University of Pisa, Pisa, Italy, discusses findings from the Phase II PRODIGE 68 - UCGI 38 - SOREGATT trial (NCT04450836) of regorafenib and trifluridine/tipiracil in patients with metastatic colorectal cancer (mCRC), who have progressed on standard therapies. Patients were randomized to receive regorafenib then trifluridine/tipiracil or the other way round. The order of therapy did not affect overall survival and progression-free survival. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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